9099e36e1a20ef7e72d3564b403dec47 277666.pdf 85473640d5e831ca7dad33b7010778f1a45e9b68 277666.pdf 31923c3ad9cd250e80a477d1a7749efae2ad6d9e98ab4eff0fc2da1b0c49a217 277666.pdf Title: A Polygenic Risk Score Based on a Cardioembolic Stroke Multitrait Analysis Improves a Clinical Prediction Model for This Stroke Subtype Subject: Background: Occult atrial fibrillation (AF) is one of the major causes of embolic stroke of undetermined source (ESUS). Keywords: polygenic risk score, GWAS, multi-trait analysis, stroke, ESUs Author: Israel Férnandez-Cadenas Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Mon Jul 4 03:51:00 2022 CEST ModDate: Mon Jul 4 09:26:43 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.26 x 779.52 pts Page rot: 0 File size: 1178246 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- QKAUEO+HelveticaNeueLTStd-Bd Type 1C Custom yes yes no 40 0 LXKEYI+HelveticaNeueLTStd-Lt Type 1C Custom yes yes no 45 0 PIAOFJ+HelveticaNeueLTStd-BdIt Type 1C WinAnsi yes yes no 57 0 CODOPM+HelveticaNeueLTStd-LtIt Type 1C Custom yes yes no 59 0 ZPSBWO+HelveticaNeueLTStd-MdIt Type 1C WinAnsi yes yes no 64 0 BFGMFY+MinionPro-It Type 1C WinAnsi yes yes no 98 0 YUGSUA+MTSY Type 1C Custom yes yes yes 72 0 OBAZBH+RMTMI Type 1C WinAnsi yes yes no 74 0 RWXRWY+MinionPro-Regular Type 1C Custom yes yes no 76 0 JTWZTZ+MinionPro-Bold Type 1C Custom yes yes no 89 0 ITXWMP+HelveticaNeueLTStd-Md Type 1C WinAnsi yes yes no 119 0 EATTMK+MTGU Type 1C Custom yes yes no 141 0 OBGWMD+MTSYB Type 1C Custom yes yes no 202 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-07-15 02:43:21 CEST RepresentationInformation: 277666.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-07-14 11:08:09 CEST Size: 1178246 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 320 FreeObjects: 17 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: true CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: A Polygenic Risk Score Based on a Cardioembolic Stroke Multitrait Analysis Improves a Clinical Prediction Model for This Strok攀 匀甀戀琀礀瀀攩㸾൥湤潢樍㘠〠潢樍㰼⽐慲敮琠㔠〠刯乥硴‷‰⁒⽄敳琯獥捴楯渪⸲⽁捴楯港䝯呯⽔楴汥⣾＀䤀渀琀爀漀搀甀挀琀椀漀温㸾൥湤潢樍㌱‰扪഼㰯偡牥湴‵‰⁒⽄敳琯獥捴楯渪⸲㜯䅣瑩潮⽇潔漯偲敶″〠〠刯呩瑬攨References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Children: Item: Title: Cohorts' Description Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Single-Nucleotide Variation Quality Controls Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: Multitrait Analysis of GWAS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Item: Title: Identification of Independent and Novel Loci Associated With CES Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612fc6eb Item: Title: Replication Stage in an Independent European Cohort Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1060b431 Children: Item: Title: Quality Control and Imputation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@612679d6 Item: Title: GWAS Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@11758f2a Item: Title: Functional Annotation and Gene Prioritization Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Item: Title: Gene Set Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Polygenic Risk Score Development Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Children: Item: Title: MTAG Analysis of CES Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: New Candidate Loci Associated With CES Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: New Candidate Locus Associated With AF Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Biological Processes of Loci Associated With CES and AF and Biological Processes of Loci Associated Exclusively With AF Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Polygenic Risk Score Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Data Availability Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Ethics Statement Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Author Contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: Acknowledgments Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Supplementary Material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Info: Title: A Polygenic Risk Score Based on a Cardioembolic Stroke Multitrait Analysis Improves a Clinical Prediction Model for This Stroke Subtype Author: Israel Férnandez-Cadenas Subject: Background: Occult atrial fibrillation (AF) is one of the major causes of embolic stroke of undetermined source (ESUS). Keywords: polygenic risk score, GWAS, multi-trait analysis, stroke, ESUs Creator: LaTeX with hyperref package + hypdvips Producer: dvips + MiKTeX GPL Ghostscript 9.0 CreationDate: Mon Jul 04 04:21:00 CEST 2022 ModDate: Mon Jul 04 09:56:43 CEST 2022 ID: 0x14c17d6dcbcef168fb1668a7b17f972d, 0x73ef2a61f2714545b6bdfc5cb653e5c5 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 279 ImageHeight: 279 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1822 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1062 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2008 ImageHeight: 1976 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Interpolate: true Fonts: Type1: Font: BaseFont: ZPSBWO+HelveticaNeueLTStd-MdIt FontSubset: true FirstChar: 42 LastChar: 243 FontDescriptor: FontName: ZPSBWO+HelveticaNeueLTStd-MdIt Flags: Symbolic FontBBox: -133, -205, 891, 928 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BFGMFY+MinionPro-It FontSubset: true FirstChar: 40 LastChar: 243 FontDescriptor: FontName: BFGMFY+MinionPro-It Flags: Symbolic FontBBox: -142, -257, 1003, 810 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: QKAUEO+HelveticaNeueLTStd-Bd FontSubset: true FirstChar: 0 LastChar: 124 FontDescriptor: FontName: QKAUEO+HelveticaNeueLTStd-Bd Flags: Serif, Symbolic FontBBox: -9, -214, 925, 786 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: YUGSUA+MTSY FontSubset: true FirstChar: 0 LastChar: 68 FontDescriptor: FontName: YUGSUA+MTSY Flags: Symbolic FontBBox: 0, -209, 944, 679 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: OBAZBH+RMTMI FontSubset: true FirstChar: 60 LastChar: 62 FontDescriptor: FontName: OBAZBH+RMTMI Flags: Nonsymbolic, AllCap FontBBox: 0, 0, 683, 455 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OBGWMD+MTSYB FontSubset: true FirstChar: 67 LastChar: 67 FontDescriptor: FontName: OBGWMD+MTSYB Flags: Symbolic, AllCap FontBBox: 0, -83, 724, 583 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: RWXRWY+MinionPro-Regular FontSubset: true FirstChar: 2 LastChar: 250 FontDescriptor: FontName: RWXRWY+MinionPro-Regular Flags: Symbolic FontBBox: -26, -257, 956, 811 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: LXKEYI+HelveticaNeueLTStd-Lt FontSubset: true FirstChar: 0 LastChar: 225 FontDescriptor: FontName: LXKEYI+HelveticaNeueLTStd-Lt Flags: Symbolic FontBBox: -30, -214, 904, 786 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: EATTMK+MTGU FontSubset: true FirstChar: 36 LastChar: 36 FontDescriptor: FontName: EATTMK+MTGU Flags: Symbolic FontBBox: 0, -201, 588, 450 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: ITXWMP+HelveticaNeueLTStd-Md FontSubset: true FirstChar: 65 LastChar: 121 FontDescriptor: FontName: ITXWMP+HelveticaNeueLTStd-Md Flags: Nonsymbolic FontBBox: 0, -205, 938, 731 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PIAOFJ+HelveticaNeueLTStd-BdIt FontSubset: true FirstChar: 42 LastChar: 121 FontDescriptor: FontName: PIAOFJ+HelveticaNeueLTStd-BdIt Flags: Nonsymbolic FontBBox: -63, -182, 717, 731 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: JTWZTZ+MinionPro-Bold FontSubset: true FirstChar: 3 LastChar: 150 FontDescriptor: FontName: JTWZTZ+MinionPro-Bold Flags: Symbolic FontBBox: -7, -245, 860, 708 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: CODOPM+HelveticaNeueLTStd-LtIt FontSubset: true FirstChar: 0 LastChar: 250 FontDescriptor: FontName: CODOPM+HelveticaNeueLTStd-LtIt Flags: Symbolic FontBBox: -137, -206, 978, 907 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true XMP: 2022-07-04T07:21+05:30 LaTeX with hyperref package + hypdvips 2022-07-04T12:56:43+05:30 2022-07-04T12:56:43+05:30 application/pdf Background: Occult atrial fibrillation (AF) is one of the major causes of embolic stroke of undetermined source (ESUS). Israel Férnandez-Cadenas A Polygenic Risk Score Based on a Cardioembolic Stroke Multitrait Analysis Improves a Clinical Prediction Model for This Stroke Subtype polygenic risk score GWAS multi-trait analysis stroke ESUs polygenic risk score, GWAS, multi-trait analysis, stroke, ESUs dvips + MiKTeX GPL Ghostscript 9.0 uuid:d9e97b6e-e540-4a42-9703-b3fc0d317a7a uuid:acb149a4-fe85-4bf6-8efd-5b17405b6507 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 43, 727, 278, 744 Annotation: Subtype: Link Rect: 457, 736, 551, 744 Annotation: Subtype: Link Rect: 477, 728, 520, 736 Annotation: Subtype: Link Rect: 520, 728, 533, 736 Annotation: Subtype: Link Rect: 533, 728, 551, 736 Annotation: Subtype: Link Rect: 451, 720, 551, 728 Annotation: Subtype: Link Rect: 521, 678, 551, 709 Annotation: Subtype: Link Rect: 43, 31, 154, 38 Annotation: Subtype: Link Rect: 157, 30, 217, 38 Annotation: Subtype: Link Rect: 437, 29, 551, 38 Annotation: Subtype: Link Rect: 87, 650, 160, 659 Annotation: Subtype: Link Rect: 85, 442, 160, 450 Annotation: Subtype: Link Rect: 74, 65, 160, 73 Annotation: Subtype: Link Rect: 176, 556, 551, 668 Page: Label: 2 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 279, 426, 285, 438 Destination: External Annotation: Subtype: Link Rect: 201, 381, 208, 392 Destination: External Annotation: Subtype: Link Rect: 80, 323, 86, 335 Destination: External Annotation: Subtype: Link Rect: 212, 277, 218, 289 Destination: External Annotation: Subtype: Link Rect: 79, 255, 86, 266 Destination: External Annotation: Subtype: Link Rect: 88, 255, 94, 266 Destination: External Annotation: Subtype: Link Rect: 88, 163, 94, 174 Destination: External Annotation: Subtype: Link Rect: 525, 303, 551, 314 Annotation: Subtype: Link Rect: 304, 291, 403, 303 Annotation: Subtype: Link Rect: 338, 246, 448, 257 Annotation: Subtype: Link Rect: 304, 211, 402, 222 Destination: External Annotation: Subtype: Link Rect: 530, 214, 537, 225 Destination: External Annotation: Subtype: Link Rect: 539, 214, 546, 225 Destination: External Annotation: Subtype: Link Rect: 469, 141, 475, 153 Destination: External Annotation: Subtype: Link Rect: 447, 130, 454, 141 Destination: External Annotation: Subtype: Link Rect: 393, 119, 399, 130 Destination: External Annotation: Subtype: Link Rect: 467, 119, 474, 130 Destination: External Annotation: Subtype: Link Rect: 421, 107, 427, 119 Destination: External Annotation: Subtype: Link Rect: 539, 107, 546, 119 Destination: External Annotation: Subtype: Link Rect: 379, 96, 386, 107 Destination: External Annotation: Subtype: Link Rect: 490, 96, 496, 107 Destination: External Annotation: Subtype: Link Rect: 43, 29, 154, 37 Annotation: Subtype: Link Rect: 157, 28, 217, 36 Annotation: Subtype: Link Rect: 437, 28, 551, 37 Page: Label: 3 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 127, 663, 134, 675 Destination: External Annotation: Subtype: Link Rect: 167, 572, 174, 583 Destination: External Annotation: Subtype: Link Rect: 82, 549, 88, 560 Destination: External Annotation: Subtype: Link Rect: 106, 526, 113, 537 Destination: External Annotation: Subtype: Link Rect: 279, 503, 285, 514 Destination: External Annotation: Subtype: Link Rect: 155, 202, 166, 213 Destination: External Annotation: Subtype: Link Rect: 168, 202, 179, 213 Destination: External Annotation: Subtype: Link Rect: 131, 131, 229, 142 Destination: External Annotation: Subtype: Link Rect: 92, 108, 198, 119 Destination: External Annotation: Subtype: Link Rect: 307, 706, 400, 717 Destination: External Annotation: Subtype: Link Rect: 514, 685, 525, 697 Destination: External Annotation: Subtype: Link Rect: 433, 660, 531, 671 Destination: External Annotation: Subtype: Link Rect: 423, 605, 434, 617 Destination: External Annotation: Subtype: Link Rect: 307, 417, 318, 428 Destination: External Annotation: Subtype: Link Rect: 367, 405, 373, 417 Destination: External Annotation: Subtype: Link Rect: 395, 394, 401, 405 Destination: External Annotation: Subtype: Link Rect: 324, 359, 331, 371 Destination: External Annotation: Subtype: Link Rect: 328, 158, 340, 170 Destination: External Annotation: Subtype: Link Rect: 43, 30, 154, 38 Annotation: Subtype: Link Rect: 157, 29, 217, 37 Annotation: Subtype: Link Rect: 437, 29, 551, 38 Page: Label: 4 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 82, 148, 94, 160 Destination: External Annotation: Subtype: Link Rect: 351, 145, 386, 155 Destination: External Annotation: Subtype: Link Rect: 410, 76, 444, 86 Destination: External Annotation: Subtype: Link Rect: 43, 30, 154, 38 Annotation: Subtype: Link Rect: 157, 29, 217, 37 Annotation: Subtype: Link Rect: 437, 29, 551, 38 Page: Label: 5 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 47, 343, 77, 352 Destination: External Annotation: Subtype: Link Rect: 104, 133, 197, 144 Destination: External Annotation: Subtype: Link Rect: 47, 99, 139, 110 Destination: External Annotation: Subtype: Link Rect: 307, 295, 400, 306 Destination: External Annotation: Subtype: Link Rect: 307, 87, 400, 98 Destination: External Annotation: Subtype: Link Rect: 43, 30, 154, 38 Annotation: Subtype: Link Rect: 157, 29, 217, 37 Annotation: Subtype: Link Rect: 437, 29, 551, 38 Page: Label: 6 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 43, 30, 154, 38 Annotation: Subtype: Link Rect: 157, 29, 217, 37 Annotation: Subtype: Link Rect: 437, 29, 551, 38 Rotate: 90 Page: Label: 7 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 43, 30, 154, 38 Annotation: Subtype: Link Rect: 157, 29, 217, 37 Annotation: Subtype: Link Rect: 437, 29, 551, 38 Rotate: 90 Page: Label: 8 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 323, 644, 420, 654 Destination: External Annotation: Subtype: Link Rect: 423, 644, 516, 654 Destination: External Annotation: Subtype: Link Rect: 452, 598, 549, 609 Destination: External Annotation: Subtype: Link Rect: 304, 586, 396, 597 Destination: External Annotation: Subtype: Link Rect: 452, 563, 549, 574 Destination: External Annotation: Subtype: Link Rect: 304, 552, 396, 563 Destination: External Annotation: Subtype: Link Rect: 323, 470, 420, 481 Destination: External Annotation: Subtype: Link Rect: 473, 436, 508, 446 Destination: External Annotation: Subtype: Link Rect: 349, 356, 447, 366 Destination: External Annotation: Subtype: Link Rect: 316, 298, 351, 309 Destination: External Annotation: Subtype: Link Rect: 365, 264, 462, 275 Destination: External Annotation: Subtype: Link Rect: 362, 232, 393, 240 Destination: External Annotation: Subtype: Link Rect: 541, 181, 548, 193 Destination: External Annotation: Subtype: Link Rect: 340, 170, 346, 181 Destination: External Annotation: Subtype: Link Rect: 43, 30, 154, 38 Annotation: Subtype: Link Rect: 157, 29, 217, 37 Annotation: Subtype: Link Rect: 437, 29, 551, 38 Page: Label: 9 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 113, 210, 124, 222 Destination: External Annotation: Subtype: Link Rect: 75, 187, 86, 199 Destination: External Annotation: Subtype: Link Rect: 198, 176, 209, 187 Destination: External Annotation: Subtype: Link Rect: 201, 153, 212, 164 Destination: External Annotation: Subtype: Link Rect: 79, 119, 90, 130 Destination: External Annotation: Subtype: Link Rect: 415, 439, 426, 451 Destination: External Annotation: Subtype: Link Rect: 307, 394, 318, 405 Destination: External Annotation: Subtype: Link Rect: 510, 382, 521, 394 Destination: External Annotation: Subtype: Link Rect: 421, 291, 432, 302 Destination: External Annotation: Subtype: Link Rect: 435, 291, 446, 302 Destination: External Annotation: Subtype: Link Rect: 519, 291, 530, 302 Destination: External Annotation: Subtype: Link Rect: 412, 268, 423, 279 Destination: External Annotation: Subtype: Link Rect: 428, 268, 439, 279 Destination: External Annotation: Subtype: Link Rect: 307, 164, 318, 176 Destination: External Annotation: Subtype: Link Rect: 365, 96, 376, 107 Destination: External Annotation: Subtype: Link Rect: 43, 30, 154, 38 Annotation: Subtype: Link Rect: 157, 29, 217, 37 Annotation: Subtype: Link Rect: 437, 29, 551, 38 Page: Label: 10 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 485, 136, 492, 147 Destination: External Annotation: Subtype: Link Rect: 539, 113, 546, 124 Destination: External Annotation: Subtype: Link Rect: 43, 30, 154, 38 Annotation: Subtype: Link Rect: 157, 29, 217, 37 Annotation: Subtype: Link Rect: 437, 29, 551, 38 Page: Label: 11 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 431, 651, 522, 662 Annotation: Subtype: Link Rect: 344, 548, 422, 559 Annotation: Subtype: Link Rect: 335, 502, 468, 513 Annotation: Subtype: Link Rect: 307, 479, 431, 490 Annotation: Subtype: Link Rect: 442, 467, 551, 479 Annotation: Subtype: Link Rect: 304, 458, 315, 465 Annotation: Subtype: Link Rect: 521, 456, 551, 467 Annotation: Subtype: Link Rect: 304, 444, 418, 456 Annotation: Subtype: Link Rect: 387, 433, 496, 444 Annotation: Subtype: Link Rect: 397, 238, 523, 249 Annotation: Subtype: Link Rect: 552, 122, 303, 146 Annotation: Subtype: Link Rect: 43, 30, 154, 38 Annotation: Subtype: Link Rect: 157, 29, 217, 37 Annotation: Subtype: Link Rect: 437, 29, 551, 38 Page: Label: 12 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 292, 659, 56, 679 Annotation: Subtype: Link Rect: 292, 630, 56, 650 Annotation: Subtype: Link Rect: 198, 603, 277, 611 Annotation: Subtype: Link Rect: 108, 566, 215, 573 Annotation: Subtype: Link Rect: 85, 527, 165, 536 Annotation: Subtype: Link Rect: 185, 500, 270, 507 Annotation: Subtype: Link Rect: 81, 462, 170, 469 Annotation: Subtype: Link Rect: 159, 434, 244, 441 Annotation: Subtype: Link Rect: 126, 404, 177, 413 Annotation: Subtype: Link Rect: 160, 377, 219, 384 Annotation: Subtype: Link Rect: 81, 339, 166, 346 Annotation: Subtype: Link Rect: 104, 309, 156, 318 Annotation: Subtype: Link Rect: 150, 282, 235, 289 Annotation: Subtype: Link Rect: 108, 244, 197, 252 Annotation: Subtype: Link Rect: 181, 224, 264, 233 Annotation: Subtype: Link Rect: 146, 205, 257, 214 Annotation: Subtype: Link Rect: 81, 167, 150, 176 Annotation: Subtype: Link Rect: 120, 139, 213, 148 Annotation: Subtype: Link Rect: 331, 697, 386, 706 Annotation: Subtype: Link Rect: 365, 659, 447, 668 Annotation: Subtype: Link Rect: 341, 623, 448, 630 Annotation: Subtype: Link Rect: 368, 583, 465, 593 Annotation: Subtype: Link Rect: 456, 555, 526, 564 Annotation: Subtype: Link Rect: 437, 528, 509, 536 Annotation: Subtype: Link Rect: 424, 498, 490, 508 Annotation: Subtype: Link Rect: 328, 479, 490, 489 Annotation: Subtype: Link Rect: 527, 460, 551, 470 Annotation: Subtype: Link Rect: 317, 451, 445, 460 Annotation: Subtype: Link Rect: 357, 415, 446, 422 Annotation: Subtype: Link Rect: 466, 385, 533, 394 Annotation: Subtype: Link Rect: 350, 348, 455, 356 Annotation: Subtype: Link Rect: 455, 168, 481, 175 Annotation: Subtype: Link Rect: 482, 168, 514, 175 Annotation: Subtype: Link Rect: 515, 168, 551, 176 Annotation: Subtype: Link Rect: 304, 159, 327, 166 Annotation: Subtype: Link Rect: 327, 158, 354, 166 Annotation: Subtype: Link Rect: 43, 29, 154, 37 Annotation: Subtype: Link Rect: 157, 28, 217, 36 Annotation: Subtype: Link Rect: 437, 28, 551, 37 Checksum: 61dca538 Type: CRC32 Checksum: 9099e36e1a20ef7e72d3564b403dec47 Type: MD5 Checksum: 85473640d5e831ca7dad33b7010778f1a45e9b68 Type: SHA-1