55780d024875589b33c4576147c7b8aa 275216.pdf 2662b96e4acfe5f6ba553bffc9d0e2b982729e64 275216.pdf 949acb1fb570a7de986a367babbb1d6a0ae1f0acc44d75a07af2b6b8deb3e43a 275216.pdf Title: Microsomal prostaglandin E synthase‐1 is involved in the metabolic and cardiovascular alterations associated with obesity Subject: British J Pharmacology 2022.179:2733-2753 Keywords: 10.1111/bph.15776 and adipose tissue alterations; inflammation; mPGES‐1; obesity; vascular function and remodelling Author: Robert Lukowski and Robert Feil Creator: Arbortext Advanced Print Publisher 9.1.520/W Unicode Producer: Acrobat Distiller 22.0 (Windows); modified using iText 4.2.0 by 1T3XT CreationDate: Tue Apr 19 04:51:28 2022 CEST ModDate: Mon Jul 3 12:16:08 2023 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 21 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 34824389 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID 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yes yes no 171 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-07-04 02:30:51 CEST RepresentationInformation: 275216.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-07-03 12:41:26 CEST Size: 34824389 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Microsomal prostaglandin E synthase-1 is involved in the metabolic and cardiovascular alterations associated with obesity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Children: Item: Title: 1 INTRODUCTION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: What is already known Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: What does this study add Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: What is the clinical significance Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: 2 METHODS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Children: Item: Title: 2.1 Human studies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: 2.2 Animal models Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: 2.3 Tissue preparation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: 2.4 Insulin and glucose tolerance tests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: 2.5 Measurement of lipid levels Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: 2.6 Histological studies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: 2.7 Immunohistochemistry studies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: 2.8 Vascular function Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: 2.9 Pressure myography Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: 2.10 Calculation of passive mechanical and structural parameters Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: 2.11 Organization of internal elastic lamina Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: 2.12 RT-PCR assay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: 2.13 Lipid peroxidation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: 2.14 PGE2 levels Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: 2.15 Western blot analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: 2.16 Data and statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: 2.17 Materials Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: 2.18 Nomenclature of targets and ligands Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: 3 RESULTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Children: Item: Title: 3.1 mPGES-1 deficiency protects against body weight gain and improves the adverse glycaemic and lipid profile induced by a HFD Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: 3.2 mPGES-1 deficiency protects against HFD-induced adiposity, fibrosis, and macrophage infiltration Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: 3.3 mPGES-1 deficiency protects against HFD-induced endothelial dysfunction and vascular insulin resistance Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: 3.4 mPGES-1 deficiency protects against HFD-induced vascular and PVAT inflammation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Item: Title: 3.5 mPGES-1 deficiency partially protects against HFD-induced structural and mechanical alterations Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3 Item: Title: 3.6 mPGES-1 deficiency partially protects against HFD-induced cardiac hypertrophy and fibrosis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca Item: Title: 3.7 mPGES-1 deficiency also protects against some of the metabolic and cardiovascular alterations associated with obesity ... Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4e718207 Item: Title: 3.8 mPGES-1 expression in human abdominal fat correlates with vascular remodelling, vascular stiffness, and SPB Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1d371b2d Item: Title: 3.9 mPGES-1 expression in PVAT of aortic abdominal aneurysm patients correlates with inflammation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@543c6f6d Item: Title: 4 DISCUSSION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13eb8acf Item: Title: ACKNOWLEDGEMENTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@51c8530f Item: Title: AUTHOR CONTRIBUTIONS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7403c468 Item: Title: CONFLICT OF INTEREST Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43738a82 Item: Title: DECLARATION OF TRANSPARENCY AND SCIENTIFIC RIGOUR Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@c81cdd1 Children: Item: Title: DATA AVAILABILITY STATEMENT Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1fc2b765 Item: Title: REFERENCES Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@75881071 Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 660 ImageHeight: 660 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 172 ImageHeight: 164 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 172 ImageHeight: 165 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 660 ImageHeight: 660 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png 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