31858a681563586878788c2c48ff92fc 270612.pdf 428a07c3d084b14ce67de39fe956c9d1ac2cf7e3 270612.pdf 17c276527d01ac60551aec850e3d191a41ede45313e165f2f70bf3a75a3bb7cd 270612.pdf Title: Early T-Cell Precursor ALL and Beyond: Immature and Ambiguous Lineage T-ALL Subsets Subject: A wide range of immature acute leukemias (AL), ranging from acute myeloid leukemias with minimal differentiation to acute leukemias with an ambiguous lineage, i.e., acute undifferentiated leukemias and mixed phenotype acute leukemia with T- or B-plus myeloid markers, cannot be definitely assigned to a single cell lineage. This somewhat “grey zone” of AL expresses partly overlapping features with the most immature forms of T-cell acute lymphoblastic leukemia (T-ALL), i.e., early T-cell precursor ALL (ETP-ALL), near-ETP-ALL, and pro-T ALL. These are troublesome cases in terms of precise diagnosis because of their similarities and overlapping phenotypic features. Moreover, it has become evident that they share several genomic alterations, raising the question of how their phenotypes reflect distinct AL entities. The aim of this review was to provide a systematic overview of the genetic events associated with immature T-ALL and outline their relationship with treatment choices and outcomes, especially looking at the most recent preclinical and clinical studies. We wish to offer a basis for using the genetic information for new diagnostic algorithms, in order to better stratify patients and improve their management with more efficient and personalized therapeutic options. Understanding the genetic profile of this high-risk T-ALL subset is a prerequisite for changing the current clinical scenario. Keywords: immature T-ALL; ETP-ALL; diagnosis; genomics; outcome; treatment Author: Eulàlia Genescà and Roberta la Starza Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri Apr 8 05:40:49 2022 CEST ModDate: Fri Apr 8 05:43:05 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1433791 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- KORLVE+VnURWPalladioL Type 1 Custom yes yes no 10 0 TQSVTJ+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 HXMVQY+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 OSGEYP+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 GQWIGS+CMSY10 Type 1 Builtin yes yes no 28 0 WNWTFR+VnURWPalladioL-Bold Type 1 Custom yes yes no 32 0 MCBCCI+SourceSansRoman-Regular Type 1C Custom yes yes no 40 0 MCBCCM+SourceSansRoman.613wght Type 1C Custom yes yes no 44 0 MCBCCO+SourceSansRoman-Bold Type 1C Custom yes yes no 48 0 LCJEVJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 61 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 88 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 92 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 96 0 BCDHEE+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 100 0 SymbolMT CID TrueType Identity-H yes no yes 107 0 QMQJLY+PazoMath Type 1 Builtin yes yes no 119 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 137 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 141 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 145 0 ULLBVI+URWPalladioL-BoldItal Type 1 Custom yes yes no 153 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 178 0 BCDFEE+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 182 0 BCDGEE+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 186 0 DORTIW+EURM10 Type 1 Builtin yes yes no 197 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-12 02:30:09 CEST RepresentationInformation: 270612.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-05-11 21:04:26 CEST Size: 1433791 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 531 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Children: Item: Title: The Grey Zone of Immature Leukemias Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Item: Title: Immature T-Cell Acute Lymphoblastic Leukemia (T-ALL) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: ETP-ALL Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Children: Item: Title: Historical Perspective of Immune Markers and Gene Expression Profiles (GEPs) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Diagnosis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Genomic Characterization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Children: Item: Title: Genomic Alterations That Cause HOXA Overexpression Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: The BCL11B-a Entity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Outcomes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Treatment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Children: Item: Title: Frontline Treatment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Cell-Immunotherapy: Allo-SCT Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: New Chemotherapy: Nelarabine Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Target Therapy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: Future Perspectives Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Info: Title: Early T-Cell Precursor ALL and Beyond: Immature and Ambiguous Lineage T-ALL Subsets Author: Eulàlia Genescà and Roberta la Starza Subject: A wide range of immature acute leukemias (AL), ranging from acute myeloid leukemias with minimal differentiation to acute leukemias with an ambiguous lineage, i.e., acute undifferentiated leukemias and mixed phenotype acute leukemia with T- or B-plus myeloid markers, cannot be definitely assigned to a single cell lineage. This somewhat “grey zone” of AL expresses partly overlapping features with the most immature forms of T-cell acute lymphoblastic leukemia (T-ALL), i.e., early T-cell precursor ALL (ETP-ALL), near-ETP-ALL, and pro-T ALL. These are troublesome cases in terms of precise diagnosis because of their similarities and overlapping phenotypic features. Moreover, it has become evident that they share several genomic alterations, raising the question of how their phenotypes reflect distinct AL entities. The aim of this review was to provide a systematic overview of the genetic events associated with immature T-ALL and outline their relationship with treatment choices and outcomes, especially looking at the most recent preclinical and clinical studies. We wish to offer a basis for using the genetic information for new diagnostic algorithms, in order to better stratify patients and improve their management with more efficient and personalized therapeutic options. Understanding the genetic profile of this high-risk T-ALL subset is a prerequisite for changing the current clinical scenario. 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