77adecc841c57563d53120eb2a1b0c02  270431.pdf
4a91dfa5c02e83fc1a2ba9f50e36d7bb5d1bcdb0  270431.pdf
5bc9839a3d89f24a3c838434f3e0d0d672ad76e03eb379310bb0b6e2bd0d9db1  270431.pdf

Title:          Overlapping biosimilar and originator follitropin alfa preparations: How much closer can they get?
Subject:        Drug Discovery Today, 27 (2022) 2071-2075. doi:10.1016/j.drudis.2022.04.022
Author:         Fernando de Mora
Creator:        Elsevier
Producer:       Acrobat Distiller 8.0.0 (Windows)
CreationDate:   Wed Jul 20 13:20:15 2022 CEST
ModDate:        Wed Jul 20 13:21:02 2022 CEST
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          5
Encrypted:      no
Page size:      629.291 x 810.709 pts
Page rot:       0
File size:      261761 bytes
Optimized:      yes
PDF version:    1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
INCKFG+AdvOTc243060c                 Type 1C           WinAnsi          yes yes no     411  0
INCKFH+AdvPSMPi6                     Type 1C           WinAnsi          yes yes no     403  0
INCKIH+AdvPSMy-R                     Type 1C           WinAnsi          yes yes no     421  0
INCKCM+AdvOT46dcae81                 Type 1C           WinAnsi          yes yes no     384  0
INCKCN+AdvOT3b30f6db.B               Type 1C           WinAnsi          yes yes no     385  0
INCKDO+AdvCORRESAST                  Type 1C           Custom           yes yes yes    386  0
INCKDP+AdvOTa554f99f.B               Type 1C           WinAnsi          yes yes no     387  0
INCKEA+AdvPSSym                      Type 1C           Custom           yes yes no     381  0
INCKEB+AdvOTa554f99f.B+20            Type 1C           WinAnsi          yes yes no     388  0
INCKEC+AdvOTa554f99f.B+fb            Type 1C           Custom           yes yes yes    389  0
INCKED+AdvOTf8f9f135                 Type 1C           WinAnsi          yes yes no     401  0
INCKFD+AdvOTf8f9f135+fb              Type 1C           Custom           yes yes yes    405  0
INCKFE+AdvOTf8f9f135+20              Type 1C           WinAnsi          yes yes no     406  0
INCKFF+AdvP4C4E74                    Type 1C           Custom           yes yes no     407  0
INCKJI+AdvOT96bfafc3.I               Type 1C           WinAnsi          yes yes no     221  0
INCKJJ+AdvOT96bfafc3.I+20            Type 1C           WinAnsi          yes yes no     220  0
INCKKJ+AdvP4C4E59                    Type 1C           Custom           yes yes yes    218  0
INCKKK+AdvOT96bfafc3.I+fb            Type 1C           Custom           yes yes yes    219  0
INCKML+AdvOT3b30f6db.B+fb            Type 1C           Custom           yes yes yes    229  0
INCKMM+AdvOT65f8a23b.I               Type 1C           WinAnsi          yes yes no     230  0
INCKMN+AdvOT46dcae81+fb              Type 1C           Custom           yes yes yes    231  0
INCKMO+AdvOT46dcae81+20              Type 1C           WinAnsi          yes yes no     232  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2023-02-08 02:34:45 CET
 RepresentationInformation: 270431.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2023-02-07 09:26:40 CET
  Size: 261761
  Format: PDF
  Version: 1.7
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec1' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64title' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para1' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para3' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec1' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para4' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para5' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para6' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec1' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para7' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para8' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para9' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para10' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64table1' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para11' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para12' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para13' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec1' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para14' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64sec1' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para15' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para16' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para17' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para18' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para19' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para20' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para21' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para22' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para23' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para24' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para25' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para26' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para27' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para28' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para29' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para30' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para31' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para32' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para33' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para34' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para35' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para36' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para37' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para38' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para39' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para40' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para41' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para42' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para43' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para44' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para45' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para46' cannot be found
   Offset: 244096
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'web64para47' cannot be found
   Offset: 244096
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 457
   FreeObjects: 46
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: EN
    Outlines: 
     Item: 
      Title: atl0
      Destination: 1
      Children: 
       Item: 
        Title: The science of rFSH biosimilar products: Learning from Gonal-f®
        Destination: 1
       Item: 
        Title: Biosimilar-to-originator rFSH: No evidence of clinical divergence
        Destination: 1
       Item: 
        Title: Conclusions
        Destination: 1
       Item: 
        Title: References
        Destination: 1
   Info: 
    Title: Overlapping biosimilar and originator follitropin alfa preparations: How much closer can they get?
    Author: Fernando de Mora
    Subject: Drug Discovery Today, 27 (2022) 2071-2075. doi:10.1016/j.drudis.2022.04.022
    Creator: Elsevier
    Producer: Acrobat Distiller 8.0.0 (Windows)
    CreationDate: Wed Jul 20 13:50:15 CEST 2022
    ModDate: Wed Jul 20 13:51:02 CEST 2022
   ID: 0x2487b057a004ec55b88c5750dfde6017, 0x885c5f8609d136488fe3c2506a464420
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: CCITTFaxDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/tiff
      CompressionScheme: CCITT Group 4
      ImageWidth: 571
      ImageHeight: 631
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     ImageMask: true
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 295
      ImageHeight: 413
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 295
      ImageHeight: 413
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: INCKCM+AdvOT46dcae81
      FontSubset: true
      FirstChar: 38
      LastChar: 252
      FontDescriptor: 
       FontName: INCKCM+AdvOT46dcae81
       Flags: Nonsymbolic
       FontBBox: -41, -250, 833, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: INCKCN+AdvOT3b30f6db.B
      FontSubset: true
      FirstChar: 40
      LastChar: 122
      FontDescriptor: 
       FontName: INCKCN+AdvOT3b30f6db.B
       Flags: Nonsymbolic
       FontBBox: -31, -250, 875, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: INCKDO+AdvCORRESAST
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: INCKDO+AdvCORRESAST
       Flags: Symbolic
       FontBBox: 0, -947, 1041, 895
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: INCKDP+AdvOTa554f99f.B
      FontSubset: true
      FirstChar: 40
      LastChar: 121
      FontDescriptor: 
       FontName: INCKDP+AdvOTa554f99f.B
       Flags: Serif, Nonsymbolic
       FontBBox: -93, -250, 1072, 937
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: INCKEB+AdvOTa554f99f.B+20
      FontSubset: true
      FirstChar: 145
      LastChar: 146
      FontDescriptor: 
       FontName: INCKEB+AdvOTa554f99f.B+20
       Flags: Nonsymbolic
       FontBBox: -187, -187, 1312, 729
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: INCKIH+AdvPSMy-R
      FontSubset: true
      FirstChar: 44
      LastChar: 121
      FontDescriptor: 
       FontName: INCKIH+AdvPSMy-R
       Flags: Nonsymbolic
       FontBBox: -41, -239, 1125, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: INCKEC+AdvOTa554f99f.B+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: INCKEC+AdvOTa554f99f.B+fb
       Flags: Symbolic
       FontBBox: 19, 0, 645, 729
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: INCKML+AdvOT3b30f6db.B+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: INCKML+AdvOT3b30f6db.B+fb
       Flags: Symbolic
       FontBBox: 0, 0, 833, 718
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: INCKMM+AdvOT65f8a23b.I
      FontSubset: true
      FirstChar: 40
      LastChar: 121
      FontDescriptor: 
       FontName: INCKMM+AdvOT65f8a23b.I
       Flags: Nonsymbolic
       FontBBox: -104, -250, 885, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: INCKMN+AdvOT46dcae81+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: INCKMN+AdvOT46dcae81+fb
       Flags: Symbolic
       FontBBox: 0, 0, 739, 718
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: INCKMO+AdvOT46dcae81+20
      FontSubset: true
      FirstChar: 146
      LastChar: 151
      FontDescriptor: 
       FontName: INCKMO+AdvOT46dcae81+20
       Flags: Nonsymbolic
       FontBBox: 0, -197, 1125, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: INCKED+AdvOTf8f9f135
      FontSubset: true
      FirstChar: 40
      LastChar: 122
      FontDescriptor: 
       FontName: INCKED+AdvOTf8f9f135
       Flags: Serif, Nonsymbolic
       FontBBox: -72, -250, 1041, 937
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: INCKFH+AdvPSMPi6
      FontSubset: true
      FirstChar: 100
      LastChar: 100
      FontDescriptor: 
       FontName: INCKFH+AdvPSMPi6
       Flags: Nonsymbolic
       FontBBox: 0, -177, 989, 739
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: INCKFD+AdvOTf8f9f135+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: INCKFD+AdvOTf8f9f135+fb
       Flags: Symbolic
       FontBBox: 19, 0, 583, 729
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: INCKFE+AdvOTf8f9f135+20
      FontSubset: true
      FirstChar: 145
      LastChar: 150
      FontDescriptor: 
       FontName: INCKFE+AdvOTf8f9f135+20
       Flags: Nonsymbolic
       FontBBox: -197, -187, 1270, 729
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: INCKFF+AdvP4C4E74
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: INCKFF+AdvP4C4E74
       Flags: Symbolic
       FontBBox: -20, -958, 1114, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
     Font: 
      BaseFont: INCKKJ+AdvP4C4E59
      FontSubset: true
      FirstChar: 2
      LastChar: 46
      FontDescriptor: 
       FontName: INCKKJ+AdvP4C4E59
       Flags: Symbolic
       FontBBox: -31, -250, 1000, 750
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: INCKFG+AdvOTc243060c
      FontSubset: true
      FirstChar: 40
      LastChar: 121
      FontDescriptor: 
       FontName: INCKFG+AdvOTc243060c
       Flags: Nonsymbolic
       FontBBox: -31, -250, 875, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: INCKKK+AdvOT96bfafc3.I+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: INCKKK+AdvOT96bfafc3.I+fb
       Flags: Symbolic
       FontBBox: 9, -239, 614, 729
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: INCKJJ+AdvOT96bfafc3.I+20
      FontSubset: true
      FirstChar: 147
      LastChar: 147
      FontDescriptor: 
       FontName: INCKJJ+AdvOT96bfafc3.I+20
       Flags: Nonsymbolic
       FontBBox: -208, -187, 1291, 729
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: INCKEA+AdvPSSym
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: INCKEA+AdvPSSym
       Flags: Symbolic
       FontBBox: -177, -291, 1083, 1010
       FontFile3: true
      EncodingDictionary: 
       Differences: true
     Font: 
      BaseFont: INCKJI+AdvOT96bfafc3.I
      FontSubset: true
      FirstChar: 44
      LastChar: 122
      FontDescriptor: 
       FontName: INCKJI+AdvOT96bfafc3.I
       Flags: Serif, Nonsymbolic
       FontBBox: -72, -250, 1125, 927
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 4.0-c316 44.253921, Sun Oct 01 2006 17:14:39">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1016/j.drudis.2022.04.022</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Overlapping biosimilar and originator follitropin alfa preparations: How much closer can they get?</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Fernando de Mora</rdf:li>
               <rdf:li>Colin M. Howles</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Bemfola®</rdf:li>
               <rdf:li>Biosimilar</rdf:li>
               <rdf:li>Follitropin alfa</rdf:li>
               <rdf:li>Gonal-f®</rdf:li>
               <rdf:li>Ovaleap®</rdf:li>
               <rdf:li>Recombinant follicle-stimulating hormone</rdf:li>
               <rdf:li>Reproductive medicine</rdf:li>
               <rdf:li>rFSH</rdf:li>
               <rdf:li>Follitropin beta</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Drug Discovery Today, 27 (2022) 2071-2075. doi:10.1016/j.drudis.2022.04.022</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>The Authors</rdf:li>
            </rdf:Bag>
         </dc:publisher>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/">
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>Drug Discovery Today</prism:publicationName>
         <prism:copyright>© 2022 The Authors. Published by Elsevier Ltd.</prism:copyright>
         <prism:issn>1359-6446</prism:issn>
         <prism:volume>27</prism:volume>
         <prism:number>8</prism:number>
         <prism:coverDisplayDate>August 2022</prism:coverDisplayDate>
         <prism:pageRange>2071-2075</prism:pageRange>
         <prism:startingPage>2071</prism:startingPage>
         <prism:endingPage>2075</prism:endingPage>
         <prism:doi>10.1016/j.drudis.2022.04.022</prism:doi>
         <prism:url>https://doi.org/10.1016/j.drudis.2022.04.022</prism:url>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1016/j.drudis.2022.04.022</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>elsevier.com</rdf:li>
               <rdf:li>sciencedirect.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:doi>10.1016/j.drudis.2022.04.022</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <d2UUdzt6Lm9yLnM6GywyMncNNy9yKlwf8mdmGnduSytmMnPuPmM39o9ePnMuQnt6MndqTma/>
         <pdfx:CrossMarkDomainsↂ005B2ↂ005D>elsevier.com</pdfx:CrossMarkDomainsↂ005B2ↂ005D>
         <pdfx:CrossMarkDomainsↂ005B1ↂ005D>sciencedirect.com</pdfx:CrossMarkDomainsↂ005B1ↂ005D>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xap="http://ns.adobe.com/xap/1.0/">
         <xap:CreatorTool>Elsevier</xap:CreatorTool>
         <xap:ModifyDate>2022-07-20T16:51:02+05:30</xap:ModifyDate>
         <xap:CreateDate>2022-07-20T16:50:15+05:30</xap:CreateDate>
         <xap:MetadataDate>2022-07-20T16:51:02+05:30</xap:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapRights="http://ns.adobe.com/xap/1.0/rights/">
         <xapRights:Marked>True</xapRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Producer>Acrobat Distiller 8.0.0 (Windows)</pdf:Producer>
         <pdf:Trapped>False</pdf:Trapped>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapMM="http://ns.adobe.com/xap/1.0/mm/">
         <xapMM:DocumentID>uuid:464b83c3-aba4-4dd5-897b-cd89e80bbc0f</xapMM:DocumentID>
         <xapMM:InstanceID>uuid:779cb284-1caa-484e-89e6-1b4d2f694bf7</xapMM:InstanceID>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:ali="http://www.niso.org/schemas/ali/1.0/">
         <ali:license_ref>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <ali:uri>http://creativecommons.org/licenses/by-nc-nd/4.0/</ali:uri>
               </rdf:li>
            </rdf:Bag>
         </ali:license_ref>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 2071
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 51, 534, 51, 594
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 51, 506, 51, 525
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 51, 431, 51, 439
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 118, 434, 122, 442
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 123, 434, 128, 447
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 192, 434, 195, 442
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 51, 171, 51, 179
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 179, 115, 183, 123
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 361, 127, 365, 135
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 432, 162, 435, 171
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 466, 127, 470, 135
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 545, 721, 557, 729
      Annotation: 
       Subtype: Link
       Rect: 545, 721, 557, 729
      Annotation: 
       Subtype: Link
       Rect: 557, 716, 587, 746
      Annotation: 
       Subtype: Link
       Rect: 369, 34, 497, 40
      Annotation: 
       Subtype: Link
       Rect: 51, 25, 169, 31
    Page: 
     Label: 2072
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 45, 729, 45, 738
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 45, 706, 45, 715
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 153, 674, 157, 682
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 192, 626, 196, 635
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 70, 483, 73, 491
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 90, 351, 99, 360
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 56, 252, 57, 260
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 155, 172, 162, 180
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 269, 507, 276, 515
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 238, 491, 238, 499
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 259, 327, 263, 336
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 293, 220, 300, 228
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 335, 124, 339, 133
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 500, 722, 508, 730
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 408, 693, 408, 702
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 408, 670, 408, 679
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 546, 662, 550, 670
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 570, 411, 578, 419
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 419, 311, 419, 320
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 526, 160, 534, 168
       Destination: 48
    Page: 
     Label: 2073
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 88, 117, 95, 125
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 62, 101, 62, 110
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 244, 185, 244, 193
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 248, 69, 255, 77
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 51, 731, 51, 738
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 230, 680, 236, 688
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 218, 640, 224, 648
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 207, 560, 214, 568
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 219, 520, 225, 528
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 215, 491, 221, 499
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 242, 450, 248, 458
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 200, 431, 206, 439
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 236, 411, 242, 419
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 208, 381, 214, 389
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 205, 351, 211, 359
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 218, 331, 224, 339
       Destination: 141
    Page: 
     Label: 2074
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 92, 722, 99, 730
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 56, 706, 57, 715
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 56, 491, 57, 499
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 56, 252, 57, 260
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 69, 244, 72, 252
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 278, 706, 308, 715
       Destination: 26
      Annotation: 
       Subtype: Link
       Rect: 314, 710, 332, 718
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 226, 682, 226, 691
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 226, 670, 226, 679
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 393, 327, 396, 336
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 389, 196, 396, 204
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 408, 696, 408, 704
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 411, 685, 411, 692
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 419, 685, 578, 692
      Annotation: 
       Subtype: Link
       Rect: 419, 676, 476, 683
      Annotation: 
       Subtype: Link
       Rect: 411, 667, 411, 674
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 450, 658, 578, 665
      Annotation: 
       Subtype: Link
       Rect: 419, 650, 569, 657
      Annotation: 
       Subtype: Link
       Rect: 419, 641, 430, 648
      Annotation: 
       Subtype: Link
       Rect: 411, 632, 411, 639
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 419, 632, 578, 639
      Annotation: 
       Subtype: Link
       Rect: 419, 623, 578, 630
      Annotation: 
       Subtype: Link
       Rect: 419, 614, 527, 621
      Annotation: 
       Subtype: Link
       Rect: 411, 605, 411, 612
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 419, 605, 578, 612
      Annotation: 
       Subtype: Link
       Rect: 419, 596, 578, 603
      Annotation: 
       Subtype: Link
       Rect: 419, 587, 578, 594
      Annotation: 
       Subtype: Link
       Rect: 419, 581, 476, 588
      Annotation: 
       Subtype: Link
       Rect: 476, 578, 578, 585
      Annotation: 
       Subtype: Link
       Rect: 419, 569, 578, 576
      Annotation: 
       Subtype: Link
       Rect: 419, 560, 578, 567
      Annotation: 
       Subtype: Link
       Rect: 419, 551, 457, 558
      Annotation: 
       Subtype: Link
       Rect: 411, 542, 411, 549
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 419, 542, 578, 549
      Annotation: 
       Subtype: Link
       Rect: 419, 533, 578, 540
      Annotation: 
       Subtype: Link
       Rect: 419, 524, 529, 531
      Annotation: 
       Subtype: Link
       Rect: 411, 515, 411, 522
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 419, 515, 578, 522
      Annotation: 
       Subtype: Link
       Rect: 419, 506, 578, 513
      Annotation: 
       Subtype: Link
       Rect: 419, 497, 578, 504
      Annotation: 
       Subtype: Link
       Rect: 419, 488, 578, 495
      Annotation: 
       Subtype: Link
       Rect: 419, 479, 445, 486
      Annotation: 
       Subtype: Link
       Rect: 411, 470, 411, 477
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 419, 470, 578, 477
      Annotation: 
       Subtype: Link
       Rect: 419, 461, 578, 468
      Annotation: 
       Subtype: Link
       Rect: 419, 452, 578, 459
      Annotation: 
       Subtype: Link
       Rect: 419, 443, 578, 450
      Annotation: 
       Subtype: Link
       Rect: 419, 437, 446, 444
      Annotation: 
       Subtype: Link
       Rect: 446, 434, 521, 441
      Annotation: 
       Subtype: Link
       Rect: 411, 425, 411, 432
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 419, 425, 578, 432
      Annotation: 
       Subtype: Link
       Rect: 419, 416, 578, 423
      Annotation: 
       Subtype: Link
       Rect: 419, 407, 578, 414
      Annotation: 
       Subtype: Link
       Rect: 419, 398, 578, 405
      Annotation: 
       Subtype: Link
       Rect: 419, 389, 573, 396
      Annotation: 
       Subtype: Link
       Rect: 411, 381, 411, 388
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 419, 381, 578, 388
      Annotation: 
       Subtype: Link
       Rect: 419, 372, 578, 379
      Annotation: 
       Subtype: Link
       Rect: 419, 363, 578, 370
      Annotation: 
       Subtype: Link
       Rect: 419, 354, 578, 361
      Annotation: 
       Subtype: Link
       Rect: 419, 345, 455, 352
      Annotation: 
       Subtype: Link
       Rect: 408, 336, 408, 343
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 420, 336, 578, 343
      Annotation: 
       Subtype: Link
       Rect: 420, 327, 578, 334
      Annotation: 
       Subtype: Link
       Rect: 420, 318, 578, 325
      Annotation: 
       Subtype: Link
       Rect: 420, 309, 491, 316
      Annotation: 
       Subtype: Link
       Rect: 408, 300, 408, 307
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 533, 282, 578, 289
      Annotation: 
       Subtype: Link
       Rect: 420, 273, 505, 280
      Annotation: 
       Subtype: Link
       Rect: 408, 264, 408, 271
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 507, 228, 578, 235
      Annotation: 
       Subtype: Link
       Rect: 420, 219, 479, 226
      Annotation: 
       Subtype: Link
       Rect: 408, 210, 408, 217
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 434, 165, 562, 172
      Annotation: 
       Subtype: Link
       Rect: 408, 156, 408, 163
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 420, 156, 578, 163
      Annotation: 
       Subtype: Link
       Rect: 420, 147, 578, 154
      Annotation: 
       Subtype: Link
       Rect: 420, 138, 578, 145
      Annotation: 
       Subtype: Link
       Rect: 420, 129, 578, 136
      Annotation: 
       Subtype: Link
       Rect: 420, 120, 500, 127
      Annotation: 
       Subtype: Link
       Rect: 408, 112, 408, 118
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 420, 112, 578, 118
      Annotation: 
       Subtype: Link
       Rect: 420, 103, 578, 110
      Annotation: 
       Subtype: Link
       Rect: 420, 94, 578, 101
      Annotation: 
       Subtype: Link
       Rect: 420, 85, 578, 92
      Annotation: 
       Subtype: Link
       Rect: 420, 76, 576, 83
      Annotation: 
       Subtype: Link
       Rect: 408, 67, 408, 74
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 420, 67, 578, 74
      Annotation: 
       Subtype: Link
       Rect: 420, 58, 578, 65
      Annotation: 
       Subtype: Link
       Rect: 420, 49, 578, 56
    Page: 
     Label: 2075
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 62, 735, 100, 742
      Annotation: 
       Subtype: Link
       Rect: 100, 735, 150, 742
      Annotation: 
       Subtype: Link
       Rect: 150, 731, 221, 738
      Annotation: 
       Subtype: Link
       Rect: 62, 723, 221, 729
      Annotation: 
       Subtype: Link
       Rect: 62, 714, 109, 721
      Annotation: 
       Subtype: Link
       Rect: 51, 705, 51, 712
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 157, 696, 221, 703
      Annotation: 
       Subtype: Link
       Rect: 62, 687, 217, 694
      Annotation: 
       Subtype: Link
       Rect: 51, 669, 51, 676
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 62, 669, 221, 676
      Annotation: 
       Subtype: Link
       Rect: 62, 660, 221, 667
      Annotation: 
       Subtype: Link
       Rect: 62, 651, 221, 658
      Annotation: 
       Subtype: Link
       Rect: 62, 642, 88, 649
      Annotation: 
       Subtype: Link
       Rect: 51, 633, 51, 640
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 62, 633, 221, 640
      Annotation: 
       Subtype: Link
       Rect: 62, 627, 148, 634
      Annotation: 
       Subtype: Link
       Rect: 148, 624, 221, 631
      Annotation: 
       Subtype: Link
       Rect: 62, 615, 221, 622
      Annotation: 
       Subtype: Link
       Rect: 62, 606, 221, 613
      Annotation: 
       Subtype: Link
       Rect: 62, 597, 221, 604
      Annotation: 
       Subtype: Link
       Rect: 62, 588, 210, 595
      Annotation: 
       Subtype: Link
       Rect: 51, 579, 51, 586
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 135, 561, 221, 568
      Annotation: 
       Subtype: Link
       Rect: 62, 552, 210, 559
      Annotation: 
       Subtype: Link
       Rect: 62, 543, 177, 550
      Annotation: 
       Subtype: Link
       Rect: 51, 525, 51, 532
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 62, 525, 221, 532
      Annotation: 
       Subtype: Link
       Rect: 62, 516, 221, 523
      Annotation: 
       Subtype: Link
       Rect: 62, 510, 93, 517
      Annotation: 
       Subtype: Link
       Rect: 93, 507, 221, 514
      Annotation: 
       Subtype: Link
       Rect: 62, 498, 221, 505
      Annotation: 
       Subtype: Link
       Rect: 62, 489, 221, 496
      Annotation: 
       Subtype: Link
       Rect: 62, 480, 206, 487
      Annotation: 
       Subtype: Link
       Rect: 51, 471, 51, 478
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 188, 436, 221, 443
      Annotation: 
       Subtype: Link
       Rect: 62, 427, 173, 434
      Annotation: 
       Subtype: Link
       Rect: 51, 418, 51, 425
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 62, 418, 221, 425
      Annotation: 
       Subtype: Link
       Rect: 62, 409, 221, 416
      Annotation: 
       Subtype: Link
       Rect: 62, 403, 93, 410
      Annotation: 
       Subtype: Link
       Rect: 93, 400, 221, 407
      Annotation: 
       Subtype: Link
       Rect: 62, 394, 94, 401
      Annotation: 
       Subtype: Link
       Rect: 94, 391, 221, 398
      Annotation: 
       Subtype: Link
       Rect: 62, 382, 221, 389
      Annotation: 
       Subtype: Link
       Rect: 62, 373, 166, 380
      Annotation: 
       Subtype: Link
       Rect: 51, 364, 51, 371
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 331, 705, 402, 712
      Annotation: 
       Subtype: Link
       Rect: 244, 696, 301, 703
      Annotation: 
       Subtype: Link
       Rect: 232, 687, 232, 694
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 244, 687, 402, 694
      Annotation: 
       Subtype: Link
       Rect: 244, 678, 402, 685
      Annotation: 
       Subtype: Link
       Rect: 244, 669, 402, 676
      Annotation: 
       Subtype: Link
       Rect: 244, 660, 402, 667
      Annotation: 
       Subtype: Link
       Rect: 244, 651, 402, 658
      Annotation: 
       Subtype: Link
       Rect: 244, 642, 258, 649
      Annotation: 
       Subtype: Link
       Rect: 232, 633, 232, 640
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 251, 579, 379, 586
      Annotation: 
       Subtype: Link
       Rect: 232, 570, 232, 577
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 259, 516, 373, 523
      Annotation: 
       Subtype: Link
       Rect: 232, 507, 232, 514
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 232, 454, 232, 461
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 262, 400, 363, 407
      Annotation: 
       Subtype: Link
       Rect: 232, 391, 232, 398
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 244, 355, 387, 362
      Annotation: 
       Subtype: Link
       Rect: 413, 345, 413, 353
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 483, 349, 486, 357
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 488, 348, 493, 361
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 474, 339, 478, 347
       Destination: 141
      Annotation: 
       Subtype: Link
       Rect: 413, 315, 413, 323
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 413, 285, 413, 293
       Destination: null
  Checksum: 72c6239b
   Type: CRC32
  Checksum: 77adecc841c57563d53120eb2a1b0c02
   Type: MD5
  Checksum: 4a91dfa5c02e83fc1a2ba9f50e36d7bb5d1bcdb0
   Type: SHA-1