1754c4dd6cd3808d06ab2c5aaf7bc785 FisSheImm_a2022v131p1051.pdf aaeea2c4294eaa430d1b8b2caccd5c4a38991fb9 FisSheImm_a2022v131p1051.pdf 639c0d25433b247c3bbe85d37742c638ffa5ab47c219d1cd05f337be93609d9f FisSheImm_a2022v131p1051.pdf Title: How modular protein nanoparticles may expand the ability of subunit anti-viral vaccines: The spring viremia carp virus (SVCV) case Subject: Fish and Shellfish Immunology, 131 (2022) 1051-1062. doi:10.1016/j.fsi.2022.10.067 Keywords: Protein nanoparticles,SVCV,Vaccine,IFNγ,Zebrafish Author: Mauricio Rojas-Peña Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Fri Dec 9 21:35:34 2022 CET ModDate: Fri Dec 9 23:08:00 2022 CET Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 16182717 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MMYXOG+CharisSIL CID TrueType Identity-H yes yes yes 654 0 BHEMDT+CharisSIL-Bold CID TrueType Identity-H yes yes yes 659 0 DYDQNN+Univers Type 1C Builtin yes yes yes 664 0 ODWXIA+STIX-Regular Type 1C Custom yes yes yes 668 0 BRWWWZ+TeX_CM_Roman Type 1C Builtin yes yes yes 673 0 SADXNB+CharisSIL-Italic CID TrueType Identity-H yes yes yes 677 0 YGGATE+CharisSIL CID TrueType Identity-H yes yes yes 645 0 VQXFPH+TeX_CM_Maths_Symbols Type 1C Builtin yes yes yes 276 0 WMRKSV+CharisSIL-Italic CID TrueType Identity-H yes yes yes 269 0 NKZSAI+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 42 0 NTMBZO+TeX_CM_Maths_Italic Type 1C Builtin yes yes yes 281 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-02-10 02:34:28 CET RepresentationInformation: FisSheImm_a2022v131p1051.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-02-09 18:31:18 CET Size: 16182717 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'cor1' cannot be found Offset: 16143691 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'cor1' cannot be found Offset: 16143691 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 16143691 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 16143691 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 16143691 MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 750 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: How modular protein nanoparticles may expand the ability of subunit anti-viral vaccines: The spring viremia carp virus (SVC ... Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Children: Item: Title: 1 Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: 2 Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Children: Item: Title: 2.1 Design, production, and characterization of nanostructured viral antigenic proteins Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Children: Item: Title: 2.1.1 Viral strains and plasmids Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: 2.2 Production of NPs, purification, quantification, and fluorescent labeling Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: 2.3 Characterization of viral recombinant protein NPs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: 2.4 Cell culture and virus Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: 2.5 Uptake of nanostructured viral antigens by ZFL cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: 2.6 RNA extraction and Q-PCR Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: 2.7 Zebrafish husbandry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: 2.8 In vivo uptake in zebrafish larvae Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: 2.9 SVCV infection challenge Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: 2.10 Statistics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: 3 Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Children: Item: Title: 3.1 Characterization of modular nanostructured protein antigens SVCVNP and SVCV-IFNNP Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: 3.2 Uptake of modular nanostructured antigens by ZFL cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: 3.3 Gene expression analysis in ZFL stimulated with NPs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: 3.4 Uptake of SVCVNP and SVCV-IFNNP by zebrafish larvae Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: 3.5 Protective effect of the vaccines against SVCV infection in zebrafish Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: 4 Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: Ethics statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3 Item: Title: CRediT authorship contribution statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca Item: Title: Declaration of competing interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4e718207 Item: Title: Data availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1d371b2d Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@543c6f6d Item: Title: Appendix A Supplementary data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13eb8acf Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@51c8530f Info: Title: How modular protein nanoparticles may expand the ability of subunit anti-viral vaccines: The spring viremia carp virus (SVCV) case Author: Mauricio Rojas-Peña Subject: Fish and Shellfish Immunology, 131 (2022) 1051-1062. doi:10.1016/j.fsi.2022.10.067 Keywords: Protein nanoparticles,SVCV,Vaccine,IFNγ,Zebrafish Creator: Elsevier 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