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     Item: 
      Title: DNA methylome combined with chromosome cluster-­oriented analysis provides an early signature for cutaneous melanoma aggressiveness
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       Item: 
        Title: Editor's evaluation
       Item: 
        Title: Introduction
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: A three-step strategy identifies differentially methylated genes that identify melanoma aggressiveness
         Item: 
          Title: Gene selection and validation
         Item: 
          Title: Validation in patient samples and identification of a methylation signature
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        Title: Discussion
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         Item: 
          Title: Conclusions
       Item: 
        Title: Materials and methods
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         Item: 
          Title: Cell culture
         Item: 
          Title: Tumour samples
         Item: 
          Title: Genomic DNA isolation
         Item: 
          Title: Illumina methylation 450K microarray analysis
         Item: 
          Title: Bisulfite pyrosequencing
         Item: 
          Title: Definition of the signature score
         Item: 
          Title: Methylation cluster identification through statistical analysis of the distribution of the hypermethylated genes
         Item: 
          Title: Functional annotation and pathway analysis
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        Title: Additional information
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          Title: Funding
         Item: 
          Title: Author contributions
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          Title: Author ORCIDs
         Item: 
          Title: Ethics
         Item: 
          Title: Decision letter and Author response
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          Title: Supplementary files
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        Title: References
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