ea2b31694d2b6b7eafa769337df3e918  275181.pdf
92a1839caf7d6675f684bff67a37c64c160aa1b8  275181.pdf
55b4caef972439159f42bf6beaa6a0a201dfdf18196e8fda6d2304fab16631a3  275181.pdf

Title:          Protocol for a randomized controlled multicenter trial assessing the efficacy of leuprorelin for severe polycystic liver disease: the AGAINST-PLD study
Subject:        BMC Gastroenterology, https://doi.org/10.1186/s12876-022-02142-y
Keywords:       Polycystic liver disease;GnRHa;Estrogen
Author:          S. E. Aapkes 
Creator:        Adobe InDesign 15.0 (Windows)
Producer:       Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:   Thu Feb 17 15:21:53 2022 CET
ModDate:        Fri Feb 25 10:48:41 2022 CET
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          11
Encrypted:      no
Page size:      595.276 x 790.866 pts
Page rot:       0
File size:      1657562 bytes
Optimized:      no
PDF version:    1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MyriadPro-Regular                    Type 1C           Custom           yes no  yes     69  0
MyriadPro-Bold                       Type 1C           Custom           yes no  yes     70  0
MyriadPro-It                         Type 1C           Custom           yes no  yes     71  0
MyriadPro-Semibold                   Type 1C           Custom           yes no  yes     77  0
MyriadPro-Light                      Type 1C           Custom           yes no  yes     73  0
EHPNPX+MTSY                          Type 1C           Custom           yes yes yes     72  0
LLQWGT+WarnockPro-It                 Type 1C           WinAnsi          yes yes yes     74  0
WarnockPro-Regular                   Type 1C           Custom           yes no  yes     75  0
MyriadPro-LightIt                    Type 1C           WinAnsi          yes no  yes     76  0
WarnockPro-Light                     Type 1C           Custom           yes no  yes    105  0
MyriadPro-Regular2                   Type 1C           WinAnsi          yes no  yes    231  0
MyriadPro-SemiboldIt                 Type 1C           WinAnsi          yes no  yes    123  0
MyriadPro-Regular3                   Type 1C           WinAnsi          yes no  yes    199  0
QUQWOS+OpenSans-Light                Type 1C           Custom           yes yes no     206  0
QUQWOS+OpenSans-Extrabold            Type 1C           WinAnsi          yes yes no     202  0
QUQWOS+OregonLDOBookSinistral        Type 1C           WinAnsi          yes yes no     212  0
QUQWOS+OpenSans-Bold                 Type 1C           WinAnsi          yes yes no     209  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2023-06-27 03:30:17 CEST
 RepresentationInformation: 275181.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2023-06-26 15:09:15 CEST
  Size: 1657562
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 389
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en-US
    Outlines: 
     Item: 
      Title: Protocol for a randomized controlled multicenter trial assessing the efficacy of leuprorelin for severe polycystic liver disease: the AGAINST-PLD study
      Children: 
       Item: 
        Title: Abstract 
        Children: 
         Item: 
          Title: Background: 
         Item: 
          Title: Methods: 
         Item: 
          Title: Discussion: 
       Item: 
        Title: Background
        Children: 
         Item: 
          Title: An unmet need for new treatments
         Item: 
          Title: Female hormones in PLD
         Item: 
          Title: Objectives
       Item: 
        Title: Methods and design
        Children: 
         Item: 
          Title: Study design
         Item: 
          Title: Study setting
         Item: 
          Title: Patient selection
         Item: 
          Title: Randomization
         Item: 
          Title: Intervention
         Item: 
          Title: Concomitant medication
         Item: 
          Title: Outcome parameters
          Children: 
           Item: 
            Title: Primary outcome
           Item: 
            Title: Secondary outcomes
           Item: 
            Title: Exploratory outcomes
         Item: 
          Title: Sample size calculation
         Item: 
          Title: Recruitment
       Item: 
        Title: Data collection and management
        Children: 
         Item: 
          Title: MRI scans
         Item: 
          Title: Laboratory measurements
         Item: 
          Title: Vital signs
         Item: 
          Title: Questionnaires
         Item: 
          Title: Criteria for withdrawal
         Item: 
          Title: Statistics
          Children: 
           Item: 
            Title: Statistical analysis
       Item: 
        Title: Discussion
        Children: 
         Item: 
          Title: Efficacy–safety ratio
         Item: 
          Title: Interim analysis
         Item: 
          Title: Perspective
       Item: 
        Title: Acknowledgements
       Item: 
        Title: References
   Info: 
    Title: Protocol for a randomized controlled multicenter trial assessing the efficacy of leuprorelin for severe polycystic liver disease: the AGAINST-PLD study
    Author:  S. E. Aapkes 
    Subject: BMC Gastroenterology, https://doi.org/10.1186/s12876-022-02142-y
    Keywords: Polycystic liver disease;GnRHa;Estrogen
    Creator: Adobe InDesign 15.0 (Windows)
    Producer: Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Thu Feb 17 15:21:53 CET 2022
    ModDate: Fri Feb 25 10:48:41 CET 2022
   ID: 0x4ebaa2042cd7cbec3948e2e73560720d, 0xe2fa0cfbc4123f1e706e1a4601c20454
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 39
      ImageHeight: 40
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 39
      ImageHeight: 75
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 82
      ImageHeight: 84
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 583
      ImageHeight: 130
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 40
      ImageHeight: 77
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 42
      ImageHeight: 77
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 898
      ImageHeight: 1047
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1961
      ImageHeight: 1516
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1961
      ImageHeight: 846
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1595
      ImageHeight: 934
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type1: 
     Font: 
      BaseFont: MyriadPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-It
       Flags: Nonsymbolic, Italic
       FontBBox: -185, -250, 1090, 953
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EHPNPX+MTSY
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: EHPNPX+MTSY
       Flags: Symbolic
       FontBBox: 0, -954, 1043, 796
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Light
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Light
       Flags: Nonsymbolic
       FontBBox: -49, -250, 1046, 883
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-Light
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-Light
       Flags: Serif, Nonsymbolic
       FontBBox: -175, -515, 1437, 929
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LLQWGT+WarnockPro-It
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: LLQWGT+WarnockPro-It
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -221, -533, 1474, 950
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -177, -533, 1474, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-SemiboldIt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-SemiboldIt
       Flags: Nonsymbolic, Italic
       FontBBox: -193, -250, 1164, 972
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-LightIt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-LightIt
       Flags: Nonsymbolic, Italic
       FontBBox: -121, -250, 1007, 863
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.6-c015 81.159809, 2016/11/11-01:42:16        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:crossmark="http://crossref.org/crossmark/1.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmp:CreateDate>2022-02-17T14:21:53</xmp:CreateDate>
         <xmp:CreatorTool>Adobe InDesign 15.0 (Windows)</xmp:CreatorTool>
         <xmp:ModifyDate>2022-02-25T10:48:41+01:00</xmp:ModifyDate>
         <xmp:MetadataDate>2022-02-25T10:48:41+01:00</xmp:MetadataDate>
         <pdf:Producer>Adobe PDF Library 15.0; modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer>
         <pdf:Keywords>Polycystic liver disease;GnRHa;Estrogen</pdf:Keywords>
         <pdf:Trapped>False</pdf:Trapped>
         <dc:format>application/pdf</dc:format>
         <dc:identifier>https://doi.org/10.1186/s12876-022-02142-y</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>BioMed Central</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">BMC Gastroenterology, https://doi.org/10.1186/s12876-022-02142-y</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Polycystic liver disease</rdf:li>
               <rdf:li>GnRHa</rdf:li>
               <rdf:li>Estrogen</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Protocol for a randomized controlled multicenter trial assessing the efficacy of leuprorelin for severe polycystic liver disease: the AGAINST-PLD study</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li> S. E. Aapkes </rdf:li>
               <rdf:li> L. H. P. Bernts </rdf:li>
               <rdf:li> A. P. van den Berg </rdf:li>
               <rdf:li> M. van den Berg </rdf:li>
               <rdf:li> H. Blokzijl </rdf:li>
               <rdf:li> A. E. P. Cantineau </rdf:li>
               <rdf:li> M. D. A. van Gastel </rdf:li>
               <rdf:li> R. J. de Haas </rdf:li>
               <rdf:li> P. Kappert </rdf:li>
               <rdf:li> R. U. Müller </rdf:li>
               <rdf:li> F. Nevens </rdf:li>
               <rdf:li> R. Torra </rdf:li>
               <rdf:li> A. Visser </rdf:li>
               <rdf:li> J. P. H. Drenth </rdf:li>
               <rdf:li> R. T. Gansevoort </rdf:li>
            </rdf:Seq>
         </dc:creator>
         <crossmark:DOI>10.1186/s12876-022-02142-y</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <prism:url>https://doi.org/10.1186/s12876-022-02142-y</prism:url>
         <prism:doi>10.1186/s12876-022-02142-y</prism:doi>
         <prism:issn>1471-230X</prism:issn>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>BMC Gastroenterology</prism:publicationName>
         <prism:copyright>The Author(s)</prism:copyright>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1186/s12876-022-02142-y</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <xmpMM:DocumentID>uuid:f333d5bd-44d6-48ee-af82-ff518f61d49c</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:81244f0c-4534-40ac-b75f-171fc2686a85</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:f333d5bd-44d6-48ee-af82-ff518f61d49c</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2022-02-17T14:25:36Z</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe Document Info PDF eXtension Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>robots</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>Crossmark Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was publishe.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article.
The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). </pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Volume number</pdfaProperty:description>
                           <pdfaProperty:name>volume</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Issue number</pdfaProperty:description>
                           <pdfaProperty:name>number</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Starting page</pdfaProperty:description>
                           <pdfaProperty:name>startingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Ending page</pdfaProperty:description>
                           <pdfaProperty:name>endingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. </pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright</pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>DocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.</pdfaProperty:description>
                           <pdfaProperty:name>DerivedFrom</pdfaProperty:name>
                           <pdfaProperty:valueType>ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Part#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stPart</pdfaType:prefix>
                           <pdfaType:type>Part</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:schema>Springer Nature ORCID Schema</pdfaSchema:schema>
                  <pdfaSchema:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>sn</pdfaSchema:prefix>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>authorInfo</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag AuthorInformation</pdfaProperty:valueType>
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors.</pdfaProperty:description>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:type>AuthorInformation</pdfaType:type>
                           <pdfaType:namespaceURI>http://springernature.com/ns/xmpExtensions/2.0/authorInfo/</pdfaType:namespaceURI>
                           <pdfaType:prefix>author</pdfaType:prefix>
                           <pdfaType:description>Specifies the types of author information: name and ORCID of an author.</pdfaType:description>
                           <pdfaType:field>
                              <rdf:Seq>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>name</pdfaField:name>
                                    <pdfaField:valueType>Text</pdfaField:valueType>
                                    <pdfaField:description>Gives the name of an author.</pdfaField:description>
                                 </rdf:li>
                                 <rdf:li rdf:parseType="Resource">
                                    <pdfaField:name>orcid</pdfaField:name>
                                    <pdfaField:valueType>URI</pdfaField:valueType>
                                    <pdfaField:description>Gives the ORCID of an author.</pdfaField:description>
                                 </rdf:li>
                              </rdf:Seq>
                           </pdfaType:field>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 212, 68, 330, 60
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 486, 68, 530, 60
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 180, 60, 276, 52
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 507, 683, 540, 650
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 242, 611, 247, 599
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 200, 575, 205, 563
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 59, 539, 64, 527
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 70, 539, 75, 527
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 150, 527, 155, 515
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 160, 527, 165, 515
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 221, 491, 226, 479
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 231, 491, 236, 479
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 181, 479, 186, 467
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 263, 467, 268, 455
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 227, 455, 232, 443
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 163, 419, 168, 407
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 174, 419, 179, 407
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 100, 383, 105, 371
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 111, 383, 116, 371
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 119, 359, 124, 347
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 180, 335, 190, 323
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 144, 299, 148, 287
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 155, 299, 160, 287
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 212, 275, 222, 263
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 226, 275, 236, 263
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 200, 213, 205, 201
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 210, 213, 215, 201
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 136, 189, 141, 177
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 283, 165, 288, 153
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 56, 153, 61, 141
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 105, 117, 110, 105
       Flags: Print
       AppearanceDictionary: true
       Destination: 3
      Annotation: 
       Subtype: Link
       Rect: 120, 117, 130, 105
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 244, 105, 249, 93
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 254, 105, 259, 93
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 264, 105, 273, 93
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 453, 315, 463, 303
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 523, 264, 533, 252
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 444, 252, 454, 240
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 460, 252, 469, 240
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 339, 216, 349, 204
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 354, 216, 364, 204
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 369, 192, 379, 180
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 485, 156, 494, 144
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 500, 156, 510, 144
       Flags: Print
       AppearanceDictionary: true
       Destination: 185
      Annotation: 
       Subtype: Link
       Rect: 347, 108, 356, 96
       Flags: Print
       AppearanceDictionary: true
       Destination: 185
      Annotation: 
       Subtype: Link
       Rect: 373, 697, 530, 685
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 63, 685, 218, 666
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 59, 596, 69, 584
       Flags: Print
       AppearanceDictionary: true
       Destination: 185
      Annotation: 
       Subtype: Link
       Rect: 59, 572, 69, 560
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 75, 572, 84, 560
       Flags: Print
       AppearanceDictionary: true
       Destination: 185
      Annotation: 
       Subtype: Link
       Rect: 238, 548, 248, 536
       Flags: Print
       AppearanceDictionary: true
       Destination: 185
      Annotation: 
       Subtype: Link
       Rect: 253, 548, 263, 536
       Flags: Print
       AppearanceDictionary: true
       Destination: 185
      Annotation: 
       Subtype: Link
       Rect: 235, 440, 244, 428
       Flags: Print
       AppearanceDictionary: true
       Destination: 185
      Annotation: 
       Subtype: Link
       Rect: 425, 619, 430, 607
       Flags: Print
       AppearanceDictionary: true
       Destination: 107
      Annotation: 
       Subtype: Link
       Rect: 437, 619, 442, 607
       Flags: Print
       AppearanceDictionary: true
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 492, 305, 497, 293
       Flags: Print
       AppearanceDictionary: true
       Destination: 126
      Annotation: 
       Subtype: Link
       Rect: 327, 196, 337, 182
       Flags: Print
       AppearanceDictionary: true
       Destination: 185
     Thumb: true
    Page: 
     Sequence: 4
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 247, 358, 252, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 126
      Annotation: 
       Subtype: Link
       Rect: 272, 103, 277, 89
       Flags: Print
       AppearanceDictionary: true
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 496, 321, 501, 307
       Flags: Print
       AppearanceDictionary: true
       Destination: 113
     Thumb: true
    Page: 
     Sequence: 6
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 198, 644, 208, 632
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 154, 536, 164, 524
       Flags: Print
       AppearanceDictionary: true
       Destination: 185
      Annotation: 
       Subtype: Link
       Rect: 168, 536, 178, 524
       Flags: Print
       AppearanceDictionary: true
       Destination: 185
      Annotation: 
       Subtype: Link
       Rect: 496, 608, 501, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: 113
      Annotation: 
       Subtype: Link
       Rect: 506, 608, 511, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 275, 693, 285, 680
       Flags: Print
       AppearanceDictionary: true
       Destination: 185
      Annotation: 
       Subtype: Link
       Rect: 283, 615, 288, 602
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
      Annotation: 
       Subtype: Link
       Rect: 115, 393, 125, 380
       Flags: Print
       AppearanceDictionary: true
       Destination: 185
      Annotation: 
       Subtype: Link
       Rect: 118, 297, 128, 284
       Flags: Print
       AppearanceDictionary: true
       Destination: 185
      Annotation: 
       Subtype: Link
       Rect: 132, 297, 142, 284
       Flags: Print
       AppearanceDictionary: true
       Destination: 185
      Annotation: 
       Subtype: Link
       Rect: 408, 177, 418, 164
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 523, 141, 533, 128
       Flags: Print
       AppearanceDictionary: true
       Destination: 185
      Annotation: 
       Subtype: Link
       Rect: 436, 105, 441, 92
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 447, 105, 457, 92
       Flags: Print
       AppearanceDictionary: true
       Destination: 178
      Annotation: 
       Subtype: Link
       Rect: 463, 105, 472, 92
       Flags: Print
       AppearanceDictionary: true
       Destination: 185
      Annotation: 
       Subtype: Link
       Rect: 478, 105, 488, 92
       Flags: Print
       AppearanceDictionary: true
       Destination: 185
      Annotation: 
       Subtype: Link
       Rect: 307, 81, 317, 68
       Flags: Print
       AppearanceDictionary: true
       Destination: 185
     Thumb: true
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 261, 621, 270, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: 185
      Annotation: 
       Subtype: Link
       Rect: 243, 405, 253, 392
       Flags: Print
       AppearanceDictionary: true
       Destination: 185
      Annotation: 
       Subtype: Link
       Rect: 221, 381, 231, 368
       Flags: Print
       AppearanceDictionary: true
       Destination: 185
      Annotation: 
       Subtype: Link
       Rect: 235, 381, 245, 368
       Flags: Print
       AppearanceDictionary: true
       Destination: 185
      Annotation: 
       Subtype: Link
       Rect: 121, 129, 131, 116
       Flags: Print
       AppearanceDictionary: true
       Destination: 185
      Annotation: 
       Subtype: Link
       Rect: 389, 609, 399, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: 185
      Annotation: 
       Subtype: Link
       Rect: 405, 609, 415, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: 185
      Annotation: 
       Subtype: Link
       Rect: 420, 609, 430, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: 185
      Annotation: 
       Subtype: Link
       Rect: 528, 537, 533, 524
       Flags: Print
       AppearanceDictionary: true
       Destination: 132
     Thumb: true
    Page: 
     Sequence: 10
     Thumb: true
    Page: 
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 187, 451, 284, 443
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 442, 172, 429
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: b530c5f6
   Type: CRC32
  Checksum: ea2b31694d2b6b7eafa769337df3e918
   Type: MD5
  Checksum: 92a1839caf7d6675f684bff67a37c64c160aa1b8
   Type: SHA-1