9baf15dc78370d92fcb677be7fa06fe5 270633.pdf a94904bb3f2ce6d6d10c1cb94998fc1b3bdf2f90 270633.pdf 29df7afef57ac4eb9c0bc5e7809413c125224245cb21d4fdb277b79e6984eb63 270633.pdf Title: Biological and clinical perspectives of the actionable gene fusions and amplifications involving tyrosine kinase receptors in lung cancer Subject: Cancer Treatment Reviews, 109 (2022) 102430. doi:10.1016/j.ctrv.2022.102430 Keywords: Lung cancer,Gene fusions,Gene amplification,Tyrosine kinase receptors,Tyrosine kinase inhibitors Author: Maria Saigí Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Wed Aug 10 15:01:15 2022 CEST ModDate: Tue Aug 16 07:18:12 2022 CEST Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 3226192 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NNLAUQ+TeX_CM_Roman Type 1C Builtin yes yes yes 1021 0 QPBWKH+CharisSIL CID TrueType Identity-H yes yes yes 1025 0 ZSFCVB+STIX-Italic Type 1C Custom yes yes yes 1030 0 EFSCCH+CharisSIL-Bold CID TrueType Identity-H yes yes yes 1035 0 MWZOII+STIX-Regular Type 1C Custom yes yes yes 1040 0 GBNAGF+Univers Type 1C Builtin yes yes yes 1045 0 MWOEPG+CharisSIL-Italic CID TrueType Identity-H yes yes yes 1049 0 VKPORJ+CharisSIL CID TrueType Identity-H yes yes yes 1012 0 MPWZYS+CharisSIL-Italic CID TrueType Identity-H yes yes yes 441 0 NTMBZO+TeX_CM_Maths_Italic Type 1C Builtin yes yes yes 450 0 LKPBEA+CharisSIL-BoldItalic CID TrueType Identity-H yes yes yes 62 0 HCHOEM+TeX_CM_Maths_Symbols Type 1C Builtin yes yes yes 455 0 IFJLCX+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 459 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-26 02:28:03 CEST RepresentationInformation: 270633.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-05-25 17:09:46 CEST Size: 3226192 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 1131 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Biological and clinical perspectives of the actionable gene fusions and amplifications involving tyrosine kinase receptors ... Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Oncogenic gene fusions involving RTK in NSCLC and their clinical implications Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Children: Item: Title: Gene fusions affecting the anaplastic lymphoma kinase receptor, ALK Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Gene fusions affecting the c-ros oncogene 1 receptor, ROS1 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Gene fusions affecting the neurotrophic tropomyosin tyrosine kinase receptor, NTRK Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Gene fusions affecting the REarranged during transfection receptor, RET Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Gene fusions affecting the fibroblast growth factor receptors, FGFRs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Other gene fusions affecting RTKs in NSCLC Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Oncogenic gene amplifications involving RTK in NSCLC and their clinical implications Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Gene amplification affecting the mesenchymal-epithelial transition factor receptor, MET Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Gene amplification affecting the epidermal growth factor receptors HER Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Gene amplification affecting the growth factor receptors KIT and PDGFRA Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: Lung cancer molecular testing in clinics: State of the art Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Therapeutic challenges and opportunities in NSCLC patients harboring oncogenic fusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Children: Item: Title: CRediT authorship contribution statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Declaration of Competing Interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Info: Title: Biological and clinical perspectives of the actionable gene fusions and amplifications involving tyrosine kinase receptors in lung cancer Author: Maria Saigí Subject: Cancer Treatment Reviews, 109 (2022) 102430. doi:10.1016/j.ctrv.2022.102430 Keywords: Lung cancer,Gene fusions,Gene amplification,Tyrosine kinase receptors,Tyrosine kinase inhibitors Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Wed Aug 10 15:01:15 CEST 2022 ModDate: Tue Aug 16 07:18:12 CEST 2022 ID: 0x6f2aea55f779cdacc104c7e382ead51d, 0x74cbf3ae8c9b8c004ee9e073b585dd46 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 236 ImageHeight: 298 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 248 ImageHeight: 271 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: QPBWKH+CharisSIL Encoding: Identity-H ToUnicode: true Font: BaseFont: MWOEPG+CharisSIL-Italic Encoding: Identity-H ToUnicode: true Font: BaseFont: EFSCCH+CharisSIL-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: IFJLCX+TimesNewRomanPSMT Encoding: Identity-H ToUnicode: true Font: BaseFont: LKPBEA+CharisSIL-BoldItalic Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: MWZOII+STIX-Regular FontSubset: true FirstChar: 1 LastChar: 9 FontDescriptor: FontName: MWZOII+STIX-Regular Flags: Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: NTMBZO+TeX_CM_Maths_Italic FontSubset: true FirstChar: 1 LastChar: 127 FontDescriptor: FontName: NTMBZO+TeX_CM_Maths_Italic Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: GBNAGF+Univers FontSubset: true FirstChar: 32 LastChar: 251 FontDescriptor: FontName: GBNAGF+Univers Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: ZSFCVB+STIX-Italic FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: ZSFCVB+STIX-Italic Flags: Nonsymbolic, Italic FontBBox: -970, -305, 1429, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: HCHOEM+TeX_CM_Maths_Symbols FontSubset: true FirstChar: 1 LastChar: 138 FontDescriptor: FontName: HCHOEM+TeX_CM_Maths_Symbols Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: NNLAUQ+TeX_CM_Roman FontSubset: true FirstChar: 1 LastChar: 128 FontDescriptor: FontName: NNLAUQ+TeX_CM_Roman Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true CIDFontType2: Font: BaseFont: LKPBEA+CharisSIL-BoldItalic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: LKPBEA+CharisSIL-BoldItalic Flags: Nonsymbolic, Italic, ForceBold FontBBox: -741, -533, 1795, 1320 FontFile2: true Font: BaseFont: QPBWKH+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: QPBWKH+CharisSIL Flags: Nonsymbolic FontBBox: -692, -533, 1623, 1319 FontFile2: true Font: BaseFont: MWOEPG+CharisSIL-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: MWOEPG+CharisSIL-Italic Flags: Nonsymbolic, Italic FontBBox: -716, -533, 1627, 1318 FontFile2: true Font: BaseFont: EFSCCH+CharisSIL-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: EFSCCH+CharisSIL-Bold Flags: Nonsymbolic, ForceBold FontBBox: -720, -533, 1759, 1320 FontFile2: true Font: BaseFont: IFJLCX+TimesNewRomanPSMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: IFJLCX+TimesNewRomanPSMT Flags: Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile2: true XMP: application/pdf 10.1016/j.ctrv.2022.102430 Elsevier Ltd Cancer Treatment Reviews, 109 (2022) 102430. doi:10.1016/j.ctrv.2022.102430 Lung cancer Gene fusions Gene amplification Tyrosine kinase receptors Tyrosine kinase inhibitors Biological and clinical perspectives of the actionable gene fusions and amplifications involving tyrosine kinase receptors in lung cancer Maria Saigí Enric Carcereny Teresa Morán Marc Cucurull Marta Domènech Ainhoa Hernandez Anna Martinez-Cardús Eva Pros Montse Sanchez-Cespedes journal Cancer Treatment Reviews © 2022 The Authors. Published by Elsevier Ltd. 0305-7372 109 1 September 2022 2022-09-01 102430 102430 10.1016/j.ctrv.2022.102430 https://doi.org/10.1016/j.ctrv.2022.102430 2010-04-23 true 10.1016/j.ctrv.2022.102430 elsevier.com sciencedirect.com http://creativecommons.org/licenses/by-nc-nd/4.0/ VoR 7.0 10.1016/j.ctrv.2022.102430 noindex 2010-04-23 true 16th August 2022 sciencedirect.com elsevier.com Elsevier 2022-08-16T05:18:12 2022-08-10T13:01:15 2022-08-16T05:18:12 True 16th August 2022 Acrobat Distiller 8.1.0 (Windows) Lung cancer,Gene fusions,Gene amplification,Tyrosine kinase receptors,Tyrosine kinase inhibitors uuid:1b499bed-4ce8-4c0c-b682-0d58baae1cbe uuid:b6ed5266-03cb-4855-90c0-636283357f42 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 93, 576, 99, 586 Flags: Print Destination: 997 Annotation: Subtype: Link Rect: 100, 576, 106, 586 Flags: Print Destination: 997 Annotation: Subtype: Link Rect: 107, 579, 111, 584 Flags: Print Destination: 997 Annotation: Subtype: Link Rect: 107, 571, 194, 582 Flags: Print Destination: 997 Annotation: Subtype: Link Rect: 194, 576, 200, 586 Flags: Print Destination: 997 Annotation: Subtype: Link Rect: 201, 571, 278, 582 Flags: Print Destination: 997 Annotation: Subtype: Link Rect: 278, 576, 284, 586 Flags: Print Destination: 997 Annotation: Subtype: Link Rect: 285, 571, 365, 582 Flags: Print Destination: 997 Annotation: Subtype: Link Rect: 365, 576, 371, 586 Flags: Print Destination: 997 Annotation: Subtype: Link Rect: 372, 571, 465, 582 Flags: Print Destination: 997 Annotation: Subtype: Link Rect: 465, 576, 472, 586 Flags: Print Destination: 997 Annotation: Subtype: Link Rect: 472, 571, 480, 582 Flags: Print Destination: 997 Annotation: Subtype: Link Rect: 126, 563, 133, 574 Flags: Print Destination: 997 Annotation: Subtype: Link Rect: 133, 558, 305, 569 Flags: Print Destination: 997 Annotation: Subtype: Link Rect: 305, 563, 444, 574 Flags: Print Destination: 997 Annotation: Subtype: Link Rect: 444, 566, 448, 571 Flags: Print Destination: 997 Annotation: Subtype: Link Rect: 444, 558, 448, 569 Flags: Print Destination: 997 Annotation: Subtype: Link Rect: 129, 206, 147, 214 Flags: Print Destination: 186 Annotation: Subtype: Link Rect: 537, 227, 555, 235 Flags: Print Destination: 186 Annotation: Subtype: Link Rect: 103, 123, 179, 130 Flags: Print Annotation: Subtype: Link Rect: 216, 123, 306, 130 Flags: Print Annotation: Subtype: Link Rect: 358, 123, 439, 130 Flags: Print Annotation: Subtype: Link Rect: 480, 123, 557, 130 Flags: Print Annotation: Subtype: Link Rect: 37, 114, 47, 121 Flags: Print Annotation: Subtype: Link Rect: 96, 114, 190, 121 Flags: Print Annotation: Subtype: Link Rect: 245, 114, 341, 121 Flags: Print Annotation: Subtype: Link Rect: 395, 114, 461, 121 Flags: Print Annotation: Subtype: Link Rect: 533, 114, 557, 121 Flags: Print Annotation: Subtype: Link Rect: 37, 104, 102, 111 Flags: Print Annotation: Subtype: Link Rect: 136, 104, 244, 111 Flags: Print Annotation: Subtype: Link Rect: 321, 722, 369, 730 Flags: Print Annotation: Subtype: Link Rect: 280, 667, 391, 675 Flags: Print Annotation: Subtype: Link Rect: 37, 87, 179, 94 Flags: Print Annotation: Subtype: Link Rect: 297, 749, 300, 757 Flags: Print Annotation: Subtype: Link Rect: 222, 748, 371, 760 Annotation: Subtype: Link Rect: 499, 616, 528, 645 Annotation: Subtype: Link Rect: 425, 59, 557, 70 Annotation: Subtype: Link Rect: 37, 49, 72, 61 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 62, 678, 73, 686 Flags: Print Destination: 186 Annotation: Subtype: Link Rect: 275, 657, 286, 665 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 91, 605, 111, 613 Flags: Print Destination: 186 Annotation: Subtype: Link Rect: 248, 553, 268, 561 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 157, 532, 168, 540 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 268, 500, 286, 508 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 89, 448, 109, 456 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 471, 699, 482, 707 Flags: Print Destination: 186 Annotation: Subtype: Link Rect: 376, 657, 396, 665 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 388, 626, 408, 634 Flags: Print Destination: 23 Annotation: Subtype: Link Rect: 438, 479, 454, 487 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 325, 416, 345, 424 Flags: Print Destination: 48 Annotation: Subtype: Link Rect: 350, 416, 366, 424 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 192, 60, 284, 67 Flags: Print Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 236, 318, 265, 326 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 163, 276, 179, 284 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 153, 255, 169, 263 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 174, 255, 200, 263 Flags: Print Destination: 48 Annotation: Subtype: Link Rect: 147, 224, 173, 232 Flags: Print Destination: 56 Annotation: Subtype: Link Rect: 210, 203, 239, 211 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 105, 171, 121, 179 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 155, 129, 184, 137 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 261, 67, 288, 75 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 40, 56, 66, 64 Flags: Print Destination: 56 Annotation: Subtype: Link Rect: 390, 318, 406, 326 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 440, 276, 456, 284 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 468, 255, 483, 263 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 420, 192, 436, 200 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 441, 192, 468, 200 Flags: Print Destination: 56 Annotation: Subtype: Link Rect: 525, 150, 541, 158 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 461, 129, 477, 137 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 339, 109, 354, 117 Flags: Print Destination: 209 Page: Label: 4 Page: Label: 5 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 184, 730, 200, 738 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 260, 689, 276, 696 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 193, 668, 213, 676 Flags: Print Destination: 48 Annotation: Subtype: Link Rect: 219, 668, 234, 676 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 186, 647, 201, 655 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 203, 626, 230, 634 Flags: Print Destination: 48 Annotation: Subtype: Link Rect: 235, 626, 251, 634 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 230, 584, 246, 592 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 37, 563, 53, 571 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 227, 553, 243, 561 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 118, 521, 134, 529 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 57, 490, 86, 498 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 92, 490, 118, 498 Flags: Print Destination: 56 Annotation: Subtype: Link Rect: 62, 427, 78, 435 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 150, 290, 171, 298 Flags: Print Destination: 48 Annotation: Subtype: Link Rect: 178, 290, 194, 298 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 78, 228, 94, 236 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 85, 186, 100, 194 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 214, 175, 230, 183 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 235, 175, 261, 183 Flags: Print Destination: 48 Annotation: Subtype: Link Rect: 37, 102, 66, 110 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 131, 71, 147, 79 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 128, 50, 154, 58 Flags: Print Destination: 56 Annotation: Subtype: Link Rect: 160, 50, 187, 58 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 480, 720, 496, 728 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 436, 689, 462, 696 Flags: Print Destination: 56 Annotation: Subtype: Link Rect: 466, 689, 495, 696 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 435, 542, 451, 550 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 342, 521, 370, 529 Flags: Print Destination: 48 Annotation: Subtype: Link Rect: 459, 510, 479, 518 Flags: Print Destination: 48 Annotation: Subtype: Link Rect: 485, 510, 512, 518 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 306, 448, 322, 456 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 333, 437, 349, 445 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 354, 437, 381, 445 Flags: Print Destination: 48 Annotation: Subtype: Link Rect: 306, 385, 335, 393 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 454, 343, 470, 351 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 477, 343, 505, 351 Flags: Print Destination: 56 Annotation: Subtype: Link Rect: 358, 322, 374, 330 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 509, 280, 525, 288 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 520, 259, 536, 267 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 306, 186, 322, 194 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 358, 133, 374, 141 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 516, 113, 527, 121 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 532, 113, 552, 121 Flags: Print Destination: 48 Annotation: Subtype: Link Rect: 309, 71, 336, 79 Flags: Print Destination: 48 Annotation: Subtype: Link Rect: 341, 71, 357, 79 Flags: Print Destination: 303 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 198, 668, 214, 676 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 63, 636, 78, 644 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 99, 615, 115, 623 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 120, 615, 146, 623 Flags: Print Destination: 56 Annotation: Subtype: Link Rect: 37, 552, 66, 560 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 195, 510, 224, 518 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 120, 448, 136, 456 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 82, 416, 109, 424 Flags: Print Destination: 48 Annotation: Subtype: Link Rect: 236, 364, 247, 372 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 40, 312, 68, 320 Flags: Print Destination: 48 Annotation: Subtype: Link Rect: 195, 280, 224, 288 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 229, 280, 250, 288 Flags: Print Destination: 48 Annotation: Subtype: Link Rect: 147, 249, 163, 257 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 193, 238, 209, 246 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 65, 144, 80, 152 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 73, 102, 89, 110 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 306, 730, 322, 738 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 309, 709, 336, 717 Flags: Print Destination: 48 Annotation: Subtype: Link Rect: 341, 709, 357, 717 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 347, 615, 362, 623 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 394, 605, 420, 612 Flags: Print Destination: 48 Annotation: Subtype: Link Rect: 350, 584, 365, 592 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 385, 573, 400, 581 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 306, 521, 322, 529 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 489, 521, 516, 529 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 541, 489, 557, 497 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 309, 479, 336, 487 Flags: Print Destination: 48 Annotation: Subtype: Link Rect: 363, 448, 379, 456 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 434, 427, 461, 435 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 363, 406, 379, 414 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 306, 385, 322, 393 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 325, 364, 341, 372 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 509, 333, 534, 341 Flags: Print Destination: 56 Annotation: Subtype: Link Rect: 539, 333, 555, 341 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 343, 301, 359, 309 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 415, 217, 431, 225 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 333, 186, 349, 194 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 438, 175, 454, 183 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 501, 133, 516, 141 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 539, 71, 555, 79 Flags: Print Destination: 303 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 125, 730, 141, 738 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 60, 689, 75, 696 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 219, 657, 235, 665 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 125, 615, 140, 623 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 37, 521, 53, 529 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 245, 521, 261, 529 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 122, 489, 138, 497 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 122, 458, 138, 466 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 221, 437, 236, 445 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 148, 416, 164, 424 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 214, 322, 232, 330 Flags: Print Destination: 186 Annotation: Subtype: Link Rect: 115, 269, 142, 277 Flags: Print Destination: 165 Annotation: Subtype: Link Rect: 37, 238, 90, 246 Flags: Print Destination: 209 Annotation: Subtype: Link Rect: 202, 186, 218, 194 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 513, 282, 529, 290 Flags: Print Destination: 303 Annotation: Subtype: Link Rect: 421, 230, 437, 238 Flags: Print Destination: 303 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 175, 689, 190, 696 Flags: Print Destination: 402 Annotation: Subtype: Link Rect: 204, 647, 233, 655 Flags: Print Destination: 402 Annotation: Subtype: Link Rect: 159, 615, 175, 623 Flags: Print Destination: 402 Annotation: Subtype: Link Rect: 123, 584, 139, 592 Flags: Print Destination: 402 Annotation: Subtype: Link Rect: 266, 490, 286, 498 Flags: Print Destination: 402 Annotation: Subtype: Link Rect: 93, 417, 113, 425 Flags: Print Destination: 402 Annotation: Subtype: Link Rect: 136, 385, 156, 393 Flags: Print Destination: 402 Annotation: Subtype: Link Rect: 184, 343, 204, 351 Flags: Print Destination: 402 Annotation: Subtype: Link Rect: 71, 270, 91, 278 Flags: Print Destination: 402 Annotation: Subtype: Link Rect: 61, 197, 81, 205 Flags: Print Destination: 402 Annotation: Subtype: Link Rect: 185, 103, 217, 111 Flags: Print Destination: 402 Annotation: Subtype: Link Rect: 198, 82, 214, 90 Flags: Print Destination: 402 Annotation: Subtype: Link Rect: 494, 114, 540, 120 Flags: Print Annotation: Subtype: Link Rect: 327, 106, 377, 112 Flags: Print Annotation: Subtype: Link Rect: 366, 82, 493, 88 Flags: Print Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 105, 716, 230, 722 Flags: Print Annotation: Subtype: Link Rect: 221, 692, 267, 698 Flags: Print Annotation: Subtype: Link Rect: 58, 684, 146, 690 Flags: Print Annotation: Subtype: Link Rect: 178, 660, 250, 666 Flags: Print Annotation: Subtype: Link Rect: 58, 652, 108, 658 Flags: Print Annotation: Subtype: Link Rect: 104, 604, 235, 611 Flags: Print Annotation: Subtype: Link Rect: 171, 557, 279, 563 Flags: Print Annotation: Subtype: Link Rect: 253, 493, 286, 499 Flags: Print Annotation: Subtype: Link Rect: 58, 485, 159, 491 Flags: Print Annotation: Subtype: Link Rect: 113, 461, 265, 467 Flags: Print Annotation: Subtype: Link Rect: 181, 437, 253, 443 Flags: Print Annotation: Subtype: Link Rect: 58, 429, 129, 435 Flags: Print Annotation: Subtype: Link Rect: 83, 381, 209, 388 Flags: Print Annotation: Subtype: Link Rect: 58, 349, 199, 356 Flags: Print Annotation: Subtype: Link Rect: 111, 325, 231, 332 Flags: Print Annotation: Subtype: Link Rect: 240, 301, 285, 308 Flags: Print Annotation: Subtype: Link Rect: 58, 294, 112, 300 Flags: Print Annotation: Subtype: Link Rect: 118, 262, 260, 268 Flags: Print Annotation: Subtype: Link Rect: 261, 230, 283, 236 Flags: Print Annotation: Subtype: Link Rect: 58, 222, 177, 228 Flags: Print Annotation: Subtype: Link Rect: 134, 198, 255, 204 Flags: Print Annotation: Subtype: Link Rect: 171, 166, 247, 172 Flags: Print Annotation: Subtype: Link Rect: 58, 158, 112, 164 Flags: Print Annotation: Subtype: Link Rect: 158, 126, 270, 133 Flags: Print Annotation: Subtype: Link Rect: 260, 102, 282, 109 Flags: Print Annotation: Subtype: Link Rect: 58, 94, 148, 101 Flags: Print Annotation: Subtype: Link Rect: 86, 70, 207, 77 Flags: Print Annotation: Subtype: Link Rect: 533, 732, 555, 738 Flags: Print Annotation: Subtype: Link Rect: 327, 724, 438, 730 Flags: Print Annotation: Subtype: Link Rect: 404, 612, 529, 619 Flags: Print Annotation: Subtype: Link Rect: 437, 557, 509, 563 Flags: Print Annotation: Subtype: Link Rect: 327, 549, 395, 555 Flags: Print Annotation: Subtype: Link Rect: 369, 517, 487, 523 Flags: Print Annotation: Subtype: Link Rect: 407, 485, 532, 491 Flags: Print Annotation: Subtype: Link Rect: 344, 453, 480, 459 Flags: Print Annotation: Subtype: Link Rect: 473, 429, 545, 435 Flags: Print Annotation: Subtype: Link Rect: 327, 421, 396, 427 Flags: Print Annotation: Subtype: Link Rect: 489, 397, 535, 403 Flags: Print Annotation: Subtype: Link Rect: 327, 389, 406, 396 Flags: Print Annotation: Subtype: Link Rect: 367, 357, 514, 364 Flags: Print Annotation: Subtype: Link Rect: 359, 325, 484, 332 Flags: Print Annotation: Subtype: Link Rect: 470, 301, 542, 308 Flags: Print Annotation: Subtype: Link Rect: 327, 294, 377, 300 Flags: Print Annotation: Subtype: Link Rect: 471, 278, 543, 284 Flags: Print Annotation: Subtype: Link Rect: 327, 270, 382, 276 Flags: Print Annotation: Subtype: Link Rect: 469, 222, 540, 228 Flags: Print Annotation: Subtype: Link Rect: 327, 214, 395, 220 Flags: Print Annotation: Subtype: Link Rect: 483, 190, 555, 196 Flags: Print Annotation: Subtype: Link Rect: 327, 182, 397, 188 Flags: Print Annotation: Subtype: Link Rect: 426, 158, 547, 164 Flags: Print Annotation: Subtype: Link Rect: 510, 134, 555, 140 Flags: Print Annotation: Subtype: Link Rect: 327, 126, 390, 133 Flags: Print Annotation: Subtype: Link Rect: 327, 94, 435, 101 Flags: Print Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 263, 676, 285, 682 Flags: Print Annotation: Subtype: Link Rect: 58, 668, 154, 674 Flags: Print Annotation: Subtype: Link Rect: 253, 620, 286, 627 Flags: Print Annotation: Subtype: Link Rect: 58, 612, 189, 619 Flags: Print Annotation: Subtype: Link Rect: 200, 588, 272, 595 Flags: Print Annotation: Subtype: Link Rect: 58, 580, 111, 587 Flags: Print Annotation: Subtype: Link Rect: 139, 549, 266, 555 Flags: Print Annotation: Subtype: Link Rect: 230, 525, 275, 531 Flags: Print Annotation: Subtype: Link Rect: 58, 517, 126, 523 Flags: Print Annotation: Subtype: Link Rect: 58, 485, 199, 491 Flags: Print Annotation: Subtype: Link Rect: 143, 453, 284, 459 Flags: Print Annotation: Subtype: Link Rect: 181, 429, 257, 435 Flags: Print Annotation: Subtype: Link Rect: 58, 421, 118, 427 Flags: Print Annotation: Subtype: Link Rect: 120, 397, 240, 403 Flags: Print Annotation: Subtype: Link Rect: 223, 373, 268, 380 Flags: Print Annotation: Subtype: Link Rect: 58, 365, 154, 372 Flags: Print Annotation: Subtype: Link Rect: 199, 341, 275, 348 Flags: Print Annotation: Subtype: Link Rect: 58, 333, 106, 340 Flags: Print Annotation: Subtype: Link Rect: 264, 317, 286, 324 Flags: Print Annotation: Subtype: Link Rect: 58, 309, 166, 316 Flags: Print Annotation: Subtype: Link Rect: 211, 262, 286, 268 Flags: Print Annotation: Subtype: Link Rect: 58, 254, 106, 260 Flags: Print Annotation: Subtype: Link Rect: 96, 222, 221, 228 Flags: Print Annotation: Subtype: Link Rect: 230, 198, 276, 204 Flags: Print Annotation: Subtype: Link Rect: 58, 190, 121, 196 Flags: Print Annotation: Subtype: Link Rect: 165, 134, 241, 140 Flags: Print Annotation: Subtype: Link Rect: 58, 126, 106, 133 Flags: Print Annotation: Subtype: Link Rect: 139, 78, 263, 85 Flags: Print Annotation: Subtype: Link Rect: 327, 668, 425, 674 Flags: Print Annotation: Subtype: Link Rect: 458, 652, 530, 658 Flags: Print Annotation: Subtype: Link Rect: 327, 644, 361, 651 Flags: Print Annotation: Subtype: Link Rect: 385, 620, 512, 627 Flags: Print Annotation: Subtype: Link Rect: 362, 596, 488, 603 Flags: Print Annotation: Subtype: Link Rect: 359, 565, 483, 571 Flags: Print Annotation: Subtype: Link Rect: 498, 509, 543, 515 Flags: Print Annotation: Subtype: Link Rect: 327, 501, 406, 507 Flags: Print Annotation: Subtype: Link Rect: 483, 477, 554, 483 Flags: Print Annotation: Subtype: Link Rect: 327, 469, 382, 475 Flags: Print Annotation: Subtype: Link Rect: 355, 445, 480, 451 Flags: Print Annotation: Subtype: Link Rect: 392, 421, 513, 427 Flags: Print Annotation: Subtype: Link Rect: 352, 381, 493, 388 Flags: Print Annotation: Subtype: Link Rect: 533, 373, 555, 380 Flags: Print Annotation: Subtype: Link Rect: 327, 365, 437, 372 Flags: Print Annotation: Subtype: Link Rect: 472, 317, 544, 324 Flags: Print Annotation: Subtype: Link Rect: 327, 309, 398, 316 Flags: Print Annotation: Subtype: Link Rect: 516, 294, 549, 300 Flags: Print Annotation: Subtype: Link Rect: 327, 286, 420, 292 Flags: Print Annotation: Subtype: Link Rect: 327, 254, 523, 260 Flags: Print Annotation: Subtype: Link Rect: 479, 230, 551, 236 Flags: Print Annotation: Subtype: Link Rect: 327, 222, 375, 228 Flags: Print Annotation: Subtype: Link Rect: 358, 190, 479, 196 Flags: Print Annotation: Subtype: Link Rect: 516, 166, 549, 172 Flags: Print Annotation: Subtype: Link Rect: 327, 158, 415, 164 Flags: Print Annotation: Subtype: Link Rect: 441, 142, 540, 148 Flags: Print Annotation: Subtype: Link Rect: 400, 118, 534, 125 Flags: Print Annotation: Subtype: Link Rect: 450, 86, 525, 93 Flags: Print Annotation: Subtype: Link Rect: 327, 78, 385, 85 Flags: Print Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 196, 732, 268, 738 Flags: Print Annotation: Subtype: Link Rect: 58, 724, 113, 730 Flags: Print Annotation: Subtype: Link Rect: 251, 708, 284, 714 Flags: Print Annotation: Subtype: Link Rect: 58, 700, 152, 706 Flags: Print Annotation: Subtype: Link Rect: 264, 668, 286, 674 Flags: Print Annotation: Subtype: Link Rect: 58, 660, 169, 666 Flags: Print Annotation: Subtype: Link Rect: 179, 636, 254, 643 Flags: Print Annotation: Subtype: Link Rect: 58, 628, 106, 635 Flags: Print Annotation: Subtype: Link Rect: 162, 604, 237, 611 Flags: Print Annotation: Subtype: Link Rect: 58, 596, 118, 603 Flags: Print Annotation: Subtype: Link Rect: 205, 580, 277, 587 Flags: Print Annotation: Subtype: Link Rect: 57, 572, 98, 579 Flags: Print Annotation: Subtype: Link Rect: 522, 732, 555, 738 Flags: Print Annotation: Subtype: Link Rect: 326, 724, 429, 730 Flags: Print Annotation: Subtype: Link Rect: 372, 692, 514, 698 Flags: Print Annotation: Subtype: Link Rect: 326, 660, 470, 666 Flags: Print Annotation: Subtype: Link Rect: 427, 636, 553, 643 Flags: Print Annotation: Subtype: Link Rect: 361, 604, 480, 611 Flags: Print Annotation: Subtype: Link Rect: 490, 580, 535, 587 Flags: Print Annotation: Subtype: Link Rect: 326, 572, 405, 579 Flags: Print Checksum: a7442e91 Type: CRC32 Checksum: 9baf15dc78370d92fcb677be7fa06fe5 Type: MD5 Checksum: a94904bb3f2ce6d6d10c1cb94998fc1b3bdf2f90 Type: SHA-1