acbb8d5629af4236ab37776649c49b1e 270512.pdf 56356d98f27bf518e3f223b42eb7e3d9155b1cf1 270512.pdf 5356278e75b57243499f8af9c3c0e8291894690bcecc76f2babe9c798a6f2105 270512.pdf Title: Latest Contributions of Genomics to T-Cell Acute Lymphoblastic Leukemia (T-ALL) Subject: As for many neoplasms, initial genetic data about T-cell acute lymphoblastic leukemia (T-ALL) came from the application of cytogenetics. This information helped identify some recurrent chromosomal alterations in T-ALL at the time of diagnosis, although it was difficult to determine their prognostic impact because of their low incidence in the specific T-ALL cohort analyzed. Genetic knowledge accumulated rapidly following the application of genomic techniques, drawing attention to the importance of using high-resolution genetic techniques to detect cryptic aberrations present in T-ALL, which are not usually detected by cytogenetics. We now have a clearer appreciation of the genetic landscape of the different T-ALL subtypes at diagnosis, explaining the particular oncogenetic processes taking place in each T-ALL, and we have begun to understand relapse-specific mechanisms. This review aims to summarize the latest advances in our knowledge of the genome in T-ALL. We highlight areas where the research in this subtype of ALL is progressing with the aim of identifying key questions that need to be answered in the medium-long term if this knowledge is to be applied in clinics. Keywords: T-cell acute lymphoblastic leukemia; genomics; non-coding; germline; aging; relapse Author: Eulàlia Genescà and Celia González-Gil Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed May 18 10:16:39 2022 CEST ModDate: Wed May 18 10:39:05 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 19 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1177307 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IBTUOG+URWPalladioL-Bold Type 1 Custom yes yes no 10 0 GIRVNQ+URWPalladioL-Roma Type 1 Custom yes yes no 15 0 NOTHGL+URWPalladioL-Ital Type 1 Custom yes yes no 19 0 AZUTVD+VnURWPalladioL-Bold Type 1 Custom yes yes no 23 0 AEITLL+VnURWPalladioL Type 1 Custom yes yes no 28 0 LCJEVJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 47 0 GOCQIR+EURM10 Type 1 Builtin yes yes no 69 0 DGYZYI+PalatinoLinotype-Italic TrueType WinAnsi yes yes yes 80 0 XCAUSU+PalatinoLinotype-Bold TrueType WinAnsi yes yes yes 84 0 VHZDQY+PalatinoLinotype-Roman TrueType WinAnsi yes yes yes 88 0 NIWPOC+CMSY10 Type 1 Builtin yes yes no 97 0 KGMPSU+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 111 0 DGYZYI+PalatinoLinotype-Italic TrueType WinAnsi yes yes yes 119 0 XCAUSU+PalatinoLinotype-Bold TrueType WinAnsi yes yes yes 123 0 VHZDQY+PalatinoLinotype-Roman TrueType WinAnsi yes yes yes 127 0 DGYZYI+PalatinoLinotype-Italic TrueType WinAnsi yes yes yes 156 0 XCAUSU+PalatinoLinotype-Bold TrueType WinAnsi yes yes yes 160 0 VHZDQY+PalatinoLinotype-Roman TrueType WinAnsi yes yes yes 164 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-01-31 02:31:47 CET RepresentationInformation: 270512.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-01-30 13:48:06 CET Size: 1177307 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 510 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4923ab24 Item: Title: T-ALL Classification by Differentiation Stage Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Children: Item: Title: Non-Coding Mutations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Item: Title: T-ALL Related Immature Subtypes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: (Epi)genetic Modification Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Germline Variants and Predisposition Alleles Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Children: Item: Title: Germline Predispostion Alterations Contributing to the Development of T-ALL Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Predisposition Alleles Affecting Drug Response Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Clonal Hematopoiesis and Aging Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Relapse Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Future Perspectives Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Info: Title: Latest Contributions of Genomics to T-Cell Acute Lymphoblastic Leukemia (T-ALL) Author: Eulàlia Genescà and Celia González-Gil Subject: As for many neoplasms, initial genetic data about T-cell acute lymphoblastic leukemia (T-ALL) came from the application of cytogenetics. This information helped identify some recurrent chromosomal alterations in T-ALL at the time of diagnosis, although it was difficult to determine their prognostic impact because of their low incidence in the specific T-ALL cohort analyzed. Genetic knowledge accumulated rapidly following the application of genomic techniques, drawing attention to the importance of using high-resolution genetic techniques to detect cryptic aberrations present in T-ALL, which are not usually detected by cytogenetics. We now have a clearer appreciation of the genetic landscape of the different T-ALL subtypes at diagnosis, explaining the particular oncogenetic processes taking place in each T-ALL, and we have begun to understand relapse-specific mechanisms. This review aims to summarize the latest advances in our knowledge of the genome in T-ALL. We highlight areas where the research in this subtype of ALL is progressing with the aim of identifying key questions that need to be answered in the medium-long term if this knowledge is to be applied in clinics. 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Link Rect: 81, 101, 119, 111 Annotation: Subtype: Link Rect: 247, 67, 284, 77 Page: Sequence: 19 Annotations: Annotation: Subtype: Link Rect: 122, 722, 159, 733 Annotation: Subtype: Link Rect: 293, 699, 331, 710 Annotation: Subtype: Link Rect: 213, 665, 251, 675 Annotation: Subtype: Link Rect: 264, 629, 301, 640 Annotation: Subtype: Link Rect: 307, 629, 343, 640 Checksum: b1869d39 Type: CRC32 Checksum: acbb8d5629af4236ab37776649c49b1e Type: MD5 Checksum: 56356d98f27bf518e3f223b42eb7e3d9155b1cf1 Type: SHA-1