7c07c0fc85b37755a6dd938934dce2ae 282283.pdf 7b561b4e9b6dd9c39762ca55c0b65aa67050d3d2 282283.pdf 57f1215fe75a5a67af146e91a2d550b6f2c11b24f1ada146fd9b1a512e77a9d9 282283.pdf Title: State‐of‐the‐art of lumbar puncture and its place in the journey of patients with Alzheimer's disease Subject: Alzheimer's & Dementia 2022.18:159-177 Keywords: Author: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 10.0.0 (Windows); modified using iText 4.2.0 by 1T3XT CreationDate: Fri Feb 11 10:56:17 2022 CET ModDate: Mon Oct 2 09:55:11 2023 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 19 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1400677 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- BFAFOI+Lato-Regular Type 1C WinAnsi yes yes no 70 0 BFAGEG+Lato-Bold Type 1C WinAnsi yes yes no 71 0 BFAGHG+Lato-Italic Type 1C WinAnsi yes yes no 150 0 BFAGOE+STIX-Regular Type 1C Custom yes yes yes 72 0 BFAGOF+STIXTwoText-Italic Type 1C Custom yes yes yes 73 0 Times-Roman Type 1 WinAnsi no no no 5 0 BFAHHE+Lato-Black Type 1C WinAnsi yes yes no 93 0 BFAHHD+STIXTwoMath Type 1C Custom yes yes yes 94 0 BFBCEN+STIXTwoText Type 1C Custom yes yes yes 143 0 BFBGPA+STIXMathCalligraphy-Regular Type 1C Custom yes yes yes 179 0 BFBONN+Lato-BoldItalic Type 1C WinAnsi yes yes no 254 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-10-03 02:30:04 CEST RepresentationInformation: 282283.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-10-02 10:07:46 CEST Size: 1400677 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: State-of-the-art of lumbar puncture and its place in the journey of patients with Alzheimer’s disease Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Children: Item: Title: Abstract Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: 1 | INTRODUCTION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Children: Item: Title: 1.1 | The challenges facing systems preparedness for AD-modifying therapies Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: 1.2 | The utility of cerebrospinal fluid biomarkers for future clinical practice Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: 1.3 | Factors that limit the widespread use of lumbar puncture and CSF biomarker assessment in AD diagnosis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: 2 | SAFETY OF LP IN SUBJECTIVE COGNITIVE DECLINE, MCI, AND AD Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Children: Item: Title: 2.1 | An overview of the most relevant clinical evidence Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Item: Title: 2.2 | Rates of adverse events Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: 2.3 | Adverse events profiles after LP Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: 2.4 | The risk of AEs is not specialist-related Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: 2.5 | Patients’ perception of the procedure Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: 3 | PSYCHOGENIC FACTORS ON THE INCIDENCE OF POST-LP COMPLICATIONS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: 4 | RECOMMENDATIONS FOR REDUCING THE RISK OF POST-LP ADVERSE EVENTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Children: Item: Title: 4.1 | Technical aspects of the LP procedure that contribute to a favorable safety profile Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Item: Title: 4.2 | Patient stratification according to risk of adverse events Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: 4.3 | Indications for use of CSF biomarkers in the diagnosis of AD and pre-procedure work-up: guidelines from international consortia Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: 5 | EMERGING TECHNIQUES AND INNOVATIONS IN LP Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: 6 | POTENTIAL CHALLENGES TO ROUTINE LP IN AD CLINICAL PRACTICE Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: 7 | CONCLUSIONS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: ACKNOWLEDGMENTS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: CONFLICTS OF INTEREST Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: AUTHOR CONTRIBUTIONS Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: REFERENCES Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2050 ImageHeight: 1155 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg 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