8dea4cc8bc477994d655d5170d5a3112 VSC_a2022v9p514.pdf 159cb8885fe13d17539baba2bd9e825464b59f93 VSC_a2022v9p514.pdf 1a12f44a87745d07174c7a7da6d3e0888460290d045479c9689d811b33ed5fba VSC_a2022v9p514.pdf Title: First Case of a Cerebrocortical Ganglioglioma in a Dog Subject: Gangliogliomas are extremely rare tumors of the nervous system composed of neoplastic glial and neuronal cells. The aim of the present paper is to describe the clinical presentation, magnetic resonance imaging (MRI) findings and histopathological and immunophenotypical characteristics of a cerebral cortex ganglioglioma in a 7-year-old Border Collie. The dog presented an acute onset of tonic-clonic epileptic seizures. MRI revealed a well-defined large intra-axial mass located on the left forebrain, mainly affecting the frontal cortex. Following humane euthanasia, the histopathological examination of the mass revealed a diffuse proliferation of neoplastic glial cells mixed with anomalous neuronal bodies. Immunohistochemical analyses confirmed the presence of two different populations of neoplastic cells. Most neoplastic glial cells were immunoreactive to glial fibrillary acidic protein (GFAP) and the other subset of neoplastic cells were positive to neuronal markers such as PGP 9.5, synaptophysin (SYN) and neuron-specific enolase (NSE), suggestive of neuronal cells. These findings confirmed the diagnosis of a cerebrocortical ganglioglioma. To the authors knowledge, this is the first description of a ganglioglioma of the cerebral cortex in a dog. Keywords: tumor; neoplasia; central nervous system; canine; glial fibrillary acidic protein; neuron-specific enolase; synaptophysin; ganglioglioma Author: Laura Martín, Martí Pumarola, Raúl Altuzarra, Javier Espinosa and María Ortega Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Thu Sep 22 03:47:59 2022 CEST ModDate: Thu Sep 22 04:07:06 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 8 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 18587980 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- XEFGQJ+VnURWPalladioL Type 1 Custom yes yes no 10 0 WNNIZQ+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 ZSUGSE+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 VOBSCY+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 LPYGPS+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 CTCXDQ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 46 0 CRUZTT+VnURWPalladioL-Italic Type 1 Custom yes yes no 68 0 BOLMEN+SFRM0900 Type 1 Custom yes yes no 76 0 OVNEXW+EURM10 Type 1 Builtin yes yes no 81 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2022-12-01 02:31:20 CET RepresentationInformation: VSC_a2022v9p514.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2022-11-30 15:26:00 CET Size: 18587980 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 246 FreeObjects: 7 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4923ab24 Item: Title: Case Presentation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Info: Title: First Case of a Cerebrocortical Ganglioglioma in a Dog Author: Laura Martín, Martí Pumarola, Raúl Altuzarra, Javier Espinosa and María Ortega Subject: Gangliogliomas are extremely rare tumors of the nervous system composed of neoplastic glial and neuronal cells. The aim of the present paper is to describe the clinical presentation, magnetic resonance imaging (MRI) findings and histopathological and immunophenotypical characteristics of a cerebral cortex ganglioglioma in a 7-year-old Border Collie. The dog presented an acute onset of tonic-clonic epileptic seizures. MRI revealed a well-defined large intra-axial mass located on the left forebrain, mainly affecting the frontal cortex. Following humane euthanasia, the histopathological examination of the mass revealed a diffuse proliferation of neoplastic glial cells mixed with anomalous neuronal bodies. Immunohistochemical analyses confirmed the presence of two different populations of neoplastic cells. Most neoplastic glial cells were immunoreactive to glial fibrillary acidic protein (GFAP) and the other subset of neoplastic cells were positive to neuronal markers such as PGP 9.5, synaptophysin (SYN) and neuron-specific enolase (NSE), suggestive of neuronal cells. These findings confirmed the diagnosis of a cerebrocortical ganglioglioma. To the authors knowledge, this is the first description of a ganglioglioma of the cerebral cortex in a dog. 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