907a88949b708c93f20392f2e8dfdbd3 266664.pdf 0e6468f2b9818d8f9935b7206a62e5895d46ca10 266664.pdf 8f717d61585e549162ab2478461ac76a880220003095139dbf241c5baa2fd22c 266664.pdf Title: Role of Mesenchymal Stem/Stromal Cells in Coagulation Subject: Mesenchymal stem/stromal cells (MSCs) are widely used in disease models in order to control several phases in the response to injuries, immune reaction, wound healing, and regeneration. MSCs can act upon both the innate and adaptive immune systems and target a broad number of functions, such as the secretion of cytokines, proteolytic enzymes, angiogenic factors, and the regulating of cell proliferation and survival. The role of MSCs in coagulation has been less studied. This review evaluates the properties and main functions of MSCs in coagulation. MSCs can regulate coagulation in a wide range of pathways. MSCs express and release tissue factors (TF), one of the key regulators of the extrinsic coagulation pathways; MSCs can trigger platelet production and contribute to platelet activation. Altogether, MSCs seem to have a pro-thrombotic role and their superior characterization prior to their administration is necessary in order to prevent adverse coagulation events. Keywords: coagulation; mesenchymal stem/stromal cells; platelets; tissue factor; phosphatidylserine; inflammation Author: Raquel Guillamat-Prats Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Thu Sep 8 12:56:56 2022 CEST ModDate: Thu Sep 8 13:00:44 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 659121 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- WREOAR+URWPalladioL-Bold Type 1 Custom yes yes no 10 0 UKOAXU+URWPalladioL-Roma Type 1 Custom yes yes no 15 0 WNTLBK+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 IRWHZX+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 37 0 CKUPDE+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 40 0 QDULQU+EURM10 Type 1 Builtin yes yes no 62 0 GHCIOB+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 76 0 GHCIOD+PalatinoLinotype TrueType WinAnsi yes yes no 79 0 GHCIOF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 82 0 DVCMRV+CMSY10 Type 1 Builtin yes yes no 98 0 OPZDHV+VnURWPalladioL Type 1 Custom yes yes no 105 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-06-21 02:32:31 CEST RepresentationInformation: 266664.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-06-20 12:03:52 CEST Size: 659121 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 333 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Coagulation Factors and Inflammatory Linked Pathways Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Tissue Factor Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Thrombin and PARs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Protein C Thrombomodulin Endothelial Cell Protein C Receptor Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Toll-Like Receptors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Complement System Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Plasminogen System and Fibrinolysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Platelets and Clot Formation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Mesenchymal Stromal Cells (MSCs) Modulate Coagulation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Children: Item: Title: TF-Mediated Pro-Coagulant Activity of the MSCs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Effect of MSCs in Platelet Formation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: MSC Released Soluble Factors Affecting Coagulation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Info: Title: Role of Mesenchymal Stem/Stromal Cells in Coagulation Author: Raquel Guillamat-Prats Subject: Mesenchymal stem/stromal cells (MSCs) are widely used in disease models in order to control several phases in the response to injuries, immune reaction, wound healing, and regeneration. MSCs can act upon both the innate and adaptive immune systems and target a broad number of functions, such as the secretion of cytokines, proteolytic enzymes, angiogenic factors, and the regulating of cell proliferation and survival. The role of MSCs in coagulation has been less studied. This review evaluates the properties and main functions of MSCs in coagulation. MSCs can regulate coagulation in a wide range of pathways. MSCs express and release tissue factors (TF), one of the key regulators of the extrinsic coagulation pathways; MSCs can trigger platelet production and contribute to platelet activation. Altogether, MSCs seem to have a pro-thrombotic role and their superior characterization prior to their administration is necessary in order to prevent adverse coagulation events. 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