5e347e1526656d566dad02efc755c7dc 282297.pdf bce4d8ed70842bb17a179f0cd28121fe4a436028 282297.pdf 5b5675e860259669a19629497aec2e173aaffdf2fa163fbd076bbd7d5eb5e769 282297.pdf Title: Real-world effectiveness of caplacizumab vs the standard of care in immune thrombotic thrombocytopenic purpura Subject: BLOOD ADVANCES, 6 (2022) 6219-6227. doi:10.1182/bloodadvances.2022008028 Author: Cristina Pascual Izquierdo Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows); modified using iTextSharp 4.1.6 by 1T3XT CreationDate: Mon Dec 26 13:33:27 2022 CET ModDate: Wed Oct 4 11:00:36 2023 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 9 Encrypted: no Page size: 593.972 x 782.986 pts Page rot: 0 File size: 390113 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- LILBPH+AdvOT702dc698.I Type 1C WinAnsi yes yes no 79 0 LILBPG+AdvTTb753ee21.I Type 1C WinAnsi yes yes no 608 0 LILBPF+AdvTT51434264+fb Type 1C Custom yes yes yes 53 0 LILBPE+AdvOT5921cb55.B+20 Type 1C WinAnsi yes yes no 609 0 LILBPD+AdvOT5921cb55.B Type 1C WinAnsi yes yes no 55 0 LILBPC+AdvOT333dc5e5+20 Type 1C WinAnsi yes yes no 56 0 LILBOC+Advstixtexrm Type 1C Custom yes yes yes 57 0 LILBOB+AdvOT333dc5e5 Type 1C WinAnsi yes yes no 58 0 LILBOA+AdvTT51434264 Type 1C WinAnsi yes yes no 59 0 PUJNFO+ArialMT TrueType WinAnsi yes yes no 1 0 LILCBJ+AdvstixtSym Type 1C Custom yes yes yes 54 0 LILCBI+AdvOTee8bf91a Type 1C WinAnsi yes yes no 52 0 LILBPI+AdvOT333dc5e5+fb Type 1C Custom yes yes yes 60 0 LILCEJ+AdvOTb0c9bf5d+03 Type 1C Custom yes yes yes 80 0 LILCGM+AdvOT28113c6d.BI Type 1C WinAnsi yes yes no 94 0 LILCGL+AkzidenzGroteskBE-Regular Type 1C WinAnsi yes yes no 95 0 LILCFK+AdvOT5921cb55.B+fb Type 1C Custom yes yes yes 96 0 LILCJM+SymbolMT Type 1C Custom yes yes no 142 0 LILCKO+AkzidenzGroteskBE-It Type 1C WinAnsi yes yes no 143 0 LILCJN+AkzidenzGroteskBE-Cn Type 1C WinAnsi yes yes no 144 0 LILCJL+AkzidenzGroteskBE-Regular Type 1C WinAnsi yes yes no 145 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-10-05 02:30:45 CEST RepresentationInformation: 282297.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-10-04 11:58:56 CEST Size: 390113 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff10' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff11' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff12' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff13' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff14' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff15' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff16' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff17' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff18' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff18' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff19' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff20' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff21' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff22' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff23' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff24' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff25' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff26' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff27' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff28' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff29' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff30' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff31' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff32' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff33' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff34' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff35' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff36' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'aff37' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib10' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib11' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib14' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib17' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib18' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl2fnlowast' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl2fndagger' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl2fnddagger' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl2fnsection' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tbl3fnlowast' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib11' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib12' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib14' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib19' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib11' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib12' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib14' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib11' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib12' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib14' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib16' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib11' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib12' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib15' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib14' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib14' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib15' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib16' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib12' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib20' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib11' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib12' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib14' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib21' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib15' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib22' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib16' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib25' cannot be found Offset: 272792 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bib26' cannot be found Offset: 272792 MIMEtype: application/pdf PDFMetadata: Objects: 709 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Real-world effectiveness of caplacizumab vs the standard of care in immune thrombotic thrombocytopenic purpura Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Children: Item: Title: Statistical analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Children: Item: Title: Patient characteristics Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: Description of caplacizumab use and disease course Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: Time to platelet count normalization, PEX, and length of hospital stay Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Influence of the use of rituximab on patient response Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Safety data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Item: Title: Authorship Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Info: Title: Real-world effectiveness of caplacizumab vs the standard of care in immune thrombotic thrombocytopenic purpura Author: Cristina Pascual Izquierdo Subject: BLOOD ADVANCES, 6 (2022) 6219-6227. doi:10.1182/bloodadvances.2022008028 Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows); modified using iTextSharp 4.1.6 by 1T3XT CreationDate: Mon Dec 26 14:03:27 CET 2022 ModDate: Wed Oct 04 11:00:36 CEST 2023 ID: 0xaa6955026f6aa859a8c72f917b3ba22b, 0xba5791e6900694e9eadb24e6bfe50113 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 296 ImageHeight: 64 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 296 ImageHeight: 64 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 363 ImageHeight: 46 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 363 ImageHeight: 46 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 363 ImageHeight: 46 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 363 ImageHeight: 46 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 363 ImageHeight: 46 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 363 ImageHeight: 46 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 363 ImageHeight: 46 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 363 ImageHeight: 46 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: LILBPG+AdvTTb753ee21.I FontSubset: true FirstChar: 80 LastChar: 80 FontDescriptor: FontName: LILBPG+AdvTTb753ee21.I Flags: Nonsymbolic FontBBox: -156, -239, 1125, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LILCFK+AdvOT5921cb55.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: LILCFK+AdvOT5921cb55.B+fb Flags: Symbolic FontBBox: 0, 0, 572, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LILBPE+AdvOT5921cb55.B+20 FontSubset: true FirstChar: 129 LastChar: 129 FontDescriptor: FontName: LILBPE+AdvOT5921cb55.B+20 Flags: Nonsymbolic FontBBox: -156, -166, 1218, 739 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LILCJM+SymbolMT FontSubset: true FirstChar: 2 LastChar: 3 FontDescriptor: FontName: LILCJM+SymbolMT Flags: Symbolic FontBBox: 0, -220, 1113, 1005 FontFile3: true EncodingDictionary: Differences: true Font: BaseFont: LILBPH+AdvOT702dc698.I FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: LILBPH+AdvOT702dc698.I Flags: Nonsymbolic FontBBox: -93, -250, 1104, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LILCKO+AkzidenzGroteskBE-It FontSubset: true FirstChar: 46 LastChar: 112 FontDescriptor: FontName: LILCKO+AkzidenzGroteskBE-It Flags: Nonsymbolic, Italic FontBBox: -123, -250, 1303, 952 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LILCEJ+AdvOTb0c9bf5d+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: LILCEJ+AdvOTb0c9bf5d+03 Flags: Symbolic FontBBox: -479, -364, 854, 927 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LILCJN+AkzidenzGroteskBE-Cn FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: LILCJN+AkzidenzGroteskBE-Cn Flags: Nonsymbolic FontBBox: -134, -250, 875, 901 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LILCJL+AkzidenzGroteskBE-Regular FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: LILCJL+AkzidenzGroteskBE-Regular Flags: Nonsymbolic FontBBox: -155, -250, 1227, 944 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LILCBI+AdvOTee8bf91a FontSubset: true FirstChar: 44 LastChar: 116 FontDescriptor: FontName: LILCBI+AdvOTee8bf91a Flags: Nonsymbolic FontBBox: -41, -250, 1010, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LILBPF+AdvTT51434264+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: LILBPF+AdvTT51434264+fb Flags: Symbolic FontBBox: 19, 0, 979, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LILCBJ+AdvstixtSym FontSubset: true FirstChar: 1 LastChar: 4 FontDescriptor: FontName: LILCBJ+AdvstixtSym Flags: Symbolic FontBBox: -20, -1114, 1135, 822 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LILBPD+AdvOT5921cb55.B FontSubset: true FirstChar: 37 LastChar: 122 FontDescriptor: FontName: LILBPD+AdvOT5921cb55.B Flags: Nonsymbolic FontBBox: -62, -250, 1104, 916 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LILBPC+AdvOT333dc5e5+20 FontSubset: true FirstChar: 134 LastChar: 150 FontDescriptor: FontName: LILBPC+AdvOT333dc5e5+20 Flags: Nonsymbolic FontBBox: -145, -145, 1218, 708 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LILBOC+Advstixtexrm FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: LILBOC+Advstixtexrm Flags: Symbolic FontBBox: -385, -229, 1041, 729 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LILBOB+AdvOT333dc5e5 FontSubset: true FirstChar: 37 LastChar: 246 FontDescriptor: FontName: LILBOB+AdvOT333dc5e5 Flags: Nonsymbolic FontBBox: -31, -250, 1010, 937 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LILBOA+AdvTT51434264 FontSubset: true FirstChar: 37 LastChar: 122 FontDescriptor: FontName: LILBOA+AdvTT51434264 Flags: Serif, Nonsymbolic FontBBox: -10, -239, 1031, 927 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LILBPI+AdvOT333dc5e5+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: LILBPI+AdvOT333dc5e5+fb Flags: Symbolic FontBBox: 0, 0, 416, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LILCGM+AdvOT28113c6d.BI FontSubset: true FirstChar: 80 LastChar: 80 FontDescriptor: FontName: LILCGM+AdvOT28113c6d.BI Flags: Nonsymbolic FontBBox: -114, -250, 1062, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LILCGL+AkzidenzGroteskBE-Regular FontSubset: true FirstChar: 32 LastChar: 122 FontDescriptor: FontName: LILCGL+AkzidenzGroteskBE-Regular Flags: Nonsymbolic FontBBox: -155, -250, 1227, 944 FontFile3: true Encoding: WinAnsiEncoding TrueType: Font: BaseFont: PUJNFO+ArialMT FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: PUJNFO+ArialMT Flags: Nonsymbolic FontBBox: -664, -324, 2000, 1039 FontFile2: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1182/bloodadvances.2022008028 Real-world effectiveness of caplacizumab vs the standard of care in immune thrombotic thrombocytopenic purpura Cristina Pascual Izquierdo María Eva Mingot-Castellano Ana E. Kerguelen Fuentes José García-Arroba Peinado Joan Cid Maria Moraima Jimenez David Valcarcel Inés Gómez-Seguí Javier de la Rubia Paz Martin Rosa Goterris Luis Hernández Inmaculada Tallón Sara Varea Marta Fernández Nadia García-Muñoz Míriam Vara Miguel Fernández Zarzoso Faustino García-Candel María Liz Paciello Irene García-García Saioa Zalba Verónica Campuzano José María Gala Julia Vidán Estévez Gemma Moreno Jiménez José Luis López Lorenzo Elena González Arias Carmen Freiría María Solé Laura Francisca Ávila Idrovo José Carlos Hernández Castellet Naylen Cruz Esperanza Lavilla Albert Pérez-Montaña Jon Ander Atucha María Esperanza Moreno Beltrán Juán Ramón Moreno Macías Ramón Salinas Julio del Rio-Garma Spanish Apheresis Group (GEA) and the Spanish Thrombotic Thrombocytopenic Purpura Registry (REPTT) BLOOD ADVANCES, 6 (2022) 6219-6227. doi:10.1182/bloodadvances.2022008028 The American Society of Hematology journal BLOOD ADVANCES © 2022 by The American Society of Hematology. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved. 2473-9529 6 24 27 December 2022 2022-12-27 6219-6227 6219 6227 10.1182/bloodadvances.2022008028 https://doi.org/10.1182/bloodadvances.2022008028 VoR 7.0 10.1182/bloodadvances.2022008028 noindex Elsevier 2022-12-26T18:03:27+05:30 2023-10-04T09:00:36+00:00 2023-10-04T09:00:36+00:00 True Acrobat Distiller 8.1.0 (Windows); modified using iTextSharp 4.1.6 by 1T3XT uuid:cca6985b-cdc1-4bb2-9f46-77a222b4e012 uuid:1c17aee6-0626-4dbf-b5f1-8b8428d52d23 https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode Pages: Page: Label: 6219 Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 136, 625, 136, 627 Annotation: Subtype: Link Rect: 138, 628, 141, 637 Destination: 502 Annotation: Subtype: Link Rect: 143, 624, 147, 633 Destination: 502 Annotation: Subtype: Link Rect: 259, 625, 259, 627 Annotation: Subtype: Link Rect: 261, 628, 265, 637 Destination: 502 Annotation: Subtype: Link Rect: 267, 624, 270, 633 Destination: 502 Annotation: Subtype: Link Rect: 373, 625, 373, 627 Annotation: Subtype: Link Rect: 375, 628, 379, 637 Destination: 502 Annotation: Subtype: Link Rect: 489, 625, 489, 627 Annotation: Subtype: Link Rect: 491, 628, 495, 637 Destination: 502 Annotation: Subtype: Link Rect: 532, 625, 532, 627 Annotation: Subtype: Link Rect: 534, 628, 538, 637 Destination: 502 Annotation: Subtype: Link Rect: 125, 613, 125, 615 Annotation: Subtype: Link Rect: 127, 616, 131, 625 Destination: 502 Annotation: Subtype: Link Rect: 193, 613, 193, 615 Annotation: Subtype: Link Rect: 195, 616, 199, 625 Destination: 502 Annotation: Subtype: Link Rect: 272, 613, 272, 615 Annotation: Subtype: Link Rect: 274, 616, 278, 625 Destination: 502 Annotation: Subtype: Link Rect: 349, 613, 349, 615 Annotation: Subtype: Link Rect: 350, 616, 354, 625 Destination: 502 Annotation: Subtype: Link Rect: 398, 613, 398, 615 Annotation: Subtype: Link Rect: 400, 616, 403, 625 Destination: 502 Annotation: Subtype: Link Rect: 460, 613, 460, 615 Annotation: Subtype: Link Rect: 462, 616, 466, 625 Destination: 502 Annotation: Subtype: Link Rect: 528, 613, 528, 615 Annotation: Subtype: Link Rect: 530, 616, 538, 625 Destination: null Annotation: Subtype: Link Rect: 105, 601, 105, 603 Annotation: Subtype: Link Rect: 107, 604, 114, 613 Destination: null Annotation: Subtype: Link Rect: 160, 601, 160, 603 Annotation: Subtype: Link Rect: 162, 604, 170, 613 Destination: null Annotation: Subtype: Link Rect: 237, 601, 237, 603 Annotation: Subtype: Link Rect: 239, 604, 246, 613 Destination: null Annotation: Subtype: Link Rect: 327, 601, 327, 603 Annotation: Subtype: Link Rect: 329, 604, 337, 613 Destination: null Annotation: Subtype: Link Rect: 385, 601, 385, 603 Annotation: Subtype: Link Rect: 387, 604, 395, 613 Destination: null Annotation: Subtype: Link Rect: 498, 601, 498, 603 Annotation: Subtype: Link Rect: 500, 604, 508, 613 Destination: null Annotation: Subtype: Link Rect: 127, 589, 127, 591 Annotation: Subtype: Link Rect: 129, 592, 136, 601 Destination: null Annotation: Subtype: Link Rect: 206, 589, 206, 591 Annotation: Subtype: Link Rect: 208, 592, 216, 601 Destination: null Annotation: Subtype: Link Rect: 294, 589, 294, 591 Annotation: Subtype: Link Rect: 296, 592, 303, 601 Destination: null Annotation: Subtype: Link Rect: 352, 589, 352, 591 Annotation: Subtype: Link Rect: 354, 592, 361, 601 Destination: null Annotation: Subtype: Link Rect: 446, 589, 446, 591 Annotation: Subtype: Link Rect: 448, 592, 456, 601 Destination: null Annotation: Subtype: Link Rect: 520, 589, 520, 591 Annotation: Subtype: Link Rect: 522, 592, 530, 601 Destination: null Annotation: Subtype: Link Rect: 109, 577, 109, 579 Annotation: Subtype: Link Rect: 111, 580, 118, 589 Destination: null Annotation: Subtype: Link Rect: 216, 577, 216, 579 Annotation: Subtype: Link Rect: 218, 580, 226, 589 Destination: null Annotation: Subtype: Link Rect: 323, 577, 323, 579 Annotation: Subtype: Link Rect: 325, 580, 333, 589 Destination: null Annotation: Subtype: Link Rect: 417, 577, 417, 579 Annotation: Subtype: Link Rect: 419, 580, 427, 589 Destination: null Annotation: Subtype: Link Rect: 486, 577, 486, 579 Annotation: Subtype: Link Rect: 488, 580, 496, 589 Destination: null Annotation: Subtype: Link Rect: 539, 577, 539, 579 Annotation: Subtype: Link Rect: 541, 580, 549, 589 Destination: null Annotation: Subtype: Link Rect: 144, 565, 144, 567 Annotation: Subtype: Link Rect: 146, 568, 154, 577 Destination: null Annotation: Subtype: Link Rect: 282, 565, 282, 567 Annotation: Subtype: Link Rect: 284, 568, 292, 577 Destination: null Annotation: Subtype: Link Rect: 341, 565, 341, 567 Annotation: Subtype: Link Rect: 343, 568, 351, 577 Destination: null Annotation: Subtype: Link Rect: 419, 565, 419, 567 Annotation: Subtype: Link Rect: 421, 568, 428, 577 Destination: null Annotation: Subtype: Link Rect: 514, 565, 514, 567 Annotation: Subtype: Link Rect: 516, 568, 524, 577 Destination: null Annotation: Subtype: Link Rect: 104, 553, 104, 555 Annotation: Subtype: Link Rect: 106, 556, 113, 565 Destination: null Annotation: Subtype: Link Rect: 239, 553, 239, 555 Annotation: Subtype: Link Rect: 241, 556, 249, 565 Destination: null Annotation: Subtype: Link Rect: 358, 553, 358, 555 Annotation: Subtype: Link Rect: 360, 556, 368, 565 Destination: null Annotation: Subtype: Link Rect: 427, 553, 427, 555 Annotation: Subtype: Link Rect: 429, 556, 436, 565 Destination: null Annotation: Subtype: Link Rect: 529, 553, 529, 555 Annotation: Subtype: Link Rect: 531, 556, 539, 565 Destination: null Annotation: Subtype: Link Rect: 89, 97, 249, 104 Annotation: Subtype: Link Rect: 95, 66, 216, 73 Annotation: Subtype: Link Rect: 500, 104, 556, 111 Annotation: Subtype: Link Rect: 305, 95, 555, 102 Annotation: Subtype: Link Rect: 493, 762, 586, 782 Page: Label: 6220 Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 132, 565, 136, 574 Destination: 221 Annotation: Subtype: Link Rect: 253, 554, 257, 563 Destination: 221 Annotation: Subtype: Link Rect: 260, 499, 264, 508 Destination: 221 Annotation: Subtype: Link Rect: 265, 499, 269, 508 Destination: 221 Annotation: Subtype: Link Rect: 60, 449, 64, 458 Destination: 221 Annotation: Subtype: Link Rect: 248, 449, 251, 458 Destination: 221 Annotation: Subtype: Link Rect: 113, 389, 117, 398 Destination: 221 Annotation: Subtype: Link Rect: 118, 389, 122, 398 Destination: 221 Annotation: Subtype: Link Rect: 104, 334, 107, 343 Destination: 221 Annotation: Subtype: Link Rect: 109, 334, 112, 343 Destination: 221 Annotation: Subtype: Link Rect: 104, 302, 108, 311 Destination: 221 Annotation: Subtype: Link Rect: 109, 302, 116, 311 Destination: null Annotation: Subtype: Link Rect: 209, 219, 226, 228 Destination: null Annotation: Subtype: Link Rect: 163, 192, 181, 201 Destination: null Annotation: Subtype: Link Rect: 324, 398, 331, 407 Destination: null Annotation: Subtype: Link Rect: 333, 398, 340, 407 Destination: null Page: Label: 6221 Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 189, 352, 221, 361 Destination: 86 Annotation: Subtype: Link Rect: 36, 259, 65, 268 Destination: 86 Annotation: Subtype: Link Rect: 179, 209, 207, 218 Destination: 110 Annotation: Subtype: Link Rect: 407, 612, 435, 621 Destination: 110 Annotation: Subtype: Link Rect: 409, 180, 441, 189 Destination: 124 Page: Label: 6222 Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 187, 377, 217, 386 Destination: 124 Annotation: Subtype: Link Rect: 243, 167, 274, 176 Destination: 86 Annotation: Subtype: Link Rect: 349, 366, 381, 375 Destination: 156 Annotation: Subtype: Link Rect: 469, 328, 501, 337 Destination: 156 Page: Label: 6223 Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 96, 634, 98, 640 Destination: null Annotation: Subtype: Link Rect: 115, 608, 118, 614 Destination: null Annotation: Subtype: Link Rect: 108, 556, 111, 562 Destination: null Annotation: Subtype: Link Rect: 116, 504, 120, 511 Destination: null Annotation: Subtype: Link Rect: 86, 118, 89, 125 Destination: null Page: Label: 6224 Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 111, 451, 115, 460 Destination: 221 Annotation: Subtype: Link Rect: 173, 336, 180, 345 Destination: null Annotation: Subtype: Link Rect: 182, 336, 190, 345 Destination: null Annotation: Subtype: Link Rect: 191, 336, 208, 345 Destination: null Annotation: Subtype: Link Rect: 403, 332, 410, 341 Destination: null Annotation: Subtype: Link Rect: 480, 256, 488, 265 Destination: null Annotation: Subtype: Link Rect: 489, 256, 497, 265 Destination: null Annotation: Subtype: Link Rect: 498, 256, 515, 265 Destination: null Annotation: Subtype: Link Rect: 450, 181, 458, 190 Destination: null Annotation: Subtype: Link Rect: 460, 181, 467, 190 Destination: null Annotation: Subtype: Link Rect: 399, 104, 407, 113 Destination: null Annotation: Subtype: Link Rect: 408, 104, 416, 113 Destination: null Annotation: Subtype: Link Rect: 499, 104, 507, 113 Destination: null Annotation: Subtype: Link Rect: 509, 104, 516, 113 Destination: null Page: Label: 6225 Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 280, 433, 287, 442 Destination: null Annotation: Subtype: Link Rect: 55, 351, 63, 360 Destination: null Annotation: Subtype: Link Rect: 124, 340, 132, 349 Destination: null Annotation: Subtype: Link Rect: 134, 340, 141, 349 Destination: null Annotation: Subtype: Link Rect: 200, 329, 208, 338 Destination: null Annotation: Subtype: Link Rect: 475, 455, 483, 464 Destination: null Annotation: Subtype: Link Rect: 342, 394, 346, 403 Destination: 221 Page: Label: 6226 Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 126, 436, 134, 445 Destination: null Annotation: Subtype: Link Rect: 270, 425, 278, 434 Destination: null Annotation: Subtype: Link Rect: 280, 425, 287, 434 Destination: null Annotation: Subtype: Link Rect: 114, 414, 132, 423 Destination: null Annotation: Subtype: Link Rect: 243, 353, 247, 362 Destination: 221 Annotation: Subtype: Link Rect: 61, 288, 69, 297 Destination: null Annotation: Subtype: Link Rect: 133, 255, 141, 264 Destination: null Annotation: Subtype: Link Rect: 142, 255, 160, 264 Destination: null Annotation: Subtype: Link Rect: 68, 222, 76, 231 Destination: null Annotation: Subtype: Link Rect: 78, 222, 85, 231 Destination: null Annotation: Subtype: Link Rect: 87, 222, 94, 231 Destination: null Annotation: Subtype: Link Rect: 418, 174, 508, 183 Annotation: Subtype: Link Rect: 305, 163, 396, 172 Annotation: Subtype: Link Rect: 430, 163, 520, 172 Annotation: Subtype: Link Rect: 305, 152, 396, 161 Annotation: Subtype: Link Rect: 434, 152, 524, 161 Annotation: Subtype: Link Rect: 305, 141, 395, 150 Annotation: Subtype: Link Rect: 431, 141, 521, 150 Annotation: Subtype: Link Rect: 305, 130, 395, 139 Annotation: Subtype: Link Rect: 420, 130, 510, 139 Annotation: Subtype: Link Rect: 407, 92, 554, 101 Page: Label: 6227 Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 54, 680, 412, 688 Annotation: Subtype: Link Rect: 54, 666, 556, 674 Annotation: Subtype: Link Rect: 54, 656, 70, 664 Annotation: Subtype: Link Rect: 54, 642, 403, 650 Annotation: Subtype: Link Rect: 54, 628, 410, 636 Annotation: Subtype: Link Rect: 54, 614, 546, 622 Annotation: Subtype: Link Rect: 54, 604, 556, 612 Annotation: Subtype: Link Rect: 54, 594, 341, 602 Annotation: Subtype: Link Rect: 54, 580, 556, 588 Annotation: Subtype: Link Rect: 54, 570, 143, 578 Annotation: Subtype: Link Rect: 54, 556, 529, 564 Annotation: Subtype: Link Rect: 54, 546, 428, 554 Annotation: Subtype: Link Rect: 54, 532, 556, 540 Annotation: Subtype: Link Rect: 54, 522, 120, 530 Annotation: Subtype: Link Rect: 54, 508, 556, 516 Annotation: Subtype: Link Rect: 54, 499, 92, 507 Annotation: Subtype: Link Rect: 54, 485, 556, 493 Annotation: Subtype: Link Rect: 54, 475, 500, 483 Annotation: Subtype: Link Rect: 54, 461, 556, 469 Annotation: Subtype: Link Rect: 54, 451, 129, 459 Annotation: Subtype: Link Rect: 54, 437, 556, 445 Annotation: Subtype: Link Rect: 54, 427, 155, 435 Annotation: Subtype: Link Rect: 54, 413, 533, 421 Annotation: Subtype: Link Rect: 54, 403, 374, 411 Annotation: Subtype: Link Rect: 54, 389, 556, 397 Annotation: Subtype: Link Rect: 54, 379, 234, 387 Annotation: Subtype: Link Rect: 54, 365, 542, 373 Annotation: Subtype: Link Rect: 54, 351, 556, 359 Annotation: Subtype: Link Rect: 54, 341, 414, 349 Annotation: Subtype: Link Rect: 54, 327, 556, 335 Annotation: Subtype: Link Rect: 54, 317, 93, 325 Annotation: Subtype: Link Rect: 54, 303, 556, 311 Annotation: Subtype: Link Rect: 54, 293, 520, 301 Annotation: Subtype: Link Rect: 54, 279, 493, 287 Annotation: Subtype: Link Rect: 54, 265, 397, 273 Annotation: Subtype: Link Rect: 54, 251, 556, 259 Annotation: Subtype: Link Rect: 54, 242, 184, 249 Annotation: Subtype: Link Rect: 54, 228, 325, 236 Annotation: Subtype: Link Rect: 54, 214, 81, 222 Annotation: Subtype: Link Rect: 85, 214, 553, 222 Annotation: Subtype: Link Rect: 54, 204, 556, 212 Annotation: Subtype: Link Rect: 54, 194, 138, 202 Annotation: Subtype: Link Rect: 54, 180, 556, 188 Annotation: Subtype: Link Rect: 54, 170, 134, 178 Annotation: Subtype: Link Rect: 54, 156, 556, 164 Annotation: Subtype: Link Rect: 54, 146, 280, 154 Annotation: Subtype: Link Rect: 54, 132, 556, 140 Annotation: Subtype: Link Rect: 54, 122, 84, 130 Checksum: b72c62fc Type: CRC32 Checksum: 5e347e1526656d566dad02efc755c7dc Type: MD5 Checksum: bce4d8ed70842bb17a179f0cd28121fe4a436028 Type: SHA-1