c7dd6ec7bf5daeb0ee88c6c4480af29a 282287.pdf e8af621fb75d11a197775cc16ff98df3f19b02d9 282287.pdf f0ba8a84108f429957ec81561910569928e6ea1f13c41545f7ca7f8eb11ad041 282287.pdf Title: Genome-Wide Association Study of Alzheimer's Disease Brain Imaging Biomarkers and Neuropsychological Phenotypes in the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery Dataset Subject: Alzheimer's disease (AD) is the most frequent neurodegenerative disease with an increasing prevalence in industrialized, aging populations. Keywords: genome-wide association study, GWAS, X chromosome, Alzheimer’s disease (AD), MRI, imaging, cognitive function Author: Lars Bertram Creator: LaTeX with hyperref package Producer: pdfTeX-1.40.16 CreationDate: Mon Mar 21 12:16:11 2022 CET ModDate: Mon Mar 21 12:22:49 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 779.528 pts Page rot: 0 File size: 3183666 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- WIJZQU+MinionPro-Regular Type 1 Custom yes yes no 25 0 VCXEGI+HelveticaNeueLTStd-Bd Type 1 Custom yes yes no 26 0 HUIYFD+HelveticaNeueLTStd-Lt Type 1 Custom yes yes no 27 0 ONEXKS+HelveticaNeueLTStd-BdIt Type 1 Custom yes yes no 32 0 HONOZS+HelveticaNeueLTStd-LtIt Type 1 Custom yes yes no 33 0 GZBORA+HelveticaNeueLTStd-MdIt Type 1 Custom yes yes no 34 0 JXRELX+MTGU Type 1 Builtin yes yes no 82 0 QQHFSQ+MinionPro-It Type 1 Custom yes yes no 83 0 XODHDR+RBLMI Type 1 Builtin yes yes no 84 0 RMSKLL+MinionPro-Bold Type 1 Custom yes yes no 148 0 MPRHNM+MTSYN Type 1 Builtin yes yes no 200 0 SPDEFI+HelveticaNeueLTStd-Md Type 1 Custom yes yes no 354 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-10-03 02:29:50 CEST RepresentationInformation: 282287.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-10-02 13:03:17 CEST Size: 3183666 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 879 FreeObjects: 11 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Genome-Wide Association Study of Alzheimer's Disease Brain Imaging Biomarkers and Neuropsychological Phenotypes in the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery Dataset Children: Item: Title: Introduction Item: Title: Materials and Methods Children: Item: Title: Sample Description Item: Title: Magnetic Resonance Imaging Phenotypes Description Item: Title: Neuropsychological Phenotypes Description Item: Title: DNA Extraction, Genotype Imputation and Quality Control Item: Title: Genome-Wide Association Studies and Post-Genome-Wide Association Studies Analyses Item: Title: Polygenic Score Analysis Item: Title: Results Children: Item: Title: Genome-Wide Association Studies on Magnetic Resonance Imaging Phenotypes Item: Title: Genome-Wide Association Studies on Neuropsychological Phenotypes Children: Item: Title: Analyses of Cross-Sectional Data Item: Title: Analyses of Longitudinal Data Item: Title: Comparison of Cross-Sectional vs. Longitudinal Genome-Wide Association Studies Results Item: Title: Role of APOE in Genome-Wide Association Studies on Magnetic Resonance Imaging and Neuropsychological Performance Item: Title: Polygenic Score Analyses Using Published Genome-Wide Association Studies Results Children: Item: Title: Polygenic Score Analyses With Magnetic Resonance Imaging Phenotypes Item: Title: Polygenic Score Analyses With Neuropsychological Phenotypes Item: Title: Discussion Item: Title: Conclusion Item: Title: Data Availability Statement Item: Title: Ethics Statement Item: Title: Author Contributions Item: Title: Funding Item: Title: Acknowledgments Item: Title: Supplementary Material Item: Title: References Info: Title: Genome-Wide Association Study of Alzheimer's Disease Brain Imaging Biomarkers and Neuropsychological Phenotypes in the European Medical Information Framework for Alzheimer's Disease Multimodal Biomarker Discovery Dataset Author: Lars Bertram Subject: Alzheimer's disease (AD) is the most frequent neurodegenerative disease with an increasing prevalence in industrialized, aging populations. 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