e03dd5d79ae9c36842059b2d8c461233 280886.pdf 48880e990d54dfb449bb1c6fe4dc81bcf01737c6 280886.pdf f2d897e6622bb55b58a5207b346c36de51c454d56258ad192b63767050d2b3a2 280886.pdf Title: Genome-Wide Studies in Ischaemic Stroke: Are Genetics Only Useful for Finding Genes? Subject: Ischaemic stroke is a complex disease with some degree of heritability. This means that heritability factors, such as genetics, could be risk factors for ischaemic stroke. The era of genome-wide studies has revealed some of these heritable risk factors, although the data generated by these studies may also be useful in other disciplines. Analysis of these data can be used to understand the biological mechanisms associated with stroke risk and stroke outcome, to determine the causality between stroke and other diseases without the need for expensive clinical trials, or to find potential drug targets with higher success rates than other strategies. In this review we will discuss several of the most relevant studies regarding the genetics of ischaemic stroke and the potential use of the data generated. Keywords: stroke; GWAS; epigenetics; microbiome Author: Cristina Gallego-Fabrega, Elena Muiño, Jara Cárcel-Márquez, Laia Llucià-Carol, Miquel Lledós, Jesús M. Martín-Campos, Natalia Cullell and Israel Fernández-Cadenas Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Mon Jun 20 17:09:52 2022 CEST ModDate: Mon Jun 20 17:13:58 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 25 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 864585 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- CCDETI+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 TZTLZP+VnURWPalladioL Type 1 Custom yes yes no 15 0 CWANHE+URWPalladioL-Bold Type 1 Custom yes yes no 19 0 WVWTBU+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 GQFERJ+URWPalladioL-Ital Type 1 Custom yes yes no 28 0 IRWHZX+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 46 0 CKUPDE+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 49 0 PICMNH+PalatinoLinotype-Bold CID TrueType Identity-H yes yes yes 78 0 PICMPI+PalatinoLinotype-Roman CID TrueType Identity-H yes yes yes 84 0 PICNBI+PalatinoLinotype-Italic CID TrueType Identity-H yes yes yes 90 0 PICNBJ+PalatinoLinotype-Italic TrueType WinAnsi yes yes no 96 0 PICNBK+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 99 0 PICNCK+PalatinoLinotype-Roman TrueType WinAnsi yes yes no 102 0 MPUDFL+PazoMath Type 1 Builtin yes yes no 113 0 QDCWHF+EURM10 Type 1 Builtin yes yes no 123 0 KSGJNG+CMSY10 Type 1 Builtin yes yes no 127 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-08-01 02:35:52 CEST RepresentationInformation: 280886.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-07-31 12:17:07 CEST Size: 864585 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 885 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@44c8afef Item: Title: Genetics of Ischaemic Stroke Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7b69c6ba Item: Title: Genetics of Stroke Outcome Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@46daef40 Item: Title: Multi-Trait Analysis of GWAS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@12f41634 Item: Title: Mendelian Randomization in Stroke Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13c27452 Item: Title: Stroke Pharmacogenomics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Children: Item: Title: Acute IS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Item: Title: Secondary Prevention: Oral Anticoagulants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Children: Item: Title: Warfarin Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Acenocoumarol Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Dabigatran Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Secondary Prevention: Antiplatelet Drugs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Children: Item: Title: Acetyl Salicylic Acid Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Clopidogrel Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Secondary Prevention: Statins Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: Future Omics Studies in Stroke Research Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Children: Item: Title: Stroke Epigenetics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Children: Item: Title: DNA Methylation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Item: Title: Histone Modifications Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Item: Title: Non-Coding RNA Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: Gut Microbiome Studies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Info: Title: Genome-Wide Studies in Ischaemic Stroke: Are Genetics Only Useful for Finding Genes? Author: Cristina Gallego-Fabrega, Elena Muiño, Jara Cárcel-Márquez, Laia Llucià-Carol, Miquel Lledós, Jesús M. Martín-Campos, Natalia Cullell and Israel Fernández-Cadenas Subject: Ischaemic stroke is a complex disease with some degree of heritability. This means that heritability factors, such as genetics, could be risk factors for ischaemic stroke. The era of genome-wide studies has revealed some of these heritable risk factors, although the data generated by these studies may also be useful in other disciplines. Analysis of these data can be used to understand the biological mechanisms associated with stroke risk and stroke outcome, to determine the causality between stroke and other diseases without the need for expensive clinical trials, or to find potential drug targets with higher success rates than other strategies. In this review we will discuss several of the most relevant studies regarding the genetics of ischaemic stroke and the potential use of the data generated. 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