2d76257dbd36aa1fa03a4ccb641d6c57 282271.pdf 786bbd6ab2945c45c9e2ee9e690a7bda4dd88e6d 282271.pdf 33bd4c3322eca94e7bbbb313142d339552a48c28077e09633e879262bc10f0eb 282271.pdf Title: IL-1 Family Cytokines in Inflammatory Dermatoses: Pathogenetic Role and Potential Therapeutic Implications Subject: The interleukin-1 (IL-1) family is involved in the correct functioning and regulation of the innate immune system, linking innate and adaptative immune responses. This complex family is composed by several cytokines, receptors, and co-receptors, all working in a balanced way to maintain homeostasis. Dysregulation of these processes results in tissue inflammation and is involved in the pathogenesis of common inflammatory dermatoses such as psoriasis, hidradenitis suppurativa, and atopic dermatitis. Therefore, therapeutic targeting of IL-1 pathways has been studied, and several monoclonal antibodies are currently being assessed in clinical trials. So far, promising results have been obtained with anti-IL-36R spesolimab and imsidolimab in pustular psoriasis, and their efficacy is being tested in other conditions. Keywords: psoriasis; pustular psoriasis; hidradenitis suppurativa; atopic dermatitis; imsidolimab; spesolimab; bermekimab; etokimab; IL-36; IL-36R; IL-1; IL-33; pathogenesis Author: Helena Iznardo and Luís Puig Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Mon Aug 22 12:51:50 2022 CEST ModDate: Mon Aug 22 12:58:02 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 908283 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- HCBGQO+VnURWPalladioL Type 1 Custom yes yes no 10 0 TAASTJ+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 VEJFLR+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 RUAROD+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 ASHNOE+EURM10 Type 1 Builtin yes yes no 28 0 WLENKM+VnURWPalladioL-Bold Type 1 Custom yes yes no 32 0 IRWHZX+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 50 0 CKUPDE+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 53 0 ABCDEE+Palatino Linotype,Bold TrueType WinAnsi yes yes no 82 0 ABCDEE+Palatino Linotype TrueType WinAnsi yes yes no 86 0 ABCDEE+Palatino Linotype,Italic TrueType WinAnsi yes yes no 90 0 ABCDEE+Palatino Linotype CID TrueType Identity-H yes yes yes 94 0 BBETNX+PazoMath Type 1 Builtin yes yes no 136 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-09-23 02:33:44 CEST RepresentationInformation: 282271.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-09-22 14:42:01 CEST Size: 908283 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 515 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: IL-1 Family Cytokines, Receptors and Co-Receptors Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Children: Item: Title: IL-1 Subfamily Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: IL-18 Subfamily Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: IL-33 Subfamily Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: IL-36 Subfamily Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: IL-37 and IL-38: Antagonist Cytokines Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Involvement of IL-1 Family Cytokines in Inflammatory Dermatoses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Children: Item: Title: Psoriasis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Atopic Dermatitis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: Hidradenitis Suppurativa Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Item: Title: Other Dermatoses Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Item: Title: Therapeutic Targeting of IL-1 Family Cytokines Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@76a3e297 Children: Item: Title: IL-1 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4d3167f4 Item: Title: IL-18 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@ed9d034 Item: Title: IL-33 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6121c9d6 Item: Title: IL-36 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@87f383f Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4eb7f003 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@eafc191 Info: Title: IL-1 Family Cytokines in Inflammatory Dermatoses: Pathogenetic Role and Potential Therapeutic Implications Author: Helena Iznardo and Luís Puig Subject: The interleukin-1 (IL-1) family is involved in the correct functioning and regulation of the innate immune system, linking innate and adaptative immune responses. This complex family is composed by several cytokines, receptors, and co-receptors, all working in a balanced way to maintain homeostasis. Dysregulation of these processes results in tissue inflammation and is involved in the pathogenesis of common inflammatory dermatoses such as psoriasis, hidradenitis suppurativa, and atopic dermatitis. Therefore, therapeutic targeting of IL-1 pathways has been studied, and several monoclonal antibodies are currently being assessed in clinical trials. So far, promising results have been obtained with anti-IL-36R spesolimab and imsidolimab in pustular psoriasis, and their efficacy is being tested in other conditions. Keywords: psoriasis; pustular psoriasis; hidradenitis suppurativa; atopic dermatitis; imsidolimab; spesolimab; bermekimab; etokimab; IL-36; IL-36R; IL-1; IL-33; pathogenesis Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Mon Aug 22 12:51:50 CEST 2022 ModDate: Mon Aug 22 12:58:02 CEST 2022 ID: 0xadd94fa61e62f6b5ebe18d58c9541f8b, 0xadd94fa61e62f6b5ebe18d58c9541f8b Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: WLENKM+VnURWPalladioL-Bold FontSubset: true FirstChar: 189 LastChar: 189 FontDescriptor: FontName: WLENKM+VnURWPalladioL-Bold Flags: Symbolic FontBBox: -152, -301, 1000, 935 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: VEJFLR+URWPalladioL-Roma FontSubset: true FirstChar: 1 LastChar: 252 FontDescriptor: FontName: VEJFLR+URWPalladioL-Roma Flags: Symbolic FontBBox: -166, -283, 1021, 943 FontFile: true EncodingDictionary: Differences: true Font: BaseFont: RUAROD+URWPalladioL-Ital FontSubset: true FirstChar: 3 LastChar: 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