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object 'appsec1' cannot be found Offset: 7268018 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 7268018 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 7268018 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found Offset: 7268018 MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 1399 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Synthesis and evaluation of novel furanones as biofilm inhibitors in opportunistic human pathogens Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Children: Item: Title: 1 Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: 2 Results and Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Children: Item: Title: 2.1 Chemistry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: 2.2 Biofilm inhibition activity of furanone library Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: 2.3 Disruption of mixed bacterial-fungal biofilms by selected furanones Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: 2.4 In vitro and in vivo toxicity and efficacy of candidate compounds Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: 3 Conclusion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: 4 Experimental section Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Children: Item: Title: 4.1 Chemistry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Children: Item: Title: 4.1.1 General procedure for the preparation of monoarylated furanones Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Children: Item: Title: 4.1.1.1 (Z)-5-(Bromo(phenyl)methylene)furan-2(5H)-one (5) [32] Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: 4.1.1.2 (Z)-5-(Bromo(2-methoxyphenyl)methylene)furan-2(5H)-one (7) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: 4.1.1.3 (Z)-5-(Bromo(3-methoxyphenyl)methylene)furan-2(5H)-one (9) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: 4.1.1.4 (Z)-5-(Bromo(4-methoxyphenyl)methylene)furan-2(5H)-one (11) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: 4.1.1.5 (Z)-5-(Bromo(4-fluorophenyl)methylene)furan-2(5H)-one (13) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: 4.1.1.6 (Z)-5-(Bromo(4-(trifluoromethyl)phenyl)methylene)furan-2(5H)-one (15) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: 4.1.1.7 (Z)-5-(Bromo(3-nitrophenyl)methylene)furan-2(5H)-one (17) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: 4.1.1.8 (Z)-5-(Bromo(4-nitrophenyl)methylene)furan-2(5H)-one (19) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: 4.1.2 General procedure for the preparation of diarylated furanones Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Children: Item: Title: 4.1.2.1 5-(Diphenylmethylene)furan-2(5H)-one (6) [32] Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: 4.1.2.2 5-(Bis(2-methoxyphenyl)methylene)furan-2(5H)-one (8) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: 4.1.2.3 5-(Bis(3-methoxyphenyl)methylene)furan-2(5H)-one (10) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Item: Title: 4.1.2.4 5-(Bis(4-methoxyphenyl)methylene)furan-2(5H)-one (12) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3 Item: Title: 4.1.2.5 5-(Bis(4-fluorophenyl)methylene)furan-2(5H)-one (14) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca Item: Title: 4.1.2.6 5-(Bis(4-(trifluoromethyl)phenyl)methylene)furan-2(5H)-one (16) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4e718207 Item: Title: 4.1.2.7 5-(Bis(3-nitrophenyl)methylene)furan-2(5H)-one (18) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1d371b2d Item: Title: 4.1.2.8 5-(Bis(4-nitrophenyl)methylene)furan-2(5H)-one (20) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@543c6f6d Item: Title: 4.1.2.9 5-(Di(thiophen-2-yl)methylene)furan-2(5H)-one (22) [32] Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13eb8acf Item: Title: 4.1.3 Synthesis of 5-(Bis(4-hydroxyphenyl)methylene)furan-2(5H)-one (21) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@51c8530f Item: Title: 4.1.4 Synthesis of 5-(Dibromomethylene)-4-methylfuran-2(5H)-one (24) [29] Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7403c468 Item: Title: 4.1.5 Synthesis of 4-(Bromomethyl)-5-(dibromomethylene)furan-2(5H)-one (27) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43738a82 Item: Title: 4.1.6 General ring-bromination procedure Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@c81cdd1 Children: Item: Title: 4.1.6.1 3-Bromo-5-(diphenylmethylene)furan-2(5H)-one (29) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1fc2b765 Item: Title: 4.1.6.2 5-(Bis(4-methoxyphenyl)methylene)-3-bromofuran-2(5H)-one (30) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@75881071 Item: Title: 4.1.6.3 5-(Bis(3-bromo-4-methoxyphenyl)methylene)-3-bromofuran-2(5H)-one (31) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2a70a3d8 Item: Title: 4.1.6.4 5-(Bis(4-(trifluoromethyl)phenyl)methylene)-3-bromofuran-2(5H)-one (32) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@289d1c02 Item: Title: 4.1.7 Synthesis of (Z)-5-(chloroiodomethylene)furan-2(5H)-one (34) [29] Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@22eeefeb Children: Item: Title: 4.1.7.1 (Z)-5-(Chloro(phenyl)methylene)furan-2(5H)-one (35) [29] Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@17d0685f Item: Title: 4.1.7.2 (Z)-5-(Chloro(4-methoxyphenyl)methylene)furan-2(5H)-one (36) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3891771e Item: Title: 4.1.8 Synthesis of 5-(1,5-dis(4-methoxyphenyl)penta-1,4-diyn-3-ylidene)furan-2(5H)-one (37) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@78ac1102 Item: Title: 4.2 Biological evaluation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2de8284b Children: Item: Title: 4.2.1 Microbial strains and growth conditions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@396e2f39 Item: Title: 4.2.2 Fluorescently labelled strains Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a74868d Item: Title: 4.2.3 Intrinsic cell growth inhibition Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12c8a2c0 Item: Title: 4.2.4 Biofilm inhibition assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7e0e6aa2 Item: Title: 4.2.5 Confocal laser-scanning microscopy of mono- and dual-species biofilms Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@365185bd Item: Title: 4.2.6 Cytotoxicity assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@18bf3d14 Item: Title: 4.2.7 In vivo efficacy in the Galleria mellonella infection model Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4fb64261 Item: Title: Declaration of competing interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42607a4f Item: Title: Data availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@782663d3 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1990a65e Item: Title: Appendix A Supplementary data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64485a47 Item: Title: Supplementary data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@25bbf683 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6ec8211c Info: Title: Synthesis and evaluation of novel furanones as biofilm inhibitors in opportunistic human pathogens Author: Andromeda-Celeste Gómez Subject: European Journal of Medicinal Chemistry, 242 (2022) 114678. doi:10.1016/j.ejmech.2022.114678 Keywords: Furanones,Biofilms,Quorum 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