dffc47810222542882f81219a1a0b4c1 cancers-14-04554-v3.pdf 27f58e39f34967a4cdc4aeb84123b36358c08fe0 cancers-14-04554-v3.pdf 8b3495ebba963c98943a7159d8b5c5badf60c1490909c89f86ae69c87d66109c cancers-14-04554-v3.pdf Title: Modern Management Options for Ph+ ALL Subject: Impressive advances have been achieved in the management of patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) since the initial concurrent use of imatinib and standard chemotherapy. The attenuation of chemotherapy has proven to be equally effective and less toxic, the use of third generation TKI upfront has improved the frequency of complete molecular response and the survival rate, and the combination of tyrosine kinase inhibitors with immunotherapy has further increased the rate of molecular response to 70–80% after consolidation, which has been translated into a survival rate of 75–90% in recent trials. As a result of these improvements, the role of allogeneic hematopoietic stem cell transplantation is being redefined. The methodology of measurable residual disease assessment and the detection of ABL1 mutations are also improving and will contribute to a more precise selection of the treatment for newly diagnosed and relapsed or refractory (R/R) patients. Finally, new compounds combined with immunotherapeutic approaches, including cellular therapy, are being used as rescue therapy and will hopefully be included in first line therapy in the near future. This article will review and update the modern management of patients with Ph+ ALL. Keywords: acute lymphoblastic leukemia; Philadelphia chromosome; modern management Author: Josep-Maria Ribera and Sabina Chiaretti Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed Sep 28 17:40:41 2022 CEST ModDate: Wed Sep 28 17:45:31 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 632435 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- KORLVE+VnURWPalladioL Type 1 Custom yes yes no 10 0 OMPEJP+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 LQPFOJ+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 LFKNOU+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 LCJEVJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 43 0 KWKPAT+CMSY10 Type 1 Builtin yes yes no 65 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 83 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 87 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 91 0 BCDHEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 95 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-06-24 02:38:09 CEST RepresentationInformation: cancers-14-04554-v3.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-02-01 17:16:18 CET Size: 632435 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 313 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Ponatinib in First Line Therapy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Item: Title: Immunotherapy Combined with TKI in First Line Therapy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Role of Allogeneic Hematopoietic Stem Cell Transplant in De Novo Ph+ ALL Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Maintenance Therapy after Allogeneic HSCT Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Management of Relapse Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Other Targeted Therapies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Info: Title: Modern Management Options for Ph+ ALL Author: Josep-Maria Ribera and Sabina Chiaretti Subject: Impressive advances have been achieved in the management of patients with Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) since the initial concurrent use of imatinib and standard chemotherapy. The attenuation of chemotherapy has proven to be equally effective and less toxic, the use of third generation TKI upfront has improved the frequency of complete molecular response and the survival rate, and the combination of tyrosine kinase inhibitors with immunotherapy has further increased the rate of molecular response to 70 80% after consolidation, which has been translated into a survival rate of 75 90% in recent trials. As a result of these improvements, the role of allogeneic hematopoietic stem cell transplantation is being redefined. The methodology of measurable residual disease assessment and the detection of ABL1 mutations are also improving and will contribute to a more precise selection of the treatment for newly diagnosed and relapsed or refractory (R/R) patients. Finally, new compounds combined with immunotherapeutic approaches, including cellular therapy, are being used as rescue therapy and will hopefully be included in first line therapy in the near future. This article will review and update the modern management of patients with Ph+ ALL. 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