9a12becc0e3836ad3440c6a222dfce99 275193.pdf 38fcc8c36b085221c5370848ced715e6eef6472c 275193.pdf 0c99a39205af9c6ac8f9f71c63e180efd20edbc81f72346d1ca523d7cca70e17 275193.pdf Title: Treatment patterns and intensification within 5 year of follow-up of the first-line anti-TNFα used for the treatment of IBD: Results from the VERNE study Subject: Digestive and Liver Disease, 54 (2022) 76-83. doi:10.1016/j.dld.2021.06.005 Keywords: "Anti-TNFα"; "Inflammatory bowel disease"; "Treatment discontinuation"; "Treatment intensification" Author: G. Bastida Creator: Elsevier Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Sun Dec 5 06:13:47 2021 CET ModDate: Sun Dec 5 06:14:11 2021 CET Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 8 Encrypted: no Page size: 595.245 x 793.92 pts Page rot: 0 File size: 713112 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JFOMMD+Gulliver-Italic Type 1C Custom yes yes yes 576 0 JFOMJC+RMTMI Type 1C Custom yes yes yes 581 0 JFOMKD+MTSY Type 1C Custom yes yes yes 586 0 JFOJMB+Gulliver Type 1C Custom yes yes yes 591 0 JFOMCE+UniversLTStd Type 1C Custom yes yes yes 596 0 JFOMPD+GulliverSCOsF Type 1C Custom yes yes yes 601 0 JFOJMC+dummy-space Type 1C WinAnsi yes yes no 606 0 JFONBD+Gulliver-Bold Type 1C Custom yes yes yes 334 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-07-06 02:32:57 CEST RepresentationInformation: 275193.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-07-05 13:24:57 CEST Size: 713112 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tb1fn1' cannot be found Offset: 688094 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tb1fn2' cannot be found Offset: 688094 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tb1fn2' cannot be found Offset: 688094 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tb1fn2' cannot be found Offset: 688094 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tb3fn1' cannot be found Offset: 688094 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tb4fn1' cannot be found Offset: 688094 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tb4fn2' cannot be found Offset: 688094 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tb4fn1' cannot be found Offset: 688094 MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 686 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Treatment patterns and intensification within 5 year of follow-up of the first-line anti-TNFα used for the treatment of IBD: Results from the VERNE study Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Children: Item: Title: 1 Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: 2 Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Children: Item: Title: 2.1 Study population Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: 2.2 Patients description Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: 2.3 Clinical outcome evaluation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: 2.4 Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: 3 Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Children: Item: Title: 3.1 Patient characteristics and follow-up times Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: 3.2 Frequency of use and time to treatment initiation of first anti-TNFα treatment Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: 3.3 Anti-TNFα therapy intensification Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: 3.4 Anti-TNFα therapy discontinuation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Children: Item: Title: 3.4.1 Discontinuations due to PNR Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: 3.4.2 Discontinuations due to LOR Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: 3.4.3 Discontinuations due to safety reasons Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: 3.5 Concomitant treatments during the induction and maintenance phases Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: 3.6 Treatments for IBD after the discontinuation of the first anti-TNFα Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: 4 Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: Data availability statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Conflict of Interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Info: Title: Treatment patterns and intensification within 5 year of follow-up of the first-line anti-TNFα used for the treatment of IBD: Results from the VERNE study Author: G. Bastida Subject: Digestive and Liver Disease, 54 (2022) 76-83. doi:10.1016/j.dld.2021.06.005 Keywords: "Anti-TNFα"; "Inflammatory bowel disease"; "Treatment discontinuation"; "Treatment intensification" Creator: Elsevier Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Sun Dec 05 06:43:47 CET 2021 ModDate: Sun Dec 05 06:44:11 CET 2021 ID: 0xe334e12f2b2ec30771b665a3af87e5ac, 0x7583b78a887818a159ded08b7eb2e394 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 249 ImageHeight: 273 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 118 ImageHeight: 118 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 224 ImageHeight: 297 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1500 ImageHeight: 1054 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1500 ImageHeight: 1047 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: JFOMMD+Gulliver-Italic FontSubset: true FirstChar: 40 LastChar: 243 FontDescriptor: FontName: JFOMMD+Gulliver-Italic Flags: Serif, Symbolic, Italic FontBBox: -141, -211, 1053, 789 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JFOMCE+UniversLTStd FontSubset: true FirstChar: 46 LastChar: 119 FontDescriptor: FontName: JFOMCE+UniversLTStd Flags: Symbolic FontBBox: -168, -250, 992, 947 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JFOMJC+RMTMI FontSubset: true FirstChar: 2 LastChar: 60 FontDescriptor: FontName: JFOMJC+RMTMI Flags: Symbolic, Italic FontBBox: 0, -213, 987, 680 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JFOMPD+GulliverSCOsF FontSubset: true FirstChar: 97 LastChar: 116 FontDescriptor: FontName: JFOMPD+GulliverSCOsF Flags: Serif, Symbolic FontBBox: -115, -211, 1407, 789 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JFOMKD+MTSY FontSubset: true FirstChar: 2 LastChar: 61 FontDescriptor: FontName: JFOMKD+MTSY Flags: Symbolic FontBBox: 0, -954, 1043, 796 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JFOJMC+dummy-space FontSubset: true FirstChar: 32 LastChar: 32 FontDescriptor: FontName: JFOJMC+dummy-space Flags: Nonsymbolic FontBBox: 0, 0, 0, 0 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JFONBD+Gulliver-Bold FontSubset: true FirstChar: 46 LastChar: 148 FontDescriptor: FontName: JFONBD+Gulliver-Bold Flags: Serif, Symbolic, ForceBold FontBBox: -150, -211, 1131, 789 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: JFOJMB+Gulliver FontSubset: true FirstChar: 2 LastChar: 252 FontDescriptor: FontName: JFOJMB+Gulliver Flags: Serif, Symbolic FontBBox: -115, -211, 1042, 789 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Pages: Page: Label: 76 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 229, 749, 365, 758 Annotation: Subtype: Link Rect: 322, 720, 375, 731 Annotation: Subtype: Link Rect: 281, 665, 391, 676 Annotation: Subtype: Link Rect: 498, 593, 528, 604 Annotation: Subtype: Link Rect: 87, 553, 93, 566 Destination: 563 Annotation: Subtype: Link Rect: 92, 553, 98, 566 Destination: 563 Annotation: Subtype: Link Rect: 185, 553, 192, 566 Destination: 563 Annotation: Subtype: Link Rect: 236, 553, 242, 566 Destination: 563 Annotation: Subtype: Link Rect: 333, 553, 340, 566 Destination: 563 Annotation: Subtype: Link Rect: 430, 553, 437, 566 Destination: 563 Annotation: Subtype: Link Rect: 83, 540, 88, 554 Destination: 563 Annotation: Subtype: Link Rect: 190, 540, 195, 554 Destination: 563 Annotation: Subtype: Link Rect: 254, 540, 259, 554 Destination: 563 Annotation: Subtype: Link Rect: 314, 540, 319, 554 Destination: 563 Annotation: Subtype: Link Rect: 369, 540, 375, 554 Destination: 563 Annotation: Subtype: Link Rect: 476, 540, 483, 554 Destination: 563 Annotation: Subtype: Link Rect: 126, 527, 133, 541 Destination: 563 Annotation: Subtype: Link Rect: 229, 527, 234, 541 Destination: 563 Annotation: Subtype: Link Rect: 288, 527, 293, 541 Destination: 563 Annotation: Subtype: Link Rect: 355, 527, 361, 541 Destination: 563 Annotation: Subtype: Link Rect: 410, 527, 415, 541 Destination: 563 Annotation: Subtype: Link Rect: 414, 527, 424, 541 Destination: 563 Annotation: Subtype: Link Rect: 470, 527, 477, 541 Destination: 563 Annotation: Subtype: Link Rect: 97, 514, 103, 528 Destination: 563 Annotation: Subtype: Link Rect: 216, 514, 220, 528 Destination: 563 Annotation: Subtype: Link Rect: 385, 134, 556, 144 Annotation: Subtype: Link Rect: 95, 80, 171, 89 Annotation: Subtype: Link Rect: 36, 57, 157, 66 Annotation: Subtype: Link Rect: 38, 40, 191, 48 Page: Label: 77 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 144, 591, 166, 602 Destination: 75 Annotation: Subtype: Link Rect: 204, 528, 217, 539 Destination: 75 Annotation: Subtype: Link Rect: 133, 507, 159, 518 Destination: 75 Annotation: Subtype: Link Rect: 249, 476, 262, 487 Destination: 75 Annotation: Subtype: Link Rect: 262, 476, 276, 487 Destination: 75 Annotation: Subtype: Link Rect: 88, 350, 118, 361 Destination: 75 Annotation: Subtype: Link Rect: 223, 340, 236, 351 Destination: 75 Annotation: Subtype: Link Rect: 236, 340, 250, 351 Destination: 75 Annotation: Subtype: Link Rect: 305, 727, 322, 738 Destination: 75 Annotation: Subtype: Link Rect: 346, 633, 363, 644 Destination: 75 Annotation: Subtype: Link Rect: 454, 143, 484, 154 Destination: 14 Page: Label: 78 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 53, 542, 57, 551 Destination: null Annotation: Subtype: Link Rect: 240, 465, 244, 474 Destination: null Annotation: Subtype: Link Rect: 354, 465, 359, 474 Destination: null Annotation: Subtype: Link Rect: 240, 397, 244, 406 Destination: null Annotation: Subtype: Link Rect: 46, 72, 75, 83 Destination: 14 Annotation: Subtype: Link Rect: 366, 184, 389, 195 Destination: 24 Annotation: Subtype: Link Rect: 493, 153, 519, 164 Destination: 24 Annotation: Subtype: Link Rect: 543, 153, 550, 164 Destination: 24 Page: Label: 79 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 36, 111, 58, 122 Destination: 24 Annotation: Subtype: Link Rect: 406, 132, 428, 143 Destination: 24 Annotation: Subtype: Link Rect: 305, 100, 328, 111 Destination: 24 Page: Label: 80 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 146, 659, 151, 668 Destination: null Annotation: Subtype: Link Rect: 237, 567, 242, 576 Destination: null Annotation: Subtype: Link Rect: 242, 567, 247, 576 Destination: null Annotation: Subtype: Link Rect: 354, 480, 359, 489 Destination: null Annotation: Subtype: Link Rect: 219, 390, 248, 401 Destination: 38 Annotation: Subtype: Link Rect: 39, 297, 68, 308 Destination: 38 Annotation: Subtype: Link Rect: 239, 224, 268, 235 Destination: 38 Annotation: Subtype: Link Rect: 168, 203, 197, 214 Destination: 38 Annotation: Subtype: Link Rect: 159, 120, 188, 131 Destination: 38 Annotation: Subtype: Link Rect: 305, 172, 322, 183 Destination: 75 Annotation: Subtype: Link Rect: 441, 109, 455, 120 Destination: 75 Annotation: Subtype: Link Rect: 455, 109, 469, 120 Destination: 75 Page: Label: 81 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 80, 716, 97, 727 Destination: 75 Annotation: Subtype: Link Rect: 36, 549, 67, 560 Destination: 75 Annotation: Subtype: Link Rect: 102, 497, 119, 508 Destination: 75 Annotation: Subtype: Link Rect: 51, 308, 68, 319 Destination: 75 Annotation: Subtype: Link Rect: 217, 235, 247, 246 Destination: 75 Annotation: Subtype: Link Rect: 224, 183, 238, 194 Destination: 75 Annotation: Subtype: Link Rect: 238, 183, 249, 194 Destination: 75 Annotation: Subtype: Link Rect: 249, 183, 260, 194 Destination: 228 Annotation: Subtype: Link Rect: 260, 183, 274, 194 Destination: 228 Annotation: Subtype: Link Rect: 73, 68, 90, 79 Destination: 228 Annotation: Subtype: Link Rect: 206, 57, 237, 68 Destination: 228 Annotation: Subtype: Link Rect: 516, 601, 533, 612 Destination: 228 Annotation: Subtype: Link Rect: 378, 559, 395, 570 Destination: 228 Annotation: Subtype: Link Rect: 397, 528, 414, 539 Destination: 75 Annotation: Subtype: Link Rect: 320, 486, 333, 497 Destination: 75 Annotation: Subtype: Link Rect: 333, 486, 360, 497 Destination: 228 Annotation: Subtype: Link Rect: 329, 382, 346, 393 Destination: 228 Annotation: Subtype: Link Rect: 391, 361, 408, 372 Destination: 228 Annotation: Subtype: Link Rect: 322, 350, 337, 361 Destination: 228 Annotation: Subtype: Link Rect: 337, 350, 351, 361 Destination: 228 Page: Label: 82 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 52, 63, 78, 72 Annotation: Subtype: Link Rect: 81, 63, 118, 72 Annotation: Subtype: Link Rect: 121, 63, 152, 72 Annotation: Subtype: Link Rect: 155, 63, 195, 72 Annotation: Subtype: Link Rect: 198, 63, 227, 72 Annotation: Subtype: Link Rect: 230, 63, 273, 72 Annotation: Subtype: Link Rect: 25, 46, 294, 73 Annotation: Subtype: Link Rect: 321, 727, 365, 736 Annotation: Subtype: Link Rect: 369, 727, 396, 736 Annotation: Subtype: Link Rect: 400, 727, 429, 736 Annotation: Subtype: Link Rect: 320, 710, 579, 737 Annotation: Subtype: Link Rect: 321, 703, 348, 712 Annotation: Subtype: Link Rect: 320, 694, 579, 713 Annotation: Subtype: Link Rect: 321, 687, 340, 696 Annotation: Subtype: Link Rect: 342, 687, 373, 696 Annotation: Subtype: Link Rect: 375, 687, 405, 696 Annotation: Subtype: Link Rect: 407, 687, 433, 696 Annotation: Subtype: Link Rect: 434, 687, 468, 696 Annotation: Subtype: Link Rect: 470, 687, 496, 696 Annotation: Subtype: Link Rect: 320, 678, 579, 697 Annotation: Subtype: Link Rect: 321, 671, 343, 680 Annotation: Subtype: Link Rect: 345, 671, 382, 680 Annotation: Subtype: Link Rect: 385, 671, 416, 680 Annotation: Subtype: Link Rect: 419, 671, 437, 680 Annotation: Subtype: Link Rect: 320, 654, 579, 681 Annotation: Subtype: Link Rect: 321, 647, 359, 656 Annotation: Subtype: Link Rect: 360, 647, 390, 656 Annotation: Subtype: Link Rect: 392, 647, 414, 656 Annotation: Subtype: Link Rect: 416, 647, 432, 656 Annotation: Subtype: Link Rect: 320, 639, 579, 657 Annotation: Subtype: Link Rect: 321, 632, 347, 641 Annotation: Subtype: Link Rect: 349, 632, 391, 641 Annotation: Subtype: Link Rect: 394, 632, 420, 641 Annotation: Subtype: Link Rect: 423, 632, 460, 641 Annotation: Subtype: Link Rect: 463, 632, 492, 641 Annotation: Subtype: Link Rect: 494, 632, 532, 641 Annotation: Subtype: Link Rect: 320, 615, 579, 641 Annotation: Subtype: Link Rect: 321, 608, 388, 617 Annotation: Subtype: Link Rect: 390, 608, 434, 617 Annotation: Subtype: Link Rect: 436, 608, 492, 617 Annotation: Subtype: Link Rect: 495, 608, 512, 617 Annotation: Subtype: Link Rect: 320, 591, 579, 618 Annotation: Subtype: Link Rect: 321, 584, 345, 593 Annotation: Subtype: Link Rect: 348, 584, 382, 593 Annotation: Subtype: Link Rect: 385, 584, 427, 593 Annotation: Subtype: Link Rect: 320, 567, 579, 594 Annotation: Subtype: Link Rect: 321, 560, 347, 569 Annotation: Subtype: Link Rect: 350, 560, 404, 569 Annotation: Subtype: Link Rect: 320, 551, 579, 570 Annotation: Subtype: Link Rect: 321, 544, 346, 553 Annotation: Subtype: Link Rect: 348, 544, 381, 553 Annotation: Subtype: Link Rect: 383, 544, 407, 553 Annotation: Subtype: Link Rect: 409, 544, 426, 553 Annotation: Subtype: Link Rect: 320, 527, 579, 554 Annotation: Subtype: Link Rect: 321, 520, 360, 529 Annotation: Subtype: Link Rect: 363, 520, 397, 529 Annotation: Subtype: Link Rect: 320, 511, 579, 530 Annotation: Subtype: Link Rect: 321, 504, 347, 513 Annotation: Subtype: Link Rect: 349, 504, 390, 513 Annotation: Subtype: Link Rect: 392, 504, 434, 513 Annotation: Subtype: Link Rect: 435, 504, 474, 513 Annotation: Subtype: Link Rect: 476, 504, 513, 513 Annotation: Subtype: Link Rect: 514, 504, 557, 513 Annotation: Subtype: Link Rect: 320, 479, 579, 514 Annotation: Subtype: Link Rect: 321, 472, 348, 481 Annotation: Subtype: Link Rect: 351, 472, 396, 481 Annotation: Subtype: Link Rect: 398, 472, 417, 481 Annotation: Subtype: Link Rect: 420, 472, 446, 481 Annotation: Subtype: Link Rect: 320, 463, 579, 482 Annotation: Subtype: Link Rect: 321, 456, 345, 465 Annotation: Subtype: Link Rect: 348, 456, 391, 465 Annotation: Subtype: Link Rect: 394, 456, 418, 465 Annotation: Subtype: Link Rect: 421, 456, 439, 465 Annotation: Subtype: Link Rect: 320, 431, 579, 466 Annotation: Subtype: Link Rect: 321, 424, 353, 433 Annotation: Subtype: Link Rect: 355, 424, 387, 433 Annotation: Subtype: Link Rect: 389, 424, 424, 433 Annotation: Subtype: Link Rect: 426, 424, 443, 433 Annotation: Subtype: Link Rect: 320, 407, 579, 434 Annotation: Subtype: Link Rect: 321, 400, 346, 409 Annotation: Subtype: Link Rect: 349, 400, 372, 409 Annotation: Subtype: Link Rect: 375, 400, 397, 409 Annotation: Subtype: Link Rect: 400, 400, 430, 409 Annotation: Subtype: Link Rect: 320, 383, 579, 410 Annotation: Subtype: Link Rect: 321, 376, 348, 385 Annotation: Subtype: Link Rect: 352, 376, 370, 385 Annotation: Subtype: Link Rect: 374, 376, 417, 385 Annotation: Subtype: Link Rect: 421, 376, 440, 385 Annotation: Subtype: Link Rect: 320, 360, 579, 386 Annotation: Subtype: Link Rect: 321, 353, 357, 362 Annotation: Subtype: Link Rect: 359, 353, 391, 362 Annotation: Subtype: Link Rect: 393, 353, 423, 362 Annotation: Subtype: Link Rect: 425, 353, 442, 362 Annotation: Subtype: Link Rect: 320, 336, 579, 363 Annotation: Subtype: Link Rect: 321, 305, 357, 314 Annotation: Subtype: Link Rect: 362, 305, 405, 314 Annotation: Subtype: Link Rect: 409, 305, 438, 314 Annotation: Subtype: Link Rect: 442, 305, 469, 314 Annotation: Subtype: Link Rect: 320, 288, 579, 315 Annotation: Subtype: Link Rect: 321, 281, 363, 290 Annotation: Subtype: Link Rect: 365, 281, 407, 290 Annotation: Subtype: Link Rect: 409, 281, 435, 290 Annotation: Subtype: Link Rect: 437, 281, 460, 290 Annotation: Subtype: Link Rect: 462, 281, 488, 290 Annotation: Subtype: Link Rect: 491, 281, 532, 290 Annotation: Subtype: Link Rect: 320, 256, 579, 291 Annotation: Subtype: Link Rect: 321, 249, 347, 258 Annotation: Subtype: Link Rect: 350, 249, 378, 258 Annotation: Subtype: Link Rect: 380, 249, 407, 258 Annotation: Subtype: Link Rect: 410, 249, 427, 258 Annotation: Subtype: Link Rect: 320, 232, 579, 259 Annotation: Subtype: Link Rect: 321, 225, 347, 234 Annotation: Subtype: Link Rect: 349, 225, 387, 234 Annotation: Subtype: Link Rect: 390, 225, 420, 234 Annotation: Subtype: Link Rect: 320, 216, 579, 235 Annotation: Subtype: Link Rect: 321, 209, 348, 218 Annotation: Subtype: Link Rect: 352, 209, 408, 218 Annotation: Subtype: Link Rect: 411, 209, 437, 218 Annotation: Subtype: Link Rect: 440, 209, 473, 218 Annotation: Subtype: Link Rect: 320, 192, 579, 219 Annotation: Subtype: Link Rect: 321, 185, 356, 194 Annotation: Subtype: Link Rect: 358, 185, 391, 194 Annotation: Subtype: Link Rect: 393, 185, 430, 194 Annotation: Subtype: Link Rect: 432, 185, 475, 194 Annotation: Subtype: Link Rect: 477, 185, 496, 194 Annotation: Subtype: Link Rect: 320, 168, 579, 195 Annotation: Subtype: Link Rect: 321, 161, 358, 170 Annotation: Subtype: Link Rect: 361, 161, 400, 170 Annotation: Subtype: Link Rect: 403, 161, 444, 170 Annotation: Subtype: Link Rect: 446, 161, 490, 170 Annotation: Subtype: Link Rect: 320, 144, 579, 171 Annotation: Subtype: Link Rect: 321, 137, 362, 146 Annotation: Subtype: Link Rect: 367, 137, 418, 146 Annotation: Subtype: Link Rect: 424, 137, 480, 146 Annotation: Subtype: Link Rect: 486, 137, 506, 146 Annotation: Subtype: Link Rect: 320, 112, 579, 147 Annotation: Subtype: Link Rect: 321, 106, 359, 114 Annotation: Subtype: Link Rect: 362, 106, 404, 114 Annotation: Subtype: Link Rect: 406, 106, 433, 114 Annotation: Subtype: Link Rect: 436, 106, 454, 114 Annotation: Subtype: Link Rect: 320, 89, 579, 115 Annotation: Subtype: Link Rect: 321, 82, 357, 91 Annotation: Subtype: Link Rect: 360, 82, 401, 91 Annotation: Subtype: Link Rect: 404, 82, 446, 91 Annotation: Subtype: Link Rect: 449, 82, 466, 91 Annotation: Subtype: Link Rect: 320, 65, 579, 92 Annotation: Subtype: Link Rect: 321, 58, 358, 67 Annotation: Subtype: Link Rect: 361, 58, 404, 67 Annotation: Subtype: Link Rect: 408, 58, 450, 67 Annotation: Subtype: Link Rect: 454, 58, 472, 67 Annotation: Subtype: Link Rect: 304, 49, 579, 68 Page: Label: 83 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 25, 718, 294, 737 Annotation: Subtype: Link Rect: 52, 711, 93, 720 Annotation: Subtype: Link Rect: 95, 711, 133, 720 Annotation: Subtype: Link Rect: 135, 711, 169, 720 Annotation: Subtype: Link Rect: 171, 711, 188, 720 Annotation: Subtype: Link Rect: 25, 686, 294, 721 Annotation: Subtype: Link Rect: 52, 679, 93, 688 Annotation: Subtype: Link Rect: 94, 679, 136, 688 Annotation: Subtype: Link Rect: 138, 679, 173, 688 Annotation: Subtype: Link Rect: 175, 679, 192, 688 Annotation: Subtype: Link Rect: 25, 662, 294, 689 Annotation: Subtype: Link Rect: 52, 655, 92, 664 Annotation: Subtype: Link Rect: 95, 655, 134, 664 Annotation: Subtype: Link Rect: 137, 655, 191, 664 Annotation: Subtype: Link Rect: 194, 655, 212, 664 Annotation: Subtype: Link Rect: 25, 639, 294, 665 Annotation: Subtype: Link Rect: 52, 632, 94, 641 Annotation: Subtype: Link Rect: 95, 632, 136, 641 Annotation: Subtype: Link Rect: 138, 632, 163, 641 Annotation: Subtype: Link Rect: 165, 632, 182, 641 Annotation: Subtype: Link Rect: 25, 615, 294, 641 Annotation: Subtype: Link Rect: 52, 608, 90, 617 Annotation: Subtype: Link Rect: 95, 608, 122, 617 Annotation: Subtype: Link Rect: 127, 608, 190, 617 Annotation: Subtype: Link Rect: 195, 608, 215, 617 Annotation: Subtype: Link Rect: 25, 591, 294, 618 Annotation: Subtype: Link Rect: 52, 584, 79, 593 Annotation: Subtype: Link Rect: 82, 584, 107, 593 Annotation: Subtype: Link Rect: 110, 584, 143, 593 Annotation: Subtype: Link Rect: 146, 584, 163, 593 Annotation: Subtype: Link Rect: 25, 567, 294, 594 Annotation: Subtype: Link Rect: 52, 560, 85, 569 Annotation: Subtype: Link Rect: 88, 560, 136, 569 Annotation: Subtype: Link Rect: 140, 560, 175, 569 Annotation: Subtype: Link Rect: 179, 560, 198, 569 Annotation: Subtype: Link Rect: 25, 535, 294, 570 Annotation: Subtype: Link Rect: 52, 528, 81, 537 Annotation: Subtype: Link Rect: 83, 528, 108, 537 Annotation: Subtype: Link Rect: 110, 528, 148, 537 Annotation: Subtype: Link Rect: 150, 528, 167, 537 Annotation: Subtype: Link Rect: 25, 511, 294, 538 Annotation: Subtype: Link Rect: 52, 504, 96, 513 Annotation: Subtype: Link Rect: 99, 504, 131, 513 Annotation: Subtype: Link Rect: 134, 504, 164, 513 Annotation: Subtype: Link Rect: 167, 504, 185, 513 Annotation: Subtype: Link Rect: 25, 487, 294, 514 Annotation: Subtype: Link Rect: 52, 480, 90, 489 Annotation: Subtype: Link Rect: 92, 480, 115, 489 Annotation: Subtype: Link Rect: 118, 480, 151, 489 Annotation: Subtype: Link Rect: 153, 480, 170, 489 Annotation: Subtype: Link Rect: 25, 49, 294, 490 Annotation: Subtype: Link Rect: 320, 718, 579, 737 Annotation: Subtype: Link Rect: 321, 711, 334, 720 Annotation: Subtype: Link Rect: 335, 711, 382, 720 Annotation: Subtype: Link Rect: 384, 711, 419, 720 Annotation: Subtype: Link Rect: 421, 711, 457, 720 Annotation: Subtype: Link Rect: 460, 711, 513, 720 Annotation: Subtype: Link Rect: 515, 711, 557, 720 Annotation: Subtype: Link Rect: 321, 703, 344, 712 Annotation: Subtype: Link Rect: 346, 703, 363, 712 Annotation: Subtype: Link Rect: 320, 686, 579, 713 Annotation: Subtype: Link Rect: 321, 679, 343, 688 Annotation: Subtype: Link Rect: 345, 679, 379, 688 Annotation: Subtype: Link Rect: 381, 679, 408, 688 Annotation: Subtype: Link Rect: 410, 679, 447, 688 Annotation: Subtype: Link Rect: 320, 662, 579, 689 Annotation: Subtype: Link Rect: 321, 655, 363, 664 Annotation: Subtype: Link Rect: 366, 655, 424, 664 Annotation: Subtype: Link Rect: 427, 655, 474, 664 Annotation: Subtype: Link Rect: 477, 655, 537, 664 Annotation: Subtype: Link Rect: 320, 646, 579, 665 Annotation: Subtype: Link Rect: 380, 647, 436, 656 Annotation: Subtype: Link Rect: 320, 631, 579, 657 Annotation: Subtype: Link Rect: 321, 624, 343, 633 Annotation: Subtype: Link Rect: 346, 624, 371, 633 Annotation: Subtype: Link Rect: 373, 624, 403, 633 Annotation: Subtype: Link Rect: 405, 624, 426, 633 Annotation: Subtype: Link Rect: 320, 607, 579, 634 Annotation: Subtype: Link Rect: 321, 600, 353, 609 Annotation: Subtype: Link Rect: 355, 600, 391, 609 Annotation: Subtype: Link Rect: 393, 600, 430, 609 Annotation: Subtype: Link Rect: 432, 600, 449, 609 Annotation: Subtype: Link Rect: 320, 583, 579, 610 Annotation: Subtype: Link Rect: 321, 576, 353, 585 Annotation: Subtype: Link Rect: 355, 576, 385, 585 Annotation: Subtype: Link Rect: 388, 576, 425, 585 Annotation: Subtype: Link Rect: 320, 559, 579, 586 Annotation: Subtype: Link Rect: 321, 552, 346, 561 Annotation: Subtype: Link Rect: 348, 552, 380, 561 Annotation: Subtype: Link Rect: 382, 552, 401, 561 Annotation: Subtype: Link Rect: 320, 535, 579, 562 Annotation: Subtype: Link Rect: 321, 528, 344, 537 Annotation: Subtype: Link Rect: 346, 528, 407, 537 Annotation: Subtype: Link Rect: 409, 528, 435, 537 Annotation: Subtype: Link Rect: 436, 528, 453, 537 Annotation: Subtype: Link Rect: 455, 528, 479, 537 Annotation: Subtype: Link Rect: 320, 511, 579, 538 Annotation: Subtype: Link Rect: 321, 504, 356, 513 Annotation: Subtype: Link Rect: 359, 504, 390, 513 Annotation: Subtype: Link Rect: 392, 504, 445, 513 Annotation: Subtype: Link Rect: 447, 504, 464, 513 Annotation: Subtype: Link Rect: 320, 487, 579, 514 Checksum: 0e4641de Type: CRC32 Checksum: 9a12becc0e3836ad3440c6a222dfce99 Type: MD5 Checksum: 38fcc8c36b085221c5370848ced715e6eef6472c Type: SHA-1