abde7b7c37dde6862d3264e2516fb824 282284.pdf 33f7f5c1a28d33e317d665cc6b7fe312ec8e6cf2 282284.pdf 83c9250ee5ceff243b7be96eeef09e04ebe7becf12c672936dc9af019f2e9c13 282284.pdf Title: Multi‐ancestry genome‐wide association study of asthma exacerbations Subject: Pediatric Allergy Immunology 2022.33:e13802 Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0; modified using iText 4.2.0 by 1T3XT CreationDate: Fri Aug 26 07:03:29 2022 CEST ModDate: Mon Oct 2 10:17:48 2023 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1566917 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- CLWOEO+STIX-Regular Type 1C Custom yes yes yes 73 0 XDKUMY+Lato-Regular TrueType WinAnsi yes yes yes 63 0 UEZXWE+Lato-Bold CID TrueType Identity-H yes yes yes 62 0 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PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-US Outlines: Item: Title: Multi-­ancestry genome-­wide association study of asthma exacerbations Children: Item: Title: Abstract Item: Title: 1|INTRODUCTION Item: Title: 2|METHODS Children: Item: Title: 2.1|Study design and study populations Item: Title: 2.2|Association analysis Item: Title: 2.3|Assessment of shared genetic basis of asthma exacerbations with other traits Item: Title: 2.4|Sensitivity analysis Item: Title: 2.5|Methylation profiling and quality control Item: Title: 2.6|Functional assessment of associated SNPs Item: Title: 2.7|Validation of previous associations Item: Title: 3|RESULTS Children: Item: Title: 3.1|Characteristics of the patients Item: Title: 3.2|Discovery phase Item: Title: 3.3|Replication phase Item: Title: 3.4|Gene-­set enrichment and genome-­wide genetic correlation analysis Item: Title: 3.5|Sensitivity analysis Item: Title: 3.6|Functional exploration of variants associated with asthma exacerbations Item: Title: 3.7|Validation of previous associations Item: Title: 4|DISCUSSION Item: Title: AUTHOR CONTRIBUTIONS Item: Title: ACKNOWLEDGMENTS Item: Title: CONFLICT OF INTEREST Children: Item: Title: DATA AVAILABILITY STATEMENT Item: Title: PEER REVIEW Item: Title: REFERENCES Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2764 ImageHeight: 1029 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1582 ImageHeight: 1549 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