af956a43ef17fde521c5370ced23d02f  277657.pdf
23ea7beda57d656736e3f2201a346b913d09760f  277657.pdf
c4c26a6ae7e47c14eb2d10e53665eae3848c83ef98801245b7efce8408506990  277657.pdf

Title:          Systematic Collaborative Reanalysis of Genomic Data Improves Diagnostic Yield in Neurologic Rare Diseases
Subject:        The Journal of Molecular Diagnostics, 24 (2022) 529-542. doi:10.1016/j.jmoldx.2022.02.003
Author:         Gemma Bullich
Creator:        Elsevier
Producer:       Acrobat Distiller 8.0.0 (Windows)
CreationDate:   Fri Dec 31 23:45:16 4 LMT
ModDate:        Wed May  4 23:38:08 2022 CEST
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          14
Encrypted:      no
Page size:      584.957 x 782.986 pts
Page rot:       0
File size:      1121632 bytes
Optimized:      yes
PDF version:    1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
GGFHKB+AdvOT24cc410c.B               Type 1C           WinAnsi          yes yes no    1478  0
GGFHKC+AdvOT4a6296b1                 Type 1C           WinAnsi          yes yes no    1481  0
GGFHKD+AdvP4C4E74                    Type 1C           Custom           yes yes yes   1486  0
GGFHLE+AdvOT21bf1298.I               Type 1C           WinAnsi          yes yes no    1489  0
GGFHLF+AdvPS44A44B                   Type 1C           WinAnsi          yes yes no    1492  0
GGFHLG+AdvOT21bf1298.I+20            Type 1C           WinAnsi          yes yes no    1495  0
GGFHLH+AdvP4C4E59                    Type 1C           Custom           yes yes no    1499  0
GGFHLI+AdvOT3c2d9f11                 Type 1C           WinAnsi          yes yes no    1479  0
GGFHLJ+AdvOT3c2d9f11+20              Type 1C           WinAnsi          yes yes no    1493  0
GGFHNJ+AdvPSSym                      Type 1C           WinAnsi          yes yes no    1500  0
GGFIFI+AdvOT4a6296b1+fb              Type 1C           Custom           yes yes yes   1201  0
GGFIFJ+AdvOT47e7c4c9.I               Type 1C           WinAnsi          yes yes no    1202  0
GGFIFK+AdvP4C4E51                    Type 1C           WinAnsi          yes yes no    1207  0
GGFIGL+AdvPS480274                   Type 1C           WinAnsi          yes yes no    1210  0
GGFIFH+AdvOT3c2d9f11+fb              Type 1C           Custom           yes yes yes   1199  0
GGFIHL+AdvPS3FDD77                   Type 1C           WinAnsi          yes yes no    1219  0
GGFIHM+AdvPSA066                     Type 1C           WinAnsi          yes yes no    1224  0
GGFLDN+AdvOT3c2d9f11+01              Type 1C           MacRoman         yes yes no    1234  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2023-07-14 02:38:41 CEST
 RepresentationInformation: 277657.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2023-07-13 10:14:00 CEST
  Size: 1121632
  Format: PDF
  Version: 1.7
  Status: Well-Formed, but not valid
  SignatureMatches:
   PDF-hul
  ErrorMessage: Improperly formed date
   Offset: 1093157
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib10' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib11' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib12' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib13' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib14' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib12' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib15' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib16' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib17' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib18' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib19' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib20' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib21' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib22' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib17' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib23' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib24' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib25' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib21' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib26' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib26' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib26' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib26' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib26' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib26' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib70' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib71' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib72' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib71' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib73' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib74' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib75' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib76' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib71' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib76' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib24' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib77' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib78' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib71' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib77' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib79' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib72' cannot be found
   Offset: 1071536
  ID: PDF-HUL-122
  ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib77' cannot be found
   Offset: 1071536
  MIMEtype: application/pdf
  Profile: Linearized PDF
  PDFMetadata: 
   Objects: 1560
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en
    Outlines: 
     Item: 
      Title: Systematic Collaborative Reanalysis of Genomic Data Improves Diagnostic Yield in Neurologic Rare Diseases
      Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f
      Children: 
       Item: 
        Title: Materials and Methods
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003
        Children: 
         Item: 
          Title: The URD-Cat Reanalysis Cohort
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191
         Item: 
          Title: Data Processing and Variant Detection
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb
         Item: 
          Title: Additional Sequencing
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431
         Item: 
          Title: Relatedness and Consanguinity Analysis
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6
         Item: 
          Title: Variant Filtering and Interpretation with the URD-Cat GPAP
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a
         Item: 
          Title: Statistical Analysis
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71
       Item: 
        Title: Results
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2
        Children: 
         Item: 
          Title: Systematic Evaluation of the Reanalysis Cohort
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9
         Item: 
          Title: Molecular Diagnosis
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f
         Item: 
          Title: Effect of the Sequencing Strategy on the Diagnostic Rate
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78
         Item: 
          Title: Quality of Standardized Phenotyping
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee
         Item: 
          Title: Reasons for Increasing the Diagnostic Rate with Data Reanalysis
          Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f
       Item: 
        Title: Discussion
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1
       Item: 
        Title: Acknowledgments
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d
       Item: 
        Title: Author Contributions
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89
       Item: 
        Title: Supplemental Data
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9
       Item: 
        Title: References
        Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e
   Info: 
    Title: Systematic Collaborative Reanalysis of Genomic Data Improves Diagnostic Yield in Neurologic Rare Diseases
    Author: Gemma Bullich
    Subject: The Journal of Molecular Diagnostics, 24 (2022) 529-542. doi:10.1016/j.jmoldx.2022.02.003
    Creator: Elsevier
    Producer: Acrobat Distiller 8.0.0 (Windows)
   ID: 0xf05b631ca0daadc5cf04ffcf765ceb44, 0x70c10f2587ef54428dc65751d61b8d28
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1494
      ImageHeight: 1458
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1494
      ImageHeight: 932
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1494
      ImageHeight: 1334
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1494
      ImageHeight: 853
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: GGFIHL+AdvPS3FDD77
      FontSubset: true
      FirstChar: 90
      LastChar: 90
      FontDescriptor: 
       FontName: GGFIHL+AdvPS3FDD77
       Flags: Nonsymbolic
       FontBBox: 0, -208, 1145, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GGFHKB+AdvOT24cc410c.B
      FontSubset: true
      FirstChar: 49
      LastChar: 121
      FontDescriptor: 
       FontName: GGFHKB+AdvOT24cc410c.B
       Flags: Nonsymbolic
       FontBBox: -31, -260, 906, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GGFHLI+AdvOT3c2d9f11
      FontSubset: true
      FirstChar: 37
      LastChar: 252
      FontDescriptor: 
       FontName: GGFHLI+AdvOT3c2d9f11
       Flags: Serif, Nonsymbolic
       FontBBox: -62, -208, 927, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GGFIHM+AdvPSA066
      FontSubset: true
      FirstChar: 40
      LastChar: 57
      FontDescriptor: 
       FontName: GGFIHM+AdvPSA066
       Flags: Nonsymbolic
       FontBBox: -72, -239, 1052, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GGFHKC+AdvOT4a6296b1
      FontSubset: true
      FirstChar: 37
      LastChar: 250
      FontDescriptor: 
       FontName: GGFHKC+AdvOT4a6296b1
       Flags: Nonsymbolic
       FontBBox: -72, -250, 875, 916
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GGFHKD+AdvP4C4E74
      FontSubset: true
      FirstChar: 2
      LastChar: 123
      FontDescriptor: 
       FontName: GGFHKD+AdvP4C4E74
       Flags: Symbolic
       FontBBox: -20, -958, 1114, 770
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GGFIFH+AdvOT3c2d9f11+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: GGFIFH+AdvOT3c2d9f11+fb
       Flags: Symbolic
       FontBBox: 19, 0, 520, 677
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GGFHLE+AdvOT21bf1298.I
      FontSubset: true
      FirstChar: 39
      LastChar: 250
      FontDescriptor: 
       FontName: GGFHLE+AdvOT21bf1298.I
       Flags: Serif, Nonsymbolic
       FontBBox: -166, -208, 906, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GGFIFI+AdvOT4a6296b1+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: GGFIFI+AdvOT4a6296b1+fb
       Flags: Symbolic
       FontBBox: 19, -10, 562, 718
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: GGFIFJ+AdvOT47e7c4c9.I
      FontSubset: true
      FirstChar: 40
      LastChar: 120
      FontDescriptor: 
       FontName: GGFIFJ+AdvOT47e7c4c9.I
       Flags: Nonsymbolic
       FontBBox: -156, -250, 875, 916
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GGFLDN+AdvOT3c2d9f11+01
      FontSubset: true
      FirstChar: 245
      LastChar: 245
      FontDescriptor: 
       FontName: GGFLDN+AdvOT3c2d9f11+01
       Flags: Serif, Nonsymbolic
       FontBBox: 0, -187, 875, 885
       FontFile3: true
      Encoding: MacRomanEncoding
     Font: 
      BaseFont: GGFHLF+AdvPS44A44B
      FontSubset: true
      FirstChar: 100
      LastChar: 101
      FontDescriptor: 
       FontName: GGFHLF+AdvPS44A44B
       Flags: Nonsymbolic
       FontBBox: 0, -197, 1000, 802
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GGFHLJ+AdvOT3c2d9f11+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: GGFHLJ+AdvOT3c2d9f11+20
       Flags: Nonsymbolic
       FontBBox: -166, -145, 1000, 697
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GGFHLG+AdvOT21bf1298.I+20
      FontSubset: true
      FirstChar: 146
      LastChar: 146
      FontDescriptor: 
       FontName: GGFHLG+AdvOT21bf1298.I+20
       Flags: Nonsymbolic
       FontBBox: -166, -156, 1000, 697
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GGFIFK+AdvP4C4E51
      FontSubset: true
      FirstChar: 60
      LastChar: 62
      FontDescriptor: 
       FontName: GGFIFK+AdvP4C4E51
       Flags: Nonsymbolic
       FontBBox: -31, -239, 1041, 750
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GGFIGL+AdvPS480274
      FontSubset: true
      FirstChar: 45
      LastChar: 45
      FontDescriptor: 
       FontName: GGFIGL+AdvPS480274
       Flags: Nonsymbolic
       FontBBox: 0, -208, 1354, 791
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: GGFHLH+AdvP4C4E59
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: GGFHLH+AdvP4C4E59
       Flags: Symbolic
       FontBBox: -31, -250, 1000, 750
       FontFile3: true
      EncodingDictionary: 
       Differences: true
     Font: 
      BaseFont: GGFHNJ+AdvPSSym
      FontSubset: true
      FirstChar: 170
      LastChar: 170
      FontDescriptor: 
       FontName: GGFHNJ+AdvPSSym
       Flags: Nonsymbolic
       FontBBox: -177, -291, 1083, 1010
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 4.0-c316 44.253921, Sun Oct 01 2006 17:14:39">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1016/j.jmoldx.2022.02.003</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Systematic Collaborative Reanalysis of Genomic Data Improves Diagnostic Yield in Neurologic Rare Diseases</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Gemma Bullich</rdf:li>
               <rdf:li>Leslie Matalonga</rdf:li>
               <rdf:li>Montserrat Pujadas</rdf:li>
               <rdf:li>Anastasios Papakonstantinou</rdf:li>
               <rdf:li>Davide Piscia</rdf:li>
               <rdf:li>Raúl Tonda</rdf:li>
               <rdf:li>Rafael Artuch</rdf:li>
               <rdf:li>Pia Gallano</rdf:li>
               <rdf:li>Glòria Garrabou</rdf:li>
               <rdf:li>Juan R. González</rdf:li>
               <rdf:li>Daniel Grinberg</rdf:li>
               <rdf:li>Míriam Guitart</rdf:li>
               <rdf:li>Steven Laurie</rdf:li>
               <rdf:li>Conxi Lázaro</rdf:li>
               <rdf:li>Cristina Luengo</rdf:li>
               <rdf:li>Ramon Martí</rdf:li>
               <rdf:li>Montserrat Milà</rdf:li>
               <rdf:li>David Ovelleiro</rdf:li>
               <rdf:li>Genís Parra</rdf:li>
               <rdf:li>Aurora Pujol</rdf:li>
               <rdf:li>Eduardo Tizzano</rdf:li>
               <rdf:li>Alfons Macaya</rdf:li>
               <rdf:li>Francesc Palau</rdf:li>
               <rdf:li>Antònia Ribes</rdf:li>
               <rdf:li>Luis A. Pérez-Jurado</rdf:li>
               <rdf:li>Sergi Beltran</rdf:li>
               <rdf:li>Undiagnosed Rare Disease Program of Catalonia (URD-Cat) Consortium</rdf:li>
               <rdf:li>Agatha Schlüter</rdf:li>
               <rdf:li>Agustí Rodriguez-Palmero</rdf:li>
               <rdf:li>Alejandro Cáceres</rdf:li>
               <rdf:li>Andrés Nascimento</rdf:li>
               <rdf:li>Àngels García-Cazorla</rdf:li>
               <rdf:li>Anna Cueto-González</rdf:li>
               <rdf:li>Anna Marcé-Grau</rdf:li>
               <rdf:li>Anna Ruiz Nel.lo</rdf:li>
               <rdf:li>Antonio Martínez-Monseny</rdf:li>
               <rdf:li>Aurora Sànchez</rdf:li>
               <rdf:li>Belén García</rdf:li>
               <rdf:li>Belén Pérez-Dueñas</rdf:li>
               <rdf:li>Bernat Gel</rdf:li>
               <rdf:li>Berta Fusté</rdf:li>
               <rdf:li>Carles Hernández-Ferrer</rdf:li>
               <rdf:li>Carlos Casasnovas</rdf:li>
               <rdf:li>Carlos Ortez</rdf:li>
               <rdf:li>César Arjona</rdf:li>
               <rdf:li>Cristina Hernando-Davalillo</rdf:li>
               <rdf:li>Daniel Natera de Benito</rdf:li>
               <rdf:li>Daniel Picó Amador</rdf:li>
               <rdf:li>David Gómez-Andrés</rdf:li>
               <rdf:li>Dèlia Yubero</rdf:li>
               <rdf:li>Dolors Pelegrí-Sisó</rdf:li>
               <rdf:li>Edgard Verdura</rdf:li>
               <rdf:li>Elena García-Arumí</rdf:li>
               <rdf:li>Elisabeth Castellanos</rdf:li>
               <rdf:li>Elisabeth Gabau</rdf:li>
               <rdf:li>Ester Tobías</rdf:li>
               <rdf:li>Fermina López-Grondona</rdf:li>
               <rdf:li>Francesc Cardellach</rdf:li>
               <rdf:li>Francesc Josep Garcia-Garcia</rdf:li>
               <rdf:li>Francina Munell</rdf:li>
               <rdf:li>Frederic Tort</rdf:li>
               <rdf:li>Gemma Aznar</rdf:li>
               <rdf:li>Gemma Olivé-Cirera</rdf:li>
               <rdf:li>Gemma Tell</rdf:li>
               <rdf:li>Gerard Muñoz-Pujol</rdf:li>
               <rdf:li>Ida Paramonov</rdf:li>
               <rdf:li>Ignacio Blanco</rdf:li>
               <rdf:li>Irene Madrigal</rdf:li>
               <rdf:li>Irene Valenzuela</rdf:li>
               <rdf:li>Ivo Gut</rdf:li>
               <rdf:li>Ivon Cusco</rdf:li>
               <rdf:li>Jean-Rémi Trotta</rdf:li>
               <rdf:li>Jordi Cruz</rdf:li>
               <rdf:li>Jordi Díaz-Manera</rdf:li>
               <rdf:li>José César Milisenda</rdf:li>
               <rdf:li>Josep Ma Grau</rdf:li>
               <rdf:li>Judit Garcia-Villoria</rdf:li>
               <rdf:li>Judith Armstrong</rdf:li>
               <rdf:li>Judith Cantó</rdf:li>
               <rdf:li>Júlia Sala-Coromina</rdf:li>
               <rdf:li>Laia Rodríguez-Revenga</rdf:li>
               <rdf:li>Laura Alias</rdf:li>
               <rdf:li>Laura Gort</rdf:li>
               <rdf:li>Lídia González-Quereda</rdf:li>
               <rdf:li>Mar Costa</rdf:li>
               <rdf:li>Marcos Fernández-Callejo</rdf:li>
               <rdf:li>Marcos López-Sánchez</rdf:li>
               <rdf:li>Maria Isabel Álvarez-Mora</rdf:li>
               <rdf:li>Marta Gut</rdf:li>
               <rdf:li>Mercedes Serrano</rdf:li>
               <rdf:li>Miquel Raspall-Chaure</rdf:li>
               <rdf:li>Mireia del Toro</rdf:li>
               <rdf:li>Mònica Bayés</rdf:li>
               <rdf:li>Neus Baena Díez</rdf:li>
               <rdf:li>Nino Spataro</rdf:li>
               <rdf:li>Núria Capdevila</rdf:li>
               <rdf:li>Olatz Ugarteburu</rdf:li>
               <rdf:li>Patricia Muñoz-Cabello</rdf:li>
               <rdf:li>Penélope Romero Duque</rdf:li>
               <rdf:li>Raquel Rabionet</rdf:li>
               <rdf:li>Ricard Rojas-García</rdf:li>
               <rdf:li>Rosa Calvo</rdf:li>
               <rdf:li>Roser Urreizti</rdf:li>
               <rdf:li>Sara Bernal</rdf:li>
               <rdf:li>Susana Boronat</rdf:li>
               <rdf:li>Susanna Balcells</rdf:li>
               <rdf:li>Teresa Vendrell</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">The Journal of Molecular Diagnostics, 24 (2022) 529-542. doi:10.1016/j.jmoldx.2022.02.003</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Association for Molecular Pathology and American Society for Investigative Pathology</rdf:li>
            </rdf:Bag>
         </dc:publisher>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/">
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>The Journal of Molecular Diagnostics</prism:publicationName>
         <prism:copyright>© 2022 Association for Molecular Pathology and American Society for Investigative Pathology. Published by Elsevier Inc.</prism:copyright>
         <prism:issn>1525-1578</prism:issn>
         <prism:volume>24</prism:volume>
         <prism:number>5</prism:number>
         <prism:coverDisplayDate>May 2022</prism:coverDisplayDate>
         <prism:pageRange>529-542</prism:pageRange>
         <prism:startingPage>529</prism:startingPage>
         <prism:endingPage>542</prism:endingPage>
         <prism:doi>10.1016/j.jmoldx.2022.02.003</prism:doi>
         <prism:url>https://doi.org/10.1016/j.jmoldx.2022.02.003</prism:url>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:crossmark="http://crossref.org/crossmark/1.0/">
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:DOI>10.1016/j.jmoldx.2022.02.003</crossmark:DOI>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>elsevier.com</rdf:li>
               <rdf:li>sciencedirect.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:ElsevierWebPDFSpecifications>7.0</pdfx:ElsevierWebPDFSpecifications>
         <pdfx:doi>10.1016/j.jmoldx.2022.02.003</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:CreationDate--Text>5th May 2022</pdfx:CreationDate--Text>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>sciencedirect.com</rdf:li>
               <rdf:li>elsevier.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xap="http://ns.adobe.com/xap/1.0/">
         <xap:CreatorTool>Elsevier</xap:CreatorTool>
         <xap:ModifyDate>2022-05-05T03:08:08+05:30</xap:ModifyDate>
         <xap:MetadataDate>2022-05-05T03:08:08+05:30</xap:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapRights="http://ns.adobe.com/xap/1.0/rights/">
         <xapRights:Marked>True</xapRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:CreationDate--Text>5th May 2022</pdf:CreationDate--Text>
         <pdf:Producer>Acrobat Distiller 8.0.0 (Windows)</pdf:Producer>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapMM="http://ns.adobe.com/xap/1.0/mm/">
         <xapMM:DocumentID>uuid:8c7177e2-00f1-4040-910b-3070580bdde7</xapMM:DocumentID>
         <xapMM:InstanceID>uuid:f8b8395f-45eb-4649-887e-96a1a1024f48</xapMM:InstanceID>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:ali="http://www.niso.org/schemas/ali/1.0/">
         <ali:license_ref>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <ali:uri>http://creativecommons.org/licenses/by-nc-nd/4.0/</ali:uri>
               </rdf:li>
            </rdf:Bag>
         </ali:license_ref>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 529
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 468, 596, 546, 611
      Annotation: 
       Subtype: Link
       Rect: 230, 29, 368, 36
      Annotation: 
       Subtype: Link
       Rect: 44, 19, 170, 26
      Annotation: 
       Subtype: Link
       Rect: 481, 665, 528, 673
      Annotation: 
       Subtype: Link
       Rect: 44, 741, 249, 749
    Page: 
     Label: 530
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 59, 662, 134, 670
      Annotation: 
       Subtype: Link
       Rect: 40, 652, 48, 660
      Annotation: 
       Subtype: Link
       Rect: 248, 579, 418, 588
      Annotation: 
       Subtype: Link
       Rect: 96, 515, 100, 525
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 164, 455, 167, 465
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 169, 455, 173, 465
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 123, 395, 127, 405
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 185, 311, 188, 321
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 273, 264, 276, 274
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 127, 235, 249, 245
      Annotation: 
       Subtype: Link
       Rect: 146, 132, 150, 142
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 152, 132, 156, 142
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 316, 18, 375, 28
    Page: 
     Label: 531
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 140, 504, 143, 513
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 239, 432, 243, 442
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 147, 415, 283, 425
      Annotation: 
       Subtype: Link
       Rect: 44, 403, 99, 413
      Annotation: 
       Subtype: Link
       Rect: 209, 392, 283, 401
      Annotation: 
       Subtype: Link
       Rect: 44, 380, 58, 389
      Annotation: 
       Subtype: Link
       Rect: 280, 372, 283, 382
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 276, 264, 283, 274
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 498, 563, 505, 573
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 434, 551, 441, 561
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 419, 528, 426, 538
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 377, 499, 523, 509
      Annotation: 
       Subtype: Link
       Rect: 455, 468, 462, 478
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 386, 432, 394, 442
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 539, 384, 546, 394
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 311, 308, 407, 318
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 519, 300, 526, 310
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 311, 272, 380, 282
      Annotation: 
       Subtype: Link
       Rect: 499, 277, 507, 286
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 352, 73, 359, 83
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 209, 18, 268, 28
    Page: 
     Label: 532
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 227, 495, 234, 505
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 172, 483, 179, 493
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 154, 447, 162, 457
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 176, 128, 276, 138
      Annotation: 
       Subtype: Link
       Rect: 37, 117, 84, 126
      Annotation: 
       Subtype: Link
       Rect: 339, 507, 347, 517
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 490, 490, 539, 500
      Annotation: 
       Subtype: Link
       Rect: 300, 478, 338, 488
      Annotation: 
       Subtype: Link
       Rect: 392, 466, 460, 476
      Annotation: 
       Subtype: Link
       Rect: 341, 459, 349, 469
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 497, 399, 504, 409
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 342, 291, 350, 301
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 352, 291, 359, 301
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 316, 18, 375, 28
    Page: 
     Label: 533
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 139, 376, 236, 386
       Destination: 23
      Annotation: 
       Subtype: Link
       Rect: 199, 352, 283, 362
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 44, 340, 55, 350
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 311, 269, 341, 279
       Destination: 55
      Annotation: 
       Subtype: Link
       Rect: 538, 94, 544, 102
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 209, 18, 268, 28
    Page: 
     Label: 534
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 41, 248, 71, 258
       Destination: 55
      Annotation: 
       Subtype: Link
       Rect: 81, 212, 114, 222
       Destination: 79
      Annotation: 
       Subtype: Link
       Rect: 41, 57, 74, 67
       Destination: 55
      Annotation: 
       Subtype: Link
       Rect: 304, 308, 398, 318
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 519, 205, 526, 215
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 532, 205, 539, 215
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 429, 105, 463, 115
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 397, 81, 432, 91
       Destination: 90
      Annotation: 
       Subtype: Link
       Rect: 316, 18, 375, 28
    Page: 
     Label: 535
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 54, 284, 149, 294
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 149, 289, 157, 299
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 162, 289, 170, 299
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 463, 57, 497, 67
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 209, 18, 268, 28
    Page: 
     Label: 536
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 41, 189, 76, 199
       Destination: 118
      Annotation: 
       Subtype: Link
       Rect: 304, 307, 340, 317
       Destination: 118
      Annotation: 
       Subtype: Link
       Rect: 485, 212, 539, 222
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 300, 200, 341, 210
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 316, 18, 375, 28
    Page: 
     Label: 537
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 142, 427, 176, 437
       Destination: 130
      Annotation: 
       Subtype: Link
       Rect: 192, 241, 199, 250
       Destination: 715
      Annotation: 
       Subtype: Link
       Rect: 84, 205, 91, 215
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 97, 205, 104, 215
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 109, 169, 116, 179
       Destination: 715
      Annotation: 
       Subtype: Link
       Rect: 460, 420, 468, 430
       Destination: 715
      Annotation: 
       Subtype: Link
       Rect: 473, 420, 481, 430
       Destination: 715
      Annotation: 
       Subtype: Link
       Rect: 342, 276, 349, 286
       Destination: 1041
      Annotation: 
       Subtype: Link
       Rect: 351, 276, 358, 286
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 504, 252, 511, 262
       Destination: 715
      Annotation: 
       Subtype: Link
       Rect: 513, 252, 520, 262
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 340, 217, 347, 227
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 337, 193, 345, 203
       Destination: 715
      Annotation: 
       Subtype: Link
       Rect: 347, 193, 354, 203
       Destination: 715
      Annotation: 
       Subtype: Link
       Rect: 356, 193, 363, 203
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 365, 193, 373, 203
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 375, 193, 382, 203
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 354, 133, 362, 143
       Destination: 715
      Annotation: 
       Subtype: Link
       Rect: 364, 133, 371, 143
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 373, 133, 381, 143
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 209, 18, 268, 28
    Page: 
     Label: 538
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 245, 372, 248, 382
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 250, 372, 258, 382
       Destination: 715
      Annotation: 
       Subtype: Link
       Rect: 260, 372, 267, 382
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 269, 372, 276, 382
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 87, 241, 91, 251
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 134, 109, 138, 119
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 140, 109, 147, 119
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 149, 109, 156, 119
       Destination: 715
      Annotation: 
       Subtype: Link
       Rect: 158, 109, 166, 119
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 168, 109, 175, 119
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 68, 73, 71, 83
       Destination: 181
      Annotation: 
       Subtype: Link
       Rect: 73, 73, 81, 83
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 83, 73, 90, 83
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 449, 623, 457, 633
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 450, 599, 457, 609
       Destination: 715
      Annotation: 
       Subtype: Link
       Rect: 459, 599, 466, 609
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 515, 468, 523, 478
       Destination: null
      Annotation: 
       Subtype: Link
       Rect: 316, 18, 375, 28
    Page: 
     Label: 539
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 44, 379, 220, 389
      Annotation: 
       Subtype: Link
       Rect: 63, 326, 283, 334
      Annotation: 
       Subtype: Link
       Rect: 63, 316, 283, 324
      Annotation: 
       Subtype: Link
       Rect: 63, 306, 283, 314
      Annotation: 
       Subtype: Link
       Rect: 63, 296, 165, 304
      Annotation: 
       Subtype: Link
       Rect: 171, 296, 183, 304
      Annotation: 
       Subtype: Link
       Rect: 63, 286, 283, 294
      Annotation: 
       Subtype: Link
       Rect: 63, 276, 283, 284
      Annotation: 
       Subtype: Link
       Rect: 63, 266, 283, 274
      Annotation: 
       Subtype: Link
       Rect: 63, 257, 283, 264
      Annotation: 
       Subtype: Link
       Rect: 63, 247, 169, 255
      Annotation: 
       Subtype: Link
       Rect: 175, 247, 187, 255
      Annotation: 
       Subtype: Link
       Rect: 63, 237, 283, 245
      Annotation: 
       Subtype: Link
       Rect: 63, 227, 206, 235
      Annotation: 
       Subtype: Link
       Rect: 212, 227, 224, 235
      Annotation: 
       Subtype: Link
       Rect: 63, 217, 283, 225
      Annotation: 
       Subtype: Link
       Rect: 63, 207, 283, 215
      Annotation: 
       Subtype: Link
       Rect: 63, 197, 283, 205
      Annotation: 
       Subtype: Link
       Rect: 63, 187, 283, 195
      Annotation: 
       Subtype: Link
       Rect: 63, 177, 283, 185
      Annotation: 
       Subtype: Link
       Rect: 63, 167, 227, 175
      Annotation: 
       Subtype: Link
       Rect: 233, 167, 248, 175
      Annotation: 
       Subtype: Link
       Rect: 63, 157, 283, 165
      Annotation: 
       Subtype: Link
       Rect: 63, 147, 283, 155
      Annotation: 
       Subtype: Link
       Rect: 63, 137, 283, 145
      Annotation: 
       Subtype: Link
       Rect: 63, 127, 283, 135
      Annotation: 
       Subtype: Link
       Rect: 63, 117, 283, 125
      Annotation: 
       Subtype: Link
       Rect: 63, 107, 283, 115
      Annotation: 
       Subtype: Link
       Rect: 63, 97, 120, 105
      Annotation: 
       Subtype: Link
       Rect: 126, 97, 142, 105
      Annotation: 
       Subtype: Link
       Rect: 63, 87, 283, 95
      Annotation: 
       Subtype: Link
       Rect: 63, 77, 283, 85
      Annotation: 
       Subtype: Link
       Rect: 63, 67, 283, 75
      Annotation: 
       Subtype: Link
       Rect: 63, 57, 283, 65
      Annotation: 
       Subtype: Link
       Rect: 326, 716, 546, 724
      Annotation: 
       Subtype: Link
       Rect: 326, 706, 414, 714
      Annotation: 
       Subtype: Link
       Rect: 420, 706, 432, 714
      Annotation: 
       Subtype: Link
       Rect: 326, 696, 546, 704
      Annotation: 
       Subtype: Link
       Rect: 326, 686, 546, 694
      Annotation: 
       Subtype: Link
       Rect: 326, 676, 546, 684
      Annotation: 
       Subtype: Link
       Rect: 326, 666, 456, 674
      Annotation: 
       Subtype: Link
       Rect: 462, 666, 478, 674
      Annotation: 
       Subtype: Link
       Rect: 326, 657, 546, 665
      Annotation: 
       Subtype: Link
       Rect: 326, 647, 546, 655
      Annotation: 
       Subtype: Link
       Rect: 326, 637, 515, 645
      Annotation: 
       Subtype: Link
       Rect: 521, 637, 533, 645
      Annotation: 
       Subtype: Link
       Rect: 326, 627, 546, 635
      Annotation: 
       Subtype: Link
       Rect: 326, 617, 546, 625
      Annotation: 
       Subtype: Link
       Rect: 326, 607, 546, 615
      Annotation: 
       Subtype: Link
       Rect: 326, 597, 369, 605
      Annotation: 
       Subtype: Link
       Rect: 375, 597, 386, 605
      Annotation: 
       Subtype: Link
       Rect: 326, 587, 546, 595
      Annotation: 
       Subtype: Link
       Rect: 326, 577, 546, 585
      Annotation: 
       Subtype: Link
       Rect: 326, 567, 546, 575
      Annotation: 
       Subtype: Link
       Rect: 326, 557, 546, 565
      Annotation: 
       Subtype: Link
       Rect: 326, 547, 546, 555
      Annotation: 
       Subtype: Link
       Rect: 326, 537, 546, 545
      Annotation: 
       Subtype: Link
       Rect: 326, 527, 546, 535
      Annotation: 
       Subtype: Link
       Rect: 326, 517, 374, 525
      Annotation: 
       Subtype: Link
       Rect: 380, 517, 398, 525
      Annotation: 
       Subtype: Link
       Rect: 326, 507, 546, 515
      Annotation: 
       Subtype: Link
       Rect: 326, 497, 546, 505
      Annotation: 
       Subtype: Link
       Rect: 326, 487, 546, 495
      Annotation: 
       Subtype: Link
       Rect: 326, 477, 546, 485
      Annotation: 
       Subtype: Link
       Rect: 326, 467, 352, 475
      Annotation: 
       Subtype: Link
       Rect: 358, 467, 374, 475
      Annotation: 
       Subtype: Link
       Rect: 326, 457, 546, 465
      Annotation: 
       Subtype: Link
       Rect: 326, 447, 546, 455
      Annotation: 
       Subtype: Link
       Rect: 326, 437, 546, 445
      Annotation: 
       Subtype: Link
       Rect: 326, 427, 546, 435
      Annotation: 
       Subtype: Link
       Rect: 326, 417, 546, 425
      Annotation: 
       Subtype: Link
       Rect: 326, 407, 460, 415
      Annotation: 
       Subtype: Link
       Rect: 466, 407, 478, 415
      Annotation: 
       Subtype: Link
       Rect: 477, 388, 546, 396
      Annotation: 
       Subtype: Link
       Rect: 326, 378, 342, 386
      Annotation: 
       Subtype: Link
       Rect: 326, 368, 546, 376
      Annotation: 
       Subtype: Link
       Rect: 326, 358, 546, 366
      Annotation: 
       Subtype: Link
       Rect: 326, 348, 546, 356
      Annotation: 
       Subtype: Link
       Rect: 326, 338, 546, 346
      Annotation: 
       Subtype: Link
       Rect: 326, 328, 387, 336
      Annotation: 
       Subtype: Link
       Rect: 393, 328, 409, 336
      Annotation: 
       Subtype: Link
       Rect: 326, 318, 546, 326
      Annotation: 
       Subtype: Link
       Rect: 326, 308, 546, 316
      Annotation: 
       Subtype: Link
       Rect: 326, 298, 546, 306
      Annotation: 
       Subtype: Link
       Rect: 326, 288, 546, 296
      Annotation: 
       Subtype: Link
       Rect: 326, 278, 546, 286
      Annotation: 
       Subtype: Link
       Rect: 326, 268, 342, 276
      Annotation: 
       Subtype: Link
       Rect: 348, 268, 364, 276
      Annotation: 
       Subtype: Link
       Rect: 326, 258, 546, 266
      Annotation: 
       Subtype: Link
       Rect: 326, 248, 546, 256
      Annotation: 
       Subtype: Link
       Rect: 326, 238, 546, 246
      Annotation: 
       Subtype: Link
       Rect: 326, 228, 546, 236
      Annotation: 
       Subtype: Link
       Rect: 326, 218, 546, 226
      Annotation: 
       Subtype: Link
       Rect: 326, 208, 546, 216
      Annotation: 
       Subtype: Link
       Rect: 326, 198, 524, 206
      Annotation: 
       Subtype: Link
       Rect: 530, 198, 542, 206
      Annotation: 
       Subtype: Link
       Rect: 326, 188, 546, 196
      Annotation: 
       Subtype: Link
       Rect: 326, 178, 546, 186
      Annotation: 
       Subtype: Link
       Rect: 326, 168, 546, 176
      Annotation: 
       Subtype: Link
       Rect: 326, 158, 344, 166
      Annotation: 
       Subtype: Link
       Rect: 350, 158, 367, 166
      Annotation: 
       Subtype: Link
       Rect: 326, 148, 546, 156
      Annotation: 
       Subtype: Link
       Rect: 326, 138, 546, 146
      Annotation: 
       Subtype: Link
       Rect: 326, 128, 546, 136
      Annotation: 
       Subtype: Link
       Rect: 326, 119, 442, 126
      Annotation: 
       Subtype: Link
       Rect: 326, 109, 546, 117
      Annotation: 
       Subtype: Link
       Rect: 326, 99, 546, 107
      Annotation: 
       Subtype: Link
       Rect: 326, 89, 546, 97
      Annotation: 
       Subtype: Link
       Rect: 326, 79, 506, 87
      Annotation: 
       Subtype: Link
       Rect: 512, 79, 524, 87
      Annotation: 
       Subtype: Link
       Rect: 326, 69, 546, 77
      Annotation: 
       Subtype: Link
       Rect: 326, 59, 546, 67
      Annotation: 
       Subtype: Link
       Rect: 209, 18, 268, 28
    Page: 
     Label: 540
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 56, 716, 276, 724
      Annotation: 
       Subtype: Link
       Rect: 56, 706, 276, 714
      Annotation: 
       Subtype: Link
       Rect: 56, 696, 276, 704
      Annotation: 
       Subtype: Link
       Rect: 56, 686, 276, 694
      Annotation: 
       Subtype: Link
       Rect: 56, 676, 116, 684
      Annotation: 
       Subtype: Link
       Rect: 122, 676, 134, 684
      Annotation: 
       Subtype: Link
       Rect: 56, 666, 276, 674
      Annotation: 
       Subtype: Link
       Rect: 56, 657, 276, 665
      Annotation: 
       Subtype: Link
       Rect: 56, 647, 211, 655
      Annotation: 
       Subtype: Link
       Rect: 217, 647, 276, 655
      Annotation: 
       Subtype: Link
       Rect: 56, 637, 276, 645
      Annotation: 
       Subtype: Link
       Rect: 56, 627, 276, 635
      Annotation: 
       Subtype: Link
       Rect: 56, 617, 276, 625
      Annotation: 
       Subtype: Link
       Rect: 56, 607, 72, 615
      Annotation: 
       Subtype: Link
       Rect: 78, 607, 94, 615
      Annotation: 
       Subtype: Link
       Rect: 56, 597, 276, 605
      Annotation: 
       Subtype: Link
       Rect: 56, 587, 276, 595
      Annotation: 
       Subtype: Link
       Rect: 56, 577, 276, 585
      Annotation: 
       Subtype: Link
       Rect: 56, 567, 276, 575
      Annotation: 
       Subtype: Link
       Rect: 56, 557, 91, 565
      Annotation: 
       Subtype: Link
       Rect: 97, 557, 105, 565
      Annotation: 
       Subtype: Link
       Rect: 56, 547, 276, 555
      Annotation: 
       Subtype: Link
       Rect: 56, 537, 276, 545
      Annotation: 
       Subtype: Link
       Rect: 56, 527, 276, 535
      Annotation: 
       Subtype: Link
       Rect: 56, 517, 276, 525
      Annotation: 
       Subtype: Link
       Rect: 56, 507, 72, 515
      Annotation: 
       Subtype: Link
       Rect: 78, 507, 94, 515
      Annotation: 
       Subtype: Link
       Rect: 56, 497, 276, 505
      Annotation: 
       Subtype: Link
       Rect: 56, 487, 276, 495
      Annotation: 
       Subtype: Link
       Rect: 56, 477, 276, 485
      Annotation: 
       Subtype: Link
       Rect: 56, 467, 276, 475
      Annotation: 
       Subtype: Link
       Rect: 56, 457, 276, 465
      Annotation: 
       Subtype: Link
       Rect: 56, 447, 276, 455
      Annotation: 
       Subtype: Link
       Rect: 56, 437, 137, 445
      Annotation: 
       Subtype: Link
       Rect: 143, 437, 155, 445
      Annotation: 
       Subtype: Link
       Rect: 56, 427, 276, 435
      Annotation: 
       Subtype: Link
       Rect: 56, 417, 276, 425
      Annotation: 
       Subtype: Link
       Rect: 56, 407, 276, 415
      Annotation: 
       Subtype: Link
       Rect: 56, 397, 276, 405
      Annotation: 
       Subtype: Link
       Rect: 56, 388, 276, 396
      Annotation: 
       Subtype: Link
       Rect: 56, 378, 276, 386
      Annotation: 
       Subtype: Link
       Rect: 56, 368, 137, 376
      Annotation: 
       Subtype: Link
       Rect: 143, 368, 155, 376
      Annotation: 
       Subtype: Link
       Rect: 56, 358, 276, 366
      Annotation: 
       Subtype: Link
       Rect: 56, 348, 276, 356
      Annotation: 
       Subtype: Link
       Rect: 56, 338, 276, 346
      Annotation: 
       Subtype: Link
       Rect: 56, 328, 276, 336
      Annotation: 
       Subtype: Link
       Rect: 56, 318, 276, 326
      Annotation: 
       Subtype: Link
       Rect: 56, 308, 276, 316
      Annotation: 
       Subtype: Link
       Rect: 56, 298, 157, 306
      Annotation: 
       Subtype: Link
       Rect: 163, 298, 171, 306
      Annotation: 
       Subtype: Link
       Rect: 56, 288, 276, 296
      Annotation: 
       Subtype: Link
       Rect: 56, 278, 276, 286
      Annotation: 
       Subtype: Link
       Rect: 56, 268, 276, 276
      Annotation: 
       Subtype: Link
       Rect: 56, 258, 276, 266
      Annotation: 
       Subtype: Link
       Rect: 56, 248, 276, 256
      Annotation: 
       Subtype: Link
       Rect: 56, 238, 276, 246
      Annotation: 
       Subtype: Link
       Rect: 56, 228, 276, 236
      Annotation: 
       Subtype: Link
       Rect: 56, 218, 276, 226
      Annotation: 
       Subtype: Link
       Rect: 56, 208, 187, 216
      Annotation: 
       Subtype: Link
       Rect: 193, 208, 205, 216
      Annotation: 
       Subtype: Link
       Rect: 56, 198, 276, 206
      Annotation: 
       Subtype: Link
       Rect: 56, 188, 276, 196
      Annotation: 
       Subtype: Link
       Rect: 56, 178, 276, 186
      Annotation: 
       Subtype: Link
       Rect: 56, 168, 276, 176
      Annotation: 
       Subtype: Link
       Rect: 56, 158, 276, 166
      Annotation: 
       Subtype: Link
       Rect: 56, 148, 276, 156
      Annotation: 
       Subtype: Link
       Rect: 56, 138, 276, 146
      Annotation: 
       Subtype: Link
       Rect: 56, 128, 276, 136
      Annotation: 
       Subtype: Link
       Rect: 56, 119, 276, 126
      Annotation: 
       Subtype: Link
       Rect: 56, 109, 155, 117
      Annotation: 
       Subtype: Link
       Rect: 161, 109, 177, 117
      Annotation: 
       Subtype: Link
       Rect: 422, 706, 496, 714
      Annotation: 
       Subtype: Link
       Rect: 319, 696, 539, 704
      Annotation: 
       Subtype: Link
       Rect: 319, 686, 539, 694
      Annotation: 
       Subtype: Link
       Rect: 319, 676, 539, 684
      Annotation: 
       Subtype: Link
       Rect: 319, 666, 539, 674
      Annotation: 
       Subtype: Link
       Rect: 319, 657, 378, 665
      Annotation: 
       Subtype: Link
       Rect: 384, 657, 400, 665
      Annotation: 
       Subtype: Link
       Rect: 319, 647, 539, 655
      Annotation: 
       Subtype: Link
       Rect: 319, 637, 539, 645
      Annotation: 
       Subtype: Link
       Rect: 319, 627, 539, 635
      Annotation: 
       Subtype: Link
       Rect: 319, 617, 539, 625
      Annotation: 
       Subtype: Link
       Rect: 319, 607, 539, 615
      Annotation: 
       Subtype: Link
       Rect: 319, 597, 362, 605
      Annotation: 
       Subtype: Link
       Rect: 368, 597, 379, 605
      Annotation: 
       Subtype: Link
       Rect: 319, 587, 539, 595
      Annotation: 
       Subtype: Link
       Rect: 319, 577, 539, 585
      Annotation: 
       Subtype: Link
       Rect: 319, 567, 539, 575
      Annotation: 
       Subtype: Link
       Rect: 319, 557, 539, 565
      Annotation: 
       Subtype: Link
       Rect: 319, 547, 539, 555
      Annotation: 
       Subtype: Link
       Rect: 319, 537, 331, 545
      Annotation: 
       Subtype: Link
       Rect: 337, 537, 349, 545
      Annotation: 
       Subtype: Link
       Rect: 319, 527, 539, 535
      Annotation: 
       Subtype: Link
       Rect: 319, 517, 539, 525
      Annotation: 
       Subtype: Link
       Rect: 319, 507, 447, 515
      Annotation: 
       Subtype: Link
       Rect: 453, 507, 465, 515
      Annotation: 
       Subtype: Link
       Rect: 319, 497, 539, 505
      Annotation: 
       Subtype: Link
       Rect: 319, 487, 539, 495
      Annotation: 
       Subtype: Link
       Rect: 319, 477, 539, 485
      Annotation: 
       Subtype: Link
       Rect: 319, 467, 539, 475
      Annotation: 
       Subtype: Link
       Rect: 319, 457, 539, 465
      Annotation: 
       Subtype: Link
       Rect: 319, 447, 491, 455
      Annotation: 
       Subtype: Link
       Rect: 497, 447, 509, 455
      Annotation: 
       Subtype: Link
       Rect: 319, 437, 539, 445
      Annotation: 
       Subtype: Link
       Rect: 319, 427, 539, 435
      Annotation: 
       Subtype: Link
       Rect: 319, 417, 426, 425
      Annotation: 
       Subtype: Link
       Rect: 432, 417, 439, 425
      Annotation: 
       Subtype: Link
       Rect: 319, 407, 539, 415
      Annotation: 
       Subtype: Link
       Rect: 319, 397, 539, 405
      Annotation: 
       Subtype: Link
       Rect: 319, 388, 539, 396
      Annotation: 
       Subtype: Link
       Rect: 319, 378, 539, 386
      Annotation: 
       Subtype: Link
       Rect: 319, 368, 383, 376
      Annotation: 
       Subtype: Link
       Rect: 389, 368, 401, 376
      Annotation: 
       Subtype: Link
       Rect: 319, 358, 539, 366
      Annotation: 
       Subtype: Link
       Rect: 319, 348, 539, 356
      Annotation: 
       Subtype: Link
       Rect: 319, 338, 539, 346
      Annotation: 
       Subtype: Link
       Rect: 319, 328, 332, 336
      Annotation: 
       Subtype: Link
       Rect: 334, 328, 539, 336
      Annotation: 
       Subtype: Link
       Rect: 319, 318, 539, 326
      Annotation: 
       Subtype: Link
       Rect: 319, 308, 402, 316
      Annotation: 
       Subtype: Link
       Rect: 408, 308, 424, 316
      Annotation: 
       Subtype: Link
       Rect: 319, 298, 539, 306
      Annotation: 
       Subtype: Link
       Rect: 319, 288, 539, 296
      Annotation: 
       Subtype: Link
       Rect: 319, 278, 539, 286
      Annotation: 
       Subtype: Link
       Rect: 319, 268, 539, 276
      Annotation: 
       Subtype: Link
       Rect: 319, 258, 539, 266
      Annotation: 
       Subtype: Link
       Rect: 319, 248, 539, 256
      Annotation: 
       Subtype: Link
       Rect: 319, 238, 539, 246
      Annotation: 
       Subtype: Link
       Rect: 319, 228, 539, 236
      Annotation: 
       Subtype: Link
       Rect: 319, 218, 539, 226
      Annotation: 
       Subtype: Link
       Rect: 319, 208, 335, 216
      Annotation: 
       Subtype: Link
       Rect: 341, 208, 357, 216
      Annotation: 
       Subtype: Link
       Rect: 319, 198, 539, 206
      Annotation: 
       Subtype: Link
       Rect: 319, 188, 539, 196
      Annotation: 
       Subtype: Link
       Rect: 319, 178, 467, 186
      Annotation: 
       Subtype: Link
       Rect: 473, 178, 489, 186
      Annotation: 
       Subtype: Link
       Rect: 319, 168, 539, 176
      Annotation: 
       Subtype: Link
       Rect: 319, 158, 539, 166
      Annotation: 
       Subtype: Link
       Rect: 319, 148, 539, 156
      Annotation: 
       Subtype: Link
       Rect: 319, 138, 539, 146
      Annotation: 
       Subtype: Link
       Rect: 319, 128, 539, 136
      Annotation: 
       Subtype: Link
       Rect: 319, 119, 539, 126
      Annotation: 
       Subtype: Link
       Rect: 319, 109, 484, 117
      Annotation: 
       Subtype: Link
       Rect: 490, 109, 506, 117
      Annotation: 
       Subtype: Link
       Rect: 319, 99, 539, 107
      Annotation: 
       Subtype: Link
       Rect: 319, 89, 539, 97
      Annotation: 
       Subtype: Link
       Rect: 319, 79, 539, 87
      Annotation: 
       Subtype: Link
       Rect: 319, 69, 469, 77
      Annotation: 
       Subtype: Link
       Rect: 316, 18, 375, 28
    Page: 
     Label: 541
     Sequence: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 63, 716, 283, 724
      Annotation: 
       Subtype: Link
       Rect: 63, 706, 283, 714
      Annotation: 
       Subtype: Link
       Rect: 63, 696, 283, 704
      Annotation: 
       Subtype: Link
       Rect: 63, 686, 283, 694
      Annotation: 
       Subtype: Link
       Rect: 63, 676, 283, 684
      Annotation: 
       Subtype: Link
       Rect: 63, 666, 283, 674
      Annotation: 
       Subtype: Link
       Rect: 63, 657, 283, 665
      Annotation: 
       Subtype: Link
       Rect: 63, 647, 283, 655
      Annotation: 
       Subtype: Link
       Rect: 63, 637, 283, 645
      Annotation: 
       Subtype: Link
       Rect: 63, 627, 218, 635
      Annotation: 
       Subtype: Link
       Rect: 224, 627, 236, 635
      Annotation: 
       Subtype: Link
       Rect: 63, 617, 283, 625
      Annotation: 
       Subtype: Link
       Rect: 63, 607, 283, 615
      Annotation: 
       Subtype: Link
       Rect: 63, 597, 283, 605
      Annotation: 
       Subtype: Link
       Rect: 63, 587, 283, 595
      Annotation: 
       Subtype: Link
       Rect: 63, 577, 143, 585
      Annotation: 
       Subtype: Link
       Rect: 149, 577, 161, 585
      Annotation: 
       Subtype: Link
       Rect: 63, 567, 283, 575
      Annotation: 
       Subtype: Link
       Rect: 63, 557, 283, 565
      Annotation: 
       Subtype: Link
       Rect: 63, 547, 283, 555
      Annotation: 
       Subtype: Link
       Rect: 63, 537, 283, 545
      Annotation: 
       Subtype: Link
       Rect: 63, 527, 79, 535
      Annotation: 
       Subtype: Link
       Rect: 63, 517, 283, 525
      Annotation: 
       Subtype: Link
       Rect: 63, 507, 283, 515
      Annotation: 
       Subtype: Link
       Rect: 63, 497, 283, 505
      Annotation: 
       Subtype: Link
       Rect: 63, 487, 141, 495
      Annotation: 
       Subtype: Link
       Rect: 147, 487, 163, 495
      Annotation: 
       Subtype: Link
       Rect: 63, 477, 283, 485
      Annotation: 
       Subtype: Link
       Rect: 63, 467, 283, 475
      Annotation: 
       Subtype: Link
       Rect: 63, 457, 283, 465
      Annotation: 
       Subtype: Link
       Rect: 63, 447, 283, 455
      Annotation: 
       Subtype: Link
       Rect: 63, 437, 223, 445
      Annotation: 
       Subtype: Link
       Rect: 229, 437, 241, 445
      Annotation: 
       Subtype: Link
       Rect: 63, 427, 283, 435
      Annotation: 
       Subtype: Link
       Rect: 63, 417, 283, 425
      Annotation: 
       Subtype: Link
       Rect: 63, 407, 283, 415
      Annotation: 
       Subtype: Link
       Rect: 63, 397, 283, 405
      Annotation: 
       Subtype: Link
       Rect: 63, 388, 283, 396
      Annotation: 
       Subtype: Link
       Rect: 63, 378, 283, 386
      Annotation: 
       Subtype: Link
       Rect: 63, 368, 206, 376
      Annotation: 
       Subtype: Link
       Rect: 212, 368, 228, 376
      Annotation: 
       Subtype: Link
       Rect: 63, 358, 283, 366
      Annotation: 
       Subtype: Link
       Rect: 63, 348, 283, 356
      Annotation: 
       Subtype: Link
       Rect: 63, 338, 283, 346
      Annotation: 
       Subtype: Link
       Rect: 63, 328, 85, 336
      Annotation: 
       Subtype: Link
       Rect: 91, 328, 103, 336
      Annotation: 
       Subtype: Link
       Rect: 63, 318, 283, 326
      Annotation: 
       Subtype: Link
       Rect: 63, 308, 283, 316
      Annotation: 
       Subtype: Link
       Rect: 63, 298, 283, 306
      Annotation: 
       Subtype: Link
       Rect: 63, 288, 110, 296
      Annotation: 
       Subtype: Link
       Rect: 115, 288, 127, 296
      Annotation: 
       Subtype: Link
       Rect: 63, 278, 283, 286
      Annotation: 
       Subtype: Link
       Rect: 63, 268, 283, 276
      Annotation: 
       Subtype: Link
       Rect: 63, 258, 283, 266
      Annotation: 
       Subtype: Link
       Rect: 63, 248, 218, 256
      Annotation: 
       Subtype: Link
       Rect: 224, 248, 240, 256
      Annotation: 
       Subtype: Link
       Rect: 63, 238, 283, 246
      Annotation: 
       Subtype: Link
       Rect: 63, 228, 283, 236
      Annotation: 
       Subtype: Link
       Rect: 63, 218, 283, 226
      Annotation: 
       Subtype: Link
       Rect: 63, 208, 283, 216
      Annotation: 
       Subtype: Link
       Rect: 63, 198, 283, 206
      Annotation: 
       Subtype: Link
       Rect: 63, 188, 175, 196
      Annotation: 
       Subtype: Link
       Rect: 181, 188, 193, 196
      Annotation: 
       Subtype: Link
       Rect: 67, 178, 110, 186
      Annotation: 
       Subtype: Link
       Rect: 116, 178, 170, 186
      Annotation: 
       Subtype: Link
       Rect: 173, 178, 214, 186
      Annotation: 
       Subtype: Link
       Rect: 218, 178, 283, 186
      Annotation: 
       Subtype: Link
       Rect: 63, 168, 283, 176
      Annotation: 
       Subtype: Link
       Rect: 63, 158, 231, 166
      Annotation: 
       Subtype: Link
       Rect: 63, 148, 283, 156
      Annotation: 
       Subtype: Link
       Rect: 63, 138, 283, 146
      Annotation: 
       Subtype: Link
       Rect: 63, 128, 283, 136
      Annotation: 
       Subtype: Link
       Rect: 63, 119, 127, 126
      Annotation: 
       Subtype: Link
       Rect: 133, 119, 145, 126
      Annotation: 
       Subtype: Link
       Rect: 63, 109, 283, 117
      Annotation: 
       Subtype: Link
       Rect: 63, 99, 283, 107
      Annotation: 
       Subtype: Link
       Rect: 63, 89, 283, 97
      Annotation: 
       Subtype: Link
       Rect: 63, 79, 79, 87
      Annotation: 
       Subtype: Link
       Rect: 85, 79, 101, 87
      Annotation: 
       Subtype: Link
       Rect: 63, 69, 283, 77
      Annotation: 
       Subtype: Link
       Rect: 63, 59, 283, 67
      Annotation: 
       Subtype: Link
       Rect: 326, 716, 546, 724
      Annotation: 
       Subtype: Link
       Rect: 326, 706, 546, 714
      Annotation: 
       Subtype: Link
       Rect: 326, 696, 546, 704
      Annotation: 
       Subtype: Link
       Rect: 326, 686, 546, 694
      Annotation: 
       Subtype: Link
       Rect: 326, 676, 546, 684
      Annotation: 
       Subtype: Link
       Rect: 326, 666, 397, 674
      Annotation: 
       Subtype: Link
       Rect: 403, 666, 419, 674
      Annotation: 
       Subtype: Link
       Rect: 326, 657, 546, 665
      Annotation: 
       Subtype: Link
       Rect: 326, 647, 546, 655
      Annotation: 
       Subtype: Link
       Rect: 326, 637, 546, 645
      Annotation: 
       Subtype: Link
       Rect: 326, 627, 546, 635
      Annotation: 
       Subtype: Link
       Rect: 326, 617, 546, 625
      Annotation: 
       Subtype: Link
       Rect: 326, 607, 546, 615
      Annotation: 
       Subtype: Link
       Rect: 326, 597, 546, 605
      Annotation: 
       Subtype: Link
       Rect: 326, 587, 546, 595
      Annotation: 
       Subtype: Link
       Rect: 326, 577, 423, 585
      Annotation: 
       Subtype: Link
       Rect: 429, 577, 437, 585
      Annotation: 
       Subtype: Link
       Rect: 326, 567, 546, 575
      Annotation: 
       Subtype: Link
       Rect: 326, 557, 546, 565
      Annotation: 
       Subtype: Link
       Rect: 326, 547, 482, 555
      Annotation: 
       Subtype: Link
       Rect: 488, 547, 500, 555
      Annotation: 
       Subtype: Link
       Rect: 326, 537, 546, 545
      Annotation: 
       Subtype: Link
       Rect: 326, 527, 546, 535
      Annotation: 
       Subtype: Link
       Rect: 326, 517, 546, 525
      Annotation: 
       Subtype: Link
       Rect: 326, 507, 546, 515
      Annotation: 
       Subtype: Link
       Rect: 326, 497, 546, 505
      Annotation: 
       Subtype: Link
       Rect: 326, 487, 338, 495
      Annotation: 
       Subtype: Link
       Rect: 344, 487, 356, 495
      Annotation: 
       Subtype: Link
       Rect: 326, 477, 546, 485
      Annotation: 
       Subtype: Link
       Rect: 326, 467, 546, 475
      Annotation: 
       Subtype: Link
       Rect: 326, 457, 546, 465
      Annotation: 
       Subtype: Link
       Rect: 326, 447, 546, 455
      Annotation: 
       Subtype: Link
       Rect: 326, 437, 389, 445
      Annotation: 
       Subtype: Link
       Rect: 395, 437, 407, 445
      Annotation: 
       Subtype: Link
       Rect: 326, 427, 546, 435
      Annotation: 
       Subtype: Link
       Rect: 326, 417, 546, 425
      Annotation: 
       Subtype: Link
       Rect: 326, 407, 546, 415
      Annotation: 
       Subtype: Link
       Rect: 326, 397, 546, 405
      Annotation: 
       Subtype: Link
       Rect: 326, 388, 546, 396
      Annotation: 
       Subtype: Link
       Rect: 326, 378, 455, 386
      Annotation: 
       Subtype: Link
       Rect: 461, 378, 472, 386
      Annotation: 
       Subtype: Link
       Rect: 326, 368, 546, 376
      Annotation: 
       Subtype: Link
       Rect: 326, 358, 546, 366
      Annotation: 
       Subtype: Link
       Rect: 326, 348, 392, 356
      Annotation: 
       Subtype: Link
       Rect: 398, 348, 410, 356
      Annotation: 
       Subtype: Link
       Rect: 326, 338, 546, 346
      Annotation: 
       Subtype: Link
       Rect: 326, 328, 546, 336
      Annotation: 
       Subtype: Link
       Rect: 326, 318, 471, 326
      Annotation: 
       Subtype: Link
       Rect: 477, 318, 485, 326
      Annotation: 
       Subtype: Link
       Rect: 326, 308, 546, 316
      Annotation: 
       Subtype: Link
       Rect: 326, 298, 546, 306
      Annotation: 
       Subtype: Link
       Rect: 326, 288, 546, 296
      Annotation: 
       Subtype: Link
       Rect: 326, 278, 546, 286
      Annotation: 
       Subtype: Link
       Rect: 326, 268, 546, 276
      Annotation: 
       Subtype: Link
       Rect: 326, 258, 529, 266
      Annotation: 
       Subtype: Link
       Rect: 326, 248, 546, 256
      Annotation: 
       Subtype: Link
       Rect: 326, 238, 546, 246
      Annotation: 
       Subtype: Link
       Rect: 326, 228, 478, 236
      Annotation: 
       Subtype: Link
       Rect: 484, 228, 496, 236
      Annotation: 
       Subtype: Link
       Rect: 326, 218, 546, 226
      Annotation: 
       Subtype: Link
       Rect: 326, 208, 546, 216
      Annotation: 
       Subtype: Link
       Rect: 326, 198, 546, 206
      Annotation: 
       Subtype: Link
       Rect: 326, 188, 546, 196
      Annotation: 
       Subtype: Link
       Rect: 326, 178, 546, 186
      Annotation: 
       Subtype: Link
       Rect: 326, 168, 546, 176
      Annotation: 
       Subtype: Link
       Rect: 326, 158, 373, 166
      Annotation: 
       Subtype: Link
       Rect: 379, 158, 394, 166
      Annotation: 
       Subtype: Link
       Rect: 326, 148, 546, 156
      Annotation: 
       Subtype: Link
       Rect: 326, 138, 546, 146
      Annotation: 
       Subtype: Link
       Rect: 326, 128, 546, 136
      Annotation: 
       Subtype: Link
       Rect: 326, 119, 546, 126
      Annotation: 
       Subtype: Link
       Rect: 326, 109, 434, 117
      Annotation: 
       Subtype: Link
       Rect: 440, 109, 456, 117
      Annotation: 
       Subtype: Link
       Rect: 326, 99, 546, 107
      Annotation: 
       Subtype: Link
       Rect: 326, 89, 546, 97
      Annotation: 
       Subtype: Link
       Rect: 326, 79, 546, 87
      Annotation: 
       Subtype: Link
       Rect: 326, 69, 546, 77
      Annotation: 
       Subtype: Link
       Rect: 326, 59, 474, 67
      Annotation: 
       Subtype: Link
       Rect: 480, 59, 492, 67
      Annotation: 
       Subtype: Link
       Rect: 209, 18, 268, 28
    Page: 
     Label: 542
     Sequence: 14
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 56, 716, 276, 724
      Annotation: 
       Subtype: Link
       Rect: 56, 706, 276, 714
      Annotation: 
       Subtype: Link
       Rect: 56, 696, 276, 704
      Annotation: 
       Subtype: Link
       Rect: 56, 686, 259, 694
      Annotation: 
       Subtype: Link
       Rect: 265, 686, 276, 694
      Annotation: 
       Subtype: Link
       Rect: 56, 676, 276, 684
      Annotation: 
       Subtype: Link
       Rect: 56, 666, 276, 674
      Annotation: 
       Subtype: Link
       Rect: 56, 657, 276, 665
      Annotation: 
       Subtype: Link
       Rect: 56, 647, 276, 655
      Annotation: 
       Subtype: Link
       Rect: 56, 637, 276, 645
      Annotation: 
       Subtype: Link
       Rect: 56, 627, 131, 635
      Annotation: 
       Subtype: Link
       Rect: 137, 627, 153, 635
      Annotation: 
       Subtype: Link
       Rect: 56, 617, 276, 625
      Annotation: 
       Subtype: Link
       Rect: 56, 607, 276, 615
      Annotation: 
       Subtype: Link
       Rect: 56, 597, 276, 605
      Annotation: 
       Subtype: Link
       Rect: 56, 587, 276, 595
      Annotation: 
       Subtype: Link
       Rect: 56, 577, 276, 585
      Annotation: 
       Subtype: Link
       Rect: 56, 567, 137, 575
      Annotation: 
       Subtype: Link
       Rect: 143, 567, 155, 575
      Annotation: 
       Subtype: Link
       Rect: 56, 557, 276, 565
      Annotation: 
       Subtype: Link
       Rect: 56, 547, 276, 555
      Annotation: 
       Subtype: Link
       Rect: 56, 537, 276, 545
      Annotation: 
       Subtype: Link
       Rect: 56, 527, 276, 535
      Annotation: 
       Subtype: Link
       Rect: 56, 517, 276, 525
      Annotation: 
       Subtype: Link
       Rect: 56, 507, 276, 515
      Annotation: 
       Subtype: Link
       Rect: 56, 497, 276, 505
      Annotation: 
       Subtype: Link
       Rect: 56, 487, 276, 495
      Annotation: 
       Subtype: Link
       Rect: 56, 477, 225, 485
      Annotation: 
       Subtype: Link
       Rect: 231, 477, 243, 485
      Annotation: 
       Subtype: Link
       Rect: 56, 467, 276, 475
      Annotation: 
       Subtype: Link
       Rect: 56, 457, 276, 465
      Annotation: 
       Subtype: Link
       Rect: 56, 447, 276, 455
      Annotation: 
       Subtype: Link
       Rect: 56, 437, 276, 445
      Annotation: 
       Subtype: Link
       Rect: 56, 427, 276, 435
      Annotation: 
       Subtype: Link
       Rect: 56, 417, 124, 425
      Annotation: 
       Subtype: Link
       Rect: 130, 417, 146, 425
      Annotation: 
       Subtype: Link
       Rect: 56, 407, 276, 415
      Annotation: 
       Subtype: Link
       Rect: 56, 397, 276, 405
      Annotation: 
       Subtype: Link
       Rect: 319, 716, 539, 724
      Annotation: 
       Subtype: Link
       Rect: 319, 706, 539, 714
      Annotation: 
       Subtype: Link
       Rect: 319, 696, 539, 704
      Annotation: 
       Subtype: Link
       Rect: 319, 686, 539, 694
      Annotation: 
       Subtype: Link
       Rect: 319, 676, 380, 684
      Annotation: 
       Subtype: Link
       Rect: 386, 676, 393, 684
      Annotation: 
       Subtype: Link
       Rect: 319, 666, 539, 674
      Annotation: 
       Subtype: Link
       Rect: 319, 657, 539, 665
      Annotation: 
       Subtype: Link
       Rect: 319, 647, 539, 655
      Annotation: 
       Subtype: Link
       Rect: 319, 637, 539, 645
      Annotation: 
       Subtype: Link
       Rect: 319, 627, 539, 635
      Annotation: 
       Subtype: Link
       Rect: 319, 617, 539, 625
      Annotation: 
       Subtype: Link
       Rect: 319, 607, 497, 615
      Annotation: 
       Subtype: Link
       Rect: 319, 597, 539, 605
      Annotation: 
       Subtype: Link
       Rect: 319, 587, 539, 595
      Annotation: 
       Subtype: Link
       Rect: 319, 577, 539, 585
      Annotation: 
       Subtype: Link
       Rect: 319, 567, 354, 575
      Annotation: 
       Subtype: Link
       Rect: 319, 557, 539, 565
      Annotation: 
       Subtype: Link
       Rect: 319, 547, 539, 555
      Annotation: 
       Subtype: Link
       Rect: 319, 537, 539, 545
      Annotation: 
       Subtype: Link
       Rect: 319, 527, 539, 535
      Annotation: 
       Subtype: Link
       Rect: 319, 517, 404, 525
      Annotation: 
       Subtype: Link
       Rect: 410, 517, 426, 525
      Annotation: 
       Subtype: Link
       Rect: 319, 507, 539, 515
      Annotation: 
       Subtype: Link
       Rect: 319, 497, 539, 505
      Annotation: 
       Subtype: Link
       Rect: 319, 487, 349, 495
      Annotation: 
       Subtype: Link
       Rect: 355, 487, 371, 495
      Annotation: 
       Subtype: Link
       Rect: 319, 477, 539, 485
      Annotation: 
       Subtype: Link
       Rect: 319, 467, 539, 475
      Annotation: 
       Subtype: Link
       Rect: 319, 457, 539, 465
      Annotation: 
       Subtype: Link
       Rect: 319, 447, 539, 455
      Annotation: 
       Subtype: Link
       Rect: 319, 437, 463, 445
      Annotation: 
       Subtype: Link
       Rect: 469, 437, 485, 445
      Annotation: 
       Subtype: Link
       Rect: 319, 427, 539, 435
      Annotation: 
       Subtype: Link
       Rect: 319, 417, 539, 425
      Annotation: 
       Subtype: Link
       Rect: 319, 407, 539, 415
      Annotation: 
       Subtype: Link
       Rect: 319, 397, 507, 405
      Annotation: 
       Subtype: Link
       Rect: 513, 397, 521, 405
      Annotation: 
       Subtype: Link
       Rect: 316, 18, 375, 28
  Checksum: 6ad2f8a2
   Type: CRC32
  Checksum: af956a43ef17fde521c5370ced23d02f
   Type: MD5
  Checksum: 23ea7beda57d656736e3f2201a346b913d09760f
   Type: SHA-1