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Battram Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Thu Sep 1 18:19:16 2022 CEST ModDate: Thu Sep 1 18:20:48 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 27 Encrypted: no Page size: 602.986 x 782.986 pts Page rot: 0 File size: 3604766 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- HBEHEI+AdvHelN-L Type 1C MacRoman yes yes no 1011 0 HBEHEJ+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 1014 0 HBEHEK+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 1017 0 HBEHFK+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 1020 0 HBEHFL+AdvOTb65e897d.B+20 Type 1C WinAnsi yes yes no 1023 0 HBEHFM+AdvOTb65e897d.B+fb Type 1C Custom yes yes yes 1028 0 HBEHFN+AdvOT45bf69de.BI Type 1C WinAnsi yes yes no 1012 0 HBEHGO+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 1022 0 HBEHIO+AdvPSSym Type 1C WinAnsi yes yes no 1033 0 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cannot be found Offset: 3569698 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib29' cannot be found Offset: 3569698 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib30' cannot be found Offset: 3569698 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib19' cannot be found Offset: 3569698 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib47' cannot be found Offset: 3569698 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib48' cannot be found Offset: 3569698 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib49' cannot be found Offset: 3569698 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib50' cannot be found Offset: 3569698 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib19' cannot be found Offset: 3569698 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib38' cannot be found Offset: 3569698 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib38' cannot be found Offset: 3569698 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib51' 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edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib31' cannot be found Offset: 3569698 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib50' cannot be found Offset: 3569698 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib52' cannot be found Offset: 3569698 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib55' cannot be found Offset: 3569698 MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 1097 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: T cells isolated from G-CSF-treated multiple myeloma patients are suitable for the generation of BCMA-directed CAR-T cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Children: Item: Title: Recombinant G-CSF had no direct effect on ARI2 h expansion or activity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Patient G-CSF treatment did not alter the T cell CD4:CD8 ratio, increase the proportion of Tregs or induce T cell dysfunction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: In vivo G-CSF reduced frequency of TSCM cells but had no effect on other effector and memory T cell populations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: High expansion rates and increased T cell isolation after G-CSF treatment compensated for reduced CAR transduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: ARI2h cells generated from PRE and POST T cells demonstrate equal anti-tumor activity in vitro and in vivo Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: G-CSF treatment does not negatively impact the ex vivo phenotype of expanded ARI2h cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Children: Item: Title: Human samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Ethical approval Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Cell culture and T cell transduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Flow cytometry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Staining of Tregs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Analysis of granzyme B expression Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: In vitro cytotoxicity assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: ELISAs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: In vivo murine experiments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Proliferation measurements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Repeated stimulation of ARI2 h cells with tumor cells Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Immunoblotting Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Data availability Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Supplemental information Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Declaration of interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Info: Title: T cells isolated from G-CSF-treated multiple myeloma patients are suitable for the generation of BCMA-directed CAR-T cells Author: Anthony M. 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Anthony M. Battram Aina Oliver-Caldés Maria Suárez-Lledó Miquel Lozano Miquel Bosch i Crespo Núria Martínez-Cibrián Joan Cid David F. Moreno Luis Gerardo Rodríguez-Lobato Alvaro Urbano-Ispizua Carlos Fernández de Larrea CAR-T cells G-CSF multiple myeloma BCMA ASCT ARI0002 Molecular Therapy: Methods & Clinical Development, 26 (2022) 207-223. doi:10.1016/j.omtm.2022.06.010 The Authors journal Molecular Therapy: Methods & Clinical Development © 2022 The Authors. 2329-0501 26 8 September 2022 2022-09-08 207-223 207 223 10.1016/j.omtm.2022.06.010 https://doi.org/10.1016/j.omtm.2022.06.010 2010-04-23 true 10.1016/j.omtm.2022.06.010 elsevier.com sciencedirect.com VoR 7.0 10.1016/j.omtm.2022.06.010 noindex 2010-04-23 true sciencedirect.com elsevier.com Elsevier 2022-09-01T21:49:16+05:30 2022-09-01T21:50:48+05:30 2022-09-01T21:50:48+05:30 True Acrobat Distiller 8.1.0 (Windows) uuid:858c7245-d46c-4ad1-b6c7-ed65db439675 uuid:beea30bd-4a87-4377-9b8a-6e73e97856ed http://creativecommons.org/licenses/by/4.0/ Pages: Page: Label: 207 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 143, 571, 147, 582 Destination: 925 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