8a9ea2b36d354b3e790c891d9c2bdb22 cancers_a2022m10v14n19p4960.pdf aeebdfae0db01e18d614fb94bb42c608a58282b0 cancers_a2022m10v14n19p4960.pdf d164adcccd7ee376dd29db5566992a3f2376cede5148e2ed0f270fb9dd65d9bc cancers_a2022m10v14n19p4960.pdf Title: Advances in Preclinical/Clinical Glioblastoma Treatment: Can Nanoparticles Be of Help? Subject: Glioblastoma multiforme (GB) is the most aggressive and frequent primary malignant tumor in the central nervous system (CNS), with unsatisfactory and challenging treatment nowadays. Current standard of care includes surgical resection followed by chemotherapy and radiotherapy. However, these treatments do not much improve the overall survival of GB patients, which is still below two years (the 5-year survival rate is below 7%). Despite various approaches having been followed to increase the release of anticancer drugs into the brain, few of them demonstrated a significant success, as the blood brain barrier (BBB) still restricts its uptake, thus limiting the therapeutic options. Therefore, enormous efforts are being devoted to the development of novel nanomedicines with the ability to cross the BBB and specifically target the cancer cells. In this context, the use of nanoparticles represents a promising non-invasive route, allowing to evade BBB and reducing systemic concentration of drugs and, hence, side effects. In this review, we revise with a critical view the different families of nanoparticles and approaches followed so far with this aim. Keywords: glioblastoma; preclinical model; nanoparticles; drug delivery; brain cancer; BBB Author: Daniel Ruiz-Molina, Xiaoman Mao, Paula Alfonso-Triguero, Julia Lorenzo, Jordi Bruna, Victor J. 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SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 852 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Glioblastoma Treatment: State-of-the-Art Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4923ab24 Item: Title: Nanoparticles for Glioblastoma Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Preclinical Studies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Representative Examples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Targeting and Theranostic Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Clinical Studies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Summary and Future Perspectives Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Info: Title: Advances in Preclinical/Clinical Glioblastoma Treatment: Can Nanoparticles Be of Help? Author: Daniel Ruiz-Molina, Xiaoman Mao, Paula Alfonso-Triguero, Julia Lorenzo, Jordi Bruna, Victor J. Yuste, Ana Paula Candiota and Fernando Novio Subject: Glioblastoma multiforme (GB) is the most aggressive and frequent primary malignant tumor in the central nervous system (CNS), with unsatisfactory and challenging treatment nowadays. Current standard of care includes surgical resection followed by chemotherapy and radiotherapy. However, these treatments do not much improve the overall survival of GB patients, which is still below two years (the 5-year survival rate is below 7%). Despite various approaches having been followed to increase the release of anticancer drugs into the brain, few of them demonstrated a significant success, as the blood brain barrier (BBB) still restricts its uptake, thus limiting the therapeutic options. Therefore, enormous efforts are being devoted to the development of novel nanomedicines with the ability to cross the BBB and specifically target the cancer cells. In this context, the use of nanoparticles represents a promising non-invasive route, allowing to evade BBB and reducing systemic concentration of drugs and, hence, side effects. In this review, we revise with a critical view the different families of nanoparticles and approaches followed so far with this aim. 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