94729d5141a3ade101d96df3c5a23acf  277715.pdf
ab68f9b4383013bba9a01dd1c917925d3ec26a11  277715.pdf
ae4e4da4e894b994ce1c7992451e31defb414858c97181ed60101a5f10a3fd90  277715.pdf

Title:          Observational cohort study of rilpivirine (RPV) utilization in Europe
Subject:        AIDS Research and Therapy, https://doi.org/10.1186/s12981-022-00457-0
Keywords:       Cohort Study; Europe; Edurant™; Eviplera™; Efavirenz; Real-world effectiveness
Author:         Alessandro Cozzi-Lepri 
Creator:        Springer
Producer:       Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
CreationDate:   Sat Aug  6 16:45:45 2022 CEST
ModDate:        Sat Aug  6 18:16:26 2022 CEST
Tagged:         no
UserProperties: no
Suspects:       no
Form:           AcroForm
JavaScript:     no
Pages:          12
Encrypted:      no
Page size:      595.276 x 790.866 pts
Page rot:       0
File size:      799060 bytes
Optimized:      no
PDF version:    1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MyriadPro-Regular                    Type 1C           Custom           yes no  yes     40  0
MyriadPro-Bold                       Type 1C           WinAnsi          yes no  yes     46  0
MyriadPro-It                         Type 1C           Custom           yes no  yes     42  0
VUCYRH+OpenSans                      Type 1C           WinAnsi          yes yes no     356  0
WarnockPro-Regular                   Type 1C           Custom           yes no  yes     41  0
MyriadPro-Semibold                   Type 1C           Custom           yes no  yes     45  0
MyriadPro-Light                      Type 1C           Custom           yes no  yes     65  0
LQSUMB+STIXMath-Regular              Type 1C           WinAnsi          yes yes yes     44  0
IIVMUK+MTSY                          Type 1C           Custom           yes yes yes     43  0
MyriadPro-Regular2                   Type 1C           WinAnsi          yes no  yes    266  0
MyriadPro-LightIt                    Type 1C           WinAnsi          yes no  yes     74  0
UUFTDJ+Calibri                       Type 1C           WinAnsi          yes yes no     104  0
UUFTDJ+Calibri-Bold                  Type 1C           WinAnsi          yes yes no     105  0
UUFTDJ+ArialMT                       Type 1C           WinAnsi          yes yes no     106  0
CKYZQT+OpenSans-Extrabold            Type 1C           WinAnsi          yes yes no     228  0
CKYZQT+OpenSans-Bold                 Type 1C           WinAnsi          yes yes no     235  0
CKYZQT+OpenSans-Light                Type 1C           Custom           yes yes no     232  0
CKYZQT+OregonLDOBookSinistral        Type 1C           WinAnsi          yes yes no     238  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2023-07-21 02:36:35 CEST
 RepresentationInformation: 277715.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2023-07-20 15:32:24 CEST
  Size: 799060
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 452
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: EN
    Outlines: 
     Item: 
      Title: Observational cohort study of rilpivirine (RPV) utilization in Europe
      Children: 
       Item: 
        Title: Abstract 
        Children: 
         Item: 
          Title: Introduction: 
         Item: 
          Title: Methods: 
         Item: 
          Title: Results: 
         Item: 
          Title: Conclusion: 
       Item: 
        Title: Introduction
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Study design
         Item: 
          Title: Data quality assurance
         Item: 
          Title: Study population
         Item: 
          Title: Statistical analysis
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Study population
         Item: 
          Title: ARV treatment status
         Item: 
          Title: Viral load and HIV drug resistance monitoring
         Item: 
          Title: Adverse events
       Item: 
        Title: Discussion
       Item: 
        Title: Acknowledgements
       Item: 
        Title: References
   Info: 
    Title: Observational cohort study of rilpivirine (RPV) utilization in Europe
    Author: Alessandro Cozzi-Lepri 
    Subject: AIDS Research and Therapy, https://doi.org/10.1186/s12981-022-00457-0
    Keywords: Cohort Study; Europe; Edurant™; Eviplera™; Efavirenz; Real-world effectiveness
    Creator: Springer
    Producer: Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)
    CreationDate: Sat Aug 06 17:15:45 CEST 2022
    ModDate: Sat Aug 06 18:16:26 CEST 2022
   ID: 0x033c56c52ad4f468be6e2a5d4ee0e445, 0x60fd2ed2ffd101bf9d2b9306e2a5316f
   Filters: 
    FilterPipeline: FlateDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 39
      ImageHeight: 39
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 40
      ImageHeight: 76
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 81
      ImageHeight: 84
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 39
      ImageHeight: 74
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 39
      ImageHeight: 76
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Decode: 0, 255
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 898
      ImageHeight: 682
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type1: 
     Font: 
      BaseFont: MyriadPro-Light
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Light
       Flags: Nonsymbolic
       FontBBox: -49, -250, 1046, 883
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: VUCYRH+OpenSans
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: VUCYRH+OpenSans
       Flags: Nonsymbolic
       FontBBox: -550, -271, 1204, 1048
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MyriadPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: UUFTDJ+Calibri
      FontSubset: true
      FirstChar: 32
      LastChar: 57
      FontDescriptor: 
       FontName: UUFTDJ+Calibri
       Flags: Nonsymbolic
       FontBBox: -503, -307, 1240, 964
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: WarnockPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -177, -533, 1474, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: UUFTDJ+Calibri-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 116
      FontDescriptor: 
       FontName: UUFTDJ+Calibri-Bold
       Flags: Nonsymbolic
       FontBBox: -519, -306, 1240, 971
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: MyriadPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-It
       Flags: Nonsymbolic, Italic
       FontBBox: -185, -250, 1090, 953
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-LightIt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-LightIt
       Flags: Nonsymbolic, Italic
       FontBBox: -121, -250, 1007, 863
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: UUFTDJ+ArialMT
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: UUFTDJ+ArialMT
       Flags: Nonsymbolic
       FontBBox: -222, -325, 1072, 1037
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: IIVMUK+MTSY
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: IIVMUK+MTSY
       Flags: Symbolic
       FontBBox: 0, -954, 1043, 796
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: LQSUMB+STIXMath-Regular
      FontSubset: true
      FirstChar: 32
      LastChar: 153
      FontDescriptor: 
       FontName: LQSUMB+STIXMath-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -524, 3238, 2566
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
   XMP: <x:xmpmeta x:xmptk="Adobe XMP Core 5.6-c142 87.162696, 2019/10/10-02:41:22        " xmlns:x="adobe:ns:meta/">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:crossmark="http://crossref.org/crossmark/1.0/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:jav="http://www.niso.org/schemas/jav/1.0/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#" xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/">
         <xmp:CreateDate>2022-08-06T20:15:45+05:30</xmp:CreateDate>
         <xmp:CreatorTool>Springer</xmp:CreatorTool>
         <xmp:ModifyDate>2022-08-06T18:16:26+02:00</xmp:ModifyDate>
         <xmp:MetadataDate>2022-08-06T18:16:26+02:00</xmp:MetadataDate>
         <pdf:Producer>Acrobat Distiller 10.1.8 (Windows); modified using iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version)</pdf:Producer>
         <pdf:Keywords>Cohort Study; Europe; Edurant™; Eviplera™; Efavirenz; Real-world effectiveness</pdf:Keywords>
         <dc:format>application/pdf</dc:format>
         <dc:identifier>https://doi.org/10.1186/s12981-022-00457-0</dc:identifier>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>BioMed Central</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">AIDS Research and Therapy, https://doi.org/10.1186/s12981-022-00457-0</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>Cohort Study</rdf:li>
               <rdf:li>Europe</rdf:li>
               <rdf:li>Edurant™</rdf:li>
               <rdf:li>Eviplera™</rdf:li>
               <rdf:li>Efavirenz</rdf:li>
               <rdf:li>Real-world effectiveness</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Observational cohort study of rilpivirine (RPV) utilization in Europe</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Alessandro Cozzi-Lepri </rdf:li>
               <rdf:li>Lars Peters </rdf:li>
               <rdf:li>Annegret Pelchen-Matthews </rdf:li>
               <rdf:li>Bastian Neesgaard </rdf:li>
               <rdf:li>Stephane De Wit</rdf:li>
               <rdf:li>Isik Somuncu Johansen </rdf:li>
               <rdf:li>Simon Edwards </rdf:li>
               <rdf:li>Christoph Stephan </rdf:li>
               <rdf:li>Georgios Adamis </rdf:li>
               <rdf:li>Therese Staub </rdf:li>
               <rdf:li>Alexandra Zagalo </rdf:li>
               <rdf:li>Pere Domingo </rdf:li>
               <rdf:li>Daniel Elbirt </rdf:li>
               <rdf:li>Katharina Kusejko </rdf:li>
               <rdf:li>Johanna Brännström </rdf:li>
               <rdf:li>Dzmitry Paduta </rdf:li>
               <rdf:li>Tatyana Trofimova </rdf:li>
               <rdf:li>Janos Szlavik </rdf:li>
               <rdf:li>Kai Zilmer </rdf:li>
               <rdf:li>Marcello Losso </rdf:li>
               <rdf:li>Veerle Van Eygen</rdf:li>
               <rdf:li>Helen Pai </rdf:li>
               <rdf:li>Jens Lundgren </rdf:li>
               <rdf:li>Amanda Mocroft </rdf:li>
               <rdf:li>A. Harxhi </rdf:li>
               <rdf:li>M. Losso </rdf:li>
               <rdf:li>M. Kundro </rdf:li>
               <rdf:li>B. Schmied </rdf:li>
               <rdf:li>I. Karpov </rdf:li>
               <rdf:li>A. Vassilenko </rdf:li>
               <rdf:li>D. Paduto </rdf:li>
               <rdf:li>V. M. Mitsura </rdf:li>
               <rdf:li>N. Clumeck </rdf:li>
               <rdf:li>S. De Wit</rdf:li>
               <rdf:li>M. Delforge </rdf:li>
               <rdf:li>V. Hadziosmanovic </rdf:li>
               <rdf:li>J. Begovac </rdf:li>
               <rdf:li>L. Machala </rdf:li>
               <rdf:li>D. Jilich </rdf:li>
               <rdf:li>J. Gerstoft </rdf:li>
               <rdf:li>C. Pedersen </rdf:li>
               <rdf:li>D. Sedlacek </rdf:li>
               <rdf:li>G. Kronborg </rdf:li>
               <rdf:li>T. Benfield </rdf:li>
               <rdf:li>I. S. Johansen </rdf:li>
               <rdf:li>L. Ostergaard </rdf:li>
               <rdf:li>L. Wiese </rdf:li>
               <rdf:li>N. F. Moller </rdf:li>
               <rdf:li>L. N. Nielsen </rdf:li>
               <rdf:li>K. Zilmer </rdf:li>
               <rdf:li>Jelena Smidt </rdf:li>
               <rdf:li>I. Aho </rdf:li>
               <rdf:li>J. P. Viard </rdf:li>
               <rdf:li>P. M. Girard </rdf:li>
               <rdf:li>C. Pradier </rdf:li>
               <rdf:li>E. Fontas </rdf:li>
               <rdf:li>C. Duvivier </rdf:li>
               <rdf:li>J. Rockstroh </rdf:li>
               <rdf:li>O. Degen </rdf:li>
               <rdf:li>C. Hoffmann </rdf:li>
               <rdf:li>H. J. Stellbrink </rdf:li>
               <rdf:li>C. Stefan </rdf:li>
               <rdf:li>J. Bogner </rdf:li>
               <rdf:li>G. Fätkenheuer </rdf:li>
               <rdf:li>N. Chkhartishvili </rdf:li>
               <rdf:li>H. Sambatakou </rdf:li>
               <rdf:li>G. Adamis </rdf:li>
               <rdf:li>N. Paissios </rdf:li>
               <rdf:li>V. Uzdaviniene </rdf:li>
               <rdf:li>T. Staub </rdf:li>
               <rdf:li>S. Dragas </rdf:li>
               <rdf:li>P. Reiss </rdf:li>
               <rdf:li>J. Trajanovska </rdf:li>
               <rdf:li>D. H. Reikvam </rdf:li>
               <rdf:li>A. Maeland </rdf:li>
               <rdf:li>J. Bruun </rdf:li>
               <rdf:li>B. Knysz </rdf:li>
               <rdf:li>B. Szetela </rdf:li>
               <rdf:li>M. Inglot </rdf:li>
               <rdf:li>E. Bakowska </rdf:li>
               <rdf:li>R. Flisiak </rdf:li>
               <rdf:li>A. Grzeszczuk </rdf:li>
               <rdf:li>M. Parczewski </rdf:li>
               <rdf:li>K. Maciejewska </rdf:li>
               <rdf:li>B. Aksak-Was </rdf:li>
               <rdf:li>M. Beniowski </rdf:li>
               <rdf:li>E. Mularska </rdf:li>
               <rdf:li>E. Jablonowska </rdf:li>
               <rdf:li>J. Kamerys </rdf:li>
               <rdf:li>K. Wojcik </rdf:li>
               <rdf:li>I. Mozer-Lisewska </rdf:li>
               <rdf:li>B. Rozplochowski </rdf:li>
               <rdf:li>A. Zagalo </rdf:li>
               <rdf:li>R. Radoi </rdf:li>
               <rdf:li>C. Oprea </rdf:li>
               <rdf:li>A. Yakovlev </rdf:li>
               <rdf:li>T. Trofimora </rdf:li>
               <rdf:li>I. Khromova </rdf:li>
               <rdf:li>E. Kuzovatova </rdf:li>
               <rdf:li>E. Borodulina </rdf:li>
               <rdf:li>E. Vdoushkina </rdf:li>
               <rdf:li>J. Ranin </rdf:li>
               <rdf:li>J. Tomazic </rdf:li>
               <rdf:li>J. M. Miro </rdf:li>
               <rdf:li>M. Laguno </rdf:li>
               <rdf:li>E. Martinez </rdf:li>
               <rdf:li>F. Garcia </rdf:li>
               <rdf:li>J. L. Blanco </rdf:li>
               <rdf:li>M. Martinez-Rebollar </rdf:li>
               <rdf:li>J. Mallolas </rdf:li>
               <rdf:li>P. Callau </rdf:li>
               <rdf:li>J. Rojas </rdf:li>
               <rdf:li>S. Moreno </rdf:li>
               <rdf:li>S. del Campo</rdf:li>
               <rdf:li>A. Jou </rdf:li>
               <rdf:li>R. Paredes </rdf:li>
               <rdf:li>J. Puig </rdf:li>
               <rdf:li>J. M. Llibre </rdf:li>
               <rdf:li>J. R. Santos </rdf:li>
               <rdf:li>P. Domingo </rdf:li>
               <rdf:li>M. Gutierrez </rdf:li>
               <rdf:li>G. M. Mateo </rdf:li>
               <rdf:li>A. Sambeat </rdf:li>
               <rdf:li>J. M. Laporte </rdf:li>
               <rdf:li>V. Svedhem </rdf:li>
               <rdf:li>A. Thalme </rdf:li>
               <rdf:li>A. Sonnerborg </rdf:li>
               <rdf:li>L. Flamholc </rdf:li>
               <rdf:li>K. Kusejko </rdf:li>
               <rdf:li>R. Weber </rdf:li>
               <rdf:li>A. Calmy </rdf:li>
               <rdf:li>H. Furrer </rdf:li>
               <rdf:li>M. Battegay </rdf:li>
               <rdf:li>P. Schmid </rdf:li>
               <rdf:li>A. Kuznetsova </rdf:li>
               <rdf:li>J. Mikhalik </rdf:li>
               <rdf:li>M. Sluzhynska </rdf:li>
               <rdf:li>A. Milinkovic </rdf:li>
               <rdf:li>A. M. Johnson </rdf:li>
               <rdf:li>E. Simons </rdf:li>
               <rdf:li>S. Edwards </rdf:li>
               <rdf:li>A. M. Phillips </rdf:li>
               <rdf:li>A. Johnson </rdf:li>
               <rdf:li>A. Mocroft </rdf:li>
               <rdf:li>C. Orkin </rdf:li>
               <rdf:li>A. Winston </rdf:li>
               <rdf:li>A. Clarke </rdf:li>
               <rdf:li>C. Leen </rdf:li>
            </rdf:Seq>
         </dc:creator>
         <crossmark:DOI>10.1186/s12981-022-00457-0</crossmark:DOI>
         <crossmark:MajorVersionDate>2010-04-23</crossmark:MajorVersionDate>
         <crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive>
         <crossmark:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </crossmark:CrossMarkDomains>
         <prism:url>https://doi.org/10.1186/s12981-022-00457-0</prism:url>
         <prism:doi>10.1186/s12981-022-00457-0</prism:doi>
         <prism:issn>1742-6405</prism:issn>
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>AIDS Research and Therapy</prism:publicationName>
         <prism:copyright>The Author(s)</prism:copyright>
         <pdfx:CrossmarkMajorVersionDate>2010-04-23</pdfx:CrossmarkMajorVersionDate>
         <pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive>
         <pdfx:doi>10.1186/s12981-022-00457-0</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:CrossMarkDomains>
            <rdf:Seq>
               <rdf:li>springer.com</rdf:li>
               <rdf:li>springerlink.com</rdf:li>
            </rdf:Seq>
         </pdfx:CrossMarkDomains>
         <jav:journal_article_version>VoR</jav:journal_article_version>
         <xmpMM:DocumentID>uuid:3b692de5-4d92-4fba-b1a0-d1217fbe08df</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:326dcefa-2749-49fd-b661-e2c15ed503e8</xmpMM:InstanceID>
         <xmpMM:RenditionClass>default</xmpMM:RenditionClass>
         <xmpMM:VersionID>1</xmpMM:VersionID>
         <xmpMM:History>
            <rdf:Seq>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:6c22d39e-3571-4e6f-806f-5ccc1b551b88</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2022-08-06T20:16:26+05:30</stEvt:when>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <stEvt:action>converted</stEvt:action>
                  <stEvt:instanceID>uuid:33fd9660-3be9-4d9e-a29d-5bac8d593e7f</stEvt:instanceID>
                  <stEvt:parameters>converted to PDF/A-2b</stEvt:parameters>
                  <stEvt:softwareAgent>pdfToolbox</stEvt:softwareAgent>
                  <stEvt:when>2022-08-06T20:17:05+05:30</stEvt:when>
               </rdf:li>
            </rdf:Seq>
         </xmpMM:History>
         <pdfaid:part>2</pdfaid:part>
         <pdfaid:conformance>B</pdfaid:conformance>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdfx/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfx</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe Document Info PDF eXtension Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:MajorVersionDate</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkMajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:DOI</pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Mirrors crossmark:CrosMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>robots</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>ID of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXVersion</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/X standard</pdfaProperty:description>
                           <pdfaProperty:name>GTS_PDFXConformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Company creating the PDF</pdfaProperty:description>
                           <pdfaProperty:name>Company</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Date when document was last modified</pdfaProperty:description>
                           <pdfaProperty:name>SourceModified</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://crossref.org/crossmark/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>crossmark</pdfaSchema:prefix>
                  <pdfaSchema:schema>Crossmark Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Usual same as prism:doi</pdfaProperty:description>
                           <pdfaProperty:name>DOI</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The date when a publication was publishe.</pdfaProperty:description>
                           <pdfaProperty:name>MajorVersionDate</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossmarkDomainExclusive</pdfaProperty:description>
                           <pdfaProperty:name>CrossmarkDomainExclusive</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>CrossMarkDomains</pdfaProperty:description>
                           <pdfaProperty:name>CrossMarkDomains</pdfaProperty:name>
                           <pdfaProperty:valueType>seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://prismstandard.org/namespaces/basic/2.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>prism</pdfaSchema:prefix>
                  <pdfaSchema:schema>Prism Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary.</pdfaProperty:description>
                           <pdfaProperty:name>url</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). </pdfaProperty:description>
                           <pdfaProperty:name>doi</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version.</pdfaProperty:description>
                           <pdfaProperty:name>issn</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Volume number</pdfaProperty:description>
                           <pdfaProperty:name>volume</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Issue number</pdfaProperty:description>
                           <pdfaProperty:name>number</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Starting page</pdfaProperty:description>
                           <pdfaProperty:name>startingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Ending page</pdfaProperty:description>
                           <pdfaProperty:name>endingPage</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. </pdfaProperty:description>
                           <pdfaProperty:name>aggregationType</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”</pdfaProperty:description>
                           <pdfaProperty:name>publicationName</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Copyright</pdfaProperty:description>
                           <pdfaProperty:name>copyright</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/pdf/1.3/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdf</pdfaSchema:prefix>
                  <pdfaSchema:schema>Adobe PDF Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A name object indicating whether the document has been modified to include trapping information</pdfaProperty:description>
                           <pdfaProperty:name>Trapped</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/mm/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpMM</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Media Management Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>UUID based identifier for specific incarnation of a document</pdfaProperty:description>
                           <pdfaProperty:name>InstanceID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>DocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>The common identifier for all versions and renditions of a document.</pdfaProperty:description>
                           <pdfaProperty:name>OriginalDocumentID</pdfaProperty:name>
                           <pdfaProperty:valueType>URI</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original.</pdfaProperty:description>
                           <pdfaProperty:name>DerivedFrom</pdfaProperty:name>
                           <pdfaProperty:valueType>ResourceRef</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Part#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stPart</pdfaType:prefix>
                           <pdfaType:type>Part</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfa/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfaid</pdfaSchema:prefix>
                  <pdfaSchema:schema>PDF/A ID Schema</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Part of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Amendment of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>amd</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Conformance level of PDF/A standard</pdfaProperty:description>
                           <pdfaProperty:name>conformance</pdfaProperty:name>
                           <pdfaProperty:valueType>Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://ns.adobe.com/xap/1.0/t/pg/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>xmpTPg</pdfaSchema:prefix>
                  <pdfaSchema:schema>XMP Paged-Text</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>A structure containing the characteristics of a font used in a document</pdfaProperty:description>
                           <pdfaProperty:name>Fonts</pdfaProperty:name>
                           <pdfaProperty:valueType>Bag Font</pdfaProperty:valueType>
                        </rdf:li>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents).</pdfaProperty:description>
                           <pdfaProperty:name>PlateNames</pdfaProperty:name>
                           <pdfaProperty:valueType>Seq Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
                  <pdfaSchema:valueType>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaType:description>A structure containing the characteristics of a font used in a document.</pdfaType:description>
                           <pdfaType:namespaceURI>http://ns.adobe.com/xap/1.0/sType/Font#</pdfaType:namespaceURI>
                           <pdfaType:prefix>stFnt</pdfaType:prefix>
                           <pdfaType:type>Font</pdfaType:type>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:valueType>
               </rdf:li>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:namespaceURI>http://www.niso.org/schemas/jav/1.0/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>jav</pdfaSchema:prefix>
                  <pdfaSchema:schema>NISO</pdfaSchema:schema>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:category>external</pdfaProperty:category>
                           <pdfaProperty:description>Values for Journal Article Version are one of the following:
AO = Author’s Original
SMUR = Submitted Manuscript Under Review
AM = Accepted Manuscript
P = Proof
VoR = Version of Record
CVoR = Corrected Version of Record
EVoR = Enhanced Version of Record</pdfaProperty:description>
                           <pdfaProperty:name>journal_article_version</pdfaProperty:name>
                           <pdfaProperty:valueType>Closed Choice of Text</pdfaProperty:valueType>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 212, 66, 330, 58
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 486, 66, 530, 58
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 180, 58, 276, 50
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 507, 683, 540, 650
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 160, 692, 165, 680
       Flags: Print
       AppearanceDictionary: true
       Destination: 196
      Annotation: 
       Subtype: Link
       Rect: 187, 596, 191, 584
       Flags: Print
       AppearanceDictionary: true
       Destination: 196
      Annotation: 
       Subtype: Link
       Rect: 197, 596, 202, 584
       Flags: Print
       AppearanceDictionary: true
       Destination: 196
      Annotation: 
       Subtype: Link
       Rect: 59, 500, 69, 488
       Flags: Print
       AppearanceDictionary: true
       Destination: 196
      Annotation: 
       Subtype: Link
       Rect: 75, 500, 85, 488
       Flags: Print
       AppearanceDictionary: true
       Destination: 196
      Annotation: 
       Subtype: Link
       Rect: 275, 320, 285, 308
       Flags: Print
       AppearanceDictionary: true
       Destination: 196
      Annotation: 
       Subtype: Link
       Rect: 152, 296, 290, 284
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 56, 284, 98, 272
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 184, 248, 193, 236
       Flags: Print
       AppearanceDictionary: true
       Destination: 196
      Annotation: 
       Subtype: Link
       Rect: 187, 224, 197, 212
       Flags: Print
       AppearanceDictionary: true
       Destination: 196
      Annotation: 
       Subtype: Link
       Rect: 410, 620, 420, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: 196
      Annotation: 
       Subtype: Link
       Rect: 503, 608, 512, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: 196
      Annotation: 
       Subtype: Link
       Rect: 517, 608, 527, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: 196
      Annotation: 
       Subtype: Link
       Rect: 395, 452, 400, 440
       Flags: Print
       AppearanceDictionary: true
       Destination: 164
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 258, 608, 263, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 350, 680, 355, 668
       Flags: Print
       AppearanceDictionary: true
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 422, 656, 427, 644
       Flags: Print
       AppearanceDictionary: true
       Destination: 48
      Annotation: 
       Subtype: Link
       Rect: 338, 644, 343, 632
       Flags: Print
       AppearanceDictionary: true
       Destination: 69
      Annotation: 
       Subtype: Link
       Rect: 320, 452, 325, 440
       Flags: Print
       AppearanceDictionary: true
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 346, 404, 351, 392
       Flags: Print
       AppearanceDictionary: true
       Destination: 92
     Thumb: true
    Page: 
     Sequence: 4
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 127, 433, 132, 421
       Flags: Print
       AppearanceDictionary: true
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 283, 265, 288, 253
       Flags: Print
       AppearanceDictionary: true
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 474, 493, 479, 481
       Flags: Print
       AppearanceDictionary: true
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 346, 361, 351, 349
       Flags: Print
       AppearanceDictionary: true
       Destination: 97
      Annotation: 
       Subtype: Link
       Rect: 399, 97, 404, 85
       Flags: Print
       AppearanceDictionary: true
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 114, 540, 118, 532
       Flags: Print
       AppearanceDictionary: true
       Destination: 164
     Thumb: true
    Page: 
     Sequence: 6
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 92, 122, 97, 110
       Flags: Print
       AppearanceDictionary: true
       Destination: 115
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 86, 295, 91, 283
       Flags: Print
       AppearanceDictionary: true
       Destination: 133
      Annotation: 
       Subtype: Link
       Rect: 328, 127, 333, 115
       Flags: Print
       AppearanceDictionary: true
       Destination: 196
      Annotation: 
       Subtype: Link
       Rect: 339, 127, 344, 115
       Flags: Print
       AppearanceDictionary: true
       Destination: 196
      Annotation: 
       Subtype: Link
       Rect: 349, 127, 359, 115
       Flags: Print
       AppearanceDictionary: true
       Destination: 196
      Annotation: 
       Subtype: Link
       Rect: 364, 127, 374, 115
       Flags: Print
       AppearanceDictionary: true
       Destination: 196
      Annotation: 
       Subtype: Link
       Rect: 186, 389, 343, 381
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 158, 194, 163, 182
       Flags: Print
       AppearanceDictionary: true
       Destination: 196
      Annotation: 
       Subtype: Link
       Rect: 169, 194, 174, 182
       Flags: Print
       AppearanceDictionary: true
       Destination: 196
      Annotation: 
       Subtype: Link
       Rect: 265, 86, 270, 74
       Flags: Print
       AppearanceDictionary: true
       Destination: 196
      Annotation: 
       Subtype: Link
       Rect: 407, 633, 412, 620
       Flags: Print
       AppearanceDictionary: true
       Destination: 196
      Annotation: 
       Subtype: Link
       Rect: 419, 633, 424, 620
       Flags: Print
       AppearanceDictionary: true
       Destination: 196
      Annotation: 
       Subtype: Link
       Rect: 321, 621, 326, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: 164
      Annotation: 
       Subtype: Link
       Rect: 452, 609, 463, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: 196
      Annotation: 
       Subtype: Link
       Rect: 469, 609, 479, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: 196
      Annotation: 
       Subtype: Link
       Rect: 384, 429, 389, 416
       Flags: Print
       AppearanceDictionary: true
       Destination: 196
      Annotation: 
       Subtype: Link
       Rect: 395, 429, 400, 416
       Flags: Print
       AppearanceDictionary: true
       Destination: 196
      Annotation: 
       Subtype: Link
       Rect: 506, 393, 511, 380
       Flags: Print
       AppearanceDictionary: true
       Destination: 196
      Annotation: 
       Subtype: Link
       Rect: 517, 393, 522, 380
       Flags: Print
       AppearanceDictionary: true
       Destination: 196
      Annotation: 
       Subtype: Link
       Rect: 414, 309, 424, 296
       Flags: Print
       AppearanceDictionary: true
       Destination: 196
     Thumb: true
    Page: 
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 233, 585, 238, 572
       Flags: Print
       AppearanceDictionary: true
       Destination: 196
      Annotation: 
       Subtype: Link
       Rect: 244, 585, 249, 572
       Flags: Print
       AppearanceDictionary: true
       Destination: 196
      Annotation: 
       Subtype: Link
       Rect: 496, 510, 529, 501
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 304, 501, 404, 492
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 306, 613, 367, 605
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 440, 472, 519, 464
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 304, 463, 525, 450
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 304, 454, 375, 446
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 71, 685, 284, 677
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 676, 85, 668
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 235, 109, 289, 101
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 100, 175, 92
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 474, 694, 529, 686
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 685, 409, 677
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 421, 676, 515, 668
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 419, 667, 473, 659
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 658, 492, 650
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: bbf2fd58
   Type: CRC32
  Checksum: 94729d5141a3ade101d96df3c5a23acf
   Type: MD5
  Checksum: ab68f9b4383013bba9a01dd1c917925d3ec26a11
   Type: SHA-1