1ef574ad38cd82406d80b103ad635e9f 270660.pdf 16721da7e8ac0f34d21ee8e705a4cd96e6e9ffae 270660.pdf 453a7b4940edee7c94de70274b16aa3661b23cbdd2755b43ec66483b89990633 270660.pdf Title: Allogeneic Stem Cell Transplantation in Mantle Cell Lymphoma; Insights into Its Potential Role in the Era of New Immunotherapeutic and Targeted Therapies:The GETH/GELTAMO Experience Subject: Allo-SCT is a curative option for selected patients with relapsed/refractory (R/R) MCL, but with significant NRM. We present the long-term results of patients receiving allo-SCT in Spain from March 1995 to February 2020. The primary endpoints were EFS, OS, and cumulative incidence (CI) of NRM, relapse, and GVHD. We included 135 patients, most (85%) receiving RIC. After a median follow-up of 68 months, 5-year EFS and OS were 47 and 50%, respectively. Overall and CR rates were 86 and 80%. The CI of relapse at 1 and 3 years were 7 and 12%. NRM at day 100 and 1 year were 17 and 32%. Previous ASCT and Grade 3–4 aGVHD were associated with a higher NRM. Grade 3–4 aGVHD, donor type (mismatch non-related), and the time-period 2006–2020 were independently related to worse EFS. Patients from 1995–2005 were younger, most from HLA-identical sibling donors, and were pretreated less. Our data confirmed that allo-SCT may be a curative option in R/R MCL with low a CI of relapse, although NRM is still high, being mainly secondary to aGVHD. The arrival of new, highly effective and low toxic immunotherapeutic or targeted therapies inevitably will relegate allo-SCT to those fit patients who fail these therapies, far away from the optimal timing of treatment. Keywords: mantle cell lymphoma; allogeneic stem-cell transplantation; non-relapse mortality; acute graft-versus-host disease; graft-versus-lymphoma effect; target therapy; CAR-T cell therapy Author: Antonio Gutierrez, Leyre Bento, Silvana Novelli, Alejandro Martin, Gonzalo Gutierrez, Maria Queralt Salas, Mariana Bastos-Oreiro, Ariadna Perez, Rafael Hernani, Maria Cruz Viguria, Oriana Lopez-Godino, Juan Montoro, Jose Luis Piñana, Christelle Ferra, Rocio Parody, Carmen Martin, Ignacio Español, Lucrecia Yañez, Guillermo Rodriguez, Joud Zanabili, Pilar Herrera, Maria Rosario Varela, Antonia Sampol, Carlos Solano, Dolores Caballero and on behalf of the Grupo Español de Trasplante de Progenitores Hematopoyéticos (GETH) and Grupo Español de Linfoma y Trasplante Autólogo (GELTAMO) Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Fri May 27 17:09:56 2022 CEST ModDate: Fri May 27 17:48:43 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1759240 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IJOHFJ+VnURWPalladioL Type 1 Custom yes yes no 10 0 TQMKLB+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 FLUARY+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 HNLKRI+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 HJOMHV+VnURWPalladioL-Bold Type 1 Custom yes yes no 28 0 LCJEVJ+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 47 0 FAECIJ+URWPalladioL-BoldItal Type 1 Custom yes yes no 75 0 KWKPAT+CMSY10 Type 1 Builtin yes yes no 79 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-05-25 02:25:58 CEST RepresentationInformation: 270660.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-05-24 13:00:29 CEST Size: 1759240 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 283 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Study Design and Patient Eligibility Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Data Recovery and Study Definitions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Children: Item: Title: Patient and Allo-SCT Characteristics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Main Outcome Data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: GVHD and NRM Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Survival Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Impact in Results of Allo-SCT Candidates’ Selection along Decades Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Info: Title: Allogeneic Stem Cell Transplantation in Mantle Cell Lymphoma; Insights into Its Potential Role in the Era of New Immunotherapeutic and Targeted Therapies:The GETH/GELTAMO Experience Author: Antonio Gutierrez, Leyre Bento, Silvana Novelli, Alejandro Martin, Gonzalo Gutierrez, Maria Queralt Salas, Mariana Bastos-Oreiro, Ariadna Perez, Rafael Hernani, Maria Cruz Viguria, Oriana Lopez-Godino, Juan Montoro, Jose Luis Piñana, Christelle Ferra, Rocio Parody, Carmen Martin, Ignacio Español, Lucrecia Yañez, Guillermo Rodriguez, Joud Zanabili, Pilar Herrera, Maria Rosario Varela, Antonia Sampol, Carlos Solano, Dolores Caballero and on behalf of the Grupo Español de Trasplante de Progenitores Hematopoyéticos (GETH) and Grupo Español de Linfoma y Trasplante Autólogo (GELTAMO) Subject: Allo-SCT is a curative option for selected patients with relapsed/refractory (R/R) MCL, but with significant NRM. We present the long-term results of patients receiving allo-SCT in Spain from March 1995 to February 2020. The primary endpoints were EFS, OS, and cumulative incidence (CI) of NRM, relapse, and GVHD. We included 135 patients, most (85%) receiving RIC. After a median follow-up of 68 months, 5-year EFS and OS were 47 and 50%, respectively. Overall and CR rates were 86 and 80%. The CI of relapse at 1 and 3 years were 7 and 12%. NRM at day 100 and 1 year were 17 and 32%. Previous ASCT and Grade 3 4 aGVHD were associated with a higher NRM. Grade 3 4 aGVHD, donor type (mismatch non-related), and the time-period 2006 2020 were independently related to worse EFS. Patients from 1995 2005 were younger, most from HLA-identical sibling donors, and were pretreated less. Our data confirmed that allo-SCT may be a curative option in R/R MCL with low a CI of relapse, although NRM is still high, being mainly secondary to aGVHD. The arrival of new, highly effective and low toxic immunotherapeutic or targeted therapies inevitably will relegate allo-SCT to those fit patients who fail these therapies, far away from the optimal timing of treatment. 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