fa972e714cbc194e79c23510a6287338 MicCelFac_a2022v21p203.pdf 59112f58edca7b7cd470a20d95c5e0861f79c075 MicCelFac_a2022v21p203.pdf 82510093ca6b07990d49d1436097ce41010cdd9a971223911d5311449f68f7e3 MicCelFac_a2022v21p203.pdf Title: Recombinant vaccines in 2022: a perspective from the cell factory Subject: Microbial Cell Factories, https://doi.org/10.1186/s12934-022-01929-8 Keywords: Recombinant proteins; Vaccines; Antigens; Nanovaccines; Nanoparticles; VLPs Author: Marianna Teixeira de Pinho Favaro Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Tue Oct 4 11:35:04 2022 CEST ModDate: Wed Oct 5 06:39:08 2022 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 17 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 1167897 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-Regular Type 1C Custom yes no yes 75 0 MyriadPro-Bold Type 1C Custom yes no yes 78 0 MyriadPro-It Type 1C Custom yes no yes 77 0 MyriadPro-Semibold Type 1C WinAnsi yes no yes 105 0 MyriadPro-Light Type 1C Custom yes no yes 103 0 ZMQMUF+OpenSans Type 1C WinAnsi yes yes no 929 0 WarnockPro-Regular Type 1C Custom yes no yes 76 0 MOPQTL+MTSY Type 1C Custom yes yes yes 102 0 MyriadPro-LightIt Type 1C Custom yes no yes 104 0 MyriadPro-Regular2 Type 1C WinAnsi yes no yes 592 0 WarnockPro-It Type 1C Custom yes no yes 148 0 ASMOID+STIXMath-Regular Type 1C Custom yes yes yes 337 0 XIQRXJ+OpenSans-Light Type 1C Custom yes yes no 582 0 XIQRXJ+OpenSans-Extrabold Type 1C WinAnsi yes yes no 578 0 XIQRXJ+OregonLDOBookSinistral Type 1C WinAnsi yes yes no 588 0 XIQRXJ+OpenSans-Bold Type 1C WinAnsi yes yes no 585 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-01-17 02:35:19 CET RepresentationInformation: MicCelFac_a2022v21p203.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-01-16 20:04:38 CET Size: 1167897 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 1007 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Recombinant vaccines in 2022: a perspective from the cell factory Children: Item: Title: Abstract Item: Title: Introduction Item: Title: Nanovaccines Item: Title: Approved recombinant vaccines Item: Title: Conventional cell factories for recombinant vaccines Children: Item: Title: Bacteria Item: Title: Yeast Item: Title: Insect cells Item: Title: Mammalian cells Item: Title: Alternative factories for recombinant vaccine production Item: Title: Recombinant vaccines for COVID-19 Item: Title: Conclusions Item: Title: Acknowledgements Item: Title: References Info: Title: Recombinant vaccines in 2022: a perspective from the cell factory Author: Marianna Teixeira de Pinho Favaro Subject: Microbial Cell Factories, https://doi.org/10.1186/s12934-022-01929-8 Keywords: Recombinant proteins; Vaccines; Antigens; Nanovaccines; Nanoparticles; VLPs Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Tue Oct 04 12:05:04 CEST 2022 ModDate: Wed Oct 05 06:39:08 CEST 2022 ID: 0x83d0915d95126706abb9c07da70c203d, 0xfaa9a4953a9967a3424507d84253bbb8 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 39 ImageHeight: 39 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 40 ImageHeight: 76 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 81 ImageHeight: 84 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 39 ImageHeight: 74 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 39 ImageHeight: 76 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1772 ImageHeight: 876 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Fonts: Type1: Font: BaseFont: ZMQMUF+OpenSans FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: ZMQMUF+OpenSans Flags: Nonsymbolic FontBBox: -550, -271, 1204, 1048 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: ASMOID+STIXMath-Regular FontSubset: true FirstChar: 31 LastChar: 176 FontDescriptor: FontName: ASMOID+STIXMath-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -524, 3238, 2566 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: WarnockPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: WarnockPro-It Flags: Serif, Nonsymbolic, Italic FontBBox: -221, -533, 1474, 950 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MOPQTL+MTSY FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MOPQTL+MTSY Flags: Symbolic FontBBox: 0, -954, 1043, 796 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Light FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Light Flags: Nonsymbolic FontBBox: -49, -250, 1046, 883 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-LightIt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-LightIt Flags: Nonsymbolic, Italic FontBBox: -121, -250, 1007, 863 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Semibold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Semibold Flags: Nonsymbolic FontBBox: -161, -250, 1198, 972 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: WarnockPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: WarnockPro-Regular Flags: Serif, Nonsymbolic FontBBox: -177, -533, 1474, 950 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-It FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-It Flags: Nonsymbolic, Italic FontBBox: -185, -250, 1090, 953 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Bold Flags: Nonsymbolic FontBBox: -163, -250, 1256, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true XMP: 2022-10-04T15:05:04+05:30 Springer 2022-10-05T06:39:08+02:00 2022-10-05T06:39:08+02:00 Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) Recombinant proteins; Vaccines; Antigens; Nanovaccines; Nanoparticles; VLPs application/pdf https://doi.org/10.1186/s12934-022-01929-8 BioMed Central Microbial Cell Factories, https://doi.org/10.1186/s12934-022-01929-8 Recombinant proteins Vaccines Antigens Nanovaccines Nanoparticles VLPs Recombinant vaccines in 2022: a perspective from the cell factory Marianna Teixeira de Pinho Favaro Jan Atienza-Garriga Carlos Martínez-Torró Eloi Parladé Esther Vázquez José Luis Corchero Neus Ferrer-Miralles Antonio Villaverde 10.1186/s12934-022-01929-8 2010-04-23 true springer.com springerlink.com https://doi.org/10.1186/s12934-022-01929-8 10.1186/s12934-022-01929-8 1475-2859 journal Microbial Cell Factories The Author(s) 2010-04-23 true 10.1186/s12934-022-01929-8 noindex springer.com springerlink.com VoR uuid:9cd3a9e8-4ba9-4419-bd47-c62381b3363e uuid:7d00b202-6966-4bf5-952c-13955ea748d2 default 1 converted uuid:eeb4fa05-2b58-418a-8ef8-d198087670e3 converted to PDF/A-2b pdfToolbox 2022-10-04T15:06:14+05:30 converted uuid:af2f650b-b302-4822-baa6-8d017b12fb35 converted to PDF/A-2b pdfToolbox 2022-10-04T15:06:51+05:30 2 B http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Mirrors crossmark:DOI doi Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains seq Text internal A name object indicating whether the document has been modified to include trapping information robots Text internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://crossref.org/crossmark/1.0/ crossmark Crossmark Schema internal Usual same as prism:doi DOI Text external The date when a publication was publishe. MajorVersionDate Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal CrossMarkDomains CrossMarkDomains seq Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism Schema external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url URI external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. issn Text internal Volume number volume Text internal Issue number number Text internal Starting page startingPage Text internal Ending page endingPage Text external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external Copyright copyright Text http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. DocumentID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text internal A structure containing the characteristics of a font used in a document Fonts Bag Font internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text A structure containing the characteristics of a font used in a document. http://ns.adobe.com/xap/1.0/sType/Font# stFnt Font http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 212, 66, 330, 58 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 486, 66, 530, 58 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 180, 58, 276, 50 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 199, 304, 203, 292 Flags: Print AppearanceDictionary: true Destination: 503 Annotation: Subtype: Link Rect: 208, 304, 213, 292 Flags: Print AppearanceDictionary: true Destination: 503 Annotation: Subtype: Link Rect: 350, 245, 355, 232 Flags: Print AppearanceDictionary: true Destination: 503 Annotation: Subtype: Link Rect: 362, 245, 367, 232 Flags: Print AppearanceDictionary: true Destination: 503 Annotation: Subtype: Link Rect: 332, 197, 337, 184 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 343, 197, 348, 184 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 379, 161, 384, 148 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 389, 161, 394, 148 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 478, 149, 483, 136 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 489, 149, 494, 136 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 507, 683, 540, 650 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 168, 680, 178, 668 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 184, 680, 194, 668 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 129, 548, 139, 536 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 145, 548, 155, 536 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 59, 536, 69, 524 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 250, 488, 260, 476 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 104, 440, 114, 428 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 113, 404, 123, 392 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 267, 392, 272, 380 Flags: Print AppearanceDictionary: true Destination: 80 Annotation: Subtype: Link Rect: 246, 332, 256, 320 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 262, 332, 272, 320 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 144, 284, 153, 272 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 159, 284, 169, 272 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 123, 236, 133, 224 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 139, 236, 149, 224 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 246, 128, 256, 116 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 59, 92, 69, 80 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 74, 92, 84, 80 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 269, 80, 279, 68 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 307, 656, 317, 644 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 323, 656, 333, 644 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 307, 584, 317, 572 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 323, 584, 333, 572 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 333, 524, 343, 512 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 494, 356, 503, 344 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 479, 320, 489, 308 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 450, 296, 460, 284 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 414, 248, 419, 236 Flags: Print AppearanceDictionary: true Destination: 107 Annotation: Subtype: Link Rect: 437, 200, 447, 188 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 453, 200, 463, 188 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 307, 116, 317, 104 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 450, 92, 459, 80 Flags: Print AppearanceDictionary: true Destination: 541 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 213, 181, 222, 169 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 225, 145, 235, 133 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 240, 145, 250, 133 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 220, 133, 230, 121 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 234, 133, 244, 121 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 278, 133, 283, 121 Flags: Print AppearanceDictionary: true Destination: 80 Annotation: Subtype: Link Rect: 512, 169, 522, 157 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 341, 97, 351, 85 Flags: Print AppearanceDictionary: true Destination: 545 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 275, 429, 285, 417 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 275, 357, 285, 345 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 59, 333, 69, 321 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 175, 321, 185, 309 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 240, 213, 250, 201 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 182, 189, 192, 177 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 197, 165, 206, 153 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 212, 165, 221, 153 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 226, 165, 236, 153 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 102, 129, 111, 117 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 117, 129, 127, 117 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 390, 345, 399, 333 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 405, 345, 415, 333 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 333, 261, 338, 249 Flags: Print AppearanceDictionary: true Destination: 80 Annotation: Subtype: Link Rect: 347, 261, 357, 249 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 363, 261, 373, 249 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 508, 165, 517, 153 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 522, 165, 531, 153 Flags: Print AppearanceDictionary: true Destination: 545 Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 259, 513, 269, 500 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 275, 513, 285, 500 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 77, 453, 87, 440 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 205, 441, 215, 428 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 220, 441, 230, 428 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 152, 357, 162, 344 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 167, 357, 176, 344 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 259, 321, 269, 308 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 275, 321, 285, 308 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 246, 285, 256, 272 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 275, 225, 285, 212 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 151, 117, 156, 104 Flags: Print AppearanceDictionary: true Destination: 80 Annotation: Subtype: Link Rect: 473, 681, 478, 668 Flags: Print AppearanceDictionary: true Destination: 80 Annotation: Subtype: Link Rect: 491, 573, 500, 560 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 473, 537, 483, 524 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 489, 537, 499, 524 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 406, 489, 416, 476 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 420, 489, 430, 476 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 438, 417, 448, 404 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 351, 261, 361, 248 Flags: Print AppearanceDictionary: true Destination: 545 Annotation: Subtype: Link Rect: 367, 261, 381, 248 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 403, 249, 418, 236 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 422, 249, 437, 236 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 328, 237, 343, 224 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 350, 237, 365, 224 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 461, 201, 476, 188 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 482, 201, 496, 188 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 388, 129, 403, 116 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 445, 105, 460, 92 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 466, 105, 481, 92 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 478, 81, 492, 68 Flags: Print AppearanceDictionary: true Destination: 549 Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 198, 633, 213, 621 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 219, 633, 234, 621 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 177, 609, 192, 597 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 79, 573, 93, 561 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 99, 573, 114, 561 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 130, 501, 145, 489 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 146, 477, 161, 465 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 132, 405, 142, 393 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 146, 405, 161, 393 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 167, 405, 182, 393 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 196, 369, 211, 357 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 99, 285, 113, 273 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 108, 237, 123, 225 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 95, 129, 109, 117 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 249, 117, 264, 105 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 109, 105, 124, 93 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 217, 105, 232, 93 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 85, 93, 99, 81 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 370, 693, 385, 680 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 447, 657, 462, 644 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 468, 657, 483, 644 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 370, 633, 385, 620 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 509, 621, 524, 608 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 520, 609, 535, 596 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 457, 597, 472, 584 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 389, 381, 403, 368 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 367, 333, 382, 320 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 307, 297, 322, 284 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 388, 273, 403, 260 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 367, 225, 382, 212 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 446, 105, 461, 92 Flags: Print AppearanceDictionary: true Destination: 553 Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 201, 693, 216, 680 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 188, 645, 203, 632 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 209, 645, 223, 632 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 172, 621, 177, 608 Flags: Print AppearanceDictionary: true Destination: 80 Annotation: Subtype: Link Rect: 270, 573, 285, 560 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 59, 525, 74, 512 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 232, 501, 247, 488 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 252, 501, 267, 488 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 59, 477, 74, 464 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 219, 417, 224, 404 Flags: Print AppearanceDictionary: true Destination: 80 Annotation: Subtype: Link Rect: 92, 333, 106, 320 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 120, 213, 134, 200 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 270, 153, 285, 140 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 331, 705, 346, 692 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 349, 645, 364, 632 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 405, 585, 419, 572 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 430, 573, 445, 560 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 307, 549, 322, 536 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 465, 501, 480, 488 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 485, 501, 499, 488 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 415, 297, 430, 284 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 476, 273, 491, 260 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 307, 201, 322, 188 Flags: Print AppearanceDictionary: true Destination: 553 Thumb: true Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 264, 549, 279, 536 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 270, 465, 285, 452 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 184, 417, 199, 404 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 205, 417, 220, 404 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 83, 357, 98, 344 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 273, 321, 288, 308 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 56, 309, 71, 296 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 267, 285, 282, 272 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 213, 177, 227, 164 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 250, 141, 265, 128 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 270, 141, 285, 128 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 97, 81, 112, 68 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 307, 693, 322, 680 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 415, 657, 429, 644 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 435, 657, 450, 644 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 403, 585, 418, 572 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 406, 537, 421, 524 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 491, 501, 506, 488 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 530, 489, 535, 476 Flags: Print AppearanceDictionary: true Destination: 80 Annotation: Subtype: Link Rect: 391, 453, 406, 440 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 307, 393, 322, 380 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 502, 297, 517, 284 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 392, 237, 407, 224 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 518, 117, 533, 104 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 492, 81, 506, 68 Flags: Print AppearanceDictionary: true Destination: 557 Thumb: true Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 222, 657, 237, 638 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 180, 621, 195, 608 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 182, 573, 197, 560 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 59, 561, 74, 548 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 176, 549, 191, 536 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 270, 465, 285, 452 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 141, 345, 156, 332 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 161, 345, 176, 332 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 270, 333, 285, 320 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 76, 285, 91, 272 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 97, 285, 111, 272 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 59, 237, 74, 224 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 81, 237, 96, 224 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 250, 153, 265, 140 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 181, 117, 196, 104 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 270, 105, 285, 92 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 391, 705, 406, 692 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 435, 669, 450, 656 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 400, 417, 414, 404 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 307, 309, 322, 296 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 327, 309, 341, 296 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 497, 225, 512, 212 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 387, 165, 402, 152 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 408, 165, 423, 152 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 489, 129, 504, 116 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 352, 81, 367, 68 Flags: Print AppearanceDictionary: true Destination: 557 Thumb: true Page: Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 59, 657, 74, 644 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 79, 657, 93, 644 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 185, 585, 200, 572 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 59, 525, 74, 512 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 186, 405, 201, 392 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 206, 405, 221, 392 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 217, 369, 231, 356 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 273, 309, 288, 296 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 56, 297, 71, 284 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 204, 249, 219, 236 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 223, 249, 238, 236 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 142, 177, 157, 164 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 162, 177, 177, 164 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 163, 129, 178, 116 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 307, 657, 322, 644 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 307, 573, 322, 560 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 366, 513, 380, 500 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 331, 405, 346, 392 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 348, 393, 362, 380 Flags: Print AppearanceDictionary: true Destination: 557 Annotation: Subtype: Link Rect: 339, 345, 354, 332 Flags: Print AppearanceDictionary: true Destination: 571 Annotation: Subtype: Link Rect: 408, 261, 422, 248 Flags: Print AppearanceDictionary: true Destination: 571 Annotation: Subtype: Link Rect: 428, 189, 443, 176 Flags: Print AppearanceDictionary: true Destination: 571 Annotation: Subtype: Link Rect: 448, 105, 463, 92 Flags: Print AppearanceDictionary: true Destination: 571 Annotation: Subtype: Link Rect: 469, 105, 484, 92 Flags: Print AppearanceDictionary: true Destination: 571 Thumb: true Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 101, 681, 115, 668 Flags: Print AppearanceDictionary: true Destination: 571 Annotation: Subtype: Link Rect: 193, 594, 208, 582 Flags: Print AppearanceDictionary: true Destination: 549 Annotation: Subtype: Link Rect: 212, 594, 227, 582 Flags: Print AppearanceDictionary: true Destination: 571 Annotation: Subtype: Link Rect: 231, 594, 246, 582 Flags: Print AppearanceDictionary: true Destination: 571 Annotation: Subtype: Link Rect: 236, 582, 241, 570 Flags: Print AppearanceDictionary: true Destination: 80 Annotation: Subtype: Link Rect: 250, 582, 265, 570 Flags: Print AppearanceDictionary: true Destination: 553 Annotation: Subtype: Link Rect: 59, 498, 74, 486 Flags: Print AppearanceDictionary: true Destination: 571 Annotation: Subtype: Link Rect: 80, 498, 95, 486 Flags: Print AppearanceDictionary: true Destination: 571 Annotation: Subtype: Link Rect: 211, 390, 225, 378 Flags: Print AppearanceDictionary: true Destination: 571 Annotation: Subtype: Link Rect: 231, 390, 246, 378 Flags: Print AppearanceDictionary: true Destination: 571 Annotation: Subtype: Link Rect: 80, 304, 90, 292 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 96, 304, 106, 292 Flags: Print AppearanceDictionary: true Destination: 541 Annotation: Subtype: Link Rect: 460, 615, 536, 606 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 304, 606, 431, 597 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 12 Thumb: true Page: Sequence: 13 Thumb: true Page: Sequence: 14 Thumb: true Page: Sequence: 15 Thumb: true Page: Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 400, 289, 531, 281 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 325, 280, 524, 272 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 325, 271, 530, 263 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 325, 262, 525, 254 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 17 Thumb: true Checksum: 1c5d4e79 Type: CRC32 Checksum: fa972e714cbc194e79c23510a6287338 Type: MD5 Checksum: 59112f58edca7b7cd470a20d95c5e0861f79c075 Type: SHA-1