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edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 's0090' cannot be found Offset: 8930833 MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 844 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Development of a mouse model for spontaneous oral squamous cell carcinoma in Fanconi anemia Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Materials and methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Children: Item: Title: Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Tumor sequencing from FA patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Mice Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Histopathology and Immunohistochemistry Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Survival curves Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Children: Item: Title: Oral squamous carcinomas from Fanconi anemia patients display mutations in TP53 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Fanca/p53EPI and p53EPI animals develop spontaneous squamous cell carcinomas in the oral cavity (OSCC) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: OSCC from FA patients and mice express squamous differentiation markers Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: Other malignancies in p53EPI and Fanca/p53EPI mice Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: Fanca mice display frequent pre-tumoral lesions in the oral cavity Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Declaration of Competing Interest Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Funding Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: Appendix A Supplementary material Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Info: Title: Development of a mouse model for spontaneous oral squamous cell carcinoma in Fanconi anemia Author: Ricardo Errazquin Subject: Oral Oncology, 134 (2022) 106184. doi:10.1016/j.oraloncology.2022.106184 Keywords: Fanconi anemia,Head and neck squamous cell carcinoma,Oral squamous cell carcinoma,Mouse model,Oral mucosa,FANCA,TP53,Trp53,p53,Mutation Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Tue Oct 11 17:27:28 CEST 2022 ModDate: Wed Oct 12 02:11:31 CEST 2022 ID: 0x0f885fe0d0d3144870acc92b5d33caf1, 0x31ea58bff56066c970e182eb1e31d909 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 236 ImageHeight: 298 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 248 ImageHeight: 271 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: JIWJJJ+CharisSIL-Italic Encoding: Identity-H ToUnicode: true Font: BaseFont: QNWJAT+TimesNewRomanPSMT Encoding: Identity-H ToUnicode: true 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FontName: QNWJAT+TimesNewRomanPSMT Flags: Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile2: true Font: BaseFont: PBKGAH+CharisSIL-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: PBKGAH+CharisSIL-Bold Flags: Nonsymbolic, ForceBold FontBBox: -720, -533, 1759, 1320 FontFile2: true Font: BaseFont: IFTBOY+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: IFTBOY+CharisSIL Flags: Nonsymbolic FontBBox: -692, -533, 1623, 1319 FontFile2: true Font: BaseFont: KXCTRO+CharisSIL-BoldItalic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: KXCTRO+CharisSIL-BoldItalic Flags: Nonsymbolic, Italic, ForceBold FontBBox: -741, -533, 1795, 1320 FontFile2: true XMP: application/pdf 10.1016/j.oraloncology.2022.106184 Elsevier Ltd Oral Oncology, 134 (2022) 106184. doi:10.1016/j.oraloncology.2022.106184 Fanconi anemia Head and neck squamous cell carcinoma Oral squamous cell carcinoma Mouse model Oral mucosa FANCA TP53 Trp53 p53 Mutation Development of a mouse model for spontaneous oral squamous cell carcinoma in Fanconi anemia Ricardo Errazquin Angustias Page Anna Suñol Carmen Segrelles Estela Carrasco Jorge Peral Alicia Garrido-Aranda Sonia Del Marro Jessica Ortiz Corina Lorz Jordi Minguillon Jordi Surralles Cristina Belendez Martina Alvarez Judith Balmaña Ana Bravo Angel Ramirez Ramon Garcia-Escudero journal Oral Oncology © 2022 The Authors. 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