660f0411029b8afc3d63fd76a7b5df37 ijms-23-15521.pdf 4b68fb2c8de918d1c60f62b46479cb12fcb917ad ijms-23-15521.pdf 251b1dcef23d6cd2a6850575aec7d4fd96a9644920436e3dcb286ab9c3007492 ijms-23-15521.pdf Title: Sensory Involvement in Amyotrophic Lateral Sclerosis Subject: Although amyotrophic lateral sclerosis (ALS) is pre-eminently a motor disease, the existence of non-motor manifestations, including sensory involvement, has been described in the last few years. Although from a clinical perspective, sensory symptoms are overshadowed by their motor manifestations, this does not mean that their pathological significance is not relevant. In this review, we have made an extensive description of the involvement of sensory and autonomic systems described to date in ALS, from clinical, neurophysiological, neuroimaging, neuropathological, functional, and molecular perspectives. Keywords: ALS; small fiber; sensory; autonomic; proprioceptive; somatosensory Author: Miguel A. Rubio, Mireia Herrando-Grabulosa and Xavier Navarro Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Thu Dec 8 07:02:01 2022 CET ModDate: Thu Dec 8 07:09:18 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 32 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2298776 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- EQCUIO+VnURWPalladioL Type 1 Custom yes yes no 10 0 SZZTVB+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 NLLBIM+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 AJJGVR+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 IRWHZX+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 42 0 CKUPDE+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 45 0 PACIAH+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 73 0 PACIAJ+PalatinoLinotype TrueType WinAnsi yes yes no 76 0 PACIAL+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 79 0 PACIAH+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 95 0 PACIAJ+PalatinoLinotype TrueType WinAnsi yes yes no 98 0 PACIAL+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 101 0 EBLVEP+EURM10 Type 1 Builtin yes yes no 114 0 PACIAH+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 124 0 PACIAJ+PalatinoLinotype TrueType WinAnsi yes yes no 127 0 PACIAL+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 130 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-06-27 03:30:48 CEST RepresentationInformation: ijms-23-15521.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-06-23 15:43:59 CEST Size: 2298776 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 1072 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: ALS as a Purely Motor Disease Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Item: Title: Non-Motor and Non-Sensory Alterations in ALS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Involvement of the Somatosensory System in ALS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Somatosensory Cortex Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Spinal Ascending Sensory Pathways Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Dorsal Root Ganglia and Dorsal Roots Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Peripheral Nerve Trunk Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Proprioceptive Afferences Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Small Sensory Nerve Fibers Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Involvement of the Visual System in ALS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Involvement of the Olfactory System in ALS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Involvement of the Gustatory System in ALS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Involvement of the Auditory System in ALS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Involvement of the Autonomic Nervous System in ALS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: Distal Axonopathy in ALS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Info: Title: Sensory Involvement in Amyotrophic Lateral Sclerosis Author: Miguel A. Rubio, Mireia Herrando-Grabulosa and Xavier Navarro Subject: Although amyotrophic lateral sclerosis (ALS) is pre-eminently a motor disease, the existence of non-motor manifestations, including sensory involvement, has been described in the last few years. Although from a clinical perspective, sensory symptoms are overshadowed by their motor manifestations, this does not mean that their pathological significance is not relevant. In this review, we have made an extensive description of the involvement of sensory and autonomic systems described to date in ALS, from clinical, neurophysiological, neuroimaging, neuropathological, functional, and molecular perspectives. 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