d8753836c1c0bbfa5f9f2b49767778e6 282313.pdf 315c9586676f09db8c65292d8945d04fc342f84e 282313.pdf 698a20254ce638e3875fe11f30ae44adfc7ce0a66182880bf83cee3d40f48cfc 282313.pdf Title: Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis Subject: npj Genomic Medicine, doi:10.1038/s41525-022-00327-8 Keywords: Author: Martin Kerick Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Tue Oct 4 18:37:55 2022 CEST ModDate: Wed Oct 5 06:19:34 2022 CEST Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 12 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 10603055 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IGBMCN+AdvOT3b30f6db.B Type 1C WinAnsi yes yes no 70 0 IGBMCK+AdvOT65f8a23b.I Type 1C 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object 'bm_CR73' cannot be found Offset: 10054807 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR74' cannot be found Offset: 10054807 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR75' cannot be found Offset: 10054807 ID: PDF-HUL-122 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_CR28' cannot be found Offset: 10054807 MIMEtype: application/pdf PDFMetadata: Objects: 879 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Complement component C4’structural variation and quantitative traits contribute to sex-biased vulnerability in’systemic sclerosis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@e720b71 Children: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1b26f7b2 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@491cc5c9 Children: Item: Title: Experimental design Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74ad1f1f Item: Title: C4 haplotype diversity and its correlation with classical HLA alleles Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6a1aab78 Item: Title: The association between C4 copy number variants and SSc is modified by sex and HERV-K Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@462d5aee Item: Title: C4 copy number affects C4 expression and C4 protein levels in whole blood Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@69b0fd6f Item: Title: C4 genetics can explain a part of the SSc association to the MHC region Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@757942a1 Item: Title: Remaining MHC signal after conditioning on C4 genetics highlights HLA-DRB1 and HLA-DPB1 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4a87761d Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@66d1af89 Item: Title: Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8646db9 Children: Item: Title: Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@37374a5e Item: Title: Cohorts and datasets Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4671e53b Item: Title: Expression data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@2db7a79b Item: Title: C4 protein data Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@6950e31 Item: Title: Imputation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@b7dd107 Children: Item: Title: SNPs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@42eca56e Item: Title: C4 haplotypes Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@52f759d7 Item: Title: C4 copy numbers Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7cbd213e Item: Title: Classical HLA alleles and HLA amino acids (AA) Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@192d3247 Item: Title: Pearson correlation of C4 haplotypes and classical HLA Alleles Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3ecd23d9 Item: Title: C4 copy number association analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@569cfc36 Item: Title: Power calculation Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43bd930a Children: Item: Title: C4 Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@33723e30 Item: Title: C4:sex interaction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@64f6106c Item: Title: Calculation of composite C4 risk score for SSc Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@553a3d88 Item: Title: Pearson correlation of C4 CN and C4 expression and C4’serum levels Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a30d1e6 Item: Title: C4 expression modeling Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5891e32e Item: Title: Modeling of C4 copy numbers using eQTLs Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@cb0ed20 Item: Title: C4 gene expression analysis in whole blood Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@8e24743 Item: Title: C4 protein blood serum analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@74a10858 Item: Title: Residual association of genetic variants across the MHC region to SSc Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@23fe1d71 Item: Title: Residual, C4-independent, the association of the MHC region with SSc Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@28ac3dc3 Item: Title: Reporting summary Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@32eebfca Item: Title: DATA AVAILABILITY Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@4e718207 Item: Title: DATA AVAILABILITY Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1d371b2d Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@543c6f6d Item: Title: Acknowledgements Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@13eb8acf Item: Title: Author contributions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@51c8530f Item: Title: Competing interests Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7403c468 Item: Title: ADDITIONAL INFORMATION Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@43738a82 Info: Title: Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis Author: Martin Kerick Subject: npj Genomic Medicine, doi:10.1038/s41525-022-00327-8 Keywords: Creator: Springer Producer: iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) CreationDate: Tue Oct 04 19:07:55 CEST 2022 ModDate: Wed Oct 05 06:19:34 CEST 2022 ID: 0x97dfccee9ffc0bd3b7872e69136cfe50, 0x8356385656fd2fbeac250d96df3863b6 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 80 ImageHeight: 62 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 95 ImageHeight: 74 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 95 ImageHeight: 74 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: 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FontDescriptor: FontName: IGBMHO+AdvTTab7e17fd Flags: Nonsymbolic FontBBox: -156, -250, 1072, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: IGBMCJ+AdvOT46dcae81 FontSubset: true FirstChar: 37 LastChar: 252 FontDescriptor: FontName: IGBMCJ+AdvOT46dcae81 Flags: Nonsymbolic FontBBox: -41, -250, 833, 875 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdf doi:10.1038/s41525-022-00327-8 Complement component C4 structural variation and quantitative traits contribute to sex-biased vulnerability in systemic sclerosis Martin Kerick Marialbert Acosta-Herrera Carmen Pilar Simeón-Aznar José Luis Callejas Shervin Assassi P. Carreira I. Castellvi R. Ríos R. García Portales A. Fernández-Nebro F. J. García-Hernández M. A. Aguirre B. Fernández-Gutiérrez L. Rodríguez-Rodríguez P. García de la Peña E. Vicente J. L. Andreu M. Fernández de Castro F. J. López-Longo V. Fonollosa A. Guillén G. Espinosa C. Tolosa A. Pros E. Beltrán M. Rodríguez Carballeira F. J. Narváez M. Rubio Rivas V. Ortiz-Santamaría A. B. Madroñero M. A. González-Gay B. Díaz L. Trapiella M. V. Egurbide P. Fanlo-Mateo L. Saez-Comet F. Díaz J. A. Roman-Ivorra J. J. Alegre Sancho M. Freire F. J. Blanco Garcia N. Oreiro T. Witte A. Kreuter G. Riemekasten P. Airò C. Magro A. E. Voskuyl M. C. Vonk R. Hesselstrand A. Nordin C. Lunardi A. Gabrielli A. Hoffmann-Vold J. H. W. Distler L. Padyukov B. P. C. Koeleman Susanna M. Proudman Mandana Nikpour W. Stevens J. Zochling J. Sahhar J. Roddy P. Nash K. Tymms M. Rischmueller S. Lester Barbara Vigone Jacques-Olivier Pers Alain Saraux Valérie Devauchelle-Pensec Divi Cornec Sandrine Jousse-Joulin Bernard Lauwerys Julie Ducreux Anne-Lise Maudoux Carlos Vasconcelos Ana Tavares Esmeralda Neves Raquel Faria Mariana Brandão Ana Campar António Marinho Fátima Farinha Isabel Almeida Miguel Angel Gonzalez-Gay Mantecón Ricardo Blanco Alonso Alfonso Corrales Martínez Ricard Cervera Ignasi Rodríguez-Pintó Gerard Espinosa Rik Lories Ellen De Langhe Doreen Belz Torsten Witte Niklas Baerlecken Georg Stummvoll Michael Zauner Michaela Lehner Eduardo Collantes Rafaela Ortega-Castro Ma Angeles Aguirre-Zamorano Alejandro Escudero-Contreras Ma Carmen Castro-Villegas María Concepción Fernández Roldán Norberto Ortego Enrique Raya Inmaculada Jiménez Moleón Enrique de Ramon Isabel Díaz Quintero Pier Luigi Meroni Maria Gerosa Tommaso Schioppo Carolina Artusi Carlo Chizzolini Aleksandra Zuber Donatienne Wynar Laszló Kovács Attila Balog Magdolna Deák Márta Bocskai Sonja Dulic Gabriella Kádár Falk Hiepe Velia Gerl Silvia Thiel Manuel Rodriguez Maresca Antonio López-Berrio Rocío Aguilar-Quesada Héctor Navarro-Linares Nicolas Hunzelmann Gianluca Moroncini Jeska K. Vries-Bouwstra Gisela Orozco Anne Barton Ariane L. Herrick Chikashi Terao Yannick Allanore Carmen Fonseca Marta Eugenia Alarcón-Riquelme Timothy R. D. J. Radstake Lorenzo Beretta Christopher P. Denton Maureen D. Mayes Javier Martin Springer US npj Genomic Medicine, doi:10.1038/s41525-022-00327-8 Springer 2022-10-05T06:19:34+02:00 2022-10-04T22:07:55+05:30 2022-10-05T06:19:34+02:00 True iText® 5.3.5 ©2000-2012 1T3XT BVBA (SPRINGER SBM; licensed version) uuid:a3965776-b1b8-427f-9d11-899165d3fe2d uuid:f698181d-0248-4da3-8144-a8666330d4b0 default 1 converted uuid:46d15320-95c1-4d04-9415-c01125853757 converted to PDF/A-2b pdfToolbox 2022-10-04T22:10:41+05:30 2 B http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. 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