c7d9c4e6adfebc883cdd8b429960d2d5  270517.pdf
ad6e41fa50d555ad75d26273950afced0bb17931  270517.pdf
0e7d1f4e9ec5c981faab296c41a5c0271a062af723af5a4cd67aa2325880d247  270517.pdf

Title:          Isatuximab plus carfilzomib and dexamethasone in relapsed multiple myeloma patients with high‐risk cytogenetics: IKEMA subgroup analysis
Subject:        European J of Haematology 2022.109:504-512
Creator:        Arbortext Advanced Print Publisher 9.1.520/W Unicode
Producer:       Acrobat Distiller 22.0 (Windows); modified using iText 4.2.0 by 1T3XT
CreationDate:   Sun Oct  2 05:21:50 2022 CEST
ModDate:        Wed Feb  8 10:45:53 2023 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          9
Encrypted:      no
Page size:      595.276 x 782.362 pts
Page rot:       0
File size:      1006213 bytes
Optimized:      no
PDF version:    1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
IIGNPH+AdvTTeb5f0e55.I               Type 1C           WinAnsi          yes yes no      41  0
IIGHCL+AdvTT6071803a.B               Type 1C           WinAnsi          yes yes no      43  0
IIGLHB+AdvP4C4E59                    Type 1C           Custom           yes yes yes     44  0
IIGLHC+AdvTTa9c1b374                 Type 1C           WinAnsi          yes yes no      45  0
IIGLHD+AdvTTa9c1b374+20              Type 1C           Custom           yes yes yes     46  0
IIGLHE+AdvTTa9c1b374+02              Type 1C           WinAnsi          yes yes no     359  0
IIGLHF+AdvOT8608a8d1+20              Type 1C           WinAnsi          yes yes no     360  0
Times-Roman                          Type 1            WinAnsi          no  no  no       5  0
IIGOBH+AdvTTa9c1b374+22              Type 1C           Custom           yes yes yes     42  0
IIHENA+AdvTT9c438aa4.BI              Type 1C           WinAnsi          yes yes no      71  0
IIHEMP+AdvTTfac587ca.B               Type 1C           WinAnsi          yes yes no      72  0
IIHJIE+HelveticaLTStd-Bold           Type 1C           WinAnsi          yes yes no      89  0
IIHJIF+HelveticaLTStd-Roman          Type 1C           WinAnsi          yes yes no      90  0
HelveticaLTStd-Obl                   Type 1C           WinAnsi          yes no  no     118  0
IIHODL+HelveticaLTStd-Bold           Type 1C           WinAnsi          yes yes no     119  0
IIHOCK+HelveticaLTStd-Roman          Type 1C           WinAnsi          yes yes no     120  0
IIIFDB+ArialMT                       Type 1C           WinAnsi          yes yes no     146  0
Arial-ItalicMT                       Type 1C           WinAnsi          yes no  no     147  0
IIIJLI+AdvTT6071803a.B+22            Type 1C           Custom           yes yes yes    168  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2023-02-09 02:35:09 CET
 RepresentationInformation: 270517.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2023-02-08 11:08:35 CET
  Size: 1006213
  Format: PDF
  Version: 1.7
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 0
   FreeObjects: 2
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseNone
    Outlines: 
     Item: 
      Title: Isatuximab plus carfilzomib and dexamethasone in relapsed multiple myeloma patients with high-risk cytogenetics: IKEMA subg...
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f
      Children: 
       Item: 
        Title: 1  INTRODUCTION
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78
       Item: 
        Title: 2  MATERIALS AND METHODS
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee
        Children: 
         Item: 
          Title: 2.1  Study design and patients
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f
         Item: 
          Title: 2.2  Outcomes
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1
         Item: 
          Title: 2.3  Statistical analyses
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d
       Item: 
        Title: 3  RESULTS
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89
        Children: 
         Item: 
          Title: 3.1  Patient baseline characteristics
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9
         Item: 
          Title: 3.2  Efficacy: PFS
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e
         Item: 
          Title: 3.3  Efficacy: Depth of response
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b
         Item: 
          Title: 3.4  Safety
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b
       Item: 
        Title: 4  DISCUSSION
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31
       Item: 
        Title: AUTHOR CONTRIBUTIONS
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107
       Item: 
        Title: ACKNOWLEDGMENTS
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e
       Item: 
        Title: CONFLICT OF INTEREST
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7
        Children: 
         Item: 
          Title: DATA AVAILABILITY STATEMENT
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e
       Item: 
        Title: REFERENCES
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 228
      ImageHeight: 45
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 672
      ImageHeight: 75
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 228
      ImageHeight: 45
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 672
      ImageHeight: 75
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 672
      ImageHeight: 75
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 672
      ImageHeight: 75
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 672
      ImageHeight: 75
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 672
      ImageHeight: 75
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 672
      ImageHeight: 75
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 672
      ImageHeight: 75
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
     Intent: Perceptual
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 672
      ImageHeight: 75
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     ColorSpace: ICCBased
     Intent: Perceptual
   Fonts: 
    Type1: 
     Font: 
      BaseFont: IIGLHE+AdvTTa9c1b374+02
      FontSubset: true
      FirstChar: 152
      LastChar: 152
      FontDescriptor: 
       FontName: IIGLHE+AdvTTa9c1b374+02
       Flags: Nonsymbolic
       FontBBox: -104, -250, 1000, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IIHENA+AdvTT9c438aa4.BI
      FontSubset: true
      FirstChar: 110
      LastChar: 110
      FontDescriptor: 
       FontName: IIHENA+AdvTT9c438aa4.BI
       Flags: Nonsymbolic
       FontBBox: -83, -177, 1010, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IIGLHF+AdvOT8608a8d1+20
      FontSubset: true
      FirstChar: 147
      LastChar: 148
      FontDescriptor: 
       FontName: IIGLHF+AdvOT8608a8d1+20
       Flags: Nonsymbolic
       FontBBox: -968, -333, 2000, 1020
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IIHEMP+AdvTTfac587ca.B
      FontSubset: true
      FirstChar: 49
      LastChar: 85
      FontDescriptor: 
       FontName: IIHEMP+AdvTTfac587ca.B
       Flags: Nonsymbolic
       FontBBox: -72, -177, 1062, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IIIJLI+AdvTT6071803a.B+22
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: IIIJLI+AdvTT6071803a.B+22
       Flags: Symbolic
       FontBBox: -10, -166, 677, 843
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IIGNPH+AdvTTeb5f0e55.I
      FontSubset: true
      FirstChar: 40
      LastChar: 122
      FontDescriptor: 
       FontName: IIGNPH+AdvTTeb5f0e55.I
       Flags: Nonsymbolic
       FontBBox: -83, -177, 989, 927
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IIGOBH+AdvTTa9c1b374+22
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: IIGOBH+AdvTTa9c1b374+22
       Flags: Symbolic
       FontBBox: 0, -166, 677, 854
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IIGHCL+AdvTT6071803a.B
      FontSubset: true
      FirstChar: 37
      LastChar: 252
      FontDescriptor: 
       FontName: IIGHCL+AdvTT6071803a.B
       Flags: Nonsymbolic
       FontBBox: -52, -177, 1041, 947
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IIGLHB+AdvP4C4E59
      FontSubset: true
      FirstChar: 1
      LastChar: 61
      FontDescriptor: 
       FontName: IIGLHB+AdvP4C4E59
       Flags: Symbolic
       FontBBox: -31, -250, 1000, 750
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IIGLHC+AdvTTa9c1b374
      FontSubset: true
      FirstChar: 37
      LastChar: 252
      FontDescriptor: 
       FontName: IIGLHC+AdvTTa9c1b374
       Flags: Nonsymbolic
       FontBBox: -41, -177, 1010, 927
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IIGLHD+AdvTTa9c1b374+20
      FontSubset: true
      FirstChar: 2
      LastChar: 151
      FontDescriptor: 
       FontName: IIGLHD+AdvTTa9c1b374+20
       Flags: Symbolic
       FontBBox: -239, -218, 1166, 937
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IIIFDB+ArialMT
      FontSubset: true
      FirstChar: 32
      LastChar: 116
      FontDescriptor: 
       FontName: IIIFDB+ArialMT
       Flags: Nonsymbolic
       FontBBox: -665, -325, 2000, 1040
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: Arial-ItalicMT
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: Arial-ItalicMT
       Flags: Nonsymbolic, Italic
       FontBBox: -517, -325, 1359, 998
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: HelveticaLTStd-Obl
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: HelveticaLTStd-Obl
       Flags: Nonsymbolic, Italic
       FontBBox: -170, -225, 1116, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IIHODL+HelveticaLTStd-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 116
      FontDescriptor: 
       FontName: IIHODL+HelveticaLTStd-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -170, -228, 1003, 962
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IIHOCK+HelveticaLTStd-Roman
      FontSubset: true
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: IIHOCK+HelveticaLTStd-Roman
       Flags: Nonsymbolic
       FontBBox: -166, -225, 1000, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IIHJIE+HelveticaLTStd-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 122
      FontDescriptor: 
       FontName: IIHJIE+HelveticaLTStd-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -170, -228, 1003, 962
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IIHJIF+HelveticaLTStd-Roman
      FontSubset: true
      FirstChar: 32
      LastChar: 150
      FontDescriptor: 
       FontName: IIHJIF+HelveticaLTStd-Roman
       Flags: Nonsymbolic
       FontBBox: -166, -225, 1000, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="" xmlns:dc="http://purl.org/dc/elements/1.1/"><dc:format>application/pdf</dc:format><dc:identifier>doi:10.1111/ejh.13835</dc:identifier></rdf:Description>
<rdf:Description rdf:about="" xmlns:prism="http://prismstandard.org/namespaces/basic/2.1/"><prism:doi>10.1111/ejh.13835</prism:doi><prism:url>https://doi.org/10.1111/ejh.13835</prism:url></rdf:Description>
<rdf:Description rdf:about="" xmlns:crossmark="http://crossref.org/crossmark/1.0/"><crossmark:MajorVersionDate>2022-08-18</crossmark:MajorVersionDate><crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive><crossmark:CrossMarkDomains><rdf:Seq><rdf:li>onlinelibrary.wiley.com</rdf:li></rdf:Seq></crossmark:CrossMarkDomains><crossmark:DOI>10.1111/ejh.13835</crossmark:DOI></rdf:Description>
<rdf:Description rdf:about="" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"><pdfx:CrossMarkDomains><rdf:Seq><rdf:li>onlinelibrary.wiley.com</rdf:li></rdf:Seq></pdfx:CrossMarkDomains><pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive><pdfx:doi>10.1111/ejh.13835</pdfx:doi><pdfx:CrossmarkMajorVersionDate>2022-08-18</pdfx:CrossmarkMajorVersionDate></rdf:Description>
<rdf:Description rdf:about="" xmlns:jav="http://www.niso.org/schemas/jav/1.0/"><jav:journal_article_version>VoR</jav:journal_article_version></rdf:Description>
</rdf:RDF></x:xmpmeta>
   Pages: 
    Page: 
     Label: 504
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 105, 574, 110, 586
       Destination: 238
      Annotation: 
       Subtype: Link
       Rect: 225, 574, 230, 586
       Destination: 238
      Annotation: 
       Subtype: Link
       Rect: 232, 573, 241, 581
      Annotation: 
       Subtype: Link
       Rect: 363, 574, 369, 586
       Destination: 238
      Annotation: 
       Subtype: Link
       Rect: 469, 574, 474, 586
       Destination: 238
      Annotation: 
       Subtype: Link
       Rect: 130, 557, 135, 568
       Destination: 238
      Annotation: 
       Subtype: Link
       Rect: 225, 557, 230, 568
       Destination: 238
      Annotation: 
       Subtype: Link
       Rect: 232, 555, 241, 563
      Annotation: 
       Subtype: Link
       Rect: 333, 557, 338, 568
       Destination: 238
      Annotation: 
       Subtype: Link
       Rect: 429, 557, 435, 568
       Destination: 238
      Annotation: 
       Subtype: Link
       Rect: 116, 538, 121, 550
       Destination: 238
      Annotation: 
       Subtype: Link
       Rect: 220, 538, 230, 550
       Destination: 238
      Annotation: 
       Subtype: Link
       Rect: 323, 538, 333, 550
       Destination: 238
      Annotation: 
       Subtype: Link
       Rect: 433, 538, 455, 550
       Destination: 238
      Annotation: 
       Subtype: Link
       Rect: 141, 521, 151, 532
       Destination: 238
      Annotation: 
       Subtype: Link
       Rect: 244, 521, 254, 532
       Destination: 238
      Annotation: 
       Subtype: Link
       Rect: 360, 521, 370, 532
       Destination: 238
      Annotation: 
       Subtype: Link
       Rect: 497, 521, 508, 532
       Destination: 238
      Annotation: 
       Subtype: Link
       Rect: 106, 502, 117, 514
       Destination: 238
      Annotation: 
       Subtype: Link
       Rect: 65, 160, 118, 167
      Annotation: 
       Subtype: Link
       Rect: 205, 62, 350, 69
      Annotation: 
       Subtype: Link
       Rect: 76, 22, 181, 29
      Annotation: 
       Subtype: Link
       Rect: 519, 782, 595, 767
     Thumb: true
    Page: 
     Label: 505
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 86, 451, 94, 459
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 233, 438, 237, 446
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 75, 373, 83, 381
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 231, 334, 234, 342
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 284, 282, 288, 290
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 82, 178, 91, 186
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 249, 126, 263, 134
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 476, 477, 490, 485
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 449, 425, 456, 433
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 486, 256, 500, 264
       Destination: 191
     Thumb: true
    Page: 
     Label: 506
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 119, 74, 126, 82
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 326, 87, 333, 95
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 105, 409, 108, 417
       Destination: 68
     Thumb: true
    Page: 
     Label: 507
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 261, 292, 265, 300
       Destination: 68
      Annotation: 
       Subtype: Link
       Rect: 279, 58, 284, 66
       Destination: 85
      Annotation: 
       Subtype: Link
       Rect: 512, 396, 517, 404
       Destination: 115
      Annotation: 
       Subtype: Link
       Rect: 442, 279, 452, 287
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 368, 266, 378, 274
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 518, 266, 527, 274
       Destination: 143
      Annotation: 
       Subtype: Link
       Rect: 417, 45, 421, 53
       Destination: 165
     Thumb: true
    Page: 
     Label: 508
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 187, 123, 192, 131
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 489, 113, 496, 121
       Destination: 191
      Annotation: 
       Subtype: Link
       Rect: 369, 35, 376, 43
       Destination: 217
     Thumb: true
    Page: 
     Label: 509
     Sequence: 6
     Thumb: true
    Page: 
     Label: 510
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 226, 139, 233, 147
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 532, 165, 549, 173
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 542, 113, 549, 121
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 525, 61, 532, 69
       Destination: 217
      Annotation: 
       Subtype: Link
       Rect: 306, 707, 309, 715
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 465, 707, 468, 715
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 157, 647, 159, 655
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 235, 511, 237, 519
       Destination: 165
      Annotation: 
       Subtype: Link
       Rect: 423, 511, 426, 519
       Destination: 165
     Thumb: true
    Page: 
     Label: 511
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 458, 591, 530, 599
      Annotation: 
       Subtype: Link
       Rect: 362, 554, 370, 562
      Annotation: 
       Subtype: Link
       Rect: 372, 552, 515, 560
      Annotation: 
       Subtype: Link
       Rect: 346, 541, 355, 549
      Annotation: 
       Subtype: Link
       Rect: 357, 539, 500, 547
      Annotation: 
       Subtype: Link
       Rect: 322, 146, 435, 153
     Thumb: true
    Page: 
     Label: 512
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 332, 577, 400, 585
     Thumb: true
  Checksum: 9137a807
   Type: CRC32
  Checksum: c7d9c4e6adfebc883cdd8b429960d2d5
   Type: MD5
  Checksum: ad6e41fa50d555ad75d26273950afced0bb17931
   Type: SHA-1