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Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: 1. Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: 2. Patients and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: 2.1. Trial design Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: 2.2. Patient selection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: 2.3. Randomisation and dose modification Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: 2.4. Evaluations during the study Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: 2.5. Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: 3. Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Children: Item: Title: 3.1. Treatment compliance and safety Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: 3.2. Treatment efficacy Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: 4. Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: 5. Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Role of the funding source Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Conflict of interest statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Conflict of interest statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Appendix A. Supplementary data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Info: Title: A randomised phase 2 study comparing different dose approaches of induction treatment of regorafenib in previously treated metastatic colorectal cancer patients (REARRANGE trial) Author: Guillem Argilés Subject: European Journal of Cancer, 177 (2022) 154-163. doi:10.1016/j.ejca.2022.09.037 Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Wed Nov 23 02:10:55 CET 2022 ModDate: Wed Nov 23 02:11:43 CET 2022 ID: 0xb0a671bfc179536ea5946a9639c32b75, 0x7e0f842eb937b341b480ac6ed37c9f76 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 120 ImageHeight: 119 ColorSpace: palette color BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: 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Symbolic FontBBox: -20, -958, 1114, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: NODIKA+AdvPSSym FontSubset: true FirstChar: 170 LastChar: 170 FontDescriptor: FontName: NODIKA+AdvPSSym Flags: Nonsymbolic FontBBox: -177, -291, 1083, 1010 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NODIPE+AdvPS3FDD77 FontSubset: true FirstChar: 90 LastChar: 90 FontDescriptor: FontName: NODIPE+AdvPS3FDD77 Flags: Nonsymbolic FontBBox: 0, -208, 1145, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: NODIMA+AdvOTb214af43 FontSubset: true FirstChar: 46 LastChar: 119 FontDescriptor: FontName: NODIMA+AdvOTb214af43 Flags: Nonsymbolic FontBBox: -41, -250, 979, 916 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1016/j.ejca.2022.09.037 A randomised phase 2 study comparing different dose approaches of induction treatment of regorafenib in previously treated metastatic colorectal cancer patients (REARRANGE trial) Guillem Argilés Nuria Mulet Manuel Valladares-Ayerbes José M. Viéitez Cristina Grávalos Pilar García-Alfonso Cristina Santos María Tobeña Beatriz García-Paredes Manuel Benavides María T. Cano Fotios Loupakis Mercedes Rodríguez-Garrote Fernando Rivera Richard M. Goldberg Chiara Cremolini Jaafar Bennouna Fortunato Ciardiello Josep M. Tabernero Enrique Aranda Spanish Cooperative Group for the Treatment of Digestive Tumors (TTD) and UNICANCER GI Josep Tabernero Guillem Argilés Alfredo Falcone Fortunato Ciardiello Richard Goldberg Jaafar Bennouna The REARRANGE investigators Argilés J. Tabernero N. Mulet M.L. Limón M. Valladares P. Jiménez J. Ma Vieitez C. Grávalos P. García-Alfonso C. Santos D. Páez M. Tobeña J. Sastre B. García Paredes M. Benavides E. Aranda M.T. Cano F. Loupakis M. Rguez Garrote C. Guillén Ma F. Rivera J. Safont S. Hiret J. Bennouna D. Pannier D. Malka A. Falcone C. Cremolini Guillem Argilés Josep Tabernero Principal investigator Steering Committee Investigators Colorectal cancer Drug administration schedule Metastasis Regorafenib European Journal of Cancer, 177 (2022) 154-163. doi:10.1016/j.ejca.2022.09.037 The Author(s) journal European Journal of Cancer © 2022 The Author(s). 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