c7015c9f2875f437691ab0b0f91bd8c8 270505.pdf 1f3069b8409b809b4e797a64f9958e6312714f6f 270505.pdf 2689cccf3694d87a27604842d60f1b2389e222ad5c03bc6f1b19c4ae89b411c9 270505.pdf Title: The Anti-Inflammatory Properties of Licorice (Glycyrrhiza glabra)-Derived Compounds in Intestinal Disorders Subject: Intestinal diseases, such as inflammatory bowel diseases (IBDs) and colorectal cancer (CRC), are a significant source of morbidity and mortality worldwide. Epidemiological data have shown that IBD patients are at an increased risk for the development of CRC. IBD-associated cancer develops against a background of chronic inflammation and oxidative stress, and their products contribute to cancer development and progression. Therefore, the discovery of novel drugs for the treatment of intestinal diseases is urgently needed. Licorice (Glycyrrhiza glabra) has been largely used for thousands of years in traditional Chinese medicine. Licorice and its derived compounds possess antiallergic, antibacterial, antiviral, anti-inflammatory, and antitumor effects. These pharmacological properties aid in the treatment of inflammatory diseases. In this review, we discuss the pharmacological potential of bioactive compounds derived from Licorice and addresses their anti-inflammatory and antioxidant properties. We also discuss how the mechanisms of action in these compounds can influence their effectiveness and lead to therapeutic effects on intestinal disorders. Keywords: Glycyrrhiza glabra-derived compounds; glycyrrhizin (G); glycyrrhetinic acid (GA); dipotassium glycyrrhizinate (DPG); inflammation; oxidative stress; intestinal disorders Author: Camila dos Santos Leite, Gabriel Alves Bonafé, Juliana Carvalho Santos, Carlos Augusto Real Martinez, Manoela Marques Ortega and Marcelo Lima Ribeiro Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri Apr 8 12:48:56 2022 CEST ModDate: Fri Apr 8 12:54:06 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1170834 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- FMDLVS+URWPalladioL-Bold Type 1 Custom yes yes no 10 0 SZZVJA+URWPalladioL-Roma Type 1 Custom yes yes no 15 0 UXCCQD+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 DAVQUJ+URWPalladioL-BoldItal Type 1 Custom yes yes no 23 0 TEIKCK+VnURWPalladioL Type 1 Custom yes yes no 27 0 BTFGED+VnURWPalladioL-Bold Type 1 Custom yes yes no 32 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 40 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 44 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 48 0 IRWHZX+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 60 0 CKUPDE+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 63 0 IOJNAF+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 88 0 IOJNAH+PalatinoLinotype TrueType WinAnsi yes yes no 91 0 IOJNBJ+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 94 0 KESBIZ+EURM10 Type 1 Builtin yes yes no 101 0 ZAPTTN+CMSY10 Type 1 Builtin yes yes no 108 0 IOJNAF+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 127 0 IOJNAH+PalatinoLinotype TrueType WinAnsi yes yes no 130 0 IOJNBJ+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 133 0 VXBVYX+PazoMath-Italic Type 1 Builtin yes yes no 143 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-03-10 02:38:16 CET RepresentationInformation: 270505.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-03-09 13:27:07 CET Size: 1170834 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 439 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: G, GA, and DPG-Mediated Anti-Inflammation Regulation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Item: Title: G, GA, and DPG-Mediated Crosstalk between Inflammation and Oxidative Stress Pathways Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Therapeutic Effect of G, GA, and DPG for Intestinal Disorders Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Conclusions and Future Perspectives Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Info: Title: The Anti-Inflammatory Properties of Licorice (Glycyrrhiza glabra)-Derived Compounds in Intestinal Disorders Author: Camila dos Santos Leite, Gabriel Alves Bonafé, Juliana Carvalho Santos, Carlos Augusto Real Martinez, Manoela Marques Ortega and Marcelo Lima Ribeiro Subject: Intestinal diseases, such as inflammatory bowel diseases (IBDs) and colorectal cancer (CRC), are a significant source of morbidity and mortality worldwide. Epidemiological data have shown that IBD patients are at an increased risk for the development of CRC. IBD-associated cancer develops against a background of chronic inflammation and oxidative stress, and their products contribute to cancer development and progression. Therefore, the discovery of novel drugs for the treatment of intestinal diseases is urgently needed. Licorice (Glycyrrhiza glabra) has been largely used for thousands of years in traditional Chinese medicine. Licorice and its derived compounds possess antiallergic, antibacterial, antiviral, anti-inflammatory, and antitumor effects. These pharmacological properties aid in the treatment of inflammatory diseases. In this review, we discuss the pharmacological potential of bioactive compounds derived from Licorice and addresses their anti-inflammatory and antioxidant properties. We also discuss how the mechanisms of action in these compounds can influence their effectiveness and lead to therapeutic effects on intestinal disorders. 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