09401ec12b8b97d801800cf7d38815da fncel-16-852151.pdf 06e1068a05e4737ac240a1ff689de13f4c98876d fncel-16-852151.pdf 03177f25811044db1063e0764ce67ca26564abd9edb91eede946db6ec1afd0df fncel-16-852151.pdf Title: The Potential of Circulating Cell-Free DNA Methylation as an Epilepsy Biomarker Subject: Circulating cell-free DNA (cfDNA) are highly degraded DNA fragments shed into the bloodstream. Keywords: cell-free DNA, DNA methylation, epilepsy, epileptogenesis, MTLE-HS, biomarker Author: Bárbara Guerra Leal Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.12 CreationDate: Tue Mar 22 07:24:23 2022 CET ModDate: Tue Mar 22 07:38:22 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 8 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 2958836 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- CAUAGK+HelveticaNeueLTStd-Bd Type 1 Custom yes yes no 377 0 DUEDKE+MinionPro-Bold Type 1 Custom yes yes no 378 0 CGNTQS+HelveticaNeueLTStd-Lt Type 1 Custom yes yes no 379 0 EAQKCY+MinionPro-Regular Type 1 Custom yes yes no 380 0 CCVXXJ+HelveticaNeueLTStd-BdIt Type 1 Custom yes yes no 381 0 ISLWCF+HelveticaNeueLTStd-LtIt Type 1 Custom yes yes no 382 0 JXYZRP+HelveticaNeueLTStd-MdIt Type 1 Custom yes yes no 383 0 EIYUGS+MTSYN Type 1 Builtin yes yes no 240 0 CMERJW+MTGU Type 1 Builtin yes yes no 236 0 GVDQGU+MinionPro-It Type 1 Custom yes yes no 244 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-07-01 02:41:34 CEST RepresentationInformation: fncel-16-852151.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-02-10 18:22:47 CET Size: 2958836 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 495 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: The Potential of Circulating Cell-Free DNA Methylation as an Epilepsy Biomarker Children: Item: Title: INTRODUCTION Item: Title: BIOGENESIS AND THE APOPTOTIC CASCADE Item: Title: GENETIC SEQUENCING AND LIQUID BIOPSIES Item: Title: DECONVOLUTING CELL-OF-ORIGIN THROUGH DNA METHYLATION Item: Title: BRAIN-DERIVED cfDNA IN NEURODEGENERATION Item: Title: POTENTIAL OF cfDNA METHYLOME PROFILING IN EPILEPSY Item: Title: CONCLUDING REMARKS Item: Title: AUTHOR CONTRIBUTIONS Item: Title: FUNDING Item: Title: ACKNOWLEDGMENTS Item: Title: REFERENCES Info: Title: The Potential of Circulating Cell-Free DNA Methylation as an Epilepsy Biomarker Author: Bárbara Guerra Leal Subject: Circulating cell-free DNA (cfDNA) are highly degraded DNA fragments shed into the bloodstream. Keywords: cell-free DNA, DNA methylation, epilepsy, epileptogenesis, MTLE-HS, biomarker Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.12 CreationDate: Tue Mar 22 07:54:23 CET 2022 ModDate: Tue Mar 22 08:08:22 CET 2022 ID: 0x9f143ded145f4190036fb8745f34a887, 0x7cd24494409b37489184ff8bc6450c83 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: EIYUGS+MTSYN FontSubset: true FirstChar: 24 LastChar: 76 FontDescriptor: FontName: EIYUGS+MTSYN Flags: Symbolic FontBBox: 0, -954, 1043, 900 FontFile: true Font: BaseFont: GVDQGU+MinionPro-It FontSubset: true FirstChar: 40 LastChar: 243 FontDescriptor: FontName: GVDQGU+MinionPro-It Flags: Symbolic FontBBox: -199, -358, 1684, 1002 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: CAUAGK+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 44 LastChar: 124 FontDescriptor: FontName: CAUAGK+HelveticaNeueLTStd-Bd Flags: Symbolic FontBBox: -164, -216, 1078, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: DUEDKE+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 118 FontDescriptor: FontName: DUEDKE+MinionPro-Bold Flags: Symbolic FontBBox: -317, -358, 1684, 1024 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: CGNTQS+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 2 LastChar: 124 FontDescriptor: FontName: CGNTQS+HelveticaNeueLTStd-Lt Flags: Symbolic FontBBox: -164, -212, 1050, 967 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: EAQKCY+MinionPro-Regular FontSubset: true FirstChar: 16 LastChar: 252 FontDescriptor: FontName: EAQKCY+MinionPro-Regular Flags: Symbolic FontBBox: -288, -358, 1684, 989 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: CMERJW+MTGU FontSubset: true FirstChar: 98 LastChar: 98 FontDescriptor: FontName: CMERJW+MTGU Flags: Symbolic FontBBox: 25, -213, 839, 683 FontFile: true Font: BaseFont: CCVXXJ+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: CCVXXJ+HelveticaNeueLTStd-BdIt Flags: Symbolic FontBBox: -164, -216, 1129, 975 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: ISLWCF+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 39 LastChar: 250 FontDescriptor: FontName: ISLWCF+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -163, -212, 1099, 951 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: JXYZRP+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 42 LastChar: 225 FontDescriptor: FontName: JXYZRP+HelveticaNeueLTStd-MdIt Flags: Symbolic FontBBox: -163, -216, 1125, 947 FontFile: true EncodingDictionary: Differences: true XMP: 2022-03-22T11:54:23+05:30 LaTeX with hyperref package 2022-03-22T12:08:22+05:30 2022-03-22T12:08:22+05:30 application/pdf Circulating cell-free DNA (cfDNA) are highly degraded DNA fragments shed into the bloodstream. 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