19318ba7f83bd3c22a6cec6b6a53d283  275802.pdf
75c03135eed12fafe4ff537e343005caa7cb6bc2  275802.pdf
550a5e14a1422d28cbdef5b620ad3bbdfb094b688ad8c0363df8d393d4b8e697  275802.pdf

Title:          T1/T2-weighted ratio in multiple sclerosis: A longitudinal study with clinical associations
Subject:        NeuroImage: Clinical, 34 (2022) 102967. doi:10.1016/j.nicl.2022.102967
Keywords:       Clinically isolated syndrome,Magnetic resonance imaging,Multiple sclerosis,T1/T2-weighted ratio
Author:         Mateus Boaventura
Creator:        Elsevier
Producer:       Acrobat Distiller 8.1.0 (Windows)
CreationDate:   Mon Feb 21 05:52:24 2022 CET
ModDate:        Mon Feb 21 07:49:49 2022 CET
Tagged:         yes
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          8
Encrypted:      no
Page size:      595.276 x 793.701 pts
Page rot:       0
File size:      1724601 bytes
Optimized:      yes
PDF version:    1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
RBCTHC+TeX_CM_Maths_Symbols          Type 1C           Builtin          yes yes yes    661  0
WHYNIA+CharisSIL                     CID TrueType      Identity-H       yes yes yes    665  0
HPEMBY+Univers                       Type 1C           Builtin          yes yes yes    670  0
YRELHE+CharisSIL-Bold                CID TrueType      Identity-H       yes yes yes    674  0
NTMBZO+TeX_CM_Maths_Italic           Type 1C           Builtin          yes yes yes    679  0
OMVSZL+STIX-Italic                   Type 1C           Custom           yes yes yes    683  0
UJAWGR+STIX-Regular                  Type 1C           Custom           yes yes yes    688  0
OUTUKK+TeX_CM_Roman                  Type 1C           Builtin          yes yes yes    693  0
MMPRCX+CharisSIL-Italic              CID TrueType      Identity-H       yes yes yes    697  0
VXTVEZ+CharisSIL                     CID TrueType      Identity-H       yes yes yes    648  0
UQLNET+CharisSIL-Italic              CID TrueType      Identity-H       yes yes yes    274  0
GNZFDN+TeX_CM_Bold_Maths_Symbols     Type 1C           Builtin          yes yes yes     48  0
OEYKJL+TimesNewRomanPSMT             CID TrueType      Identity-H       yes yes yes    282  0
KWQHFG+CharisSIL-BoldItalic          CID TrueType      Identity-H       yes yes yes     67  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2023-06-28 02:28:16 CEST
 RepresentationInformation: 275802.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2023-06-23 12:01:15 CEST
  Size: 1724601
  Format: PDF
  Version: 1.7
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 's0115' cannot be found
   Offset: 1685648
  MIMEtype: application/pdf
  Profile: Linearized PDF, Tagged PDF
  PDFMetadata: 
   Objects: 759
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en
    Outlines: 
     Item: 
      Title: T1/T2-weighted ratio in multiple sclerosis: A longitudinal study with clinical associations
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee
      Children: 
       Item: 
        Title: 1 Introduction
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f
       Item: 
        Title: 2 Subjects/Materials and methods
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1
        Children: 
         Item: 
          Title: 2.1 Patients and clinical assessments
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d
         Item: 
          Title: 2.2 MRI acquisition
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89
         Item: 
          Title: 2.3 MRI qualitative analysis
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9
         Item: 
          Title: 2.4 Processing of the T1-w/T2-w ratio imaging data
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e
         Item: 
          Title: 2.5 Brain tissue segmentation and T1-w/T2-w for NAWM and NAGM
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b
       Item: 
        Title: 3 Generation of lesion masks and T1-w/T2-w for lesional tissue
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b
        Children: 
         Item: 
          Title: 3.1 Baseline, follow-up and evolved lesion masks
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31
         Item: 
          Title: 3.2 New lesions and pre-lesional tissue masks
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107
         Item: 
          Title: 3.3 T1-w/T2-w Ratio in lesion masks
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e
         Item: 
          Title: 3.4 Statistical analysis
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7
       Item: 
        Title: 4 Data availability
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e
       Item: 
        Title: 5 Results
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247
        Children: 
         Item: 
          Title: 5.1 Demographic, clinical and radiological characteristics
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9
         Item: 
          Title: 5.2 T1-w/T2-w In NAGM, NAWM and lesional tissue
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36
         Item: 
          Title: 5.3 T1-w/T2-w And clinical outcomes
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a
       Item: 
        Title: 6 Discussion
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30
       Item: 
        Title: Disclosures
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c
       Item: 
        Title: Funding
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88
        Children: 
         Item: 
          Title: CRediT authorship contribution statement
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6
       Item: 
        Title: Declaration of Competing Interest
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e
       Item: 
        Title: Acknowledgements
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20
       Item: 
        Title: Appendix A Supplementary data
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743
       Item: 
        Title: References
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858
   Info: 
    Title: T1/T2-weighted ratio in multiple sclerosis: A longitudinal study with clinical associations
    Author: Mateus Boaventura
    Subject: NeuroImage: Clinical, 34 (2022) 102967. doi:10.1016/j.nicl.2022.102967
    Keywords: Clinically isolated syndrome,Magnetic resonance imaging,Multiple sclerosis,T1/T2-weighted ratio
    Creator: Elsevier
    Producer: Acrobat Distiller 8.1.0 (Windows)
    CreationDate: Mon Feb 21 05:52:24 CET 2022
    ModDate: Mon Feb 21 07:49:49 CET 2022
   ID: 0x3e90f8aed6ac9a3cc9878c2023584e80, 0xbf88085bae496f5c811e6b991fef58cb
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 248
      ImageHeight: 271
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 236
      ImageHeight: 298
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type0: 
     Font: 
      BaseFont: YRELHE+CharisSIL-Bold
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: KWQHFG+CharisSIL-BoldItalic
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: WHYNIA+CharisSIL
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: MMPRCX+CharisSIL-Italic
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: OEYKJL+TimesNewRomanPSMT
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: UJAWGR+STIX-Regular
      FontSubset: true
      FirstChar: 1
      LastChar: 2
      FontDescriptor: 
       FontName: UJAWGR+STIX-Regular
       Flags: Nonsymbolic
       FontBBox: -970, -486, 2208, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GNZFDN+TeX_CM_Bold_Maths_Symbols
      FontSubset: true
      FirstChar: 1
      LastChar: 255
      FontDescriptor: 
       FontName: GNZFDN+TeX_CM_Bold_Maths_Symbols
       Flags: Symbolic, ForceBold
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
     Font: 
      BaseFont: OUTUKK+TeX_CM_Roman
      FontSubset: true
      FirstChar: 1
      LastChar: 128
      FontDescriptor: 
       FontName: OUTUKK+TeX_CM_Roman
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
     Font: 
      BaseFont: RBCTHC+TeX_CM_Maths_Symbols
      FontSubset: true
      FirstChar: 1
      LastChar: 138
      FontDescriptor: 
       FontName: RBCTHC+TeX_CM_Maths_Symbols
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
     Font: 
      BaseFont: NTMBZO+TeX_CM_Maths_Italic
      FontSubset: true
      FirstChar: 1
      LastChar: 127
      FontDescriptor: 
       FontName: NTMBZO+TeX_CM_Maths_Italic
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
     Font: 
      BaseFont: OMVSZL+STIX-Italic
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: OMVSZL+STIX-Italic
       Flags: Nonsymbolic, Italic
       FontBBox: -970, -305, 1429, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HPEMBY+Univers
      FontSubset: true
      FirstChar: 32
      LastChar: 251
      FontDescriptor: 
       FontName: HPEMBY+Univers
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: YRELHE+CharisSIL-Bold
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: YRELHE+CharisSIL-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -720, -533, 1759, 1320
       FontFile2: true
     Font: 
      BaseFont: KWQHFG+CharisSIL-BoldItalic
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: KWQHFG+CharisSIL-BoldItalic
       Flags: Nonsymbolic, Italic, ForceBold
       FontBBox: -741, -533, 1795, 1320
       FontFile2: true
     Font: 
      BaseFont: WHYNIA+CharisSIL
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: WHYNIA+CharisSIL
       Flags: Nonsymbolic
       FontBBox: -692, -533, 1623, 1319
       FontFile2: true
     Font: 
      BaseFont: MMPRCX+CharisSIL-Italic
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: MMPRCX+CharisSIL-Italic
       Flags: Nonsymbolic, Italic
       FontBBox: -716, -533, 1627, 1318
       FontFile2: true
     Font: 
      BaseFont: OEYKJL+TimesNewRomanPSMT
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: OEYKJL+TimesNewRomanPSMT
       Flags: Nonsymbolic
       FontBBox: -568, -307, 2000, 1007
       FontFile2: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="XMP Core 5.1.2">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>10.1016/j.nicl.2022.102967</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Elsevier Inc.</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">NeuroImage: Clinical, 34 (2022) 102967. doi:10.1016/j.nicl.2022.102967</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Clinically isolated syndrome</rdf:li>
               <rdf:li>Magnetic resonance imaging</rdf:li>
               <rdf:li>Multiple sclerosis</rdf:li>
               <rdf:li>T1/T2-weighted ratio</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">T1/T2-weighted ratio in multiple sclerosis: A longitudinal study with clinical associations</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Mateus Boaventura</rdf:li>
               <rdf:li>Jaume Sastre-Garriga</rdf:li>
               <rdf:li>Aran Garcia-Vidal</rdf:li>
               <rdf:li>Angela Vidal-Jordana</rdf:li>
               <rdf:li>Davide Quartana</rdf:li>
               <rdf:li>René Carvajal</rdf:li>
               <rdf:li>Cristina Auger</rdf:li>
               <rdf:li>Manel Alberich</rdf:li>
               <rdf:li>Mar Tintoré</rdf:li>
               <rdf:li>Àlex Rovira</rdf:li>
               <rdf:li>Xavier Montalban</rdf:li>
               <rdf:li>Deborah Pareto</rdf:li>
            </rdf:Seq>
         </dc:creator>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/">
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>NeuroImage: Clinical</prism:publicationName>
         <prism:copyright>© 2022 Published by Elsevier Inc.</prism:copyright>
         <prism:issn>2213-1582</prism:issn>
         <prism:volume>34</prism:volume>
         <prism:coverDisplayDate>21 February 2022</prism:coverDisplayDate>
         <prism:coverDate>2022-01-01</prism:coverDate>
         <prism:pageRange>102967</prism:pageRange>
         <prism:startingPage>102967</prism:startingPage>
         <prism:doi>10.1016/j.nicl.2022.102967</prism:doi>
         <prism:url>https://doi.org/10.1016/j.nicl.2022.102967</prism:url>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:ali="http://www.niso.org/schemas/ali/1.0/">
         <ali:license_ref>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <ali:uri>http://creativecommons.org/licenses/by-nc-nd/4.0/</ali:uri>
               </rdf:li>
            </rdf:Bag>
         </ali:license_ref>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:ElsevierWebPDFSpecifications>7.0</pdfx:ElsevierWebPDFSpecifications>
         <pdfx:doi>10.1016/j.nicl.2022.102967</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CreationDate--Text>21st February 2022</pdfx:CreationDate--Text>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmp="http://ns.adobe.com/xap/1.0/">
         <xmp:CreatorTool>Elsevier</xmp:CreatorTool>
         <xmp:ModifyDate>2022-02-21T06:49:49</xmp:ModifyDate>
         <xmp:CreateDate>2022-02-21T04:52:24</xmp:CreateDate>
         <xmp:MetadataDate>2022-02-21T06:49:49</xmp:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/">
         <xmpRights:Marked>True</xmpRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:CreationDate--Text>21st February 2022</pdf:CreationDate--Text>
         <pdf:Producer>Acrobat Distiller 8.1.0 (Windows)</pdf:Producer>
         <pdf:Keywords>Clinically isolated syndrome,Magnetic resonance imaging,Multiple sclerosis,T1/T2-weighted ratio</pdf:Keywords>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmpMM:DocumentID>uuid:1b499bed-4ce8-4c0c-b682-0d58baae1cbe</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:b6ed5266-03cb-4855-90c0-636283357f42</xmpMM:InstanceID>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 129, 571, 339, 582
       Flags: Print
       Destination: 642
      Annotation: 
       Subtype: Link
       Rect: 339, 571, 453, 582
       Flags: Print
       Destination: 642
      Annotation: 
       Subtype: Link
       Rect: 453, 571, 460, 582
       Flags: Print
       Destination: 642
      Annotation: 
       Subtype: Link
       Rect: 119, 558, 276, 569
       Flags: Print
       Destination: 642
      Annotation: 
       Subtype: Link
       Rect: 276, 558, 430, 569
       Flags: Print
       Destination: 642
      Annotation: 
       Subtype: Link
       Rect: 430, 558, 437, 569
       Flags: Print
       Destination: 642
      Annotation: 
       Subtype: Link
       Rect: 94, 545, 191, 556
       Flags: Print
       Destination: 642
      Annotation: 
       Subtype: Link
       Rect: 191, 545, 276, 556
       Flags: Print
       Destination: 642
      Annotation: 
       Subtype: Link
       Rect: 276, 550, 283, 561
       Flags: Print
       Destination: 642
      Annotation: 
       Subtype: Link
       Rect: 284, 553, 288, 558
       Flags: Print
       Destination: 642
      Annotation: 
       Subtype: Link
       Rect: 284, 545, 288, 556
       Flags: Print
       Destination: 642
      Annotation: 
       Subtype: Link
       Rect: 239, 174, 288, 182
       Flags: Print
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 37, 163, 55, 171
       Flags: Print
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 349, 247, 418, 255
       Flags: Print
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 445, 153, 519, 161
       Flags: Print
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 98, 104, 195, 111
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 321, 722, 369, 730
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 278, 667, 393, 675
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 37, 87, 178, 94
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 297, 749, 300, 757
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 233, 748, 361, 760
      Annotation: 
       Subtype: Link
       Rect: 386, 57, 552, 69
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 94, 720, 288, 728
       Flags: Print
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 37, 709, 78, 717
       Flags: Print
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 169, 699, 288, 707
       Flags: Print
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 37, 689, 197, 696
       Flags: Print
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 262, 678, 288, 686
       Flags: Print
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 37, 668, 159, 676
       Flags: Print
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 248, 636, 288, 644
       Flags: Print
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 37, 626, 130, 634
       Flags: Print
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 157, 416, 225, 424
       Flags: Print
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 265, 406, 288, 414
       Flags: Print
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 37, 396, 93, 403
       Flags: Print
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 40, 249, 121, 257
       Flags: Print
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 432, 615, 516, 623
       Flags: Print
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 309, 563, 379, 571
       Flags: Print
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 306, 542, 439, 550
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 502, 531, 557, 539
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 306, 521, 370, 529
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 455, 437, 475, 445
       Flags: Print
       Destination: 29
      Annotation: 
       Subtype: Link
       Rect: 499, 311, 557, 319
       Flags: Print
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 306, 301, 324, 309
       Flags: Print
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 380, 165, 400, 173
       Flags: Print
       Destination: 39
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 67, 264, 87, 272
       Flags: Print
       Destination: 39
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 37, 271, 64, 279
       Flags: Print
       Destination: 39
      Annotation: 
       Subtype: Link
       Rect: 214, 113, 234, 121
       Flags: Print
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 249, 92, 270, 100
       Flags: Print
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 81, 71, 101, 79
       Flags: Print
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 337, 81, 362, 89
       Flags: Print
       Destination: 57
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 74, 386, 101, 394
       Flags: Print
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 96, 229, 166, 237
       Flags: Print
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 536, 266, 557, 274
       Flags: Print
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 306, 256, 494, 264
       Flags: Print
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 471, 235, 557, 243
       Flags: Print
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 306, 224, 375, 232
       Flags: Print
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 400, 151, 494, 159
       Flags: Print
       Destination: 109
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 40, 730, 121, 738
       Flags: Print
       Destination: 206
      Annotation: 
       Subtype: Link
       Rect: 248, 730, 288, 738
       Flags: Print
       Destination: 206
      Annotation: 
       Subtype: Link
       Rect: 37, 720, 55, 728
       Flags: Print
       Destination: 206
      Annotation: 
       Subtype: Link
       Rect: 90, 689, 177, 696
       Flags: Print
       Destination: 206
      Annotation: 
       Subtype: Link
       Rect: 40, 584, 128, 592
       Flags: Print
       Destination: 206
      Annotation: 
       Subtype: Link
       Rect: 265, 584, 288, 592
       Flags: Print
       Destination: 206
      Annotation: 
       Subtype: Link
       Rect: 37, 573, 226, 581
       Flags: Print
       Destination: 206
      Annotation: 
       Subtype: Link
       Rect: 88, 563, 162, 571
       Flags: Print
       Destination: 206
      Annotation: 
       Subtype: Link
       Rect: 191, 511, 288, 519
       Flags: Print
       Destination: 206
      Annotation: 
       Subtype: Link
       Rect: 37, 500, 77, 508
       Flags: Print
       Destination: 206
      Annotation: 
       Subtype: Link
       Rect: 84, 479, 235, 487
       Flags: Print
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 40, 406, 107, 414
       Flags: Print
       Destination: 206
      Annotation: 
       Subtype: Link
       Rect: 217, 396, 288, 404
       Flags: Print
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 37, 385, 103, 393
       Flags: Print
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 247, 354, 288, 362
       Flags: Print
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 37, 343, 55, 351
       Flags: Print
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 40, 302, 106, 309
       Flags: Print
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 40, 239, 93, 247
       Flags: Print
       Destination: 206
      Annotation: 
       Subtype: Link
       Rect: 174, 239, 244, 247
       Flags: Print
       Destination: 206
      Annotation: 
       Subtype: Link
       Rect: 103, 228, 180, 236
       Flags: Print
       Destination: 206
      Annotation: 
       Subtype: Link
       Rect: 251, 113, 288, 121
       Flags: Print
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 37, 103, 55, 111
       Flags: Print
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 115, 82, 207, 90
       Flags: Print
       Destination: 109
      Annotation: 
       Subtype: Link
       Rect: 60, 71, 126, 79
       Flags: Print
       Destination: 206
      Annotation: 
       Subtype: Link
       Rect: 395, 709, 469, 717
       Flags: Print
       Destination: 206
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 247, 108, 288, 116
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 37, 97, 153, 105
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 37, 58, 286, 65
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 50, 286, 57
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 732, 543, 738
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 724, 408, 730
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 306, 716, 555, 722
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 708, 548, 714
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 700, 507, 706
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 306, 692, 555, 698
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 684, 538, 690
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 676, 552, 682
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 668, 505, 674
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 306, 660, 550, 666
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 652, 542, 658
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 644, 357, 651
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 306, 636, 555, 643
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 628, 544, 635
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 620, 390, 627
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 363, 596, 497, 603
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 306, 588, 555, 595
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 580, 553, 587
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 572, 553, 579
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 565, 488, 571
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 306, 557, 555, 563
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 549, 552, 555
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 541, 463, 547
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 533, 517, 555, 523
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 509, 426, 515
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 306, 501, 555, 507
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 493, 555, 499
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 485, 540, 491
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 477, 515, 483
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 306, 469, 554, 475
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 461, 540, 467
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 453, 343, 459
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 306, 445, 548, 451
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 437, 555, 443
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 429, 544, 435
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 421, 493, 427
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 306, 389, 555, 396
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 381, 535, 388
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 373, 555, 380
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 365, 552, 372
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 357, 420, 364
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 306, 349, 543, 356
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 341, 555, 348
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 333, 548, 340
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 325, 553, 332
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 317, 542, 324
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 309, 343, 316
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 306, 301, 535, 308
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 294, 545, 300
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 286, 542, 292
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 278, 530, 284
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 270, 538, 276
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 262, 555, 268
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 254, 474, 260
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 306, 206, 551, 212
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 198, 541, 204
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 190, 343, 196
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 306, 182, 555, 188
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 174, 539, 180
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 166, 452, 172
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 349, 142, 476, 148
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 306, 134, 555, 140
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 126, 546, 133
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 118, 452, 125
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 306, 94, 546, 101
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 86, 555, 93
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 78, 512, 85
       Flags: Print
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 81, 692, 216, 698
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 37, 684, 283, 690
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 676, 274, 682
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 668, 81, 674
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 37, 660, 269, 666
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 652, 281, 658
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 644, 273, 651
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 37, 636, 280, 643
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 628, 279, 635
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 620, 284, 627
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 37, 612, 260, 619
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 604, 282, 611
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 596, 286, 603
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 588, 93, 595
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 37, 580, 274, 587
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 572, 268, 579
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 565, 286, 571
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 557, 99, 563
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 37, 549, 286, 555
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 541, 281, 547
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 533, 258, 539
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 49, 525, 81, 531
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 306, 732, 555, 738
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 724, 555, 730
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 716, 516, 722
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 306, 708, 552, 714
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 700, 555, 706
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 692, 555, 698
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 684, 409, 690
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 306, 676, 555, 682
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 668, 555, 674
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 660, 555, 666
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 652, 422, 658
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 306, 644, 555, 651
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 636, 549, 643
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 306, 604, 555, 611
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 596, 555, 603
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 588, 395, 595
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 306, 580, 555, 587
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 572, 555, 579
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 565, 555, 571
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 557, 417, 563
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 306, 549, 549, 555
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 541, 555, 547
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 318, 533, 336, 539
       Flags: Print
  Checksum: 877cd55e
   Type: CRC32
  Checksum: 19318ba7f83bd3c22a6cec6b6a53d283
   Type: MD5
  Checksum: 75c03135eed12fafe4ff537e343005caa7cb6bc2
   Type: SHA-1