49c8fa1c992c090ee80e292ea2e82dfc  283189.pdf
5c1c8d3f8eea891a581e8a7846fb8b3a733bc28f  283189.pdf
e515cf649309597f9e9175dd082bb2e69b922c6a20d582f00d3f005c25647e66  283189.pdf

Title:          Cabozantinib for the treatment of solid tumors: a systematic review
Subject:        Ther Adv Med Oncol 2022.14:17588359221107112
Keywords:       cabozantinib,hepatocellular carcinoma,renal cell carcinoma,solid tumor,tyrosine kinase inhibitor,vascular endothelial growth factor
Author:         Pablo Maroto, Camillo Porta, Jaume Capdevila, Andrea B. Apolo, Santiago Viteri, Cristina Rodriguez-Antona, Lidia Martin, and Daniel Castellano
Creator:        Adobe InDesign CS5.5 (7.5)
Producer:       Adobe PDF Library 9.9; modified using iText 4.2.0 by 1T3XT
CreationDate:   Fri Jun 24 13:38:16 2022 CEST
ModDate:        Wed Oct 18 11:29:12 2023 CEST
Tagged:         no
UserProperties: no
Suspects:       no
Form:           none
JavaScript:     no
Pages:          28
Encrypted:      no
Page size:      595.276 x 793.701 pts
Page rot:       0
File size:      905717 bytes
Optimized:      no
PDF version:    1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
BKCLQM+DIN-Regular                   Type 1C           WinAnsi          yes yes yes     48  0
XEENMU+DIN-Bold                      Type 1C           WinAnsi          yes yes yes     49  0
ZHDZOQ+DIN-RegularItalic             Type 1C           WinAnsi          yes yes yes     50  0
KIQNMU+DIN-BoldItalic                Type 1C           WinAnsi          yes yes yes     51  0
WAPHYW+PlantinStd                    Type 1C           Custom           yes yes yes     52  0
HBCVWA+TimesNewRomanPS-BoldMT        Type 1C           WinAnsi          yes yes yes     53  0
JEBHYW+MathematicalPiLTStd           Type 1C           Custom           yes yes yes     54  0
UFXHGA+DIN-MediumAlternate           Type 1C           WinAnsi          yes yes yes    265  0
FATREE+DIN-MediumAlternate           Type 1C           WinAnsi          yes yes yes    167  0
GCNKIC+PlantinStd-Italic             Type 1C           WinAnsi          yes yes yes     66  0
DNBXSI+DIN-Regular                   CID Type 0C       Identity-H       yes yes yes     70  0
XMCIMU+PlantinStd-Bold               Type 1C           WinAnsi          yes yes yes    110  0
SCPEUE+PlantinStd-BoldItalic         Type 1C           WinAnsi          yes yes yes    121  0
RDAYGG+HelveticaLTStd-Roman          Type 1C           WinAnsi          yes yes yes    128  0


Jhove (Rel. 1.22.1, 2019-04-17)
 Date: 2023-10-19 02:25:35 CEST
 RepresentationInformation: 283189.pdf
  ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17)
  LastModified: 2023-10-18 11:43:49 CEST
  Size: 905717
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 0
   FreeObjects: 2
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseNone
   Filters: 
    FilterPipeline: FlateDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 228
      ImageHeight: 45
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 200
      ImageHeight: 70
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 228
      ImageHeight: 45
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
   Fonts: 
    Type0: 
     Font: 
      BaseFont: DNBXSI+DIN-Regular
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: BKCLQM+DIN-Regular
      FontSubset: true
      FirstChar: 32
      LastChar: 237
      FontDescriptor: 
       FontName: BKCLQM+DIN-Regular
       Flags: Nonsymbolic
       FontBBox: -104, -226, 1115, 985
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: RDAYGG+HelveticaLTStd-Roman
      FontSubset: true
      FirstChar: 32
      LastChar: 117
      FontDescriptor: 
       FontName: RDAYGG+HelveticaLTStd-Roman
       Flags: Nonsymbolic
       FontBBox: -166, -225, 1000, 931
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: XEENMU+DIN-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 122
      FontDescriptor: 
       FontName: XEENMU+DIN-Bold
       Flags: Nonsymbolic
       FontBBox: -115, -206, 1158, 1015
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: ZHDZOQ+DIN-RegularItalic
      FontSubset: true
      FirstChar: 32
      LastChar: 122
      FontDescriptor: 
       FontName: ZHDZOQ+DIN-RegularItalic
       Flags: Nonsymbolic
       FontBBox: -148, -225, 1066, 984
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: GCNKIC+PlantinStd-Italic
      FontSubset: true
      FirstChar: 32
      LastChar: 122
      FontDescriptor: 
       FontName: GCNKIC+PlantinStd-Italic
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -148, -250, 1123, 920
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: KIQNMU+DIN-BoldItalic
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: KIQNMU+DIN-BoldItalic
       Flags: Nonsymbolic
       FontBBox: -161, -203, 1107, 1006
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: WAPHYW+PlantinStd
      FontSubset: true
      FirstChar: 29
      LastChar: 252
      FontDescriptor: 
       FontName: WAPHYW+PlantinStd
       Flags: Serif, Nonsymbolic
       FontBBox: -132, -250, 1052, 908
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: HBCVWA+TimesNewRomanPS-BoldMT
      FontSubset: true
      FirstChar: 48
      LastChar: 55
      FontDescriptor: 
       FontName: HBCVWA+TimesNewRomanPS-BoldMT
       Flags: Serif, Nonsymbolic
       FontBBox: -557, -216, 2000, 891
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: JEBHYW+MathematicalPiLTStd
      FontSubset: true
      FirstChar: 27
      LastChar: 31
      FontDescriptor: 
       FontName: JEBHYW+MathematicalPiLTStd
       Flags: Symbolic
       FontBBox: -30, -292, 1023, 981
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: SCPEUE+PlantinStd-BoldItalic
      FontSubset: true
      FirstChar: 69
      LastChar: 84
      FontDescriptor: 
       FontName: SCPEUE+PlantinStd-BoldItalic
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -214, -250, 1191, 939
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: XMCIMU+PlantinStd-Bold
      FontSubset: true
      FirstChar: 32
      LastChar: 122
      FontDescriptor: 
       FontName: XMCIMU+PlantinStd-Bold
       Flags: Serif, Nonsymbolic
       FontBBox: -84, -250, 1153, 934
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
    CIDFontType0: 
     Font: 
      BaseFont: DNBXSI+DIN-Regular
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: DNBXSI+DIN-Regular
       Flags: Symbolic
       FontBBox: -104, -226, 1115, 985
       FontFile3: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
<rdf:Description rdf:about="" xmlns:dc="http://purl.org/dc/elements/1.1/"><dc:format>application/pdf</dc:format><dc:identifier>doi:10.1177/17588359221107112</dc:identifier></rdf:Description>
<rdf:Description rdf:about="" xmlns:prism="http://prismstandard.org/namespaces/basic/2.1/"><prism:doi>10.1177/17588359221107112</prism:doi><prism:url>https://doi.org/10.1177/17588359221107112</prism:url></rdf:Description>
<rdf:Description rdf:about="" xmlns:crossmark="http://crossref.org/crossmark/1.0/"><crossmark:MajorVersionDate>2022-07-13</crossmark:MajorVersionDate><crossmark:CrossmarkDomainExclusive>true</crossmark:CrossmarkDomainExclusive><crossmark:CrossMarkDomains><rdf:Seq><rdf:li>journals.sagepub.com</rdf:li></rdf:Seq></crossmark:CrossMarkDomains><crossmark:DOI>10.1177/17588359221107112</crossmark:DOI></rdf:Description>
<rdf:Description rdf:about="" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"><pdfx:CrossMarkDomains><rdf:Seq><rdf:li>journals.sagepub.com</rdf:li></rdf:Seq></pdfx:CrossMarkDomains><pdfx:CrossmarkDomainExclusive>true</pdfx:CrossmarkDomainExclusive><pdfx:doi>10.1177/17588359221107112</pdfx:doi><pdfx:CrossmarkMajorVersionDate>2022-07-13</pdfx:CrossmarkMajorVersionDate></rdf:Description>
</rdf:RDF></x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 42, 50, 138, 42
      Annotation: 
       Subtype: Link
       Rect: 491, 633, 558, 626
      Annotation: 
       Subtype: Link
       Rect: 491, 625, 527, 617
      Annotation: 
       Subtype: Link
       Rect: 491, 373, 555, 365
      Annotation: 
       Subtype: Link
       Rect: 25, 788, 89, 775
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 456, 39, 552, 31
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 42, 39, 138, 31
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 456, 39, 552, 31
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 42, 39, 138, 31
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 456, 39, 552, 31
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 42, 39, 138, 31
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 456, 39, 552, 31
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 42, 39, 138, 31
    Page: 
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 456, 39, 552, 31
    Page: 
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 42, 39, 138, 31
    Page: 
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 456, 39, 552, 31
    Page: 
     Sequence: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 42, 39, 138, 31
    Page: 
     Sequence: 14
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 456, 39, 552, 31
    Page: 
     Sequence: 15
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 42, 39, 138, 31
    Page: 
     Sequence: 16
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 456, 39, 552, 31
    Page: 
     Sequence: 17
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 42, 39, 138, 31
    Page: 
     Sequence: 18
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 456, 39, 552, 31
    Page: 
     Sequence: 19
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 42, 39, 138, 31
    Page: 
     Sequence: 20
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 456, 39, 552, 31
    Page: 
     Sequence: 21
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 42, 39, 138, 31
      Annotation: 
       Subtype: Link
       Rect: 157, 209, 256, 195
      Annotation: 
       Subtype: Link
       Rect: 42, 194, 116, 183
      Annotation: 
       Subtype: Link
       Rect: 157, 179, 256, 165
      Annotation: 
       Subtype: Link
       Rect: 42, 164, 116, 153
      Annotation: 
       Subtype: Link
       Rect: 455, 710, 481, 699
      Annotation: 
       Subtype: Link
       Rect: 268, 698, 361, 687
    Page: 
     Sequence: 22
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 456, 39, 552, 31
      Annotation: 
       Subtype: Link
       Rect: 182, 366, 304, 356
      Annotation: 
       Subtype: Link
       Rect: 131, 355, 325, 345
      Annotation: 
       Subtype: Link
       Rect: 131, 344, 241, 334
      Annotation: 
       Subtype: Link
       Rect: 182, 294, 304, 284
      Annotation: 
       Subtype: Link
       Rect: 131, 283, 318, 273
      Annotation: 
       Subtype: Link
       Rect: 131, 272, 241, 262
      Annotation: 
       Subtype: Link
       Rect: 244, 222, 312, 212
      Annotation: 
       Subtype: Link
       Rect: 131, 211, 299, 201
      Annotation: 
       Subtype: Link
       Rect: 131, 200, 327, 190
      Annotation: 
       Subtype: Link
       Rect: 131, 189, 156, 179
      Annotation: 
       Subtype: Link
       Rect: 408, 722, 532, 712
      Annotation: 
       Subtype: Link
       Rect: 357, 711, 540, 701
      Annotation: 
       Subtype: Link
       Rect: 408, 661, 532, 651
      Annotation: 
       Subtype: Link
       Rect: 357, 650, 540, 640
      Annotation: 
       Subtype: Link
       Rect: 481, 101, 530, 90
      Annotation: 
       Subtype: Link
       Rect: 357, 90, 545, 79
    Page: 
     Sequence: 23
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 42, 39, 138, 31
    Page: 
     Sequence: 24
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 456, 39, 552, 31
    Page: 
     Sequence: 25
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 42, 39, 138, 31
    Page: 
     Sequence: 26
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 456, 39, 552, 31
    Page: 
     Sequence: 27
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 42, 39, 138, 31
    Page: 
     Sequence: 28
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 456, 39, 552, 31
      Annotation: 
       Subtype: Link
       Rect: 25, 467, 91, 459
      Annotation: 
       Subtype: Link
       Rect: 25, 459, 55, 451
  Checksum: 86b11b7d
   Type: CRC32
  Checksum: 49c8fa1c992c090ee80e292ea2e82dfc
   Type: MD5
  Checksum: 5c1c8d3f8eea891a581e8a7846fb8b3a733bc28f
   Type: SHA-1