b80cec6821909dcfd54ab4354a10d20e 270637.pdf 0272fc8cc52b70e231e698e778ddee5fa57b0153 270637.pdf d8a9f681a6be643af762bbe06afb5b9c391b30c93613f8254ef84903f38591a5 270637.pdf Title: Azacitidine vs. Decitabine in Unfit Newly Diagnosed Acute Myeloid Leukemia Patients: Results from the PETHEMA Registry Subject: The hypomethylating agents, decitabine (DEC) and azacitidine (AZA), allowed more elderly acute myeloid leukemia (AML) patients to be treated. However, there are little direct comparative data on AZA and DEC. This multicenter retrospective study compared the outcomes of AZA and DEC in terms of response and overall survival (OS). Potential predictors associated with response and OS were also evaluated. A total of 626 AML patients were included (487 treated with AZA and 139 with DEC). Response rates were similar in both groups: CR was 18% with AZA vs. 23% with DEC (p = 0.20), CR/CRi was 20.5% vs. 25% (p = 0.27) and ORR was 32% vs. 39.5% (p = 0.12), respectively. Patients with leukocytes < 10 109/L, bone marrow blasts < 50% and ECOG 2 had higher ORR with DEC than with AZA. OS was similar in both groups: 10.4 months (95% CI: 9.2–11.7) vs. 8.8 months (95% CI: 6.7–11.0, p = 0.455), for AZA and DEC, respectively. Age (80 years), leukocytes ( 10 109/L), platelet count (<20 109/L) and eGFR (45 mL/min/1.73 m2) were associated with higher OS with AZA compared to DEC. In conclusion, we found no differences in response and OS rates in AML patients treated with AZA or DEC. Keywords: acute myeloid leukemia; elderly; treatment; azacitidine; decitabine; hypomethylating agents; PETHEMA Author: Jorge Labrador, David Martínez-Cuadrón, Adolfo de la Fuente, Rebeca Rodríguez-Veiga, Josefina Serrano, Mar Tormo, Eduardo Rodriguez-Arboli, Fernando Ramos, Teresa Bernal, María López-Pavía, Fernanda Trigo, María Pilar Martínez-Sánchez, Juan-Ignacio Rodríguez-Gutiérrez, Carlos Rodríguez-Medina, Cristina Gil, Daniel García Belmonte, Susana Vives, María-Ángeles Foncillas, Manuel Pérez-Encinas, Andrés Novo, Isabel Recio, Gabriela Rodríguez-Macías, Juan Miguel Bergua, Víctor Noriega, Esperanza Lavilla, Alicia Roldán-Pérez, Miguel A. Sanz, Pau Montesinos and on behalf of PETHEMA Group Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed May 11 03:22:15 2022 CEST ModDate: Wed May 11 03:26:30 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 2628325 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- AFQOAQ+VnURWPalladioL Type 1 Custom yes yes no 10 0 GRWYLM+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 PFOIUE+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 FZKDAB+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 FFAYKL+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 LCJEVJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 47 0 HCPSKZ+CMSY10 Type 1 Builtin yes yes no 69 0 WBVKDJ+URWPalladioL-BoldItal Type 1 Custom yes yes no 79 0 CGLEMH+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 110 0 CGLEOH+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 116 0 DFGDED+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 137 0 DFGDFD+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 143 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-27 02:36:47 CEST RepresentationInformation: 270637.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-05-26 14:33:32 CEST Size: 2628325 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 308 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Patients and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: PETHEMA Registry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Eligibility Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Treatment Schedules Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Study Definitions and Endpoints Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Children: Item: Title: Accrual and Patient Characteristics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Short-Term Outcomes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Long-Term Outcomes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Children: Item: Title: Overall Survival Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Other Time-to-Event End Points Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Salvage Therapy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Info: Title: Azacitidine vs. Decitabine in Unfit Newly Diagnosed Acute Myeloid Leukemia Patients: Results from the PETHEMA Registry Author: Jorge Labrador, David Martínez-Cuadrón, Adolfo de la Fuente, Rebeca Rodríguez-Veiga, Josefina Serrano, Mar Tormo, Eduardo Rodriguez-Arboli, Fernando Ramos, Teresa Bernal, María López-Pavía, Fernanda Trigo, María Pilar Martínez-Sánchez, Juan-Ignacio Rodríguez-Gutiérrez, Carlos Rodríguez-Medina, Cristina Gil, Daniel García Belmonte, Susana Vives, María-Ángeles Foncillas, Manuel Pérez-Encinas, Andrés Novo, Isabel Recio, Gabriela Rodríguez-Macías, Juan Miguel Bergua, Víctor Noriega, Esperanza Lavilla, Alicia Roldán-Pérez, Miguel A. Sanz, Pau Montesinos and on behalf of PETHEMA Group Subject: The hypomethylating agents, decitabine (DEC) and azacitidine (AZA), allowed more elderly acute myeloid leukemia (AML) patients to be treated. However, there are little direct comparative data on AZA and DEC. This multicenter retrospective study compared the outcomes of AZA and DEC in terms of response and overall survival (OS). Potential predictors associated with response and OS were also evaluated. A total of 626 AML patients were included (487 treated with AZA and 139 with DEC). Response rates were similar in both groups: CR was 18% with AZA vs. 23% with DEC (p = 0.20), CR/CRi was 20.5% vs. 25% (p = 0.27) and ORR was 32% vs. 39.5% (p = 0.12), respectively. Patients with leukocytes < 10 109/L, bone marrow blasts < 50% and ECOG 2 had higher ORR with DEC than with AZA. OS was similar in both groups: 10.4 months (95% CI: 9.2 11.7) vs. 8.8 months (95% CI: 6.7 11.0, p = 0.455), for AZA and DEC, respectively. Age (80 years), leukocytes ( 10 109/L), platelet count (<20 109/L) and eGFR (45 mL/min/1.73 m2) were associated with higher OS with AZA compared to DEC. In conclusion, we found no differences in response and OS rates in AML patients treated with AZA or DEC. Keywords: acute myeloid leukemia; elderly; treatment; azacitidine; decitabine; hypomethylating agents; PETHEMA Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Wed May 11 03:22:15 CEST 2022 ModDate: Wed May 11 03:26:30 CEST 2022 ID: 0xa625064b5a1f4691adf4c8139761bdaa, 0xa625064b5a1f4691adf4c8139761bdaa Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: PFOIUE+URWPalladioL-Roma FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: PFOIUE+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: HCPSKZ+CMSY10 FontSubset: true FirstChar: 2 LastChar: 21 FontDescriptor: FontName: HCPSKZ+CMSY10 Flags: Symbolic FontBBox: -29, -960, 1116, 775 FontFile: true Font: BaseFont: FZKDAB+URWPalladioL-Ital FontSubset: true FirstChar: 2 LastChar: 121 FontDescriptor: FontName: FZKDAB+URWPalladioL-Ital Flags: Symbolic FontBBox: -170, -305, 1010, 941 FontFile: true 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