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Title:          Generation and proof-of-concept for allogeneic CD123 CAR-Delta One T (DOT) cells in acute myeloid leukemia
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     Item: 
      Title: Generation and proof-­of-­concept for allogeneic CD123 CAR-­Delta One T (DOT) cells in acute myeloid leukemia
      Children: 
       Item: 
        Title: Abstract
       Item: 
        Title: Introduction
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: DOT cell generation
         Item: 
          Title: CD123-CAR retroviral production and transduction
         Item: 
          Title: Immunophenotyping of DOT cells, cell lines and primary AML samples
         Item: 
          Title: In vitro cytotoxicity assays and cytokine release determination
         Item: 
          Title: In vivo AML patient-derived xenograft models
         Item: 
          Title: Statistical analysis
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: CD123-directed DOT cells (CD123CAR-DOTs) expand robustly while preserving DOT phenotype
         Item: 
          Title: CD123CAR-DOTs specifically augment cytotoxicity against AML cell lines and primary blasts in vitro
         Item: 
          Title: Serial infusions of CD123CAR-DOTs exhibit robust anti-leukemic effect in vivo
         Item: 
          Title: Provision of IL-15 supports single-dose CD123CAR-DOT activity in vivo
         Item: 
          Title: Daily provision of IL-15 maximizes DOT-cell therapeutic efficacy in vivo
         Item: 
          Title: Optimized CD123CAR-DOT treatment controls AML growth on in vivo rechallenge
       Item: 
        Title: Discussion
       Item: 
        Title: References
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  Checksum: 0b38686c
   Type: CRC32
  Checksum: 1132636f2e5eff88c50ffb7787e32c8c
   Type: MD5
  Checksum: d3931403fe711cada193a78c7434e947315cb5e4
   Type: SHA-1