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found Offset: 7962982 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'B49' cannot be found Offset: 7962982 MIMEtype: application/pdf PDFMetadata: Objects: 784 FreeObjects: 1 IncrementalUpdates: 2 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Children: Item: Title: Patient Selection Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Collection of Samples, Irradiation, and Incubation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Microarray Assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Item: Title: Statistical Analysis to Detect Differentially Expressed Genes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: Gene Set Enrichment Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Quantitative RT-PCR Validation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Children: Item: Title: Basal Expression: Toxicity vs. Non-Toxicity Patients in Non-Irradiated Samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: 8 Gy-Induced Expression: Toxicity vs. Non-Toxicity Patients in Irradiated Samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Overall In-Vitro Radiation Response: Irradiated vs. Non-Irradiated Samples Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Data Availability Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Ethics Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Supplementary Material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Info: Title: Cell Senescence-Related Pathways Are Enriched in Breast Cancer Patients With Late 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(Windows) radiotherapy—adverse effects, radiation-induced lymphocyte apoptosis (RILA), gene set enrichment analysis (GSEA), late skin toxicity, breast cancer 2022-05-19T07:44:19+08:00 2022-05-19T05:22:59+08:00 Arbortext Advanced Print Publisher 10.0.1306/W Unicode 2022-05-19T07:44:19+08:00 application/pdf Cell Senescence-Related Pathways Are Enriched in Breast Cancer Patients With Late Toxicity After Radiotherapy and Low Radiation-Induced Lymphocyte Apoptosis Ester Aguado-Flor Maria J. Fuentes-Raspall Ricardo Gonzalo Carmen Alonso Teresa Ramon y Cajal David Fisas Alejandro Seoane Alex Sánchez-Pla Jordi Giralt Orland Diez Sara Gutiérrez-Enriquez Background: Radiation-induced late effects are a common cause of morbidity among cancer survivors radiotherapy—adverse effects radiation-induced lymphocyte apoptosis (RILA) gene set enrichment analysis (GSEA) late skin toxicity breast cancer uuid:77e0b41d-b27f-4947-b699-b6c7969e1676 uuid:39f3e532-ccdc-470e-b0fb-c6cd877ad37b Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 175, 583, 529, 604 Annotation: Subtype: Link Rect: 175, 560, 478, 581 Annotation: Subtype: Link Rect: 175, 537, 495, 558 Annotation: Subtype: Link Rect: 175, 514, 509, 535 Annotation: Subtype: Link Rect: 175, 491, 489, 512 Annotation: Subtype: Link Rect: 45, 29, 108, 36 Annotation: Subtype: Link Rect: 117, 29, 175, 36 Annotation: Subtype: Link Rect: 427, 29, 549, 36 Annotation: Subtype: Link Rect: 87, 444, 158, 452 Annotation: Subtype: Link 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