fb045cba82cac9bce7edcdcdb51d290c 270529.pdf 20b5ea37ae28ff52aa2d2a62a1c2b4b2a5cdcef6 270529.pdf d4176cb3368f0f5f7191311380454a7e2a1b003dbf6be59f70a03ada9587368b 270529.pdf Title: Cancer Survival in Adults in Spain: A Population-Based Study of the Spanish Network of Cancer Registries (REDECAN) Subject: The assessment of cancer survival at the population level is essential for monitoring progress in cancer control. We aimed to assess cancer survival and its trends in adults in Spain. Individual records of 601,250 adults with primary cancer diagnosed during 2002–2013 and followed up to 2015 were included from 13 population-based cancer registries. We estimated net survival up to five years after diagnosis and analyzed absolute changes between 2002–2007 and 2008–2013. Estimates were age-standardized. Analyses were performed for 29 cancer groups, by age and sex. Overall, age-standardized five-year net survival was higher in women (61.7%, 95% CI 61.4–62.1%) than in men (55.3%, 95% CI 55.0–55.6%), and ranged by cancer from 7.2% (pancreas) to 89.6% (prostate) in men, and from 10.0% (pancreas) to 93.1% (thyroid) in women in the last period. Survival declined with age, showing different patterns by cancer. Between both periods, age-standardized five-year net survival increased overall by 3.3% (95% CI 3.0–3.7%) in men and 2.5% (95% CI 2.0–3.0%) in women, and for most cancer groups. Improvements were greater in patients younger than 75 years than in older patients. Chronic myeloid leukemia and myeloma showed the largest increases. Among the most common malignancies, the greatest absolute increases in survival were observed for colon (5.0%, 95% CI 4.0–6.0%) and rectal cancers (4.5%, 95% CI 3.2–5.9%). Survival improved even for some cancers with poor prognosis (pancreas, esophagus, lung, liver, and brain cancer). Further investigation of possible sociodemographic inequalities is warranted. This study contributes to the evaluation of cancer control and health services’ effectiveness. Keywords: cancer; survival; prognosis; epidemiology; population-based study; cancer registries Author: Marcela Guevara, Amaia Molinuevo, Diego Salmerón, Rafael Marcos-Gragera, Marià Carulla, María-Dolores Chirlaque, Marta Rodríguez Camblor, Araceli Alemán, Dolores Rojas, Ana Vizcaíno Batllés, Matilde Chico, Rosario Jiménez Chillarón, Arantza López de Munain, Visitación de Castro, Maria-José Sánchez, Enrique Ramalle-Gómara, Paula Franch, Jaume Galceran and Eva Ardanaz Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Sun May 15 13:02:22 2022 CEST ModDate: Sun May 15 13:07:11 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 18 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 907953 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- LMAKNS+VnURWPalladioL Type 1 Custom yes yes no 10 0 QSQACG+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 RLPSXT+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 PLPDNI+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 JUXSQN+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 LCJEVJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 47 0 GQWIGS+CMSY10 Type 1 Builtin yes yes no 78 0 AKFOHD+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 95 0 AKFOHF+PalatinoLinotype TrueType WinAnsi yes yes no 98 0 AKFOHH+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 101 0 AKGDKI+Arial CID TrueType Identity-H yes yes yes 104 0 AKGEBG+Arial,Bold CID TrueType Identity-H yes yes yes 110 0 AKFOHD+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 126 0 AKFOHF+PalatinoLinotype TrueType WinAnsi yes yes no 129 0 AKFOHH+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 132 0 AKGDKI+Arial CID TrueType Identity-H yes yes yes 135 0 AKGEBG+Arial,Bold CID TrueType Identity-H yes yes yes 141 0 AKFOHD+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 163 0 AKFOHF+PalatinoLinotype TrueType WinAnsi yes yes no 166 0 AKFOHH+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 169 0 AKGDKI+Arial CID TrueType Identity-H yes yes yes 172 0 AKGEBG+Arial,Bold CID TrueType Identity-H yes yes yes 178 0 KGSZMU+VnURWPalladioL-Italic Type 1 Custom yes yes no 197 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-02-10 02:34:12 CET RepresentationInformation: 270529.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-02-09 10:52:52 CET Size: 907953 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 388 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Study Design and Population Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Follow-Up for Vital Status Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Quality Control Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Statistical Analyses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Children: Item: Title: Study Population and Quality Indicators Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Cancer Survival in Patients Diagnosed in 2008 2013 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Survival Trends between 2002 2007 and 2008 2013 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Info: Title: Cancer Survival in Adults in Spain: A Population-Based Study of the Spanish Network of Cancer Registries (REDECAN) Author: Marcela Guevara, Amaia Molinuevo, Diego Salmerón, Rafael Marcos-Gragera, Marià Carulla, María-Dolores Chirlaque, Marta Rodríguez Camblor, Araceli Alemán, Dolores Rojas, Ana Vizcaíno Batllés, Matilde Chico, Rosario Jiménez Chillarón, Arantza López de Munain, Visitación de Castro, Maria-José Sánchez, Enrique Ramalle-Gómara, Paula Franch, Jaume Galceran and Eva Ardanaz Subject: The assessment of cancer survival at the population level is essential for monitoring progress in cancer control. We aimed to assess cancer survival and its trends in adults in Spain. Individual records of 601,250 adults with primary cancer diagnosed during 2002 2013 and followed up to 2015 were included from 13 population-based cancer registries. We estimated net survival up to five years after diagnosis and analyzed absolute changes between 2002 2007 and 2008 2013. Estimates were age-standardized. Analyses were performed for 29 cancer groups, by age and sex. Overall, age-standardized five-year net survival was higher in women (61.7%, 95% CI 61.4 62.1%) than in men (55.3%, 95% CI 55.0 55.6%), and ranged by cancer from 7.2% (pancreas) to 89.6% (prostate) in men, and from 10.0% (pancreas) to 93.1% (thyroid) in women in the last period. Survival declined with age, showing different patterns by cancer. Between both periods, age-standardized five-year net survival increased overall by 3.3% (95% CI 3.0 3.7%) in men and 2.5% (95% CI 2.0 3.0%) in women, and for most cancer groups. Improvements were greater in patients younger than 75 years than in older patients. Chronic myeloid leukemia and myeloma showed the largest increases. Among the most common malignancies, the greatest absolute increases in survival were observed for colon (5.0%, 95% CI 4.0 6.0%) and rectal cancers (4.5%, 95% CI 3.2 5.9%). Survival improved even for some cancers with poor prognosis (pancreas, esophagus, lung, liver, and brain cancer). Further investigation of possible sociodemographic inequalities is warranted. This study contributes to the evaluation of cancer control and health services’ effectiveness. 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