3ab394e47de25326e70da574ff94df7f 282332.pdf b1f9d89cd46c876798b475176d7efd7fec2654a6 282332.pdf fe23032955716b5a500cbd9686dc4eb04273ecf64dd4e5ec0616994256a3b051 282332.pdf Title: Cognitive Performance and Health-Related Quality of Life in Patients with Neuromyelitis Optica Spectrum Disorder Subject: Background: The frequency of cognitive impairment (CI) reported in neuromyelitis optica spectrum disorder (NMOSD) is highly variable, and its relationship with demographic and clinical characteristics is poorly understood. We aimed to describe the cognitive profile of NMOSD patients, and to analyse the cognitive differences according to their serostatus; furthermore, we aimed to assess the relationship between cognition, demographic and clinical characteristics, and other aspects linked to health-related quality of life (HRQoL). Methods: This cross-sectional study included 41 patients (median age, 44 years; 85% women) from 13 Spanish centres. Demographic and clinical characteristics were collected along with a cognitive z-score (Rao’s Battery) and HRQoL patient-centred measures, and their relationship was explored using linear regression. We used the Akaike information criterion to model which characteristics were associated with cognition. Results: Fourteen patients (34%) had CI, and the most affected cognitive domain was visual memory. Cognition was similar in AQP4-IgG-positive and -negative patients. Gender, mood, fatigue, satisfaction with life, and perception of stigma were associated with cognitive performance (adjusted R2 = 0.396, p < 0.001). Conclusions: The results highlight the presence of CI and its impact on HRQoL in NMOSD patients. Cognitive and psychological assessments may be crucial to achieve a holistic approach in patient care. Keywords: neuromyelitis optica spectrum disorder; cognition; health-related quality of life; mood Author: Elisabet Lopez-Soley, Jose E. Meca-Lallana, Sara Llufriu, Yolanda Blanco, Rocío Gómez-Ballesteros, Jorge Maurino, Francisco Pérez-Miralles, Lucía Forero, Carmen Calles, María L. Martinez-Gines, Inés Gonzalez-Suarez, Sabas Boyero, Lucía Romero-Pinel, Ángel P. Sempere, Virginia Meca-Lallana, Luis Querol, Lucienne Costa-Frossard, Maria Sepulveda and Elisabeth Solana Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Thu May 26 12:00:10 2022 CEST ModDate: Thu May 26 12:03:36 2022 CEST Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 570340 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- QZKPTP+VnURWPalladioL-Bold Type 1 Custom yes yes no 10 0 YQOTQA+VnURWPalladioL Type 1 Custom yes yes no 15 0 BFMEWM+URWPalladioL-Bold Type 1 Custom yes yes no 19 0 KGCQGS+URWPalladioL-Roma Type 1 Custom yes yes no 24 0 TIRSXB+URWPalladioL-Ital Type 1 Custom yes yes no 28 0 UIJACC+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 46 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 49 0 EILUJF+CMSY10 Type 1 Builtin yes yes no 71 0 QLBIEB+URWPalladioL-BoldItal Type 1 Custom yes yes no 81 0 JMDKPB+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 95 0 JMDLAD+PalatinoLinotype TrueType WinAnsi yes yes no 98 0 JMDLAF+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 101 0 LWLIVD+EURM10 Type 1 Builtin yes yes no 109 0 ZYYJXI+EURB10 Type 1 Builtin yes yes no 116 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-10-19 02:25:41 CEST RepresentationInformation: 282332.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-10-18 11:21:29 CEST Size: 570340 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 273 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Children: Item: Title: Participants Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Cognitive Functions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Patient-Centred Measures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Children: Item: Title: Demographic, Clinical and Patient-Centred Measures of the Cohort Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: Cognitive Characteristics in NMOSD Patients Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Item: Title: Association between Cognition, Demographic, Clinical and Patient-Centred Measures Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77f99a05 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@63440df3 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@3aeaafa6 Info: Title: Cognitive Performance and Health-Related Quality of Life in Patients with Neuromyelitis Optica Spectrum Disorder Author: Elisabet Lopez-Soley, Jose E. Meca-Lallana, Sara Llufriu, Yolanda Blanco, Rocío Gómez-Ballesteros, Jorge Maurino, Francisco Pérez-Miralles, Lucía Forero, Carmen Calles, María L. Martinez-Gines, Inés Gonzalez-Suarez, Sabas Boyero, Lucía Romero-Pinel, Ángel P. Sempere, Virginia Meca-Lallana, Luis Querol, Lucienne Costa-Frossard, Maria Sepulveda and Elisabeth Solana Subject: Background: The frequency of cognitive impairment (CI) reported in neuromyelitis optica spectrum disorder (NMOSD) is highly variable, and its relationship with demographic and clinical characteristics is poorly understood. We aimed to describe the cognitive profile of NMOSD patients, and to analyse the cognitive differences according to their serostatus; furthermore, we aimed to assess the relationship between cognition, demographic and clinical characteristics, and other aspects linked to health-related quality of life (HRQoL). Methods: This cross-sectional study included 41 patients (median age, 44 years; 85% women) from 13 Spanish centres. Demographic and clinical characteristics were collected along with a cognitive z-score (Rao’s Battery) and HRQoL patient-centred measures, and their relationship was explored using linear regression. We used the Akaike information criterion to model which characteristics were associated with cognition. Results: Fourteen patients (34%) had CI, and the most affected cognitive domain was visual memory. Cognition was similar in AQP4-IgG-positive and -negative patients. Gender, mood, fatigue, satisfaction with life, and perception of stigma were associated with cognitive performance (adjusted R2 = 0.396, p < 0.001). Conclusions: The results highlight the presence of CI and its impact on HRQoL in NMOSD patients. Cognitive and psychological assessments may be crucial to achieve a holistic approach in patient care. 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