4272a42976f8daddd09ec53f85605b80 277681.pdf af1344f7b728cefea7baca13446757255c021647 277681.pdf a28e22b7ea97a978e069ad6866792ba04f1fdcb07b332ba1cf4a74763b18fd82 277681.pdf Title: Vortioxetine in major depressive disorder: from mechanisms of action to clinical studies. An updated Keywords: Antidepressant; cognition; efficacy; interactions; major depressive disorder; neurotransmission; pharmacology; safety; vortioxetine Creator: Arbortext Advanced Print Publisher 11.0.3433/W Unicode Producer: PDFlib+PDI 9.0.3p4 (C++/Win32) CreationDate: Mon Apr 25 20:07:57 2022 CEST ModDate: Mon Apr 25 20:07:57 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 19 Encrypted: no Page size: 634.32 x 833.04 pts Page rot: 0 File size: 1174724 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- EBGBEG+OpenSans-Semibold CID TrueType Identity-H yes yes yes 967 0 EBGBEF+OpenSans CID TrueType Identity-H yes yes yes 968 0 BWGMGX+MyriadPro-Regular Type 1C Custom yes yes yes 974 0 BXDJBV+MyriadPro-Semibold Type 1C Custom yes yes yes 975 0 YMMPVH+MyriadPro-SemiCn Type 1C Custom yes yes yes 976 0 YQRORR+MyriadPro-Black Type 1C Custom yes yes yes 977 0 AXYEQZ+MyriadPro-Bold Type 1C Custom yes yes yes 978 0 GPZZTI+ArialUnicodeMS-Identity-H CID TrueType Identity-H yes yes yes 979 0 FPHHAG+MyriadPro-SemiboldSemiCn Type 1C Custom yes yes yes 992 0 IAFXGU+MyriadPro-BoldIt Type 1C Custom yes yes yes 996 0 AZZPUT+MyriadPro-SemiboldIt Type 1C Custom yes yes yes 1003 0 QPKKDK+MyriadPro-SemiCnIt Type 1C Custom yes yes yes 1004 0 YZYGKD+ArialMT Type 1 Custom yes yes no 1084 0 FGTPXM+Arial-BoldMT Type 1 Custom yes yes no 1085 0 YEDORU+Calibri Type 1 Custom yes yes no 1086 0 DNWXOS+ArialMT Type 1 Custom yes yes no 1087 0 INLEAK+ArialMT Type 1 Custom yes yes no 1088 0 RIDRKF+Calibri Type 1 Custom yes yes no 1089 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-07-18 02:34:13 CEST RepresentationInformation: 277681.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-07-17 11:59:57 CEST Size: 1174724 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul ID: PDF-HUL-87 InfoMessage: File header gives version as 1.5, but catalog dictionary gives version as 1.4 MIMEtype: application/pdf PDFMetadata: Objects: 1142 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Abstract Destination: 1 Item: Title: 1. Introduction Destination: 1 Item: Title: 2. Pharmacological profile and preclinical studies Destination: 1 Item: Title: 3. Therapeutic efficacy Destination: 1 Children: Item: Title: 3.1. General antidepressant effects Destination: 1 Item: Title: 3.2. Cognition Destination: 1 Item: Title: 3.3. Other specific symptom domain effects Destination: 1 Children: Item: Title: 3.3.1. Anhedonia Destination: 1 Item: Title: 3.3.2. Physical-symptoms and sleep disturbances Destination: 1 Item: Title: 3.3.3. Suicidal ideation Destination: 1 Item: Title: 3.4. Anxiety and other psychiatric comorbidities Destination: 1 Item: Title: 3.5. Older people, menopause, and non-psychiatric comorbidities Destination: 1 Item: Title: 3.6. Inadequate response to first-line antidepressant treatment Destination: 1 Item: Title: 3.7. Functioning outcomes and cost-utility Destination: 1 Item: Title: 4. Safety/Tolerability Destination: 1 Item: Title: 5. Interactions Destination: 1 Item: Title: 6. Summary and Conclusions Destination: 1 Item: Title: 7. Expert opinion Destination: 1 Item: Title: Funding Destination: 1 Item: Title: Declaration of interests Destination: 1 Item: Title: Reviewer disclosures Destination: 1 Item: Title: References Destination: 1 Info: Title: Vortioxetine in major depressive disorder: from mechanisms of action to clinical studies. An updated Keywords: Antidepressant; cognition; efficacy; interactions; major depressive disorder; neurotransmission; pharmacology; safety; vortioxetine Creator: Arbortext Advanced Print Publisher 11.0.3433/W Unicode Producer: PDFlib+PDI 9.0.3p4 (C++/Win32) CreationDate: Mon Apr 25 20:37:57 CEST 2022 ModDate: Mon Apr 25 20:37:57 CEST 2022 ID: 0x95473d46433efe429ba99c0edccf5f9d, 0x95473d46433efe429ba99c0edccf5f9d Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 512 ImageHeight: 346 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Name: Im10 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 694 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: Im13 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 694 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Name: Im14 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 448 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: Im11 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 448 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Name: Im12 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 600 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: Im17 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 600 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Name: Im18 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 674 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: Im15 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 674 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Name: Im16 Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 200 ImageHeight: 261 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Name: Im1 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 1010 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: Im3 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 3150 ImageHeight: 746 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Name: Im2 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 641 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: Im5 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 1010 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Name: Im4 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 470 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: Im7 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 641 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Name: Im6 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 512 ImageHeight: 346 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Name: Im9 Image: NisoImageMetadata: FormatName: image/png ImageWidth: 600 ImageHeight: 470 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Name: Im8 Fonts: Type0: Font: BaseFont: GPZZTI+ArialUnicodeMS-Identity-H Encoding: Identity-H ToUnicode: true Font: BaseFont: EBGBEG+OpenSans-Semibold Encoding: Identity-H ToUnicode: true Font: BaseFont: EBGBEF+OpenSans Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: YMMPVH+MyriadPro-SemiCn FontSubset: true FirstChar: 1 LastChar: 88 FontDescriptor: FontName: MyriadPro-SemiCn Flags: Nonsymbolic FontBBox: -128, -250, 1059, 876 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: FPHHAG+MyriadPro-SemiboldSemiCn FontSubset: true FirstChar: 1 LastChar: 22 FontDescriptor: FontName: MyriadPro-SemiboldSemiCn Flags: Nonsymbolic FontBBox: -131, -250, 1115, 886 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: YQRORR+MyriadPro-Black FontSubset: true FirstChar: 1 LastChar: 16 FontDescriptor: FontName: MyriadPro-Black Flags: Nonsymbolic, ForceBold FontBBox: -166, -251, 1313, 1005 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: AXYEQZ+MyriadPro-Bold FontSubset: true FirstChar: 1 LastChar: 50 FontDescriptor: FontName: MyriadPro-Bold Flags: Nonsymbolic, ForceBold FontBBox: -163, -250, 1256, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: IAFXGU+MyriadPro-BoldIt FontSubset: true FirstChar: 1 LastChar: 38 FontDescriptor: FontName: MyriadPro-BoldIt Flags: Nonsymbolic, Italic, ForceBold FontBBox: -201, -250, 1225, 987 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: AZZPUT+MyriadPro-SemiboldIt FontSubset: true FirstChar: 1 LastChar: 26 FontDescriptor: FontName: MyriadPro-SemiboldIt Flags: Nonsymbolic, Italic FontBBox: -103, -250, 1165, 882 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: QPKKDK+MyriadPro-SemiCnIt FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: MyriadPro-SemiCnIt Flags: Nonsymbolic, Italic FontBBox: -151, -250, 1036, 870 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: BWGMGX+MyriadPro-Regular FontSubset: true FirstChar: 1 LastChar: 106 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: BXDJBV+MyriadPro-Semibold FontSubset: true FirstChar: 1 LastChar: 25 FontDescriptor: FontName: MyriadPro-Semibold Flags: Nonsymbolic FontBBox: -161, -250, 1198, 972 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: EBGBEG+OpenSans-Semibold CIDSystemInfo: Registry: Adobe Registry: UCS Supplement: 0 FontDescriptor: FontName: EBGBEG+OpenSans-Semibold Flags: FixedPitch, Nonsymbolic FontBBox: -583, -282, 1261, 1048 FontFile2: true Font: BaseFont: EBGBEF+OpenSans CIDSystemInfo: Registry: Adobe Registry: UCS Supplement: 0 FontDescriptor: FontName: EBGBEF+OpenSans Flags: FixedPitch, Nonsymbolic FontBBox: -549, -270, 1204, 1047 FontFile2: true Font: BaseFont: GPZZTI+ArialUnicodeMS CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: ArialUnicodeMS Flags: Nonsymbolic FontBBox: -1011, -330, 2260, 1078 FontFile2: true XMP: application/pdf 10.1080/14740338.2022.2019705 Vortioxetine in major depressive disorder: from mechanisms of action to clinical studies. An updated review Javier De Diego-Adeliño José Manuel Crespo Fernando Mora Adrián Neyra Pedro Iborra Luis Gutiérrez-Rojas Selman F. Salonia Taylor & Francis Expert Opinion on Drug Safety, 2022. doi:10.1080/14740338.2022.2019705 Antidepressant cognition efficacy interactions major depressive disorder neurotransmission pharmacology safety vortioxetine en Journal Expert Opinion on Drug Safety © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 1474-0338 1744-764X 21 5 673 690 10.1080/14740338.2022.2019705 https://doi.org/10.1080/14740338.2022.2019705 VoR 10.1080/14740338.2022.2019705 2021-12-29 True www.tandfonline.com 10.1080/14740338.2022.2019705 2021-12-29 True www.tandfonline.com Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 156, 42, 478, 51 Annotation: Subtype: Link Rect: 283, 688, 437, 696 Annotation: Subtype: Link Rect: 300, 475, 455, 485 Annotation: Subtype: Link Rect: 202, 455, 427, 465 Annotation: Subtype: Link Rect: 106, 356, 124, 365 Annotation: Subtype: Link Rect: 131, 356, 286, 365 Annotation: Subtype: Link Rect: 106, 309, 122, 318 Annotation: Subtype: Link Rect: 131, 313, 230, 322 Annotation: Subtype: Link Rect: 326, 306, 344, 315 Annotation: Subtype: Link Rect: 351, 313, 452, 322 Annotation: Subtype: Link Rect: 106, 267, 124, 276 Annotation: Subtype: Link Rect: 131, 270, 292, 279 Page: Label: 1 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 154, 641, 165, 652 Flags: Print Annotation: Subtype: Link Rect: 165, 641, 168, 652 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 261, 641, 265, 652 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 338, 641, 349, 652 Flags: Print Annotation: Subtype: Link Rect: 349, 641, 352, 652 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 414, 641, 418, 652 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 478, 641, 489, 652 Flags: Print Annotation: Subtype: Link Rect: 489, 641, 492, 652 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 71, 629, 82, 640 Flags: Print Annotation: Subtype: Link Rect: 82, 629, 84, 640 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 84, 629, 84, 640 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 186, 629, 190, 640 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 178, 298, 183, 308 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 186, 214, 191, 224 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 289, 202, 294, 212 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 282, 190, 287, 200 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 289, 190, 294, 200 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 50, 142, 55, 152 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 57, 142, 62, 152 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 211, 118, 216, 128 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 427, 298, 432, 308 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 434, 298, 444, 308 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 535, 250, 545, 260 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 547, 250, 556, 260 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 313, 178, 323, 188 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 459, 744, 561, 751 Flags: Print Annotation: Subtype: Link Rect: 500, 702, 561, 714 Flags: Print Page: Label: 2 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 50, 443, 60, 452 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 63, 371, 73, 380 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 50, 335, 60, 344 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 183, 299, 197, 308 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 197, 299, 207, 308 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 231, 191, 241, 200 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 252, 155, 262, 164 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 264, 155, 274, 164 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 223, 83, 233, 92 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 97, 59, 106, 68 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 429, 629, 443, 638 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 443, 629, 453, 638 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 447, 617, 457, 626 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 459, 617, 468, 626 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 470, 617, 480, 626 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 543, 581, 552, 590 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 515, 521, 530, 530 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 530, 521, 539, 530 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 499, 497, 513, 506 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 513, 497, 523, 506 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 547, 435, 556, 444 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 437, 351, 447, 360 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 354, 291, 364, 300 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 537, 255, 547, 264 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 345, 207, 355, 216 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 500, 207, 510, 216 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 313, 159, 323, 168 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 325, 159, 334, 168 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 453, 123, 463, 132 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 468, 87, 478, 96 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 353, 51, 363, 60 Flags: Print Destination: 1 Page: Label: 3 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 257, 731, 267, 740 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 142, 707, 152, 716 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 108, 659, 118, 668 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 68, 623, 78, 632 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 284, 587, 294, 596 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 159, 371, 168, 380 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 72, 311, 82, 320 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 230, 275, 240, 284 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 85, 227, 94, 236 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 235, 227, 245, 236 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 123, 191, 133, 200 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 350, 695, 360, 704 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 379, 659, 389, 668 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 391, 659, 400, 668 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 432, 599, 441, 608 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 443, 599, 453, 608 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 455, 599, 465, 608 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 547, 401, 556, 411 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 547, 377, 556, 387 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 362, 353, 372, 363 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 379, 317, 388, 327 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 470, 317, 499, 327 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 467, 269, 477, 279 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 408, 233, 441, 243 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 505, 233, 515, 243 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 394, 158, 404, 168 Flags: Print Destination: 1 Page: Label: 4 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 171, 462, 181, 472 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 92, 450, 96, 460 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 131, 438, 141, 448 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 242, 306, 275, 316 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 284, 306, 294, 316 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 50, 210, 60, 220 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 227, 174, 237, 184 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 202, 102, 212, 112 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 214, 102, 223, 112 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 176, 42, 185, 52 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 187, 42, 197, 52 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 313, 426, 323, 436 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 403, 366, 413, 376 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 398, 318, 407, 328 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 345, 294, 355, 304 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 472, 258, 482, 268 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 416, 186, 426, 196 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 547, 174, 556, 184 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 493, 138, 503, 148 Flags: Print Destination: 1 Page: Label: 5 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 80, 240, 90, 249 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 256, 180, 266, 189 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 284, 132, 294, 141 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 70, 84, 80, 93 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 284, 60, 294, 69 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 523, 180, 533, 189 Flags: Print Destination: 1 Page: Label: 6 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 50, 515, 55, 525 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 126, 491, 136, 501 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 138, 491, 147, 501 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 160, 431, 193, 441 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 201, 431, 211, 441 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 70, 251, 80, 261 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 272, 191, 282, 201 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 284, 191, 294, 201 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 201, 83, 211, 93 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 519, 491, 529, 501 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 547, 443, 556, 453 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 395, 395, 429, 405 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 437, 395, 447, 405 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 384, 335, 394, 345 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 492, 203, 502, 213 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 490, 155, 500, 165 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 313, 107, 323, 117 Flags: Print Destination: 1 Page: Label: 7 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 272, 323, 281, 332 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 284, 323, 293, 332 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 255, 263, 264, 272 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 267, 263, 277, 272 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 226, 191, 235, 200 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 237, 191, 247, 200 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 182, 119, 192, 128 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 194, 119, 203, 128 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 74, 47, 83, 56 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 362, 179, 372, 188 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 433, 83, 443, 92 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 329, 47, 338, 56 Flags: Print Destination: 1 Page: Label: 8 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 235, 659, 245, 668 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 284, 527, 294, 536 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 286, 503, 295, 512 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 259, 479, 269, 488 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 271, 479, 281, 488 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 171, 395, 181, 404 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 131, 227, 140, 236 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 272, 215, 282, 224 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 284, 215, 294, 224 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 119, 155, 129, 164 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 131, 155, 140, 164 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 184, 83, 194, 92 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 519, 635, 528, 644 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 380, 467, 390, 476 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 352, 383, 367, 392 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 443, 347, 457, 356 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 542, 179, 556, 188 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 353, 143, 368, 152 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 370, 143, 385, 152 Flags: Print Destination: 1 Page: Label: 9 Sequence: 10 Annotations: Annotation: Subtype: Link Rect: 109, 407, 124, 416 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 117, 323, 132, 332 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 279, 251, 294, 260 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 265, 47, 280, 56 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 528, 215, 538, 224 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 438, 167, 452, 176 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 383, 131, 398, 140 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 400, 131, 414, 140 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 508, 59, 542, 68 Flags: Print Destination: 1 Page: Label: 10 Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 256, 719, 271, 728 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 50, 587, 65, 596 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 67, 587, 81, 596 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 279, 406, 294, 415 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 130, 322, 144, 331 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 215, 190, 229, 199 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 256, 46, 271, 55 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 273, 46, 287, 55 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 313, 616, 323, 626 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 405, 592, 414, 602 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 423, 544, 438, 554 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 468, 472, 498, 482 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 506, 472, 521, 482 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 495, 304, 509, 314 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 372, 244, 387, 254 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 368, 184, 382, 194 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 384, 184, 399, 194 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 539, 148, 554, 158 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 542, 88, 556, 98 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 342, 40, 357, 50 Flags: Print Destination: 1 Page: Label: 11 Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 124, 424, 138, 434 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 216, 376, 231, 386 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 233, 376, 248, 386 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 214, 280, 228, 290 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 59, 269, 89, 278 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 441, 448, 450, 458 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 452, 448, 462, 458 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 335, 352, 350, 362 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 391, 292, 405, 302 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 511, 269, 540, 278 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 446, 244, 461, 254 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 368, 197, 378, 206 Flags: Print Destination: 1 Page: Label: 12 Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 171, 719, 186, 728 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 117, 683, 132, 692 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 166, 599, 181, 608 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 180, 563, 194, 572 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 50, 491, 65, 500 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 279, 431, 293, 440 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 50, 407, 65, 416 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 270, 239, 285, 248 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 279, 191, 294, 200 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 313, 700, 323, 710 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 352, 664, 362, 674 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 444, 604, 454, 614 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 455, 604, 465, 614 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 467, 604, 481, 614 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 445, 520, 455, 530 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 472, 398, 482, 408 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 443, 276, 458, 286 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 413, 204, 423, 214 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 542, 180, 556, 190 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 470, 60, 485, 70 Flags: Print Destination: 1 Page: Label: 13 Sequence: 14 Annotations: Annotation: Subtype: Link Rect: 65, 611, 80, 620 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 194, 551, 204, 560 Flags: Print Destination: 1 Page: Label: 14 Sequence: 15 Annotations: Annotation: Subtype: Link Rect: 378, 115, 395, 123 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 442, 95, 458, 103 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 492, 95, 561, 103 Flags: Print Annotation: Subtype: Link Rect: 334, 85, 447, 93 Flags: Print Annotation: Subtype: Link Rect: 334, 55, 351, 63 Flags: Print Destination: 1 Page: Label: 15 Sequence: 16 Annotations: Annotation: Subtype: Link Rect: 72, 722, 88, 730 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 268, 702, 284, 710 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 110, 662, 126, 670 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 166, 632, 183, 640 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 72, 592, 88, 600 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 98, 562, 114, 570 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 72, 532, 88, 540 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 139, 492, 156, 500 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 85, 462, 102, 470 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 110, 402, 126, 410 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 272, 372, 288, 380 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 114, 322, 130, 330 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 272, 302, 288, 310 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 195, 262, 211, 270 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 195, 242, 212, 250 Flags: Print Destination: External Annotation: Subtype: Link Rect: 272, 212, 288, 220 Flags: Print Destination: External Annotation: Subtype: Link Rect: 160, 172, 176, 180 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 126, 122, 142, 130 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 261, 82, 278, 90 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 466, 721, 482, 729 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 391, 711, 561, 719 Flags: Print Annotation: Subtype: Link Rect: 334, 701, 434, 709 Flags: Print Annotation: Subtype: Link Rect: 535, 681, 551, 689 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 352, 641, 368, 649 Flags: Print Destination: External Annotation: Subtype: Link Rect: 487, 611, 504, 619 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 392, 581, 408, 589 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 334, 541, 351, 549 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 350, 501, 366, 509 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 471, 461, 487, 469 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 334, 421, 351, 429 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 334, 381, 351, 389 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 429, 351, 445, 359 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 400, 321, 416, 329 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 483, 291, 499, 299 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 426, 261, 442, 269 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 380, 201, 396, 209 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 380, 181, 396, 189 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 411, 151, 427, 159 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 479, 121, 495, 129 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 437, 91, 454, 99 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 463, 51, 479, 59 Flags: Print Destination: 1 Page: Label: 16 Sequence: 17 Annotations: Annotation: Subtype: Link Rect: 272, 692, 288, 700 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 272, 652, 288, 660 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 117, 602, 133, 610 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 210, 562, 227, 570 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 185, 502, 201, 510 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 246, 462, 262, 470 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 72, 432, 88, 440 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 179, 392, 196, 400 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 179, 322, 196, 330 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 173, 292, 190, 300 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 171, 242, 188, 250 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 225, 202, 241, 210 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 97, 122, 114, 130 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 180, 82, 197, 90 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 163, 52, 179, 60 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 388, 692, 405, 700 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 334, 652, 351, 660 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 462, 612, 479, 620 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 424, 582, 441, 590 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 531, 552, 547, 560 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 484, 502, 501, 510 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 470, 482, 486, 490 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 391, 442, 408, 450 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 367, 392, 384, 400 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 372, 342, 389, 350 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 535, 312, 551, 320 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 461, 262, 477, 270 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 497, 232, 514, 240 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 334, 202, 351, 210 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 334, 162, 351, 170 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 404, 132, 420, 140 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 535, 102, 551, 110 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 535, 62, 551, 70 Flags: Print Destination: 1 Page: Label: 17 Sequence: 18 Annotations: Annotation: Subtype: Link Rect: 111, 702, 128, 710 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 210, 682, 227, 690 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 272, 642, 288, 650 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 212, 592, 229, 600 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 91, 542, 107, 550 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 178, 502, 194, 510 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 115, 472, 132, 480 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 220, 452, 236, 460 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 115, 422, 132, 430 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 215, 382, 232, 390 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 150, 332, 167, 340 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 72, 292, 88, 300 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 125, 242, 142, 250 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 131, 212, 147, 220 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 178, 182, 194, 190 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 72, 132, 88, 140 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 231, 102, 248, 110 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 270, 102, 298, 110 Flags: Print Annotation: Subtype: Link Rect: 72, 92, 142, 100 Flags: Print Annotation: Subtype: Link Rect: 113, 62, 130, 70 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 388, 722, 405, 730 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 535, 692, 551, 700 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 495, 652, 511, 660 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 334, 602, 351, 610 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 483, 572, 500, 580 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 391, 542, 407, 550 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 535, 522, 551, 530 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 407, 482, 424, 490 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 353, 442, 370, 450 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 431, 402, 447, 410 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 334, 352, 351, 360 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 531, 332, 548, 340 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 494, 322, 561, 330 Flags: Print Annotation: Subtype: Link Rect: 334, 312, 538, 320 Flags: Print Annotation: Subtype: Link Rect: 334, 302, 400, 310 Flags: Print Annotation: Subtype: Link Rect: 408, 272, 424, 280 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 334, 242, 351, 250 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 464, 212, 481, 220 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 398, 152, 414, 160 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 508, 122, 525, 130 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 334, 72, 351, 80 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 413, 42, 430, 50 Flags: Print Destination: 1 Page: Label: 18 Sequence: 19 Annotations: Annotation: Subtype: Link Rect: 218, 712, 234, 720 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 101, 672, 118, 680 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 148, 642, 164, 650 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 272, 602, 288, 610 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 98, 552, 114, 560 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 216, 512, 232, 520 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 186, 472, 202, 480 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 272, 452, 288, 460 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 177, 402, 193, 410 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 272, 372, 288, 380 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 112, 332, 128, 340 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 178, 292, 195, 300 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 232, 272, 248, 280 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 334, 722, 351, 730 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 448, 682, 464, 690 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 464, 652, 480, 660 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 539, 612, 555, 620 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 334, 562, 351, 570 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 535, 542, 551, 550 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 374, 492, 391, 500 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 413, 462, 430, 470 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 530, 442, 547, 450 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 470, 402, 486, 410 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 471, 372, 487, 380 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 400, 342, 416, 350 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 368, 312, 385, 320 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 467, 282, 484, 290 Flags: Print Destination: 1 Annotation: Subtype: Link Rect: 351, 252, 368, 260 Flags: Print Destination: 1 Checksum: b0c206c0 Type: CRC32 Checksum: 4272a42976f8daddd09ec53f85605b80 Type: MD5 Checksum: af1344f7b728cefea7baca13446757255c021647 Type: SHA-1