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Title:          Acute lymphoblastic leukemia necessitates GSH-dependent ferroptosis defenses to overcome FSP1 -epigenetic silencing
Subject:        Redox Biology, 55 (2022) 102408. doi:10.1016/j.redox.2022.102408
Keywords:       Glutathione,Ferroptosis,Acute lymphoblastic leukemia,GPX4,FSP1,DNA Methylation
Author:         Lucas B. Pontel
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      Title: Acute lymphoblastic leukemia necessitates GSH-dependent ferroptosis defenses to overcome FSP1-epigenetic silencing
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        Title: 1 Introduction
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        Title: 2 Material and methods
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          Title: 2.1 Cell lines
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          Title: 2.2 Patient data
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          Title: 2.3 Viability assays
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          Title: 2.4 Flow cytometry
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          Title: 2.5 FSP1 in trans expression
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          Title: 2.6 Expression analysis
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          Title: 2.7 DNA methylation analyses
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          Title: 2.8 Glutathione (GSH) determination
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          Title: 2.9 Chick embryo chorioallantoic membrane (CAM) model
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          Title: 2.10 Statistics
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          Title: 2.11 Datasets
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        Title: 3 Results and discussion
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          Title: 3.1 GSH metabolism is required for growth of hematopoietic cancer cell lines
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          Title: 3.2 Ferroptosis inducers selectively eliminate ALL cells
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          Title: 3.3 ALL cells lack the expression of FSP1
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          Title: 3.4 FSP1 is hypermethylated in ALL cell lines
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          Title: 3.5 FSP1 expression favors cancer progression
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        Title: 4 Conclusions
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        Title: Funding
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        Title: Declaration of competing interest
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        Title: Acknowledgements
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        Title: Appendix A Supplementary data
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  Checksum: d669a46715353607b344f2179dd84eb24b66579c
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