0d2396a7ac2aedbc564c8065a63b125d 275208.pdf 8b710334624a9f8eb525d7717a41ac17807f5f24 275208.pdf fade07bbcf82c0efefbef784aa2fe45d15c3ef4bb92cda75f2623f94b5dd3c4c 275208.pdf Title: Novel Antithrombotic Agents in Ischemic Cardiovascular Disease: Progress in the Search for the Optimal Treatment Subject: Ischemic cardiovascular diseases have a high incidence and high mortality worldwide. Therapeutic advances in the last decades have reduced cardiovascular mortality, with antithrombotic therapy being the cornerstone of medical treatment. Yet, currently used antithrombotic agents carry an inherent risk of bleeding associated with adverse cardiovascular outcomes and mortality. Advances in understanding the pathophysiology of thrombus formation have led to the discovery of new targets and the development of new anticoagulants and antiplatelet agents aimed at preventing thrombus stabilization and growth while preserving hemostasis. In the following review, we will comment on the key limitation of the currently used antithrombotic regimes in ischemic heart disease and ischemic stroke and provide an in-depth and state-of-the-art overview of the emerging anticoagulant and antiplatelet agents in the pipeline with the potential to improve clinical outcomes. Keywords: cardiovascular diseases; novel antithrombotic agents; antiplatelet drugs; anticoagulants; hemostasis Author: Ignacio Barriuso, Fernando Worner and Gemma Vilahur Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Tue Nov 22 08:05:20 2022 CET ModDate: Tue Nov 22 08:34:51 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 21 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 1177445 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DUFXDP+VnURWPalladioL Type 1 Custom yes yes no 10 0 RFFRDP+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 DKUJUX+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 THTTHO+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 VGVAWT+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 43 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 46 0 SPDANV+EURB10 Type 1 Builtin yes yes no 68 0 QWEFBN+URWPalladioL-BoldItal Type 1 Custom yes yes no 72 0 NXAVJS+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 79 0 BIZWXQ+PalatinoLinotype-Italic TrueType WinAnsi yes yes yes 87 0 INNRRC+PalatinoLinotype-Bold TrueType WinAnsi yes yes yes 91 0 PIXCLO+PalatinoLinotype-Roman TrueType WinAnsi yes yes yes 95 0 RTZONK+PalatinoLinotype-BoldItalic TrueType WinAnsi yes yes yes 99 0 BIZWXQ+PalatinoLinotype-Italic TrueType WinAnsi yes yes yes 111 0 INNRRC+PalatinoLinotype-Bold TrueType WinAnsi yes yes yes 115 0 PIXCLO+PalatinoLinotype-Roman TrueType WinAnsi yes yes yes 119 0 GOCQIR+EURM10 Type 1 Builtin yes yes no 138 0 YYNJHW+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 145 0 BIZWXQ+PalatinoLinotype-Italic TrueType WinAnsi yes yes yes 153 0 INNRRC+PalatinoLinotype-Bold TrueType WinAnsi yes yes yes 157 0 PIXCLO+PalatinoLinotype-Roman TrueType WinAnsi yes yes yes 161 0 QGUKZH+CMSY10 Type 1 Builtin yes yes no 179 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-07-04 02:31:24 CEST RepresentationInformation: 275208.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-07-03 13:59:28 CEST Size: 1177445 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 648 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: The Coagulation Cascade: Targeting the Intrinsic Coagulation Pathway Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Children: Item: Title: Targeting Factor XII Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Targeting Factor XI Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Targeting Factor IX Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Targeting the Platelet: What Is in the Pipeline for Novel Antiplatelet Agents? Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Children: Item: Title: Targeting Platelet Adhesion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Children: Item: Title: Inhibition of Von Willebrand Factor-Glycoprotein 1b-Mediated Platelet Activation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Glycoprotein VI: Inhibition of Collagen-Mediated Platelet Activation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Targeting Platelet Activation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Children: Item: Title: PAR1 and PAR4: Inhibition of Thrombin-Mediated Platelet Activation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Inhibition of Phosphoinositide 3-Kinase Beta (PI3K) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Selatogrel: The New Antagonist of the P2Y12 Receptor Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: New P2Y1 Receptor Antagonists Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Targeting Platelet Aggregation and Thrombus Propagation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Children: Item: Title: New Inhibitor of GP IIb/IIIa Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Item: Title: Inhibition of Protein Disulfide Isomerase (PDI) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Info: Title: Novel Antithrombotic Agents in Ischemic Cardiovascular Disease: Progress in the Search for the Optimal Treatment Author: Ignacio Barriuso, Fernando Worner and Gemma Vilahur Subject: Ischemic cardiovascular diseases have a high incidence and high mortality worldwide. Therapeutic advances in the last decades have reduced cardiovascular mortality, with antithrombotic therapy being the cornerstone of medical treatment. Yet, currently used antithrombotic agents carry an inherent risk of bleeding associated with adverse cardiovascular outcomes and mortality. Advances in understanding the pathophysiology of thrombus formation have led to the discovery of new targets and the development of new anticoagulants and antiplatelet agents aimed at preventing thrombus stabilization and growth while preserving hemostasis. In the following review, we will comment on the key limitation of the currently used antithrombotic regimes in ischemic heart disease and ischemic stroke and provide an in-depth and state-of-the-art overview of the emerging anticoagulant and antiplatelet agents in the pipeline with the potential to improve clinical outcomes. 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281, 157 Annotation: Subtype: Link Rect: 288, 147, 324, 157 Annotation: Subtype: Link Rect: 59, 124, 96, 134 Annotation: Subtype: Link Rect: 199, 89, 236, 100 Annotation: Subtype: Link Rect: 242, 89, 278, 100 Annotation: Subtype: Link Rect: 479, 66, 517, 77 Page: Sequence: 21 Annotations: Annotation: Subtype: Link Rect: 203, 710, 241, 721 Annotation: Subtype: Link Rect: 59, 688, 96, 698 Annotation: Subtype: Link Rect: 296, 652, 333, 664 Annotation: Subtype: Link Rect: 391, 629, 428, 640 Checksum: b160f452 Type: CRC32 Checksum: 0d2396a7ac2aedbc564c8065a63b125d Type: MD5 Checksum: 8b710334624a9f8eb525d7717a41ac17807f5f24 Type: SHA-1