22c7bf6aa3ca56c3a8fce60b7b41b226 282303.pdf 22802bc4f1e9c3b30420c3119b9b0928050a107d 282303.pdf ec123ae1e761d448961af94eaaf3d869f6bfbe620d01bb321ec8135e0bb98385 282303.pdf Title: Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers Subject: Acta Neuropathologica, https://doi.org/10.1007/s00401-022-02454-z Keywords: GWAS; Alzheimer’s disease; Cerebrospinal fluid; Amyloid-beta; Tau Author: Iris E. Jansen Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows) CreationDate: Tue Sep 6 01:33:09 2022 CEST ModDate: Thu Sep 29 22:03:09 2022 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 22 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 1472314 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-SemiCn Type 1C WinAnsi yes no yes 1373 0 MyriadPro-Semibold Type 1C Custom yes no yes 1374 0 MyriadPro-SemiboldSemiCn Type 1C Custom yes no yes 1375 0 YRALER+STIX-Regular Type 1C Custom yes yes yes 1393 0 FUGDBI+MyriadPro-SemiCn2 Type 1C WinAnsi yes yes yes 1455 0 Springnew-Regular Type 1C WinAnsi yes no yes 1404 0 MyriadPro-Bold Type 1C Custom yes no yes 573 0 STIX-Italic Type 1C Custom yes no yes 588 0 MyriadPro-BoldSemiCn Type 1C Custom yes no yes 593 0 IYEFOX+Code2000 CID TrueType Identity-H yes yes yes 643 0 CFUIIE+STIX-Bold Type 1C WinAnsi yes yes yes 754 0 WLIYDI+Wingdings-Regular Type 1C WinAnsi yes yes yes 1196 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-10-06 02:26:20 CEST RepresentationInformation: 282303.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-10-05 17:01:50 CEST Size: 1472314 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 1553 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers Children: Item: Title: Abstract Item: Title: Introduction Item: Title: Materials and methods Children: Item: Title: Participants Item: Title: CSF measurements Item: Title: Genotyping, quality control and imputation Item: Title: Heritability and genetic correlation Item: Title: Single-marker association Item: Title: Independent replication Item: Title: Meta-analyses Item: Title: Colocalization Item: Title: Gene-based analysis Item: Title: Gene mapping Item: Title: Phenome-wide association studies (PheWAS) Item: Title: Association with CSF proteomics Item: Title: Effects of AD-associated variants on Aβ42 and pTau Item: Title: Results Children: Item: Title: Genetic architecture Item: Title: GWAS variants associated with CSF Aβ42 and pTau Item: Title: Functional interpretation Item: Title: Relation to AD-associated genetic variants Item: Title: Discussion Item: Title: Acknowledgements Item: Title: References Info: Title: Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers Author: Iris E. Jansen Subject: Acta Neuropathologica, https://doi.org/10.1007/s00401-022-02454-z Keywords: GWAS; Alzheimer’s disease; Cerebrospinal fluid; Amyloid-beta; Tau Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows) CreationDate: Tue Sep 06 02:03:09 CEST 2022 ModDate: Thu Sep 29 22:33:09 CEST 2022 ID: 0x85f01f036fe71744b955975182295215, 0x0e86a156fb7cd049a8e97ebc3f3e2b78 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1772 ImageHeight: 1441 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2032 ImageHeight: 1854 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2740 ImageHeight: 987 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Fonts: Type0: Font: BaseFont: IYEFOX+Code2000 Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: YRALER+STIX-Regular FontSubset: true FirstChar: 22 LastChar: 252 FontDescriptor: FontName: YRALER+STIX-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-BoldSemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-BoldSemiCn Flags: Nonsymbolic FontBBox: -133, -250, 1161, 894 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: CFUIIE+STIX-Bold FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: CFUIIE+STIX-Bold Flags: Serif, Nonsymbolic FontBBox: -998, -552, 2000, 1055 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: STIX-Italic FirstChar: 0 LastChar: 255 FontDescriptor: FontName: STIX-Italic Flags: Serif, Nonsymbolic, Italic FontBBox: -970, -305, 1429, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: WLIYDI+Wingdings-Regular FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: WLIYDI+Wingdings-Regular Flags: Nonsymbolic FontBBox: 0, -103, 1359, 439 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-SemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-SemiCn Flags: Nonsymbolic FontBBox: -128, -250, 1059, 876 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Bold Flags: Nonsymbolic FontBBox: -163, -250, 1256, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Semibold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Semibold Flags: Nonsymbolic FontBBox: -161, -250, 1198, 972 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-SemiboldSemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-SemiboldSemiCn Flags: Nonsymbolic FontBBox: -131, -250, 1115, 886 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: IYEFOX+Code2000 CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: IYEFOX+Code2000 Flags: Serif, Symbolic FontBBox: -1111, -295, 2107, 977 FontFile2: true XMP: 2022-09-06T05:03:09+05:30 Springer 2022-09-30T01:33:09+05:30 2022-09-30T01:33:09+05:30 Acrobat Distiller 10.1.8 (Windows) GWAS; Alzheimer’s disease; Cerebrospinal fluid; Amyloid-beta; Tau application/pdf https://doi.org/10.1007/s00401-022-02454-z Springer Berlin Heidelberg Acta Neuropathologica, https://doi.org/10.1007/s00401-022-02454-z GWAS Alzheimer’s disease Cerebrospinal fluid Amyloid-beta Tau Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers Iris E. Jansen Sven J. van der Lee Duber Gomez-Fonseca Itziar de Rojas Maria Carolina Dalmasso Benjamin Grenier-Boley Anna Zettergren Aniket Mishra Muhammad Ali Victor Andrade Céline Bellenguez Luca Kleineidam Fahri Küçükali Yun Ju Sung Niccolo Tesí Ellen M. Vromen Douglas P. Wightman Daniel Alcolea Montserrat Alegret Ignacio Alvarez Philippe Amouyel Lavinia Athanasiu Shahram Bahrami Henri Bailly Olivia Belbin Sverre Bergh Lars Bertram Geert Jan Biessels Kaj Blennow Rafael Blesa Mercè Boada Anne Boland Katharina Buerger Ángel Carracedo Laura Cervera-Carles Geneviève Chene Jurgen A. H. R. 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Andreassen Jordi Clarimón Kristel Sleegers Agustín Ruiz Alfredo Ramirez Carlos Cruchaga Jean-Charles Lambert Wiesje van der Flier 10.1007/s00401-022-02454-z 2010-04-23 true springer.com springerlink.com https://doi.org/10.1007/s00401-022-02454-z 10.1007/s00401-022-02454-z 1432-0533 144 5 821 842 journal Acta Neuropathologica The Author(s) 2010-04-23 true 10.1007/s00401-022-02454-z noindex springer.com springerlink.com VoR uuid:bdda64f9-a3aa-40e2-a70b-512110492583 uuid:a3d88087-ca3b-4318-96e6-ca9c123f3db3 default 1 converted uuid:57afb3b4-3cef-447c-a8e8-af5e8189841a converted to PDF/A-2b pdfToolbox 2022-09-30T01:32:25+05:30 converted uuid:35315395-7d4a-4451-810c-8b376e1ac39e converted to PDF/A-2b pdfToolbox 2022-09-30T01:33:08+05:30 2 B Iris E. 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