97ebc1d70bc256b0f5341d4ead78a7a3 s41598-022-17271-3.pdf 009c0b8c3631692b12dfa827dacf4221d303c142 s41598-022-17271-3.pdf 337e2afa4cdad25b52e2a071f4b1f4b1dd38eede0d70021f96bf157b440b6b86 s41598-022-17271-3.pdf Title: Detection of kinase domain mutations in BCR::ABL1 leukemia by ultra-deep sequencing of genomic DNA Subject: Scientific Reports, https://doi.org/10.1038/s41598-022-17271-3 Author: Ricardo Sánchez Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Fri Jul 29 06:20:21 2022 CEST ModDate: Fri Jul 29 15:25:37 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 2773451 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- SFAXIB+Wingdings-Regular Type 1C WinAnsi yes yes yes 518 0 YKUOMM+Corbel-Bold CID TrueType Identity-H yes yes yes 52 0 Corbel2 TrueType WinAnsi yes no yes 53 0 DRIXEC+Corbel CID TrueType Identity-H yes yes yes 54 0 Corbel3 CID TrueType Identity-H yes no yes 548 0 Corbel4 TrueType WinAnsi yes no yes 63 0 MinionPro-Regular Type 1C Custom yes no yes 49 0 MinionPro-It Type 1C Custom yes no yes 50 0 BCAWCG+Corbel-BoldItalic CID TrueType Identity-H yes yes yes 51 0 MinionPro-Bold Type 1C Custom yes no yes 71 0 OAQTXG+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 194 0 GOPSPW+Code2000 CID TrueType Identity-H yes yes yes 195 0 TimesNewRomanPSMT2 TrueType WinAnsi yes no yes 225 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-06-30 02:37:22 CEST RepresentationInformation: s41598-022-17271-3.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-02-02 19:55:53 CET Size: 2773451 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 584 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: Detection of kinase domain mutations in BCR::ABL1 leukemia by ultra-deep sequencing of genomic DNA Children: Item: Title: Results Children: Item: Title: Screening of BCR::ABL1 KD mutation by RNA-NestedNGS. Item: Title: Detection of kinase domain mutations in genomic DNA. Item: Title: Impact of KD mutations in the clinical outcome of the chronic myeloid leukemia patients. Item: Title: Impact of KD mutations in the clinical outcome of B-cell precursor acute lymphoblastic leukemia BCR::ABL1 positive. Item: Title: Discussion Item: Title: Methods Children: Item: Title: Patients and study design. Item: Title: Sanger Sequencing. Item: Title: RNA-NestedNGS methodology. Item: Title: Digital PCR. Item: Title: DNA-DeepNGS methodology and automated bioinformatic pipeline. Item: Title: Statistical analyses. Item: Title: References Item: Title: Acknowledgements Info: Title: Detection of kinase domain mutations in BCR::ABL1 leukemia by ultra-deep sequencing of genomic DNA Author: Ricardo Sánchez Subject: Scientific Reports, https://doi.org/10.1038/s41598-022-17271-3 Creator: Springer Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Fri Jul 29 06:50:21 CEST 2022 ModDate: Fri Jul 29 15:25:37 CEST 2022 ID: 0x56153fa2a09e9bb0f775341d9c77256d, 0xdf0304fad698802e426303fcabb5c4d5 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1998 ImageHeight: 1158 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1772 ImageHeight: 950 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode 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https://doi.org/10.1038/s41598-022-17271-3 Detection of kinase domain mutations in BCR::ABL1 leukemia by ultra-deep sequencing of genomic DNA Ricardo Sánchez Sara Dorado Yanira Ruíz-Heredia Alejandro Martín-Muñoz Juan Manuel Rosa-Rosa Jordi Ribera Olga García Ana Jimenez-Ubieto Gonzalo Carreño-Tarragona María Linares Laura Rufián Alexandra Juárez Jaime Carrillo María José Espino Mercedes Cáceres Sara Expósito Beatriz Cuevas Raúl Vanegas Luis Felipe Casado Anna Torrent Lurdes Zamora Santiago Mercadal Rosa Coll Marta Cervera Mireia Morgades José Ángel Hernández-Rivas Pilar Bravo Cristina Serí Eduardo Anguita Eva Barragán Claudia Sargas Francisca Ferrer-Marín Jorge Sánchez-Calero Julián Sevilla Elena Ruíz Lucía Villalón María del Mar Herráez Rosalía Riaza Elena Magro Juan Luis Steegman Chongwu Wang Paula de Toledo Valentín García-Gutiérrez Rosa Ayala Josep-Maria Ribera Santiago Barrio Joaquín Martínez-López 10.1038/s41598-022-17271-3 2010-04-23 true springer.com springerlink.com 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