e266ca8d9371568dfa7486b2b23ecb68 cancers-14-01179-v2.pdf 2adc615476c1b6241ed8f3835a03fb41b4ac19d2 cancers-14-01179-v2.pdf ea67447453491f140c9c567edeef1089578b30b8d9a79132cd5e3f178db68591 cancers-14-01179-v2.pdf Title: Epigenetics of Dendritic Cells in Tumor Immunology Subject: Dendritic cells (DCs) are professional antigen-presenting cells with the distinctive property of inducing the priming and differentiation of naïve CD4+ and CD8+ T cells into helper and cytotoxic effector T cells to develop efficient tumor-immune responses. DCs display pathogenic and tumorigenic antigens on their surface through major histocompatibility complexes to directly influence the differentiation of T cells. Cells in the tumor microenvironment (TME), including cancer cells and other immune-infiltrated cells, can lead DCs to acquire an immune-tolerogenic phenotype that facilitates tumor progression. Epigenetic alterations contribute to cancer development, not only by directly affecting cancer cells, but also by their fundamental role in the differentiation of DCs that acquire a tolerogenic phenotype that, in turn, suppresses T cell-mediated responses. In this review, we focus on the epigenetic regulation of DCs that have infiltrated the TME and discuss how knowledge of the epigenetic control of DCs can be used to improve DC-based vaccines for cancer immunotherapy. Keywords: dendritic cells; tumor microenvironment; epigenetics; DNA methylation; tolerogenesis; cancer epigenetics; histone modification; tumor immunology Author: Gerard Godoy-Tena and Esteban Ballestar Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri Feb 25 09:57:41 2022 CET ModDate: Fri Feb 25 09:59:56 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 22 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1510746 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- VBXEUC+URWPalladioL-Bold Type 1 Custom yes yes no 10 0 CAUGGU+URWPalladioL-Roma Type 1 Custom yes yes no 15 0 KHXAFA+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 27 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 31 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 35 0 LCJEVJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 48 0 AOPHAZ+CMSY10 Type 1 Builtin yes yes no 70 0 ASHNOE+EURM10 Type 1 Builtin yes yes no 84 0 ABCDEE+Palatino Linotype,Bold TrueType WinAnsi yes yes no 92 0 ABCDEE+Palatino Linotype TrueType WinAnsi yes yes no 96 0 ABCDEE+Palatino Linotype,Italic TrueType WinAnsi yes yes no 100 0 ABCDEE+Palatino Linotype CID TrueType Identity-H yes yes yes 104 0 ABCDEE+Palatino Linotype,Bold TrueType WinAnsi yes yes no 139 0 ABCDEE+Palatino Linotype TrueType WinAnsi yes yes no 143 0 ABCDEE+Palatino Linotype,Italic TrueType WinAnsi yes yes no 147 0 ABCDEE+Palatino Linotype CID TrueType Identity-H yes yes yes 151 0 UEMIXH+VnURWPalladioL Type 1 Custom yes yes no 169 0 ITYRUV+VnURWPalladioL-Italic Type 1 Custom yes yes no 192 0 MPUDFL+PazoMath Type 1 Builtin yes yes no 196 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-01-21 02:45:09 CET RepresentationInformation: cancers-14-01179-v2.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-01-17 18:04:34 CET Size: 1510746 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 713 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4923ab24 Item: Title: Mechanisms Underlying Epigenetic Dysregulation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Dendritic Cell Subtypes and Epigenetic Regulation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Item: Title: Recruitment of Dendritic Cells in the TME and Involvement of Epigenetics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Functions of Dendritic Cells in the TME Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Epigenetic Impact of the TME on Dendritic Cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Epigenetic Modifications in Dendritic Cells in Cancer Immunotherapy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Info: Title: Epigenetics of Dendritic Cells in Tumor Immunology Author: Gerard Godoy-Tena and Esteban Ballestar Subject: Dendritic cells (DCs) are professional antigen-presenting cells with the distinctive property of inducing the priming and differentiation of naïve CD4+ and CD8+ T cells into helper and cytotoxic effector T cells to develop efficient tumor-immune responses. DCs display pathogenic and tumorigenic antigens on their surface through major histocompatibility complexes to directly influence the differentiation of T cells. Cells in the tumor microenvironment (TME), including cancer cells and other immune-infiltrated cells, can lead DCs to acquire an immune-tolerogenic phenotype that facilitates tumor progression. Epigenetic alterations contribute to cancer development, not only by directly affecting cancer cells, but also by their fundamental role in the differentiation of DCs that acquire a tolerogenic phenotype that, in turn, suppresses T cell-mediated responses. In this review, we focus on the epigenetic regulation of DCs that have infiltrated the TME and discuss how knowledge of the epigenetic control of DCs can be used to improve DC-based vaccines for cancer immunotherapy. 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