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Title:          GSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal can
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     Item: 
      Title: Abstract
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       Item: 
        Title: Introduction
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       Item: 
        Title: Materials and methods
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        Children: 
         Item: 
          Title: Protein production, purification and characterization
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         Item: 
          Title: Cell culture and CXCR4 expression analysis
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6
         Item: 
          Title: Cytotoxic effect assays
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         Item: 
          Title: Antitumor activity assessment in a subcutaneous CRC model
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         Item: 
          Title: Antimetastatic effect assessment in an orthotopic CRC model
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         Item: 
          Title: In vivo and ex vivo bioluminescence monitoring
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         Item: 
          Title: Histopathological analysis and metastatic foci quantitation
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         Item: 
          Title: Immunocytochemistry and immunohistochemistry
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         Item: 
          Title: Statistical analysis
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       Item: 
        Title: Results
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        Children: 
         Item: 
          Title: Highly potent and CXCR4-dependent T22-PE24-H6 cytotoxic effect in CXCR4+ CRC cells
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1
         Item: 
          Title: T22-PE24-H6 repeated dose administration reducestumor volume without toxicity in non-target organs
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         Item: 
          Title: Lack of apoptosis activation after T22-PE24-H6 nanotoxin treatment
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         Item: 
          Title: T22-PE24-H6 induction of the pyroptotic cell death pathway
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         Item: 
          Title: Selective pyroptotic effect on CXCR4+ cancer cells based on T22-PE24-H6 multivalency
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         Item: 
          Title: T22-PE24-H6 prevents the development of lymphatic and hematogenous metastases in the CXCR4+ SW1417 cell-derived CRC model
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b
         Item: 
          Title: Lack of toxicity of T22-PE24-H6 repeated administration in normal and metastasis-affected organs
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       Item: 
        Title: Discussion
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       Item: 
        Title: Conclusion
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       Item: 
        Title: Acknowledgements
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       Item: 
        Title: Ethical approval
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        Title: Disclosure statement
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        Title: Funding
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       Item: 
        Title: References
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9
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