febf8996ad4bd9b03c64c397538ebf28 283196.pdf 27182624f6d94ab2085d9f900e26dd631bfd0775 283196.pdf c5b2cc733454fc33c6726bc273e3ffde6f1dc80052714881ae95296da83a919e 283196.pdf Title: Pulmonary Vascular Remodeling and Prognosis in Patients Evaluated for Heart Transplantation: Insights from the OCTOPUS-CHF Study Subject: Objective: In patients with advanced heart failure, the intravascular optical coherence tomography (OCT) of subsegmental pulmonary artery measurements is correlated with right heart catheterization parameters. Our aim was to study the prognostic value of pulmonary OCT, right heart catheterization data, and the echocardiographic estimation of pulmonary pressure in patients studied for elective heart transplants. Methods: This research is an observational, prospective, multicenter study involving 90 adults with a one-year follow-up. Results: A total of 10 patients (11.1%) died due to worsening heart failure before heart transplantation, 50 underwent a heart transplant (55.6%), and 9 died in the first year after the transplant. The patients with and without events (mortality or heart failure-induced hospitalization) had similar data regarding echocardiography, right heart catheterization, and pulmonary OCT (with a median estimated pulmonary artery systolic pressure of 42.0 mmHg, interquartile range (IQR) of 30.3–50.0 vs. 47.0 mmHg, IQR 34.6–59.5 and p = 0.79, median pulmonary vascular resistance of 2.2 Wood units, IQR 1.3–3.7 vs. 2.0 Wood units, IQR 1.4–3.2 and p = 0.99, and a median pulmonary artery wall thickness of 0.2 0.5 mm vs. 0.2 0.6 mm and p = 0.87). Conclusion: Pulmonary vascular remodeling (evaluated with echocardiography, right heart catheterization, and pulmonary OCT) was not associated with prognosis in a selected sample of adults evaluated for elective heart transplants. Pulmonary OCT is safe and feasible for the evaluation of these patients. Keywords: pulmonary hypertension; pulmonary vascular remodeling; advanced heart failure; optical coherence tomography; intravascular imaging; right heart catheterization; heart transplant Author: Jorge Martínez-Solano, Enrique Gutiérrez-Ibañes, Carlos Ortiz-Bautista, María Dolores García-Cosío, Fernando Sarnago-Cebada, Beatriz Díaz-Molina, Isaac Pascual, Juan Francisco Oteo-Domínguez, Manuel Gómez-Bueno, Ramón Calviño-Santos, María G. Crespo-Leiro, Joan Antoni Gómez-Hospital, Carles Díez-López, Juan García-Lara, Iris P. Garrido-Bravo, Luis de la Fuente-Galán, Javier López-Díaz, Sonia Mirabet-Pérez and Manuel Martínez-Sellés Creator: LaTeX with hyperref Producer: pdfTeX-1.40.21 CreationDate: Thu Dec 8 05:02:58 2022 CET ModDate: Thu Dec 8 07:27:39 2022 CET Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 10 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 969532 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- RHFCRE+VnURWPalladioL Type 1 Custom yes yes no 10 0 BPICEY+URWPalladioL-Bold Type 1 Custom yes yes no 15 0 ZOUUAX+URWPalladioL-Roma Type 1 Custom yes yes no 20 0 KRRWGK+URWPalladioL-Ital Type 1 Custom yes yes no 24 0 JGMOZW+CMSY10 Type 1 Builtin yes yes no 28 0 JYPLJJ+VnURWPalladioL-Bold Type 1 Custom yes yes no 32 0 VGVAWT+TimesNewRomanPS-BoldItalicMT Type 1C WinAnsi yes yes no 51 0 BSDWLC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 54 0 WBVKDJ+URWPalladioL-BoldItal Type 1 Custom yes yes no 79 0 JBCOBL+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 99 0 JBCOCN+PalatinoLinotype TrueType WinAnsi yes yes no 102 0 JBCOCP+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 105 0 JBCOBL+PalatinoLinotype,Bold TrueType WinAnsi yes yes no 117 0 JBCOCN+PalatinoLinotype TrueType WinAnsi yes yes no 120 0 JBCOCP+PalatinoLinotype,Italic TrueType WinAnsi yes yes no 123 0 Jhove (Rel. 1.22.1, 2019-04-17) Date: 2023-10-24 02:25:50 CEST RepresentationInformation: 283196.pdf ReportingModule: PDF-hul, Rel. 1.12.1 (2019-04-17) LastModified: 2023-10-23 10:22:13 CEST Size: 969532 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 308 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@262b2c86 Item: Title: Materials and Methods Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@371a67ec Children: Item: Title: Study Design Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@5ed828d Item: Title: Statistical Analysis Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@50d0686 Item: Title: Ethical Aspects Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@7a3d45bd Item: Title: Results Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1e7c7811 Item: Title: Discussion Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@77ec78b9 Item: Title: Conclusions Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@1a3869f4 Item: Title: References Destination: edu.harvard.hul.ois.jhove.module.pdf.PdfSimpleObject@a38d7a3 Info: Title: Pulmonary Vascular Remodeling and Prognosis in Patients Evaluated for Heart Transplantation: Insights from the OCTOPUS-CHF Study Author: Jorge Martínez-Solano, Enrique Gutiérrez-Ibañes, Carlos Ortiz-Bautista, María Dolores García-Cosío, Fernando Sarnago-Cebada, Beatriz Díaz-Molina, Isaac Pascual, Juan Francisco Oteo-Domínguez, Manuel Gómez-Bueno, Ramón Calviño-Santos, María G. Crespo-Leiro, Joan Antoni Gómez-Hospital, Carles Díez-López, Juan García-Lara, Iris P. Garrido-Bravo, Luis de la Fuente-Galán, Javier López-Díaz, Sonia Mirabet-Pérez and Manuel Martínez-Sellés Subject: Objective: In patients with advanced heart failure, the intravascular optical coherence tomography (OCT) of subsegmental pulmonary artery measurements is correlated with right heart catheterization parameters. Our aim was to study the prognostic value of pulmonary OCT, right heart catheterization data, and the echocardiographic estimation of pulmonary pressure in patients studied for elective heart transplants. Methods: This research is an observational, prospective, multicenter study involving 90 adults with a one-year follow-up. Results: A total of 10 patients (11.1%) died due to worsening heart failure before heart transplantation, 50 underwent a heart transplant (55.6%), and 9 died in the first year after the transplant. The patients with and without events (mortality or heart failure-induced hospitalization) had similar data regarding echocardiography, right heart catheterization, and pulmonary OCT (with a median estimated pulmonary artery systolic pressure of 42.0 mmHg, interquartile range (IQR) of 30.3 50.0 vs. 47.0 mmHg, IQR 34.6 59.5 and p = 0.79, median pulmonary vascular resistance of 2.2 Wood units, IQR 1.3 3.7 vs. 2.0 Wood units, IQR 1.4 3.2 and p = 0.99, and a median pulmonary artery wall thickness of 0.2 0.5 mm vs. 0.2 0.6 mm and p = 0.87). Conclusion: Pulmonary vascular remodeling (evaluated with echocardiography, right heart catheterization, and pulmonary OCT) was not associated with prognosis in a selected sample of adults evaluated for elective heart transplants. Pulmonary OCT is safe and feasible for the evaluation of these patients. 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