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Subject: Acta Diabetologica, https://doi.org/10.1007/s00592-022-02014-7 Keywords: Pancreatic extracts; Organotherapy; Acomatol; Pancreina; Insulin; Patents Author: Alberto de Leiva-Hidalgo Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows) CreationDate: Fri Dec 30 15:28:18 2022 CET ModDate: Fri Dec 30 15:31:07 2022 CET Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 27 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 6724974 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- HMSWDK+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 820 0 MyriadPro-SemiCn Type 1C WinAnsi yes no yes 799 0 MyriadPro-Semibold Type 1C Custom yes no yes 800 0 MyriadPro-SemiboldSemiCn Type 1C Custom yes no yes 809 0 MyriadPro-Bold Type 1C Custom yes no yes 810 0 XPUOTE+STIX-Regular Type 1C Custom yes yes yes 807 0 Springnew-Regular Type 1C WinAnsi yes no yes 827 0 MyriadPro-BoldSemiCn Type 1C Custom yes no yes 361 0 STIX-Italic Type 1C Custom yes no yes 393 0 JKILIA+STIX-Bold Type 1C WinAnsi yes yes yes 501 0 JSVEQD+Wingdings-Regular Type 1C WinAnsi yes yes yes 731 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-01-19 02:29:46 CET RepresentationInformation: s00592-022-02014-7.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-01-11 18:38:20 CET Size: 6724974 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 945 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: On the occasion of the centennial of insulin therapy (1922–2022), II-Organotherapy of diabetes mellitus (1906–1923): Acomato氀⸀ 倀愀渀挀爀攀椀渀愀⸀ 䤀渀猀甀氀椀渀⸩㸾൥湤潢樍㠵㤠〠潢樍㰼⽄⠵㤲弲〲㉟㈰ㄴ彁牴楣汥⹩湤携䅮捨潲‱㨱 Children: Item: Title: Abstract Children: Item: Title: Aims Item: Title: Methods Item: Title: Main results and conclusions Item: Title: Georg Ludwig Zülzer (1870–1949): Acomatol Children: Item: Title: Zülzer's experiences with pancreatic extracts in experimental diabetes Item: Title: Treatment of eight patients with pancreatic extracts Item: Title: Obtaining patents for the pancreatic extract: Acomatol Item: Title: Collaboration between Georg Zülzer and Camille Reuter Item: Title: Georg L. Zülzer claimed his priority right on the discovery of the antidiabetic hormone. Other scientists’ views on Zülzer's a挀琀椀瘀椀琀椀攀猀 愀渀搀ꀀ琀栀攀ꀀ爀攀氀攀瘀愀渀挀攀 漀昀ꀀ䄀挀漀洀愀琀漀氩㸾൥湤潢樍㠸㜠〠潢樍㰼⽄⠵㤲弲〲㉟㈰ㄴ彁牴楣汥⹩湤携䅮捨潲‱ㄺㄱ Item: Title: J.J.R. Macleod publicly acknowledged Zülzer's research on pancreatic extracts Item: Title: Criticisms of Zülzer Item: Title: Ernest L. Scott (1877–1966) Item: Title: John R Murlin (1874–1960) Item: Title: Israel Kleiner (1885–1966) Item: Title: Nicolae C. Paulescu: The discovery of pancreina Children: Item: Title: Paulescu, outstanding endocrine researcher Item: Title: Tecnique and metabolic effects of pancreatectomy Item: Title: Development of the pancreatic extract. Intravenous administration to the experimental animal Item: Title: Pancreina Children: Item: Title: The patent of pancreina (1922) Item: Title: Paulescu’s letters to Frederick Banting and to the President of the Nobel Commission in 1923 Item: Title: International experts publicly expressed their solidarity with the vindication of Paulescu's scientific merits and recognized 栀椀猀 瀀爀椀漀爀椀琀礀 椀渀ꀀ琀栀攀ꀀ搀椀猀挀漀瘀攀爀礀 漀昀ꀀ琀栀攀ꀀ愀渀琀椀搀椀愀戀攀琀椀挀 栀漀爀洀漀渀攀 ㄀㤀㈀㌠ጀ㄀㤀㌀㐀㸾൥湤潢樍㠹㜠〠潢樍㰼⽄⠵㤲弲〲㉟㈰ㄴ彁牴楣汥⹩湤携䅮捨潲′㐺㈴ Item: Title: Paulescu died on July 7, 1931 Item: Title: The discovery of insulin Children: Item: Title: The first pancreatic extract (Banting and Best) Item: Title: Organization of diabetes treatment in the Department of Medicine at Toronto General Hospital, University of Toronto Item: Title: Collip’s extract Item: Title: Announcement of the discovery of insulin on May 3, 1922 Item: Title: Collaboration between the University of Toronto (UT), Connaught Laboratories and Laboratories Eli Lilly & Co. Item: Title: JJR Macleod definitely established that islet tissue is the source of insulin Item: Title: Insulin: Canadian and US patent offices Item: Title: Unit of Insulin: standards (1922–1923) Item: Title: Insulin treatment in the months which followed its discovery (short report) Item: Title: The disclosing of documents explaining the true story of the discovery of insulin Item: Title: Banting, responsible for and organiser of the Anglo-Canadian germ warfare programme (1938–1941) Item: Title: Charles Best reinvented the history of the discovery of insulin (1941–1978) Item: Title: Best’s death (1978) Children: Item: Title: The myth of Banting and Best Children: Item: Title: Concluding remarks Item: Title: Acknowledgements Item: Title: References Info: Title: On the occasion of the centennial of insulin therapy (1922 2022), II-Organotherapy of diabetes mellitus (1906 1923): Acomatol. Pancreina. Insulin. Author: Alberto de Leiva-Hidalgo Subject: Acta Diabetologica, https://doi.org/10.1007/s00592-022-02014-7 Keywords: Pancreatic extracts; Organotherapy; Acomatol; Pancreina; Insulin; Patents Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows) CreationDate: Fri Dec 30 15:58:18 CET 2022 ModDate: Fri Dec 30 16:01:07 CET 2022 ID: 0xac3e038492d82347983b23bcbea27ad5, 0x4087033c780e554681d20fcefc31dfc0 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2032 ImageHeight: 1062 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2032 ImageHeight: 1032 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 945 ImageHeight: 1195 ColorSpace: 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Pancreina. Insulin. 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