ad1ac3a61346731f3db783810d9faf09 Clonal_heterogeneity.pdf 649f0c98c24695ff24fd70d84e436444d75637e2 Clonal_heterogeneity.pdf 61cb0399b85d6ad6332390a7ce094f9e1f0ceb1abd71389a1ca68b379ccafcf1 Clonal_heterogeneity.pdf Title: Clonal heterogeneity and rates of specific chromosome gains are risk predictors in childhood high‐hyperdiploid B‐cell acute lymphoblastic leukemia Subject: Molecular Oncology 2022.16:2899-2919 Creator: Arbortext Advanced Print Publisher 9.1.531/W Unicode Producer: Acrobat Distiller 15.0 (Windows); modified using iText 4.2.0 by 1T3XT CreationDate: Tue Aug 16 10:02:00 2022 CEST ModDate: Mon Jan 23 18:31:22 2023 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 21 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 3284428 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- KEPCPM+AdvPSUnv-LO Type 1C WinAnsi yes yes no 75 0 KEPCMK+AdvPSUnv-B Type 1C MacRoman yes yes no 76 0 KEPCNL+AdvTimes Type 1C MacRoman yes yes no 78 0 KEPCPL+AdvPSSym Type 1C Custom yes yes no 79 0 KEPBMK+AdvPS-UVBL Type 1C MacRoman yes yes no 80 0 KEPBML+AdvPSUnv Type 1C MacRoman yes yes no 81 0 KEPBMM+AdvPSPAL-R Type 1C WinAnsi yes yes no 277 0 KEPCFK+AdvPSUnv-L Type 1C MacRoman yes yes no 82 0 KEPCHK+AdvOTb0c9bf5d+20 Type 1C WinAnsi yes yes no 83 0 KEPCKK+AdvOTb0c9bf5d Type 1C WinAnsi yes yes no 84 0 Times-Roman Type 1 WinAnsi no no no 5 0 KEPEFF+AdvTimes-i Type 1C WinAnsi yes yes no 77 0 KEPEPC+AdvPSUnv-BO Type 1C WinAnsi yes yes no 107 0 KEPFKP+AdvOTb0c9bf5d+22 Type 1C Custom yes yes yes 125 0 KEPFIP+AdvP4C4E74 Type 1C Custom yes yes yes 126 0 KEPGCN+AdvP4C4E59 Type 1C WinAnsi yes yes no 138 0 KFAIJN+AdvOTb0c9bf5d+03 Type 1C Custom yes yes yes 175 0 KFBKNO+AdvOTe3b1fbf3.B Type 1C WinAnsi yes yes no 221 0 KFDIIJ+AdvTimes-b Type 1C WinAnsi yes yes no 286 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-06-28 02:28:47 CEST RepresentationInformation: Clonal_heterogeneity.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-01-23 19:46:57 CET Size: 3284428 Format: PDF Version: 1.6 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lmol213276-supitem' cannot be found Offset: 3247372 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lmol213276-supitem' cannot be found Offset: 3247372 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lmol213276-supitem' cannot be found Offset: 3247372 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lmol213276-supitem' cannot be found Offset: 3247372 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lmol213276-supitem' cannot be found Offset: 3247372 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lmol213276-supitem' cannot be found Offset: 3247372 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lmol213276-supitem' cannot be found Offset: 3247372 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lmol213276-supitem' cannot be found Offset: 3247372 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'lmol213276-supitem' cannot be found Offset: 3247372 MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseThumbs Outlines: Item: Title: Outline placeholder Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Children: Item: Title: mol213276-aff-0001 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: mol213276-aff-0002 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: mol213276-aff-0003 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: mol213276-aff-0004 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: mol213276-aff-0005 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: mol213276-aff-0006 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: mol213276-aff-0007 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: mol213276-aff-0008 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: mol213276-aff-0009 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: mol213276-aff-0010 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: mol213276-aff-0011 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: mol213276-aff-0012 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: mol213276-aff-0013 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: mol213276-aff-0014 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: mol213276-aff-0015 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: mol213276-aff-0016 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: mol213276-aff-0017 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: mol213276-aff-0018 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: mol213276-aff-0019 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: mol213276-aff-0020 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: mol213276-aff-0021 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: mol213276-aff-0022 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: mol213276-aff-0023 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: mol213276-aff-0024 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: mol213276-aff-0025 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: mol213276-aff-0026 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Item: Title: mol213276-tbl-0001 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3 Item: Title: mol213276-fig-0001 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca Item: Title: mol213276-fig-0002 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4e718207 Item: Title: mol213276-tbl-0002 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1d371b2d Item: Title: mol213276-fig-0003 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@543c6f6d Item: Title: mol213276-fig-0004 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13eb8acf Item: Title: mol213276-tbl-0003 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@51c8530f Item: Title: mol213276-fig-0005 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7403c468 Item: Title: mol213276-fig-0006 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43738a82 Item: Title: mol213276-bib-0001 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@c81cdd1 Item: Title: mol213276-bib-0002 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1fc2b765 Item: Title: mol213276-bib-0003 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@75881071 Item: Title: mol213276-bib-0004 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2a70a3d8 Item: Title: mol213276-bib-0005 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@289d1c02 Item: Title: mol213276-bib-0006 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@22eeefeb Item: Title: mol213276-bib-0007 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@17d0685f Item: Title: mol213276-bib-0008 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3891771e Item: Title: mol213276-bib-0009 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@78ac1102 Item: Title: mol213276-bib-0010 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2de8284b Item: Title: mol213276-bib-0011 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@396e2f39 Item: Title: mol213276-bib-0012 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a74868d Item: Title: mol213276-bib-0013 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12c8a2c0 Item: Title: mol213276-bib-0014 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7e0e6aa2 Item: Title: mol213276-bib-0015 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@365185bd Item: Title: mol213276-bib-0016 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@18bf3d14 Item: Title: mol213276-bib-0017 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4fb64261 Item: Title: mol213276-bib-0018 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42607a4f Item: Title: mol213276-bib-0019 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@782663d3 Item: Title: mol213276-bib-0020 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1990a65e Item: Title: mol213276-bib-0021 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64485a47 Item: Title: mol213276-bib-0022 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@25bbf683 Item: Title: mol213276-bib-0023 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6ec8211c Item: Title: mol213276-bib-0024 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7276c8cd Item: Title: mol213276-bib-0025 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@544a2ea6 Item: Title: mol213276-bib-0026 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2e3fc542 Item: Title: mol213276-bib-0027 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@150c158 Item: Title: mol213276-bib-0028 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4524411f Item: Title: mol213276-bib-0029 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@401e7803 Item: Title: mol213276-bib-0030 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@10dba097 Item: Title: mol213276-bib-0031 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1786f9d5 Item: Title: mol213276-bib-0032 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@704d6e83 Item: Title: mol213276-bib-0033 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43a0cee9 Item: Title: mol213276-bib-0034 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eb21112 Item: Title: mol213276-bib-0035 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2eda0940 Item: Title: mol213276-bib-0036 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3578436e Item: Title: mol213276-bib-0037 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@706a04ae Item: Title: mol213276-bib-0038 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6eceb130 Item: Title: mol213276-bib-0039 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@10a035a0 Item: Title: mol213276-bib-0040 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@67b467e9 Item: Title: mol213276-bib-0041 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@47db50c5 Item: Title: mol213276-bib-0042 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5c072e3f Item: Title: mol213276-bib-0043 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d1b0d2a Item: Title: mol213276-bib-0044 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@954b04f Item: Title: mol213276-bib-0045 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@149494d8 Item: Title: mol213276-bib-0046 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@710726a3 Item: Title: mol213276-bib-0047 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@646007f4 Item: Title: mol213276-bib-0048 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@481a15ff Item: Title: mol213276-bib-0049 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@78186a70 Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1680 ImageHeight: 158 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 40 ImageHeight: 35 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1289 ImageHeight: 1332 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1862 ImageHeight: 2569 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1927 ImageHeight: 2063 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1938 ImageHeight: 1583 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1815 ImageHeight: 2582 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1759 ImageHeight: 2576 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Fonts: Type1: Font: BaseFont: KEPGCN+AdvP4C4E59 FontSubset: true FirstChar: 46 LastChar: 46 FontDescriptor: FontName: KEPGCN+AdvP4C4E59 Flags: Nonsymbolic FontBBox: -31, -250, 1000, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KEPCPM+AdvPSUnv-LO FontSubset: true FirstChar: 45 LastChar: 121 FontDescriptor: FontName: KEPCPM+AdvPSUnv-LO Flags: Nonsymbolic FontBBox: -145, -187, 1135, 750 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KEPEPC+AdvPSUnv-BO FontSubset: true FirstChar: 105 LastChar: 117 FontDescriptor: FontName: KEPEPC+AdvPSUnv-BO Flags: Nonsymbolic FontBBox: -145, -218, 1135, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KEPCMK+AdvPSUnv-B FontSubset: true FirstChar: 45 LastChar: 223 FontDescriptor: FontName: KEPCMK+AdvPSUnv-B Flags: Nonsymbolic FontBBox: -145, -218, 1000, 770 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: KEPEFF+AdvTimes-i FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: KEPEFF+AdvTimes-i Flags: Nonsymbolic FontBBox: -253, -211, 1078, 766 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KEPCNL+AdvTimes FontSubset: true FirstChar: 37 LastChar: 245 FontDescriptor: FontName: KEPCNL+AdvTimes Flags: Serif, Nonsymbolic FontBBox: -217, -212, 1005, 766 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: KEPCPL+AdvPSSym FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: KEPCPL+AdvPSSym Flags: Symbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: KFAIJN+AdvOTb0c9bf5d+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: KFAIJN+AdvOTb0c9bf5d+03 Flags: Symbolic FontBBox: -479, -364, 854, 927 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KEPBMK+AdvPS-UVBL FontSubset: true FirstChar: 45 LastChar: 223 FontDescriptor: FontName: KEPBMK+AdvPS-UVBL Flags: Nonsymbolic FontBBox: -145, -208, 1000, 802 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: KEPBML+AdvPSUnv FontSubset: true FirstChar: 44 LastChar: 245 FontDescriptor: FontName: KEPBML+AdvPSUnv Flags: Nonsymbolic FontBBox: -156, -229, 1000, 791 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: KEPCFK+AdvPSUnv-L FontSubset: true FirstChar: 37 LastChar: 245 FontDescriptor: FontName: KEPCFK+AdvPSUnv-L Flags: Nonsymbolic FontBBox: -145, -187, 1000, 750 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: KEPCHK+AdvOTb0c9bf5d+20 FontSubset: true FirstChar: 134 LastChar: 151 FontDescriptor: FontName: KEPCHK+AdvOTb0c9bf5d+20 Flags: Nonsymbolic FontBBox: -968, -333, 2000, 1020 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KEPCKK+AdvOTb0c9bf5d FontSubset: true FirstChar: 43 LastChar: 215 FontDescriptor: FontName: KEPCKK+AdvOTb0c9bf5d Flags: Nonsymbolic FontBBox: -62, -208, 927, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KEPBMM+AdvPSPAL-R FontSubset: true FirstChar: 96 LastChar: 180 FontDescriptor: FontName: KEPBMM+AdvPSPAL-R Flags: Nonsymbolic FontBBox: -156, -281, 1072, 729 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KEPFKP+AdvOTb0c9bf5d+22 FontSubset: true FirstChar: 2 LastChar: 21 FontDescriptor: FontName: KEPFKP+AdvOTb0c9bf5d+22 Flags: Symbolic FontBBox: 0, -322, 1218, 968 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KFBKNO+AdvOTe3b1fbf3.B FontSubset: true FirstChar: 43 LastChar: 43 FontDescriptor: FontName: KFBKNO+AdvOTe3b1fbf3.B Flags: Nonsymbolic FontBBox: -62, -208, 979, 1000 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KEPFIP+AdvP4C4E74 FontSubset: true FirstChar: 1 LastChar: 240 FontDescriptor: FontName: KEPFIP+AdvP4C4E74 Flags: Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: KFDIIJ+AdvTimes-b FontSubset: true FirstChar: 46 LastChar: 108 FontDescriptor: FontName: KFDIIJ+AdvTimes-b Flags: Nonsymbolic FontBBox: -168, -210, 1002, 766 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdfdoi:10.1002/1878-0261.13276 10.1002/1878-0261.13276https://doi.org/10.1002/1878-0261.13276 2022-07-19truefebs.onlinelibrary.wiley.com10.1002/1878-0261.13276 febs.onlinelibrary.wiley.comtrue10.1002/1878-0261.132762022-07-19 VoR Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 165, 629, 169, 638 Destination: 311 Annotation: Subtype: Link Rect: 255, 629, 272, 638 Destination: 311 Annotation: Subtype: Link Rect: 337, 629, 341, 638 Destination: 311 Annotation: Subtype: Link Rect: 405, 629, 422, 638 Destination: 311 Annotation: Subtype: Link Rect: 187, 617, 197, 627 Destination: 311 Annotation: Subtype: Link Rect: 263, 617, 280, 627 Destination: 311 Annotation: Subtype: Link Rect: 377, 617, 387, 627 Destination: 311 Annotation: Subtype: Link Rect: 461, 617, 466, 627 Destination: 311 Annotation: Subtype: Link Rect: 135, 605, 139, 615 Destination: 311 Annotation: Subtype: Link Rect: 212, 605, 216, 615 Destination: 311 Annotation: Subtype: Link Rect: 296, 605, 305, 615 Destination: 311 Annotation: Subtype: Link Rect: 395, 605, 403, 615 Destination: 311 Annotation: Subtype: Link Rect: 173, 593, 181, 603 Destination: 311 Annotation: Subtype: Link Rect: 270, 593, 279, 603 Destination: 311 Annotation: Subtype: Link Rect: 351, 593, 359, 603 Destination: 311 Annotation: Subtype: Link Rect: 456, 593, 464, 603 Destination: 311 Annotation: Subtype: Link Rect: 119, 581, 148, 591 Destination: 311 Annotation: Subtype: Link Rect: 223, 581, 231, 591 Destination: 311 Annotation: Subtype: Link Rect: 326, 581, 334, 591 Destination: 311 Annotation: Subtype: Link Rect: 396, 581, 414, 591 Destination: 311 Annotation: Subtype: Link Rect: 140, 569, 169, 579 Destination: 311 Annotation: Subtype: Link Rect: 300, 569, 309, 579 Destination: 311 Annotation: Subtype: Link Rect: 398, 569, 407, 579 Destination: 311 Annotation: Subtype: Link Rect: 506, 569, 514, 579 Destination: 311 Annotation: Subtype: Link Rect: 151, 557, 155, 567 Destination: 311 Annotation: Subtype: Link Rect: 240, 557, 267, 567 Destination: 311 Annotation: Subtype: Link Rect: 355, 557, 365, 567 Destination: 311 Annotation: Subtype: Link Rect: 365, 552, 367, 562 Annotation: Subtype: Link Rect: 365, 552, 367, 562 Annotation: Subtype: Link Rect: 367, 552, 375, 563 Annotation: Subtype: Link Rect: 519, 782, 595, 767 Thumb: true Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 94, 691, 194, 698 Annotation: Subtype: Link Rect: 94, 680, 207, 688 Annotation: Subtype: Link Rect: 98, 373, 103, 382 Destination: 283 Annotation: Subtype: Link Rect: 141, 313, 151, 322 Destination: 283 Annotation: Subtype: Link Rect: 141, 313, 155, 322 Destination: 283 Annotation: Subtype: Link Rect: 93, 265, 103, 274 Destination: 283 Annotation: Subtype: Link Rect: 93, 265, 107, 274 Destination: 283 Annotation: Subtype: Link Rect: 72, 205, 77, 215 Destination: 283 Annotation: Subtype: Link Rect: 72, 157, 89, 167 Destination: 283 Annotation: Subtype: Link Rect: 422, 420, 431, 430 Destination: 283 Annotation: Subtype: Link Rect: 367, 361, 376, 370 Destination: 283 Annotation: Subtype: Link Rect: 526, 325, 536, 334 Destination: 283 Annotation: Subtype: Link Rect: 526, 265, 536, 274 Destination: 283 Annotation: Subtype: Link Rect: 381, 229, 390, 239 Destination: 283 Annotation: Subtype: Link Rect: 432, 193, 446, 203 Destination: 283 Annotation: Subtype: Link Rect: 432, 193, 456, 203 Destination: 283 Annotation: Subtype: Link Rect: 439, 145, 461, 155 Destination: 283 Thumb: true Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 80, 619, 101, 628 Destination: 283 Annotation: Subtype: Link Rect: 141, 523, 151, 532 Destination: 289 Annotation: Subtype: Link Rect: 91, 451, 101, 461 Destination: 289 Annotation: Subtype: Link Rect: 167, 427, 181, 437 Destination: 289 Annotation: Subtype: Link Rect: 167, 427, 191, 437 Destination: 289 Annotation: Subtype: Link Rect: 155, 320, 164, 329 Destination: 289 Annotation: Subtype: Link Rect: 397, 511, 402, 520 Destination: 122 Annotation: Subtype: Link Rect: 518, 427, 522, 437 Destination: 122 Annotation: Subtype: Link Rect: 318, 415, 323, 425 Destination: 135 Annotation: Subtype: Link Rect: 509, 391, 519, 401 Destination: null Annotation: Subtype: Link Rect: 392, 116, 413, 126 Destination: 172 Thumb: true Page: Label: 4 Thumb: true Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 462, 571, 483, 580 Destination: 289 Annotation: Subtype: Link Rect: 364, 248, 373, 257 Destination: 289 Annotation: Subtype: Link Rect: 403, 104, 413, 114 Destination: 289 Thumb: true Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 481, 243, 490, 252 Destination: 289 Annotation: Subtype: Link Rect: 415, 159, 425, 169 Destination: 289 Annotation: Subtype: Link Rect: 402, 99, 412, 109 Destination: 289 Thumb: true Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 191, 702, 201, 712 Destination: 289 Annotation: Subtype: Link Rect: 422, 654, 431, 664 Destination: 289 Annotation: Subtype: Link Rect: 454, 475, 466, 485 Destination: 135 Annotation: Subtype: Link Rect: 515, 475, 519, 485 Destination: 122 Annotation: Subtype: Link Rect: 356, 439, 376, 449 Destination: 135 Annotation: Subtype: Link Rect: 424, 439, 429, 449 Destination: 122 Annotation: Subtype: Link Rect: 510, 391, 525, 401 Destination: 172 Annotation: Subtype: Link Rect: 299, 379, 305, 389 Destination: 172 Annotation: Subtype: Link Rect: 502, 332, 519, 341 Destination: 172 Annotation: Subtype: Link Rect: 502, 332, 525, 341 Destination: 172 Annotation: Subtype: Link Rect: 348, 320, 358, 329 Destination: null Annotation: Subtype: Link Rect: 499, 284, 519, 293 Destination: 172 Annotation: Subtype: Link Rect: 321, 236, 331, 245 Destination: null Annotation: Subtype: Link Rect: 451, 176, 460, 186 Destination: 289 Annotation: Subtype: Link Rect: 345, 152, 358, 162 Destination: 172 Annotation: Subtype: Link Rect: 413, 152, 418, 162 Destination: 172 Annotation: Subtype: Link Rect: 453, 104, 457, 114 Destination: 172 Thumb: true Page: Label: 8 Thumb: true Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 182, 100, 194, 109 Destination: 183 Annotation: Subtype: Link Rect: 499, 112, 519, 121 Destination: 183 Thumb: true Page: Label: 10 Thumb: true Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 95, 678, 106, 688 Destination: 183 Annotation: Subtype: Link Rect: 70, 619, 103, 628 Destination: 283 Annotation: Subtype: Link Rect: 262, 547, 274, 556 Destination: 183 Annotation: Subtype: Link Rect: 251, 499, 265, 508 Destination: 289 Annotation: Subtype: Link Rect: 251, 499, 275, 508 Destination: 289 Annotation: Subtype: Link Rect: 144, 451, 154, 461 Destination: 289 Annotation: Subtype: Link Rect: 124, 427, 133, 437 Destination: 289 Annotation: Subtype: Link Rect: 180, 391, 191, 401 Destination: 183 Annotation: Subtype: Link Rect: 237, 176, 258, 186 Destination: 289 Annotation: Subtype: Link Rect: 447, 702, 459, 712 Destination: 211 Annotation: Subtype: Link Rect: 409, 630, 430, 640 Destination: 211 Annotation: Subtype: Link Rect: 498, 583, 519, 592 Destination: 211 Annotation: Subtype: Link Rect: 495, 535, 505, 544 Destination: null Annotation: Subtype: Link Rect: 299, 523, 309, 532 Destination: null Annotation: Subtype: Link Rect: 486, 332, 497, 341 Destination: 211 Annotation: Subtype: Link Rect: 301, 176, 311, 186 Destination: 289 Annotation: Subtype: Link Rect: 428, 152, 440, 162 Destination: 245 Annotation: Subtype: Link Rect: 431, 81, 442, 90 Destination: 245 Thumb: true Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 220, 170, 242, 180 Destination: 289 Annotation: Subtype: Link Rect: 506, 218, 518, 228 Destination: 245 Thumb: true Page: Label: 13 Annotations: Annotation: Subtype: Link Rect: 176, 702, 188, 712 Destination: 245 Annotation: Subtype: Link Rect: 208, 475, 218, 485 Destination: null Annotation: Subtype: Link Rect: 76, 344, 88, 353 Destination: 245 Annotation: Subtype: Link Rect: 111, 296, 122, 305 Destination: 245 Annotation: Subtype: Link Rect: 168, 296, 178, 305 Destination: null Annotation: Subtype: Link Rect: 79, 128, 84, 138 Destination: 245 Annotation: Subtype: Link Rect: 318, 690, 329, 700 Destination: 245 Annotation: Subtype: Link Rect: 460, 630, 464, 640 Destination: 172 Annotation: Subtype: Link Rect: 508, 630, 519, 640 Destination: 183 Annotation: Subtype: Link Rect: 481, 475, 493, 485 Destination: 245 Annotation: Subtype: Link Rect: 404, 403, 414, 413 Destination: null Annotation: Subtype: Link Rect: 387, 236, 392, 245 Destination: 122 Annotation: Subtype: Link Rect: 352, 188, 364, 198 Destination: 257 Annotation: Subtype: Link Rect: 358, 152, 378, 162 Destination: 257 Annotation: Subtype: Link Rect: 398, 104, 410, 114 Destination: 257 Thumb: true Page: Label: 14 Thumb: true Page: Label: 15 Annotations: Annotation: Subtype: Link Rect: 235, 201, 246, 211 Destination: 257 Annotation: Subtype: Link Rect: 131, 117, 142, 127 Destination: 257 Annotation: Subtype: Link Rect: 189, 117, 198, 127 Destination: null Thumb: true Page: Label: 16 Thumb: true Page: Label: 17 Annotations: Annotation: Subtype: Link Rect: 186, 429, 227, 438 Destination: 283 Annotation: Subtype: Link Rect: 89, 405, 103, 414 Destination: 289 Annotation: Subtype: Link Rect: 89, 405, 112, 414 Destination: 289 Annotation: Subtype: Link Rect: 218, 405, 228, 414 Destination: 289 Annotation: Subtype: Link Rect: 175, 393, 184, 402 Destination: 289 Annotation: Subtype: Link Rect: 157, 369, 167, 378 Destination: 289 Annotation: Subtype: Link Rect: 253, 238, 275, 247 Destination: 289 Annotation: Subtype: Link Rect: 144, 190, 165, 199 Destination: 289 Annotation: Subtype: Link Rect: 77, 166, 86, 175 Destination: 293 Annotation: Subtype: Link Rect: 120, 118, 129, 127 Destination: 289 Annotation: Subtype: Link Rect: 411, 429, 437, 438 Destination: 283 Annotation: Subtype: Link Rect: 411, 429, 459, 438 Destination: 283 Annotation: Subtype: Link Rect: 447, 357, 456, 367 Destination: 283 Thumb: true Page: Label: 18 Annotations: Annotation: Subtype: Link Rect: 93, 642, 102, 652 Destination: 289 Annotation: Subtype: Link Rect: 140, 344, 149, 353 Destination: 283 Annotation: Subtype: Link Rect: 105, 296, 115, 305 Destination: 293 Annotation: Subtype: Link Rect: 197, 128, 206, 138 Destination: 293 Thumb: true Page: Label: 19 Annotations: Annotation: Subtype: Link Rect: 53, 666, 271, 676 Thumb: true Page: Label: 20 Thumb: true Page: Label: 21 Thumb: true Checksum: 2d94d728 Type: CRC32 Checksum: ad1ac3a61346731f3db783810d9faf09 Type: MD5 Checksum: 649f0c98c24695ff24fd70d84e436444d75637e2 Type: SHA-1